    <SEC-DOCUMENT>0001493152-25-003718-index.html : 20250127
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    <ACCEPTANCE-DATETIME>20250127083104
    ACCESSION NUMBER:		0001493152-25-003718
    CONFORMED SUBMISSION TYPE:	S-1/A
    PUBLIC DOCUMENT COUNT:		16
    FILED AS OF DATE:		20250127
    DATE AS OF CHANGE:		20250127

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			GT Biopharma, Inc.
    		CENTRAL INDEX KEY:			0000109657
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		IRS NUMBER:				941620407
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-1/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-284032
    		FILM NUMBER:		25555832

    	BUSINESS ADDRESS:
    		STREET 1:		315 MONTGOMERY STREET
    		STREET 2:		10TH FLOOR
    		CITY:			SAN FRANCISCO
    		STATE:			CA
    		ZIP:			94104
    		BUSINESS PHONE:		(800) 304-9888

    	MAIL ADDRESS:
    		STREET 1:		315 MONTGOMERY STREET
    		STREET 2:		10TH FLOOR
    		CITY:			SAN FRANCISCO
    		STATE:			CA
    		ZIP:			94104

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	OXIS INTERNATIONAL INC
    		DATE OF NAME CHANGE:	19940916

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	DDI PHARMACEUTICALS INC
    		DATE OF NAME CHANGE:	19920703

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	DIAGNOSTIC DATA INC /DE/
    		DATE OF NAME CHANGE:	19850312
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>S-1/A
    <SEQUENCE>1
    <FILENAME>forms-1a.htm
    <TEXT>
    Document 1 - file: forms-1a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.35
    <SEQUENCE>2
    <FILENAME>ex4-35.htm
    <TEXT>
    Document 2 - file: ex4-35.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.36
    <SEQUENCE>3
    <FILENAME>ex4-36.htm
    <TEXT>
    Document 3 - file: ex4-36.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.37
    <SEQUENCE>4
    <FILENAME>ex4-37.htm
    <TEXT>
    Document 4 - file: ex4-37.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.51
    <SEQUENCE>5
    <FILENAME>ex10-51.htm
    <TEXT>
    Document 5 - file: ex10-51.htm

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    <DOCUMENT>
    <TYPE>EX-10.52
    <SEQUENCE>6
    <FILENAME>ex10-52.htm
    <TEXT>
    Document 6 - file: ex10-52.htm

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    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>7
    <FILENAME>ex23-1.htm
    <TEXT>
    Document 7 - file: ex23-1.htm

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    <DOCUMENT>
    <TYPE>EX-FILING FEES
    <SEQUENCE>8
    <FILENAME>ex107.htm
    <TEXT>
    Document 8 - file: ex107.htm

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    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>forms-1_001.jpg
    <TEXT>
    Document 9 - file: forms-1_001.jpg

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    <SEQUENCE>10
    <FILENAME>forms-1_012.jpg
    <TEXT>
    Document 10 - file: forms-1_012.jpg

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    <SEQUENCE>11
    <FILENAME>forms-1_003.jpg
    <TEXT>
    Document 11 - file: forms-1_003.jpg

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    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>forms-1_004.jpg
    <TEXT>
    Document 12 - file: forms-1_004.jpg

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    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>forms-1_005.jpg
    <TEXT>
    Document 13 - file: forms-1_005.jpg

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    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>forms-1_010.jpg
    <TEXT>
    Document 14 - file: forms-1_010.jpg

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    <SEQUENCE>15
    <FILENAME>forms-1_011.jpg
    <TEXT>
    Document 15 - file: forms-1_011.jpg

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    <SEQUENCE>16
    <FILENAME>forms-1_009.jpg
    <TEXT>
    Document 16 - file: forms-1_009.jpg

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