<SEC-DOCUMENT>0001178913-21-001652.txt : 20210507
<SEC-HEADER>0001178913-21-001652.hdr.sgml : 20210507
<ACCEPTANCE-DATETIME>20210507170554
ACCESSION NUMBER:		0001178913-21-001652
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		7
FILED AS OF DATE:		20210507
DATE AS OF CHANGE:		20210507

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Entera Bio Ltd.
		CENTRAL INDEX KEY:			0001638097
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-239843
		FILM NUMBER:		21903818

	BUSINESS ADDRESS:	
		STREET 1:		KIRYAT HADASSAH, MINRAV BUILDING
		STREET 2:		FIFTH FLOOR
		CITY:			JERUSALEM
		STATE:			L3
		ZIP:			9112002
		BUSINESS PHONE:		972-2-532-7151

	MAIL ADDRESS:	
		STREET 1:		KIRYAT HADASSAH, MINRAV BUILDING
		STREET 2:		FIFTH FLOOR
		CITY:			JERUSALEM
		STATE:			L3
		ZIP:			9112002
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>zk2126001.htm
<DESCRIPTION>424B5
<TEXT>
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  <div>
    <div style="text-align: right; line-height: 1.25; font-weight: bold;">
      <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"><font style="color: rgb(255, 0, 0);">Filed pursuant to Rule 424(b)(5)<br>
        Registration No. 333-239843</font></div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25;"><font style="font-weight: bold;">Prospectus Supplement</font><br>
      <div style="line-height: 1.25;">(to Prospectus dated July 22, 2020)</div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;"><img width="208" height="133" src="image0.jpg"></div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">5,000,000 Ordinary Shares</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">We have entered into a Sales Agreement with B. Riley Securities, Inc., or B. Riley Securities, dated May 7, 2021, relating to the sale of our ordinary shares offered by this
      prospectus supplement. In accordance with the terms of the Sales Agreement, under this prospectus supplement we may offer and sell up to 5,000,000 of our ordinary shares, par value NIS 0.0000769 per share from time to time through or to B. Riley
      Securities, acting as our sales agent or principal.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Sales of our ordinary shares, if any, under this prospectus supplement will be made by any method deemed an &#8220;at the market offering&#8221; as defined in Rule 415 under the Securities Act
      of 1933, as amended, or the Securities Act. B. Riley Securities is not required to sell any specific amount, but will act as our sales agent or principal using commercially reasonable efforts consistent with its normal trading and sales practices.
      There is no arrangement for funds to be received in any escrow, trust or similar arrangement.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">
      <div style="text-indent: 18pt; line-height: 1.25;">B. Riley Securities will be entitled to compensation at a commission rate equal to up to 3.0% of the gross sales price per share sold under the Sales Agreement. See &#8220;Plan of Distribution&#8221; beginning
        on page S-10 for additional information regarding the compensation to be paid to B. Riley Securities. In connection with the sale of the ordinary shares on our behalf, B. Riley Securities will be deemed to be an &#8220;underwriter&#8221; within the meaning of
        the Securities Act and the compensation to B. Riley Securities will be deemed to be underwriting commissions or discounts. We have also agreed to provide indemnification and contribution to B. Riley Securities with respect to certain liabilities,
        including liabilities under the Securities Act.</div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">
      <div style="text-indent: 18pt; line-height: 1.25;">Our ordinary shares trade on The Nasdaq Capital Market under the trading symbol &#8220;ENTX&#8221;. On May 4, 2021, the closing prices for our ordinary shares on The Nasdaq Capital Market was $3.09 per share. </div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25; font-weight: bold;">Investing in our ordinary shares involves risks. See &#8220;Risk Factors&#8221; beginning on page S-3 of this prospectus supplement, the accompanying prospectus, and in the
      reports we file with the Securities and Exchange Commission pursuant to the&#160;Securities Exchange Act of 1934, as amended, incorporated by reference in this prospectus supplement before making a decision to invest in our common stock.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25; font-weight: bold;">Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or
      accuracy of this prospectus supplement or the accompanying prospectus. Any representation to the contrary is a criminal offense.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-style: normal; font-variant: normal; text-transform: none;">B. Riley Securities</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25;">
      <div style="line-height: 1.25;">May 7, 2021</div>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="text-align: center; line-height: 1.25;"> <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">TABLE OF CONTENTS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: right; line-height: 1.25;"><u>Page</u></div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">PROSPECTUS SUPPLEMENT</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"> <br>
    </div>
    <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z667c7ca7de594d688080060a642a41fc">

        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#ABOUTTHISPROSPECTUSSUPPLE">About This Prospectus Supplement</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-ii</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#SPECIALNOTEREGARDINGFORWA">Special Note Regarding Forward-Looking Statements</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-iii</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#PROSPECTUSSUPPLEMENTSUMMA">Prospectus Supplement Summary</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-1</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#THEOFFERING">The Offering</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-2</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#RISKFACTORS">Risk Factors</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-3</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#USEOFPROCEEDS">Use of Proceeds</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-7</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#DIVIDENDPOLICY">Dividend Policy</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-8</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#DILUTION">Dilution</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-9</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#PLANOFDISTRIBUTION">Plan of Distribution</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-10</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#LEGALMATTERS">Legal Matters</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-14</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#EXPERTS">Experts</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-14</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#WHEREYOUCANFINDMOREINFORM">Where You Can Find More Information</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-14</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#INCORPORATIONBYREFERENCE">Incorporation By Reference</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-14</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">PROSPECTUS</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table cellspacing="0" cellpadding="3" border="0" style="width: 100%;">

          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td style="width: 90%;"><a href="#a_001">About This Prospectus</a></td>
            <td style="width: 10%; text-align: right;">1</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_002">Where You Can Find More Information</a></td>
            <td style="text-align: right;">1</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_003">Special Note Regarding Forward-Looking Statements</a></td>
            <td style="text-align: right;">2</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_004">Entera Bio Ltd.</a></td>
            <td style="text-align: right;">4</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_005">Risk Factors</a></td>
            <td style="text-align: right;">4</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_006">Use of Proceeds</a></td>
            <td style="text-align: right;">5</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_007">Description of Securities</a></td>
            <td style="text-align: right;">6</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_008">Plan of Distribution</a></td>
            <td style="text-align: right;">15</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_009">Incorporation of Certain Documents by Reference</a></td>
            <td style="text-align: right;">17</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_010">Service of Process and Enforcement of Judgments</a></td>
            <td style="text-align: right;">18</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_011">Expenses</a></td>
            <td style="text-align: right;">19</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_012">Legal Matters</a></td>
            <td style="text-align: right;">19</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_013">Experts</a></td>
            <td style="text-align: right;">19</td>
          </tr>

