<SEC-DOCUMENT>0001213900-20-010932.txt : 20200504
<SEC-HEADER>0001213900-20-010932.hdr.sgml : 20200504
<ACCEPTANCE-DATETIME>20200504172512
ACCESSION NUMBER:		0001213900-20-010932
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20200430
FILED AS OF DATE:		20200504
DATE AS OF CHANGE:		20200504

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Essetifin SPA
		CENTRAL INDEX KEY:			0001092601
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32295
		FILM NUMBER:		20845955

	MAIL ADDRESS:	
		STREET 1:		VIA SUDAFRICA 20
		CITY:			ROME
		STATE:			L6
		ZIP:			00144

	FORMER NAME:	
		FORMER CONFORMED NAME:	SIGMA TAU FINANZIARIA SPA
		DATE OF NAME CHANGE:	20030516

	FORMER NAME:	
		FORMER CONFORMED NAME:	SIGMA TAU FINANZIARIA
		DATE OF NAME CHANGE:	19990805

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			CAVAZZA PAOLO
		CENTRAL INDEX KEY:			0001163608

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32295
		FILM NUMBER:		20845956

	MAIL ADDRESS:	
		STREET 1:		VIA TESSERETE, 10
		CITY:			LUGANO
		STATE:			V8
		ZIP:			V8

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Cavazza Enrico
		CENTRAL INDEX KEY:			0001525744

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32295
		FILM NUMBER:		20845957

	MAIL ADDRESS:	
		STREET 1:		VIA PONTINA KM 30,400
		CITY:			POMEZIA (ROME)
		STATE:			L6
		ZIP:			00040

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Cavazza Francesca
		CENTRAL INDEX KEY:			0001525742

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32295
		FILM NUMBER:		20845958

	MAIL ADDRESS:	
		STREET 1:		VIA PONTINA KM 30,400
		CITY:			POMEZIA (ROME)
		STATE:			L6
		ZIP:			00040

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Cavazza Silvia
		CENTRAL INDEX KEY:			0001525743

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32295
		FILM NUMBER:		20845959

	MAIL ADDRESS:	
		STREET 1:		VIA PONTINA KM 30,400
		CITY:			POMEZIA (ROME)
		STATE:			L6
		ZIP:			00040

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Cavazza Preta Martina
		CENTRAL INDEX KEY:			0001718557

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32295
		FILM NUMBER:		20845960

	MAIL ADDRESS:	
		STREET 1:		VIA SUDAFRICA 20
		CITY:			ROME
		STATE:			L6
		ZIP:			00144

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			FENNEC PHARMACEUTICALS INC.
		CENTRAL INDEX KEY:			0001211583
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			A1
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		PO BOX 13628
		STREET 2:		68 TW ALEXANDER DRIVE
		CITY:			RESEARCH TRIANGLE PARK
		STATE:			NC
		ZIP:			27709
		BUSINESS PHONE:		(919) 636-4530

	MAIL ADDRESS:	
		STREET 1:		PO BOX 13628
		STREET 2:		68 TW ALEXANDER DRIVE
		CITY:			RESEARCH TRIANGLE PARK
		STATE:			NC
		ZIP:			27709

