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BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables) | 9 Months Ended | 11 Months Ended | 12 Months Ended
--- | --- | --- | ---
Sep. 30, 2022 | Dec. 31, 2021 | Dec. 31, 2021
Summary of Disaggregation of revenue | The following table represents disaggregation of royalty revenue, license fees, milestone revenue and service revenue (in thousands):
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2022 |  |  | 2021 |  |  | 2022 |  |  | 2021 |
Royalty revenue |  | $ | 582 |  |  | $ | — |  |  | $ | 984 |  |  | $ | — |
License fees |  |  | 400 |  |  |  | 200 |  |  |  | 2,455 |  |  |  | 1,950 |
Milestone revenue |  |  | 1,000 |  |  |  | 1,200 |  |  |  | 5,371 |  |  |  | 3,264 |
Service revenue |  |  | 4,928 |  |  |  | 4,877 |  |  |  | 14,922 |  |  |  | 14,254 |
|  | $ | 6,910 |  |  | $ | 6,277 |  |  | $ | 23,732 |  |  | $ | 19,468 |
|  | Disaggregation of Revenue The following table represents disaggregation of service revenue, license fees and milestone revenue (in thousands):
|  | Year ended December 31, |
|  | 2021 |  |  | 2020 |  |  | 2019 |
License fees |  | $ | 4,500 |  |  | $ | 4,260 |  |  | $ | 5,700 |
Milestone revenue |  |  | 10,164 |  |  |  | 7,125 |  |  |  | 7,050 |
Service revenue |  |  | 20,084 |  |  |  | 11,883 |  |  |  | 5,568 |
|  | $ | 34,748 |  |  | $ | 23,268 |  |  | $ | 18,318 |
Summary of Revenue from Significant Partners |  |  | Revenue from significant partners, which is defined as 10% or more of our total revenue, was as follows:
|  | Year-ended December 31, |
|  | 2021 |  |  | 2020 |  |  | 2019 (1) |
Partner A |  |  | 28 | % |  |  | 26 | % |  |  | 17 | %
Partner B |  |  | 24 | % |  |  | 21 | % |  |  | 12 | %
Partner C |  |  | 11 | % |  |  | 10 | % |  |  | 11 | %
(1) | Partner A, B and C in 2019 represent different customers than 2020 and 2021.
Avista Public Acquisition Corp. II [Member] |  |  |
Summary of reconciliation of Class A ordinary shares subject to possible redemption reflected in the balance sheet | As of September 30, 2022 and December 31, 2021, the Class A ordinary shares subject to possible redemption reflected in the balance sheet are reconciled in the following table:
Gross proceeds |  | $ | 230,000,000 |
Less: |  |  |  |
Proceeds allocated to Public Warrants |  |  | (9,813,334 | )
Issuance costs allocated to Class A ordinary shares |  |  | (13,029,901 | )
Plus: |  |  |  |
Remeasurement of Class A ordinary shares to redemption amount |  |  | 28,593,235 |
Class A ordinary shares subject to possible redemption, December 31, 2021 |  |  | 235,750,000 |
Plus: |  |  |  |
Remeasurement of Class A ordinary shares to redemption amount |  |  | 1,438,875 |
Class A ordinary shares subject to possible redemption, September 30, 2022 |  | $ | 237,188,875 |
Gross proceeds |  | $ | 230,000,000 |
Less: |  |  |  |
Proceeds allocated to Public Warrants |  |  | (9,813,334 | )
Issuance costs allocated to Class A ordinary shares |  |  | (13,029,901 | )
Plus: |  |  |  |
Accretion of carrying value to redemption value |  |  | 28,593,235 |
Class A ordinary shares subject to possible redemption |  | $ | 235,750,000 |
Summary of calculation of basic and diluted net loss per ordinary share | The following table reflects the calculation of basic and diluted net loss per ordinary share (in dollars, except per share amounts):
|  | Three Months Ended September 30, 2022 |  |  | Three Months Ended September 30, 2021 |  |  | Nine Months Ended September 30, 2022 |  |  | For the Period from February 5, 2021 (Inception) Through September 30, 2022 |
|  | Class A |  |  | Class B |  |  | Class A |  |  | Class B |  |  | Class A |  |  | Class B |  |  | Class A |  |  | Class B |
Basic and diluted net loss per share: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Numerator: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss |  | $ | (1,973,144 | ) |  | $ | (493,286 | ) |  | $ | (118,394 | ) |  | $ | (52,185 | ) |  | $ | (6,762,069 | ) |  | $ | (1,690,517 | ) |  | $ | (86,633 | ) |  | $ | (93,917 | )
Denominator: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basic and diluted weighted average shares outstanding |  |  | 23,000,000 |  |  |  | 5,750,000 |  |  |  | 12,250,000 |  |  |  | 5,399,457 |  |  |  | 23,000,000 |  |  |  | 5,750,000 |  |  |  | 4,755,274 |  |  |  | 5,155,063 |
Basic and diluted net loss per share |  | $ | (0.09 | ) |  | $ | (0.09 | ) |  | $ | (0.01 | ) |  | $ | (0.01 | ) |  | $ | (0.29 | ) |  | $ | (0.29 | ) |  | $ | (0.02 | ) |  | $ | (0.02 | )
|  | For the Period from February 5, 2021 (inception) Through December 31, 2021 |
|  | Class A |  |  | Class B |
Basic and diluted net loss per share: |  |  |  |  |  |  |  |
Numerator: |  |  |  |  |  |  |  |
Net loss |  | $ | (335,384 | ) |  | $ | (181,058 | )
Denominator: |  |  |  |  |  |  |  |
Basic and diluted weighted average shares outstanding |  |  | 9,857,143 |  |  |  | 5,321,429 |
Basic and diluted net loss per share |  | $ | (0.03 | ) |  | $ | (0.03 | )

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