      </table>
      &#160;&#160;
      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-transform: uppercase; font-size-adjust: none; font-stretch: normal;"><br>
      </p>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageBreak" style="page-break-after: always;">
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      </div>
      <!--PROfilePageNumberReset%LCR%2%S - %%--></div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="ABOUTTHISPROSPECTUSSUPPLE"><!--Anchor--></a>ABOUT THIS PROSPECTUS SUPPLEMENT</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">This document consists of two parts. The first part is this prospectus supplement, which describes the specific terms of this offering. The second part is the accompanying
      prospectus, which is part of a registration statement that we filed with the SEC using a &#8220;shelf&#8221; registration process.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">The accompanying prospectus describes more general information, some of which may not apply to this offering. Under this shelf registration process, we may from time to time
      sell up to 5,000,000 of our ordinary shares, par value NIS 0.0000769 per share under this prospectus supplement at prices and on terms to be determined by market conditions at the time of the offering. The maximum offering price under this prospectus
      supplement shall not exceed the amount available under our prospectus filed on Form F-3 on July 13, 2020.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Before buying any of the ordinary shares that we are offering, we urge you to carefully read both this prospectus supplement and the accompanying prospectus together with all of
      the information incorporated by reference herein, as well as the additional information described under the headings &#8220;Where You Can Find More Information&#8221; and &#8220;Incorporation by Reference.&#8221; These documents contain important information that you should
      consider when making your investment decision.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">To the extent there is a conflict between the information contained in this prospectus supplement, on the one hand, and the information contained in the accompanying prospectus
      or in any document incorporated by reference in this prospectus supplement, on the other hand, you should rely on the information in this prospectus supplement, provided that if any statement in one of these documents is inconsistent with a statement
      in another document having a later date&#8212;for example, a document incorporated by reference in this prospectus supplement&#8212;the statement in the document having the later date modifies or supersedes the earlier statement.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">We have not authorized anyone to provide any information other than that contained in or incorporated by reference in this prospectus supplement, the accompanying prospectus and
      any related free writing prospectus filed by us with the SEC. We have not, and B. Riley Securities has not, authorized anyone to provide you with different information. We take no responsibility for, and provide no assurance as to the reliability of
      any other information that others may give you. This prospectus supplement does not constitute an offer to sell or the solicitation of an offer to buy any securities other than the securities described in this prospectus supplement or an offer to
      sell or the solicitation of an offer to buy such securities in any circumstances in which such offer or solicitation is unlawful. You should assume that the information appearing in this prospectus supplement, the documents incorporated by reference
      and any related free writing prospectus are accurate only as of their respective dates. Our business, financial condition, results of operations and prospects may have changed materially since those dates.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">You should also read and consider the information in the documents to which we have referred you in the sections entitled &#8220;Where You Can Find More Information&#8221; and
      &#8220;Incorporation by Reference&#8221; in this prospectus supplement.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Unless otherwise indicated, all references to the &#8220;Company,&#8221; &#8220;we,&#8221; &#8220;us,&#8221; &#8220;our&#8221; and &#8220;Entera&#8221; refer to Entera Bio Ltd. and its wholly owned subsidiary, Entera Bio Inc., a Delaware
      corporation, unless the context otherwise requires.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - ii</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="SPECIALNOTEREGARDINGFORWA"><!--Anchor--></a>SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Various statements in this report are &#8220;forward-looking statements&#8221; within the meaning of the Private Securities Litigation Reform Act of 1995 and other U.S. Federal securities
      laws. In addition, historic results of scientific research and clinical and preclinical trials do not guarantee that the conclusions of future research or trials would not be different, and historic results referred to in this Annual Report may be
      interpreted differently in light of additional research and clinical and preclinical trials results. Forward-looking statements include all statements that are not historical facts. We have based these forward-looking statements largely on our
      management&#8217;s current expectations and future events and financial trends that we believe may affect our financial condition, results of operations, business strategy and financial needs. Forward-looking statements involve substantial risks and
      uncertainties. All statements, other than statements of historical facts, included in this report regarding our strategy, future operations, future financial position, projected costs, prospects, plans and objectives of management are forward-looking
      statements. These statements are subject to risks and uncertainties and are based on information currently available to our management. Words such as, but not limited to, &#8220;anticipate,&#8221; &#8220;believe,&#8221; &#8220;contemplates,&#8221; &#8220;continue,&#8221; &#8220;could,&#8221; &#8220;design,&#8221;
      &#8220;estimate,&#8221; &#8220;expect,&#8221; &#8220;intend,&#8221; &#8220;likely,&#8221; &#8220;may,&#8221; &#8220;ongoing,&#8221; &#8220;plan,&#8221; &#8220;potential,&#8221; &#8220;predict,&#8221; &#8220;project,&#8221; &#8220;will,&#8221; &#8220;would,&#8221; &#8220;seek,&#8221; &#8220;should,&#8221; &#8220;target,&#8221; or the negative of these terms and similar expressions or words, identify as forward-looking
      statements. The events and circumstances reflected in our forward-looking statements may not occur and actual results could differ materially from those projected in our forward-looking statements. Meaningful factors which could cause actual results
      to differ include, but are not limited to:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div>
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          <tr>
            <td style="width: 33.4pt; vertical-align: top; align: right;">
              <div style="margin-left: 15.4pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">the scope, progress and costs of developing our product candidates such as EB613 for Osteoporosis and EB612 for Hypoparathyroidism, including without limitation any changes to the design of
                the ongoing Phase 2 clinical trial of EB613 or the need for additional clinical trials or development work based on further analysis of the interim data from the ongoing EB613 Phase 2 clinical trial;</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div>
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          <tr>
            <td style="width: 33.4pt; vertical-align: top; align: right;">
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            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">the accuracy of our estimates regarding expenses, capital requirements, the sufficiency of our cash resources and the need for additional financing;</div>
            </td>
          </tr>

      </table>
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div>
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              <div style="margin-left: 15.4pt; line-height: 1.25;">&#8226;</div>
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            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">our ability to raise additional funds on commercially reasonable terms;</div>
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          </tr>

      </table>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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    <div>
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            <td style="width: 33.4pt; vertical-align: top; align: right;">
              <div style="margin-left: 15.4pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">our ability to develop, advance product candidates into, and successfully complete, clinical studies such as our ongoing Phase 2 clinical trial of EB613 in osteoporosis;</div>
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          </tr>

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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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              <div style="text-align: justify; line-height: 1.25;">our reliance on third parties to conduct our clinical trials and on third-party suppliers to supply or produce our product candidates;</div>
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          </tr>

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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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    <div>
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              <div style="text-align: justify; line-height: 1.25;">our interpretation of FDA feedback and guidance and how such guidance may impact our clinical development plans, specifically our ability to utilize the 505(b)(2) pathway for the
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          </tr>

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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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              <div style="text-align: justify; line-height: 1.25;">our expectations regarding licensing, business transactions and strategic collaborations, including our ongoing collaboration with Amgen;</div>
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              <div style="margin-left: 15.4pt; line-height: 1.25;">&#8226;</div>
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            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">our ability to use and expand our drug delivery technology to additional product candidates;</div>
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              <div style="text-align: justify; line-height: 1.25;">our operation as a development stage company with limited operating history and a history of operating losses and our ability to fund our operations going forward;</div>
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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              <div style="text-align: justify; line-height: 1.25;">our ability to continue as a going concern absent access to sources of liquidity;</div>
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              <div style="text-align: justify; line-height: 1.25;">our ability to obtain and maintain regulatory approval for any of our product candidates;</div>
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              <div style="text-align: justify; line-height: 1.25;">our ability to establish and maintain development and commercialization collaborations;</div>
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              <div style="text-align: justify; line-height: 1.25;">any potential commercial launch of current or future product candidates, and the timing, cost or other aspects of such commercialization;</div>
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">our ability to manufacture and supply sufficient amounts of material to support our clinical trials and any potential future commercial requirements;</div>
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              <div style="margin-left: 15.4pt; line-height: 1.25;">&#8226;</div>
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            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">the safety and efficacy of therapeutics marketed by competitors that are targeted toward indications for which we are developing product candidates;</div>
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          </tr>