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FENNEC PHARMACEUTICALS, INC.
		DATE OF NAME CHANGE:	20140903

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADHEREX TECHNOLOGIES INC
		DATE OF NAME CHANGE:	20021223
</SEC-HEADER>
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<TYPE>4
<SEQUENCE>1
<FILENAME>ownership.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2020-04-30</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001211583</issuerCik>
        <issuerName>FENNEC PHARMACEUTICALS INC.</issuerName>
        <issuerTradingSymbol>FENC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001092601</rptOwnerCik>
            <rptOwnerName>Essetifin SPA</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VIA SUDAFRICA, 20</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ROME</rptOwnerCity>
            <rptOwnerState>L6</rptOwnerState>
            <rptOwnerZipCode>00144</rptOwnerZipCode>
            <rptOwnerStateDescription>ITALY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001163608</rptOwnerCik>
            <rptOwnerName>CAVAZZA PAOLO</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VIA TESSERETE, 10</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUGANO</rptOwnerCity>
            <rptOwnerState>V8</rptOwnerState>
            <rptOwnerZipCode>0000</rptOwnerZipCode>
            <rptOwnerStateDescription>SWITZERLAND</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001525744</rptOwnerCik>
            <rptOwnerName>Cavazza Enrico</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VIA SUDAFRICA, 20</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ROME</rptOwnerCity>
            <rptOwnerState>L6</rptOwnerState>
            <rptOwnerZipCode>00144</rptOwnerZipCode>
            <rptOwnerStateDescription>ITALY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001525742</rptOwnerCik>
            <rptOwnerName>Cavazza Francesca</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VIA SUDAFRICA, 20</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ROME</rptOwnerCity>
            <rptOwnerState>L6</rptOwnerState>
            <rptOwnerZipCode>00144</rptOwnerZipCode>
            <rptOwnerStateDescription>ITALY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001525743</rptOwnerCik>
            <rptOwnerName>Cavazza Silvia</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VIA SUDAFRICA, 20</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ROME</rptOwnerCity>
            <rptOwnerState>L6</rptOwnerState>
            <rptOwnerZipCode>00144</rptOwnerZipCode>
            <rptOwnerStateDescription>ITALY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001718557</rptOwnerCik>
            <rptOwnerName>Cavazza Preta Martina</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VIA SUDAFRICA, 20</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ROME</rptOwnerCity>
            <rptOwnerState>L6</rptOwnerState>
            <rptOwnerZipCode>00144</rptOwnerZipCode>
            <rptOwnerStateDescription>ITALY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2020-04-30</value>
                <footnoteId id="F1"/>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness></transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>768000</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>6.25</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3993694</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Such shares were purchased in connection with an underwritten public offering by the issuer, which closed on May 4, 2020.</footnote>
        <footnote id="F2">Dispositive power over the shares of common stock owned by Essetifin S.p.A. is shared by Enrico Cavazza, Silvia Cavazza, Francesca Cavazza, Martina Cavazza Preta and Paolo Cavazza. Each of Enrico Cavazza, Silvia Cavazza, Francesca Cavazza, Martina Cavazza Preta and Paolo Cavazza disclaims beneficial ownership of all shares of common stock held by Essetifin S.p.A. except to the extent of any pecuniary interest therein.</footnote>
    </footnotes>

    <remarks>Exhibit 99.1 - Joint Filers' Signatures</remarks>

    <ownerSignature>
        <signatureName>Essetifin S.p.A. By: /s/ Marino Zigrossi</signatureName>
        <signatureDate>2020-05-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Marino Zigrossi for Enrico Cavazza by power of attorney</signatureName>
        <signatureDate>2020-05-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Marino Zigrossi for Francesca Cavazza by power of attorney</signatureName>
        <signatureDate>2020-05-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Marino Zigrossi for Silvia Cavazza by power of attorney</signatureName>
        <signatureDate>2020-05-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Marino Zigrossi for Martina Cavazza Preta by power of attorney</signatureName>
        <signatureDate>2020-05-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Fabio Poma for Paolo Cavazza by power of attorney</signatureName>
        <signatureDate>2020-05-04</signatureDate>
    </ownerSignature>
</ownershipDocument>
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<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>ea121345ex99-1_fennec.htm
<DESCRIPTION>JOINT FILERS? SIGNATURES
<TEXT>
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<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 8pt; text-align: right"><B>Exhibit 99.1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 8pt; text-align: center"><B><U>JOINT FILERS&rsquo; SIGNATURES</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 8pt"><B>ESSETIFIN S.P.A.&#9;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 8pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">By: <U>/s/ Marino Zigrossi&#9;&#9;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Name: Marino Zigrossi</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Title: Managing Director</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Date: <U>May 4, 2020&#9;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Enrico Cavazza</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">By: <U>/s/ Marino Zigrossi&#9;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Name: Marino Zigrossi</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Title: Attorney-in-fact</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Date: <U>May 4, 2020&#9;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Francesca Cavazza</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">By: <U>/s/ Marino Zigrossi&#9;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Name: Marino Zigrossi</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Title: Attorney-in-fact</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Date: <U>May 4, 2020&#9;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Silvia Cavazza</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">By: <U>/s/ Marino Zigrossi&#9;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Name: Marino Zigrossi</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Title: Attorney-in-fact</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Date: <U>May 4, 2020&#9;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Martina Cavazza Preta</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">By: <U>/s/ Marino Zigrossi&#9;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Name: Marino Zigrossi</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Title: Attorney-in-fact</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Date: <U>May 4, 2020&#9;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Paolo Cavazza</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">By: <U>/s/ Fabio Poma&#9;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Name: Fabio Poma</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Title: Attorney-in-fact</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Date: <U>May 4, 2020&#9;</U></P>



<P STYLE="margin: 0"></P>

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