<SEC-DOCUMENT>0001415889-24-011584.txt : 20240426
<SEC-HEADER>0001415889-24-011584.hdr.sgml : 20240426
<ACCEPTANCE-DATETIME>20240426161012
ACCESSION NUMBER:		0001415889-24-011584
CONFORMED SUBMISSION TYPE:	4/A
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20240415
FILED AS OF DATE:		20240426
DATE AS OF CHANGE:		20240426

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Haigh Adrian
		CENTRAL INDEX KEY:			0001717425
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32295
		FILM NUMBER:		24883748

	MAIL ADDRESS:	
		STREET 1:		83 ANGLESSA ROAD
		CITY:			BALLSBRIDGE, DUBLIN
		STATE:			L2
		ZIP:			D04H27

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			FENNEC PHARMACEUTICALS INC.
		CENTRAL INDEX KEY:			0001211583
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			A1
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		PO BOX 13628
		STREET 2:		68 TW ALEXANDER DRIVE
		CITY:			RESEARCH TRIANGLE PARK
		STATE:			NC
		ZIP:			27709
		BUSINESS PHONE:		(919) 636-4530

	MAIL ADDRESS:	
		STREET 1:		PO BOX 13628
		STREET 2:		68 TW ALEXANDER DRIVE
		CITY:			RESEARCH TRIANGLE PARK
		STATE:			NC
		ZIP:			27709

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FENNEC PHARMACEUTICALS, INC.
		DATE OF NAME CHANGE:	20140903

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADHEREX TECHNOLOGIES INC
		DATE OF NAME CHANGE:	20021223
</SEC-HEADER>
<DOCUMENT>
<TYPE>4/A
<SEQUENCE>1
<FILENAME>form4a-04262024_040402.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4/A</documentType>

    <periodOfReport>2024-04-15</periodOfReport>

    <dateOfOriginalSubmission>2024-04-16</dateOfOriginalSubmission>

    <issuer>
        <issuerCik>0001211583</issuerCik>
        <issuerName>FENNEC PHARMACEUTICALS INC.</issuerName>
        <issuerTradingSymbol>FENC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001717425</rptOwnerCik>
            <rptOwnerName>Haigh Adrian</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O FENNEC PHARMACEUTICALS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>PO BOX 13628, 68 TW ALEXANDER DRIVE</rptOwnerStreet2>
            <rptOwnerCity>RESEARCH TRIANGLE PARK</rptOwnerCity>
            <rptOwnerState>NC</rptOwnerState>
            <rptOwnerZipCode>27709</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>CHIEF OPERATING OFFICER</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>1</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Shares</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <transactionDate>
                <value>2024-04-15</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>22222</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>2.31</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>22222</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Shares</value>
                <footnoteId id="F2"/>
            </securityTitle>
            <transactionDate>
                <value>2024-04-16</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>22222</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>2.31</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>44444</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">On April 16, 2024, the reporting person filed a Form 4 that mistakenly indicated a transaction code of &quot;S&quot; in Column 3 of Table I concerning the reporting person's acquisition of 22,222 common shares on April 15, 2024, and an additional 22,222 common shares on April 16, 2024, each pursuant to an option exercise pursuant to a 10b5-1 plan dated August 17, 2023.  The correct transaction code for the reporting person's acquisition of these shares is &quot;M&quot;.</footnote>
        <footnote id="F2">On April 16, 2024, the reporting person filed a Form 4 that mistakenly indicated a transaction code of &quot;S&quot; in Column 3 of Table I concerning the reporting person's acquisition of 22,222 common shares on April 15, 2024, and an additional 22,222 common shares on April 16, 2024, each pursuant to an option exercise pursuant to a 10b5-1 plan dated August 17, 2023.  The correct transaction code for the reporting person's acquisition of these shares is &quot;M&quot;.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Adrian Haigh</signatureName>
        <signatureDate>2024-04-26</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