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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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              <div style="margin-left: 15.4pt; line-height: 1.25;">&#8226;</div>
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            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">the size of any market we may target and the adoption of our product candidates, if approved, by physicians and patients;</div>
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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              <div style="margin-left: 15.4pt; line-height: 1.25;">&#8226;</div>
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            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">our ability to obtain, maintain and protect our intellectual property and operate our business without infringing misappropriating or otherwise violating any intellectual property rights of
                others;</div>
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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              <div style="margin-left: 15.4pt; line-height: 1.25;">&#8226;</div>
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            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">our ability to retain key personnel and recruit additional qualified personnel;</div>
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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              <div style="margin-left: 15.4pt; line-height: 1.25;">&#8226;</div>
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            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">the possibility that competing products or technologies may make any product candidates we may develop and commercialize or our oral delivery technology obsolete;</div>
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          </tr>

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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
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              <div style="margin-left: 15.4pt; line-height: 1.25;">&#8226;</div>
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            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">the pricing and reimbursement of our product candidates, if approved;</div>
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              <div style="margin-left: 15.4pt; line-height: 1.25;">&#8226;</div>
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            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">our ability to develop a sales, marketing and distribution infrastructure, if any;</div>
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
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            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">our ability to manage growth; and</div>
            </td>
          </tr>

      </table>
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
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          <tr>
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              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">the duration and severity of the recent&#160;coronavirus&#160;(COVID-19) outbreak, the actions that may be required to contain the coronavirus or treat its impact, and its impact on our operations
                and workforce, including our research and development and clinical trials.</div>
            </td>
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">All written and verbal forward-looking statements attributable to us or any person acting on our behalf are expressly qualified in their entirety by the cautionary statements
      contained or referred to in this section. We caution investors not to rely too heavily on the forward-looking statements we make or that are made on our behalf. Except as required by law, we are under no duty, and expressly disclaim any obligation,
      to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise. You are advised, however, to consult any further disclosures we make on related subjects in any annual, quarterly or
      current reports that we may file with the Securities and Exchange Commission.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">There can be no assurance that the actual results or developments anticipated by us will be realized or, even if substantially realized, that they will have the expected
      consequences to, or effects on us. Therefore, no assurance can be given that the outcomes stated in such forward-looking statements and estimates will be achieved.</div>
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      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - iv</font></div>
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    <!--PROfilePageNumberReset%Num%1%S - %%-->
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">
        <div style="border: #000000 2px solid; padding: 5px; width: 99%;">
          <div>&#160;</div>
          <div>
            <div style="text-align: center; margin-right: 6pt; line-height: 1.25; font-weight: bold;"><a name="PROSPECTUSSUPPLEMENTSUMMA"><!--Anchor--></a>PROSPECTUS SUPPLEMENT SUMMARY</div>
            <div style="line-height: 1.25;"><br style="line-height: 1.25;">
            </div>
            <div style="text-align: justify; text-indent: 18pt; margin-right: 6pt; margin-left: 6pt; line-height: 1.25; font-style: italic;">This summary highlights selected information contained elsewhere in this prospectus supplement, the accompanying
              prospectus and in the documents we incorporate by reference. This summary does not contain all of the information you should consider before making an investment decision. You should read this entire prospectus supplement carefully,
              especially the risks of investing in our ordinary shares discussed under &#8220;Risk Factors&#8221; beginning on page S-3 of this prospectus supplement, the accompanying prospectus, our Annual Report on Form 20-F for the fiscal year ended December 31,
              2020, and any amendment or update thereto reflected in subsequent filings with the SEC and incorporated by reference in this prospectus supplement and the accompanying prospectus,, along with our consolidated financial statements and notes to
              those consolidated financial statements and the other information incorporated by reference in this prospectus supplement and the accompanying prospectus.</div>
            <div style="line-height: 1.25;"><br style="line-height: 1.25;">
            </div>
            <div style="text-align: justify; margin-right: 6pt; margin-left: 6pt; line-height: 1.25; font-weight: bold;">Entera Bio Ltd.</div>
            <div style="line-height: 1.25">&#160;</div>
            <div style="text-align: justify; margin-right: 6pt; margin-left: 6pt; line-height: 1.25; font-weight: bold;">Our Business</div>
            <div style="line-height: 1.25">&#160;</div>
            <div style="text-align: justify; text-indent: 18pt; margin-right: 6pt; margin-left: 6pt; line-height: 1.25;">We are a clinical-stage biopharmaceutical company focused on the development and commercialization of orally delivered macromolecule
              therapeutics for use in areas with significant unmet medical need where adoption of injectable therapies is limited due to cost, convenience and compliance challenges for patients. Our current strategy for our lead product candidates is to
              use our technology to develop an oral formulation of human parathyroid hormone (1-34), or PTH, which has been approved in the United States in injectable form for over a decade. Our lead oral PTH product candidates are EB613 for the treatment
              of osteoporosis and EB612 for the treatment of hypoparathyroidism.</div>
            <div style="line-height: 1.25">&#160;</div>
            <div style="text-align: justify; margin-right: 6pt; margin-left: 6pt; line-height: 1.25; font-weight: bold;">Corporate Information</div>
            <div style="line-height: 1.25">&#160;</div>
            <div style="text-align: justify; text-indent: 18pt; margin-right: 6pt; margin-left: 6pt; line-height: 1.25;">Our principal and registered office is located at Kiryat Hadassah Minrav Building - Fifth Floor, Jerusalem, Israel, and our telephone
              number is +972-2-532-7151. Our corporate website is located at www.enterabio.com. The information on our website shall not be deemed part of this prospectus supplement.</div>
            <div style="line-height: 1.25">&#160;</div>
            <div style="text-align: justify; margin-right: 6pt; margin-left: 6pt; line-height: 1.25; font-weight: bold;">Implications of Being an &#8220;Emerging Growth Company&#8221;</div>
            <div style="line-height: 1.25">&#160;</div>
            <div style="text-align: justify; text-indent: 18pt; margin-right: 6pt; margin-left: 6pt; line-height: 1.25;">We qualify as an &#8220;emerging growth company&#8221; as defined in the Jumpstart our Business Startups Act of 2012, or the JOBS Act. An emerging
              growth company may take advantage of specified reduced reporting and other burdens that are otherwise applicable generally to public companies. These provisions include an exemption from the auditor attestation requirement in the assessment
              of our internal control over financial reporting pursuant to the Sarbanes-Oxley Act of 2002.</div>
            <div style="line-height: 1.25">&#160;</div>
            <div style="text-align: justify; text-indent: 18pt; margin-right: 6pt; margin-left: 6pt; line-height: 1.25;">We may take advantage of these provisions for a period of five years following the completion of our initial public offering (which
              occurred in July 2018) or such earlier time that we are no longer an emerging growth company. We would cease to be an emerging growth company if we have more than $1.07 billion in annual revenue, have more than $700 million in market value of
              our ordinary shares held by non-affiliates or issue more than $1.0 billion of non-convertible debt over a three-year period. We may choose to take advantage of some but not all of these reduced burdens.</div>
            <div style="text-align: justify; text-indent: 18pt; margin-right: 6pt; margin-left: 6pt; line-height: 1.25;"> <br>
            </div>
          </div>
        </div>
      </div>
      <div style="line-height: 1.25">&#160;</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - 1</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <br>
    <div style="border: #000000 2px solid; padding: 5px; width: 99%;">
      <div>&#160;</div>
      <div>
        <div style="text-align: center; margin-right: 6pt; line-height: 1.25; font-weight: bold;"><a name="THEOFFERING"><!--Anchor--></a>THE OFFERING</div>
        <div style="line-height: 1.25">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold; margin-left: 18pt;">Ordinary Shares Offered by Us</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">Up to 5,000,000 ordinary shares.</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div style="margin-left: 18pt;">&#160;</div>
              </td>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; margin-left: 18pt;"><font style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Ordinary Shares to be Outstanding after this</font>&#160;<font style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Offering</font></div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">Up to 28,782,060 ordinary shares assuming sales of the entire offering amount, at a price of $3.09 per share, which was the last sale price of our ordinary shares as reported on The
                  Nasdaq Capital Market on May 4, 2021. The actual number of shares issued will vary depending on the sales price under this offering.</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div style="margin-left: 18pt;">&#160;</div>
              </td>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold; margin-left: 18pt;">Plan of Distribution</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">Sales of ordinary shares, if any, will be made from time to time in sales deemed to be an &#8220;at the market&#8221; offering as defined in Rule 415 promulgated under the Securities Act. B. Riley
                  Securities will act as agent or principal and will use reasonable best efforts to sell on our behalf all of the ordinary shares requested to be sold by us, consistent with its normal trading and sales practices. See &#8220;Plan of
                  Distribution.&#8221;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div style="margin-left: 18pt;">&#160;</div>
              </td>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold; margin-left: 18pt;">Use of Proceeds</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">We intend to use the net proceeds from this offering, if any, together with our other cash resources, primarily for general corporate purposes, which may include, but are not limited to,
                  research and development costs, including the conduct of one or more clinical trials and process development and manufacturing of our product candidates, potential strategic acquisitions of complementary businesses, services or
                  technologies, expansion of our technology infrastructure and capabilities, working capital, capital expenditures and other general corporate purposes. See &#8220;Use of Proceeds.&#8221;</div>
                <div style="text-align: justify; line-height: 1.25;"> <br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold; margin-left: 18pt;">Risk Factors</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">You should read the &#8220;Risk Factors&#8221; section of this prospectus supplement and in our Annual Report on Form 20-F for the year ended December 31, 2020, and in any updates to those risk
                  factors in our reports on Form 6-K or subsequent Annual Reports on Form 20-F incorporated by reference herein, for a discussion of factors to consider carefully before deciding to purchase our ordinary shares.</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div style="margin-left: 18pt;">&#160;</div>
              </td>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold; margin-left: 18pt;">Nasdaq Capital Market Symbol</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">Our ordinary shares are listed for trading on The Nasdaq Capital Market under the symbol &#8220;ENTX.&#8221;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div style="margin-left: 18pt;">&#160;</div>
              </td>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold; margin-left: 18pt;">Passive Foreign Investment Company Considerations</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">We may be a passive foreign investment company for the current or any other taxable year, which generally would result in adverse U.S. federal income tax consequences to our U.S.
                  investors. See &#8220;Risk Factors&#8221; beginning on page S-3 for further information.</div>
              </td>
            </tr>

        </table>
        <div style="text-align: justify; text-indent: 18pt; margin-right: 6pt; margin-left: 6pt; line-height: 1.25;"> <br>
        </div>
        <div style="text-align: justify; text-indent: 18pt; margin-right: 6pt; margin-left: 6pt; line-height: 1.25;">The number of shares to be outstanding after this offering above is based on our actual ordinary shares outstanding as of December 31, 2020
          and excludes:</div>
        <div style="line-height: 1.25">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 3.85%; vertical-align: top;">&#160;</td>
              <td style="width: 3.85%; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: 92.31%; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">2,570,109 of our ordinary shares issuable upon the exercise of options and RSUs outstanding as of December 31, 2020, at a weighted average exercise price of $4.85 per ordinary share&#894;</div>
                <div style="text-align: justify; line-height: 1.25;"> <br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 3.85%; vertical-align: top;">&#160;</td>
              <td style="width: 3.85%; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: 92.31%; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">4,244,025 of our ordinary shares issuable upon the exercise of warrants outstanding as of December 31, 2020, at a weighted average exercise price of $2.67 per ordinary share; and</div>
                <div style="text-align: justify; line-height: 1.25;"> <br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 3.85%; vertical-align: top;">&#160;</td>
              <td style="width: 3.85%; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: 92.31%; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">1,263,454 ordinary shares covered by awards available for issuance under our equity incentive plan as of December 31, 2020.</div>
              </td>
            </tr>

        </table>
        <div style="line-height: 1.25">&#160;</div>
      </div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - 2</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <br>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="RISKFACTORS"><!--Anchor--></a>RISK FACTORS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25; font-style: italic;">You should carefully consider the risks and uncertainties described under &#8220;Risk Factors&#8221; in our Annual Report on Form 20-F for the year ended December 31, 2020,
      and in any updates to those risk factors in our reports on Form 6-K or subsequent Annual Reports on Form 20-F incorporated by reference herein, as well as the other information in this prospectus supplement and the accompanying prospectus before
      making an investment in our ordinary shares. Our business, financial condition or results of operations could be materially and adversely affected if any of these risks occurs, and as a result, the market price of our ordinary shares could decline
      and you could lose all or part of your investment. To the extent the COVID-19 pandemic adversely affects our business and financial results, it may also have the effect of heightening many of the other risks described in this section and in our
      Annual Report on Form 20-F and other public filings. This prospectus supplement also contains forward-looking statements that involve risks and uncertainties. See &#8220;Special Note Regarding Forward-Looking Statements.&#8221; Our actual results could differ
      materially and adversely from those anticipated in these forward-looking statements as a result of certain factors.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25; font-weight: bold;">Risks related to this offering and ownership of our ordinary shares</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25; font-style: italic; font-weight: bold;">The price of our ordinary shares and tradeable warrants may be volatile, and holders of our ordinary shares could lose all or part of their
      investment.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">The price of securities for publicly traded emerging biopharmaceutical and drug discovery and development companies has been highly volatile and is likely to remain highly volatile
      in the future. The market price of our ordinary shares and tradeable warrants on Nasdaq may fluctuate as a result of a number of factors, some of which are beyond our control, including, but not limited to:</div>
    <div style="line-height: 1.25">&#160;</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z2f708658bd2d44409d0a6e474a548916">

        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">clinical trial results and the timing of the release of such results;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">the amount of our cash resources and our ability to obtain additional funding;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">actual or anticipated fluctuations in our and our competitors&#8217; results of operations and financial condition;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">announcements of research activities, business developments, technological innovations or new products, or acquisitions or expansion plans by us or our competitors;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">success or failure of our research and development projects or those of our competitors;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">our entering into or terminating strategic relationships;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">changes in laws or government regulation;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">regulatory developments and the decisions of regulatory authorities as to the approval or rejection of new or modified products;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">departure of our key personnel;<br>
              <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">disputes related to proprietary rights, including patents, litigation matters and our ability to obtain intellectual property protection for our technologies;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">our sale, or the sale by our significant shareholders, of ordinary shares, warrants or other securities in the future;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">public concern regarding the safety, efficacy or other aspects of the products or methodologies we are developing;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">market conditions in our industry and changes in estimates of the future size and growth rate of our markets;</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - 3</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">market acceptance of our products;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">the mix of products that we sell and related services that we provide;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">the success or failure of our licensees to develop, obtain approval for and commercialize our licensed products, for which we are entitled to contingent payments and royalties;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">publication of the results of preclinical or clinical trials for EB613, EB612 or any other product candidates we may develop;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">failure by us to achieve a publicly announced milestone;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">delays between our expenditures to develop and market new or enhanced products and the generation of sales from those products;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">changes in the amounts that we spend to develop, acquire or license new products, technologies or businesses;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">changes in our expenditures to promote our products;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">variance in our financial performance from the expectations of market analysts;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">the limited trading volume of our ordinary shares and tradeable warrants;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">impacts or disruptions resulting from the COVID-19 pandemic; and</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">general economic and market conditions, including factors unrelated to our industry or operating performance.</div>
          </td>
        </tr>

    </table>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;"> <br>
    </div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">In addition, the stock market in general has recently experienced extreme price and volume fluctuations that have often been unrelated or disproportionate to the operating
      performance of individual companies. Broad market and industry factors may materially affect the market price of companies&#8217; stock, including ours, regardless of actual operating performance.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-indent: 18pt; line-height: 1.25; font-weight: bold;"><font style="font-style: italic;">Our ordinary shares may become the target of a</font>&#160;&#8220;<font style="font-style: italic;">short squeeze.</font>&#8221;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">In 2021, the securities of several companies have increasingly experienced significant and extreme volatility in share price due to short sellers of ordinary shares and
      buy-and-hold decisions of longer investors, resulting in what is sometimes described as a &#8220;short squeeze.&#8221; Short squeezes have caused extreme volatility in those companies and in the market and have led to the price per share of those companies to
      trade at a significantly inflated rate that is disconnected from the underlying value of the company. Sharp rises in a company&#8217;s share price may force traders in a short position to buy the shares to avoid even greater losses. Many investors who have
      purchased shares in those companies at an inflated rate face the risk of losing a significant portion of their original investment as the price per share has declined steadily as interest in those shares have abated. We may be a target of a short
      squeeze, and investors may lose a significant portion or all of their investment if they purchase our shares at a rate that is significantly disconnected from our underlying value.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25; font-style: italic; font-weight: bold;">Future sales of our ordinary shares, other securities convertible into our ordinary shares or preferred shares could cause the market value
      of our ordinary shares to decline and could result in dilution of your shares.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">We may issue up to 5,000,000 of our ordinary shares as part of the offering contemplated by this prospectus supplement and the accompanying prospectus. In addition, our board of
      directors is authorized, without your approval, to cause us to issue additional shares of our ordinary shares or to raise capital through the issuance of debt securities convertible into ordinary shares, options, warrants and other rights, on terms
      and for consideration as our board of directors in its sole discretion may determine. Sales of substantial amounts of our ordinary shares could cause the market price of our ordinary shares to decrease significantly. We cannot predict the effect, if
      any, of future sales of our ordinary shares, or the availability of our ordinary shares for future sales, on the value of our ordinary shares. Sales of substantial amounts of our ordinary shares by our directors or officers or another large
      shareholder, or the perception that such sales could occur, may adversely affect the market price of our ordinary shares.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - 4</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25; font-style: italic; font-weight: bold;">We may be a passive foreign investment company for U.S. federal income tax purposes for the current or any other taxable year, which
      generally would result in adverse U.S. federal income tax consequences to our U.S. investors.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">2</sup></div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">
      <div style="text-indent: 18pt; line-height: 1.25;">Based on current and expected composition of our income and assets and the value of our assets, we believe we were not a passive foreign investment company, or PFIC, for 2020.&#160; However, no assurances
        regarding our PFIC status can be provided for the current taxable year or any future taxable years and there is a risk that we may be treated as a PFIC for any taxable year. In general, a non-U.S. corporation is a PFIC for any taxable year in which
        (i) 75% or more of its gross income consists of passive income (the &#8220;income test&#8221;) or (ii) 50% or more of the average value of its assets (generally determined on a quarterly basis) consists of assets that produce, or are held for the production
        of, passive income (the &#8220;assets test&#8221;). Generally, passive income includes interest, dividends, rents, royalties and certain gains. Cash is a passive asset for PFIC purposes. The assets shown on our balance sheet consist, and are expected to
        continue to consist, primarily of cash and cash equivalents for the foreseeable future. Therefore, whether we will satisfy the assets test for the current or any future taxable year will depend largely on the quarterly value of our goodwill, and on
        how quickly we utilize our current and future cash balances in our business. We may also be a PFIC under the income test. Specifically, there is a risk that we may be or become a PFIC for the current or any other taxable year because (i) for
        purposes of the assets test the value of our goodwill may be determined by reference to the market price of our ordinary shares, which has been, and may continue to be, volatile given the nature of our business and the early stage of our drug
        candidates (and such price has generally been in decline since our initial public offering), (ii) we hold, and expect to continue to hold, cash in amounts that are substantial relative to the value of our goodwill, (iii) our PFIC status for any
        taxable year under the income test may depend on the amount of our interest income compared to the total amount of our gross income, as calculated for U.S. federal income tax purposes (and the revenue shown on our financial statements is not
        calculated based on U.S. tax principles), (iv) the application of the PFIC rules to a company like us is subject to uncertainties in certain respects, and (v) a company&#8217;s annual PFIC status can be determined only after the end of each taxable year.
        We therefore cannot express a view as to whether we will be a PFIC for the current or any future taxable year. If we were a PFIC for any taxable year during which a U.S. investor owned our ordinary shares, such U.S. investor generally will be
        subject to certain adverse U.S. federal income tax consequences, including increased tax liability on gains from dispositions of the ordinary shares and certain distributions, and a requirement to file annual reports with the Internal Revenue
        Service. See &#8220;Item 10.E.&#8212;Taxation&#8212;Material U.S. Federal Income Tax Considerations for U.S. Holders&#8212;Passive Foreign Investment Company Rules&#8221; in our Annual Report on Form 20-F for more information.</div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25; font-style: italic; font-weight: bold;">We have broad discretion to use the proceeds from this offering, and our investment of those proceeds may not yield a favorable return.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Our management has broad discretion to use the proceeds from this offering in ways with which you may not agree. The failure of our management to apply these funds effectively
      could result in unfavorable returns. This could harm our business and could cause the market value of our ordinary shares to decline.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25; font-style: italic; font-weight: bold;">You may experience future dilution as a result of future equity offerings.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">In order to raise additional capital, we may in the future offer additional shares of our ordinary shares, including pursuant to our at-the-market sales program. We cannot predict
      the effect, if any, of future sales of our ordinary shares, or the availability of our ordinary shares for future sales, on the value of our ordinary shares, and investors purchasing shares or other securities in the future could have rights superior
      to existing shareholders, including investors who purchase shares of ordinary shares pursuant to our at-the-market sales program.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25; font-style: italic; font-weight: bold;">It is not possible to predict the actual number of shares we will sell under the Sales Agreement, or the gross proceeds resulting from those
      sales.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Subject to certain limitations in the Sales Agreement and compliance with applicable law, we have the discretion to deliver a placement notice to the sales agent at any time
      throughout the term of the Sales Agreement. The number of shares that are sold through the sales agent after delivering a placement notice will fluctuate based on a number of factors, including the market price of the ordinary shares during the sales
      period, the limits we set with the sales agent in any applicable placement notice, and the demand for our ordinary shares during the sales period. Because the price per share of each share sold will fluctuate during the sales period, it is not
      currently possible to predict the number of shares that will be sold or the gross proceeds to be raised in connection with those sales, if any.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - 5</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25; font-weight: bold;"><font style="font-style: italic;">The ordinary shares offered hereby will be sold in&#160;</font>&#8220;<font style="font-style: italic;">at the market offerings,</font>&#8221;<font style="font-style: italic;">&#160;and investors who buy shares at different times will likely pay different prices.</font></div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Investors who purchase shares in this offering at different times will likely pay different prices, and so they may experience different levels of dilution and different outcomes
      in their investment results. We will have discretion, subject to market demand, to vary the timing, prices, and numbers of shares sold in this offering. In addition, there is no minimum or maximum sales price for shares to be sold in this offering.
      Investors may experience a decline in the value of the shares they purchase in this offering as a result of sales made at prices lower than the prices they paid.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25; font-style: italic; font-weight: bold;">If securities or industry analysts fail to continue publishing research about our business, if they change their recommendations adversely or
      if our results of operations do not meet their expectations, our share price and trading volume could decline.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">The trading market for our ordinary shares will be influenced by the research and reports that industry or securities analysts publish about us or our business. If one or more of
      these analysts cease coverage of our company or fail to publish reports on us regularly, we could lose visibility in the financial markets, which in turn could cause our share price or trading volume to decline. In addition, it is likely that in some
      future period our operating results will be below the expectations of securities analysts or investors. If one or more<font style="font-weight: bold;">&#160;</font>of the analysts who cover us downgrade our shares, or if our results of operations do not
      meet their expectations, our share price could decline.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - 6</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <br>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="USEOFPROCEEDS"><!--Anchor--></a>USE OF PROCEEDS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">We may issue and sell our ordinary shares having aggregate gross sales proceeds of up to 5,000,000 shares of our common stock from time to time. Because there is no minimum
      offering amount required as a condition to close this offering, the actual total public offering amount, commissions and proceeds to us, if any, are not determinable at this time.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">We currently intend to use the net proceeds from this offering primarily for general corporate purposes, which may include, but are not limited to, research and development costs,
      including the conduct of one or more clinical trials and process development and manufacturing of our product candidates, potential strategic acquisitions of complementary businesses, services or technologies, expansion of our technology
      infrastructure and capabilities, working capital, capital expenditures and other general corporate purposes.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Our expected use of net proceeds from this offering represents our current intentions based upon our present plans and business condition. As of the date of this prospectus
      supplement, we cannot predict with certainty all of the particular uses for the net proceeds to be received upon the completion of this offering, if any, or the amounts that we will actually spend on the uses set forth above. The amounts and timing
      of our actual use of net proceeds will vary depending on numerous factors, including our ability to obtain additional financing, the relative success and cost of our research, preclinical and clinical development programs, including a change in our
      planned course of development or the termination of a clinical program necessitated by the results of data received from clinical trials, the amount and timing of additional revenues, if any, received from our collaborations and whether we enter into
      future collaborations. As a result, management will have broad discretion in the application of the net proceeds, and investors will be relying on our judgment regarding the application of the net proceeds of this offering. In addition, we might
      decide to postpone or not pursue other clinical trials or preclinical activities if the net proceeds from this offering and our other sources of cash are less than expected.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Pending their use, we plan to invest the net proceeds, if any, from this offering in short- and intermediate-term interest-bearing financial assets and certificates of deposit.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - 7</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DIVIDENDPOLICY"><!--Anchor--></a>DIVIDEND POLICY</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">We have never paid or declared any cash dividends on our ordinary shares, and we do not anticipate paying any cash dividends on our ordinary shares in the foreseeable future. We
      intend to retain all available funds and any future earnings to fund the development and expansion of our business.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - 8</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DILUTION"><!--Anchor--></a>DILUTION</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">If you invest in our ordinary shares in this offering, your ownership interest will be diluted immediately to the extent of the difference between the price you pay in this
      offering and the net tangible book value per ordinary share after this offering.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">
      <div style="text-indent: 18pt; line-height: 1.25;">Our net tangible book value as of December 31, 2020 was $6.1 million, or $0.29 per ordinary share, based on 21,057,922 ordinary shares then outstanding. After giving effect to the assumed sale by us
        of 5,000,000 our ordinary shares at an assumed public offering price of $3.09 per share (the last sale price of our ordinary shares on May 4, 2021 as reported on The Nasdaq Capital Market), less the estimated commissions and estimated offering
        expenses payable by us, our net tangible book value at December 31, 2020 would have been $20.95 million, or $0.80 per ordinary share. This represents an immediate increase in net tangible book value of $0.51 per share to existing shareholders and
        an immediate dilution of $2.29 per share to investors in this offering. The following table illustrates this per share dilution. The as adjusted information is illustrative only and will adjust based on the actual price to the public, the actual
        number of shares sold and other terms of the offering determined at the time our ordinary shares are sold pursuant to this prospectus supplement and the accompanying prospectus. The shares sold in this offering, if any, will be sold from time to
        time at various prices.</div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
    <table align="center" cellspacing="0" cellpadding="0" border="0" id="zca5cb7272ec4431b9e303ea9f4bf8a1c" style="width: 80%; color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">

        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Assumed public offering price per share</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="2" style="vertical-align: bottom; background-color: #CCEEFF;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom;">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right;">
            <div style="line-height: 1.25;">3.09</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; width: 76%;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Net tangible book value per share as of December 31, 2020</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;">
            <div style="line-height: 1.25;">0.29</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 76%;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Increase in net tangible book value per share after giving effect to this offering</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;">
            <div style="line-height: 1.25;">0.51</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; width: 76%;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Adjusted net tangible book value per share after giving effect to this offering</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;">
            <div style="line-height: 1.25;">0.80</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 76%;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Dilution per share to new investors</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;">
            <div style="line-height: 1.25;">2.29</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
        </tr>

    </table>
    <div style="text-indent: 18pt; line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">The above is based on our actual ordinary shares outstanding as of December 31, 2020 and excludes:</div>
    <div style="line-height: 1.25">&#160;</div>
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        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">2,570,109 of our ordinary shares issuable upon the exercise of options and RSUs outstanding as of December 31, 2020, at a weighted average exercise price of $4.85 per ordinary share&#894;</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">4,244,025 of our ordinary shares issuable upon the exercise of warrants outstanding as of December 31, 2020, at a weighted average exercise price of $2.67 per ordinary share; and</div>
            <div style="text-align: justify; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3.85%; vertical-align: top;">&#160;</td>
          <td style="width: 3.85%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 92.31%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">1,263,454 ordinary shares covered by awards available for issuance under our equity incentive plan as of December 31, 2020.</div>
          </td>
        </tr>

    </table>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;"> <br>
    </div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">To the extent that outstanding options are exercised, you will experience further dilution. In addition, we may choose to raise additional capital due to market conditions or
      strategic considerations even if we believe we have sufficient funds for our current or future operating plans. To the extent that additional capital is raised through the sale of equity or convertible debt securities, the issuance of such securities
      may result in further dilution to our shareholders.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - 9</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <!--PROfilePageNumberReset%Num%10%S - %%-->
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="PLANOFDISTRIBUTION"><!--Anchor--></a>PLAN OF DISTRIBUTION</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">We have entered into a Sales Agreement with B. Riley Securities under which we may issue and sell up to 5,000,000 of our ordinary shares from time to time through or to B. Riley
      Securities acting as our sales agent or principal.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Upon delivery of a placement notice and subject to the terms and conditions of the Sales Agreement, B. Riley Securities may sell our ordinary shares by any method permitted by law
      deemed to be an &#8220;at the market offering&#8221; as defined in Rule 415 promulgated under the Securities Act. We may instruct B. Riley Securities not to sell ordinary shares if the sales cannot be effected at or above the price designated by us from time to
      time. We or B. Riley Securities may suspend the offering of ordinary shares upon notice and subject to other conditions.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">We will pay B. Riley Securities commissions, in cash, for its services in acting as agent in the sale of our ordinary shares. B. Riley Securities will be entitled to compensation
      at a fixed commission rate equal to up to 3.0% of the gross sales price per share sold pursuant to the Sales Agreement. Because there is no minimum offering amount required as a condition to close this offering, the actual total public offering
      amount, commissions and proceeds to us, if any, are not determinable at this time. We have also agreed to reimburse B. Riley Securities for certain specified expenses, including the fees and disbursements of its legal counsel, in an amount not to
      exceed $50,000. Additionally, pursuant to the terms of the Sales Agreement, we agreed to reimburse B. Riley Securities for the documented fees and costs of its legal counsel reasonably incurred in connection with B. Riley Securities&#8217; ongoing
      diligence&#160;arising from the transactions contemplated by the Sales Agreement in an amount not to exceed $2,500 per calendar quarter. We estimate that the total expenses for the offering, excluding compensation and reimbursement payable to B. Riley
      Securities under the terms of the Sales Agreement, will be approximately $170,000.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Settlement for sales of ordinary shares will occur on the second business day following the date on which any sales are made, or on some other date that is agreed upon by us and B.
      Riley Securities in connection with a particular transaction, in return for payment of the net proceeds to us. Sales of our ordinary shares as contemplated in this prospectus supplement will be settled through the facilities of The Depository Trust
      Company or by such other means as we and B. Riley Securities may agree upon. There is no arrangement for funds to be received in an escrow, trust or similar arrangement.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">B. Riley Securities will use its commercially reasonable efforts, consistent with its sales and trading practices, to solicit offers to purchase the ordinary shares under the terms
      and subject to the conditions set forth in the Sales Agreement. In connection with the sale of the ordinary shares on our behalf, B. Riley Securities will be deemed to be an &#8220;underwriter&#8221; within the meaning of the Securities Act and the compensation
      of B. Riley Securities will be deemed to be underwriting commissions or discounts. We have agreed to provide indemnification and contribution to B. Riley Securities against certain civil liabilities, including liabilities under the Securities Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">
      <div style="text-indent: 18pt; line-height: 1.25;">This offering of our ordinary shares pursuant to Sales Agreement will terminate upon the earlier of (1) sale of all shares of our ordinary shares subject to this prospectus supplement or (2) the
        termination of the Sales Agreement as permitted therein. We and B. Riley Securities may each terminate the Sales Agreement at any time upon five days&#8217; prior written notice.</div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Any portion of the 5,000,000 ordinary shares included in this prospectus supplement that is not previously sold or included in an active placement notice pursuant to the Sales
      Agreement is available for sale in other offerings pursuant to the accompanying base prospectus, and if no shares are sold under the Sales Agreement, the full 5,000,000 of ordinary shares may be sold in other offerings pursuant to the accompanying
      base prospectus.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Our ordinary shares are listed on The Nasdaq Capital Market and trades under the symbol &#8220;ENTX.&#8221; The transfer agent of our ordinary shares is American Stock Transfer &amp; Trust
      Company.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - 10</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="MATERIALU.S.FEDERALINCOME"><!--Anchor--></a>MATERIAL U.S. FEDERAL INCOME TAX CONSIDERATIONS FOR U.S. HOLDERS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">The following are material U.S. federal income tax consequences to the U.S. Holders described below of owning and disposing of our Ordinary Shares, but it does not purport to be a
      comprehensive description of all the tax considerations that may be relevant to a particular person&#8217;s decision to own the Ordinary Shares. This discussion applies only to a U.S. Holder that holds our Ordinary Shares as capital assets for U.S. federal
      income tax purposes. In addition, it does not describe all of the tax consequences that may be relevant in light of a U.S. Holder&#8217;s particular circumstances, including alternative minimum tax consequences, any aspect of the provisions of the Internal
      Revenue Code of 1986, as amended, or the Code, commonly known as the Medicare tax and tax consequences applicable to U.S. Holders subject to special rules, such as:</div>
    <div>
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          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">certain financial institutions;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-bottom: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zd10984251fc840a7a08e388b0830fd38">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">dealers or traders in securities that use a mark-to-market method of tax accounting;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-bottom: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z9d362af8d0784e8ba987afb22d9f98d5">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">persons holding Ordinary Shares as part of a &#8220;straddle&#8221; or integrated transaction or persons entering into a constructive sale with respect to the Ordinary Shares;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-bottom: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2f632ca8157344cc9f4727f7b7ef7e98">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">persons whose functional currency for U.S. federal income tax purposes is not the U.S. dollar;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-bottom: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z97ce7957117040ef9343e6d6145f7e9e">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">entities classified as partnerships for U.S. federal income tax purposes;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-bottom: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z6ff1f870bbcd4ab696cc4587a188e8b1">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">tax exempt entities, &#8220;individual retirement accounts&#8221; or &#8220;Roth IRAs&#8221;;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-bottom: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z7a6d523f684e49b7be013464c599011b">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">persons that own or are deemed to own 10% or more of our stock by vote or value; or</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-bottom: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb95c2ac8b62a4f9db7656c4e79642405">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">persons holding our Ordinary Shares in connection with a trade or business conducted outside of the United States.</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">If an entity that is classified as a partnership for U.S. federal income tax purposes owns our Ordinary Shares, the U.S. federal income tax treatment of a partner will generally
      depend on the status of the partner and the activities of the partnership. Partnerships owning our Ordinary Shares and partners in such partnerships should consult their tax advisers as to the particular U.S. federal tax consequences of owning and
      disposing of the Ordinary Shares.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">This discussion is based on the Code, administrative pronouncements, judicial decisions, and final and proposed Treasury regulations, changes to any of which subsequent to the date
      of this Annual Report may affect the tax consequences described herein.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">For purposes of this discussion, a &#8220;U.S. Holder&#8221; is a person who, for U.S. federal income tax purposes, is a beneficial owner of Ordinary Shares, as the case may be, and is:</div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-bottom: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zebb98d14eee64c408a69bfcaaf2e67a8">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">a citizen or individual resident of the United States;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-bottom: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zfddb491ee9cf425b9fdc088c84e6346e">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">a corporation, or other entity taxable as a corporation, created or organized in or under the laws of the United States, any state therein or the District of Columbia; or</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-bottom: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zfdd3ed812791496ebc09d09cb64298de">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25;">an estate or trust the income of which is subject to U.S. federal income taxation regardless of its source.</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="text-align: justify; text-indent: 14.2pt; line-height: 1.25;">U.S. Holders should consult their tax advisers concerning the U.S. federal, state, local and foreign tax consequences of owning and disposing of our Ordinary Shares in their
      particular circumstances.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Taxation of Distributions on Ordinary Shares</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">We currently do not expect to make distributions on our Ordinary Shares. Subject to the discussion below under &#8220;&#8212;Passive Foreign Investment Company Rules,&#8221; any distributions paid
      on our Ordinary Shares (other than certain pro-rata distributions of Ordinary Shares) will be treated as dividends to the extent paid out of our current or accumulated earnings and profits (as determined under U.S. federal income tax principles).
      Because we do not calculate our earnings and profits under U.S. federal income tax principles, it is expected that distributions generally will be reported to U.S. Holders as dividends. Subject to applicable limitations, dividends paid to certain
      non-corporate U.S. Holders may be taxable at the favorable tax rates applicable to &#8220;qualified dividend income.&#8221; Non-corporate U.S. Holders should consult their tax advisers regarding the availability of these favorable rates on dividends in their
      particular circumstances. Dividends will not be eligible for the dividends received deduction generally available to U.S. corporations under the Code and will generally be included in a U.S. Holder&#8217;s income on the date of receipt.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - 11</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Dividend income will include any amounts withheld in respect of Israeli taxes, and will be treated as foreign source income for foreign tax credit purposes. Subject to applicable
      limitations, some of which vary depending upon the U.S. Holder&#8217;s circumstances, Israeli taxes withheld from dividends on our Ordinary Shares will be creditable against the U.S. Holder&#8217;s U.S. federal income tax liability. The rules governing foreign
      tax credits are complex and U.S. Holders should consult their tax advisers regarding the creditability of foreign taxes in their particular circumstances. In lieu of claiming a foreign tax credit, U.S. Holders may elect to deduct foreign taxes
      (including Israeli taxes) in computing their taxable income, subject to applicable limitations. An election to deduct foreign taxes instead of claiming foreign tax credits applies to all foreign taxes paid or accrued in the taxable year.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">If any dividend is paid in foreign currency, the amount of dividend income will be the dividend&#8217;s U.S. dollar amount calculated by reference to the exchange rate in effect on the
      date of receipt, regardless of whether the payment is in fact converted into U.S. dollars. If the dividend is converted into U.S. dollars on the date of receipt, a U.S. Holder should not be required to recognize foreign currency gain or loss in
      respect of the dividend income. A U.S. Holder may have foreign currency gain or loss if the dividend is converted into U.S. dollars after the date of receipt. Such gain or loss would generally be treated as U.S.-source ordinary income or loss.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Sale or Other Taxable Disposition of Ordinary Shares</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Subject to the discussion below under &#8220;Passive Foreign Investment Company Rules,&#8221; gain or loss realized on the sale or other taxable disposition of our Ordinary Shares will be
      capital gain or loss and will be long-term capital gain or loss if the U.S. Holder held the Ordinary Shares for more than one year. The amount of the gain or loss will equal the difference between the U.S. Holder&#8217;s tax basis in the Ordinary Shares
      disposed of and the amount realized on the disposition. This gain or loss will generally be U.S. source gain or loss for foreign tax credit purposes. The deductibility of capital losses is subject to limitations.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Passive Foreign Investment Company Rules</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">
      <div style="text-indent: 18pt; line-height: 1.25;">There is a risk that we may be treated as a PFIC for any taxable year. Although the application of the PFIC rules to a company like us is subject to uncertainties in some respects, based on our
        market capitalization value and our income (including governmental grants) for 2020, we believe that it is reasonable to take the position that we were not a PFIC for 2020, but there can be no assurance that the Internal Revenue Service will agree
        or that a court will uphold this position. For the reasons described below, we cannot express a view as to whether we will be a PFIC for the current or any future taxable year. In general, a non-U.S. corporation is a PFIC for any taxable year in
        which (i) 75% or more of its gross income consists of passive income, or the income test, or (ii) 50% or more of the average&#160; value of its assets consists of assets (generally determined on a quarterly basis) that produce, or are held for the
        production of, passive income, or the assets test. Generally, passive income includes interest, dividends, rents, royalties and certain gains, and cash is a passive asset for PFIC purposes.</div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">The assets shown on our balance sheet consist, and are expected to continue to consist, primarily of cash and cash equivalents for the foreseeable future. Therefore, whether we
      will satisfy the assets test for the current or any future taxable year will depend largely on the quarterly value of our goodwill and on how quickly we utilize our cash in our business. Because (i) the value of our goodwill may be determined by
      reference to the market price of our Ordinary Shares, which has been, and may continue to be volatile given the nature and early stage of our business, (ii) we hold, and expect to continue to hold, a significant amount of cash, and (iii) a company&#8217;s
      annual PFIC status can be determined only after the end of each taxable year, we cannot express a view as to whether we will be a PFIC for the current or any future taxable year. In addition, it is not clear how to apply the income test to a company
      like us, which is still developing its key intangible assets and whose overall losses from research activities significantly exceed the amount of its income (including passive income). If our losses from research and development activities are
      disregarded for purposes of the income test, we may be a PFIC for any taxable year if 75% or more of our gross income (as determined for U.S. federal income tax purposes) for the relevant year is from interest and financial investments. Because the
      revenue shown on our financial statements is not calculated based on U.S. tax principles, and because for any taxable year we may not have sufficient (or any) non-passive revenue, there is a risk that we may be or become a PFIC under the income test
      for any taxable year.</div>
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      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">S - 12</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">For purposes of the PFIC rules for any taxable year, a non-U.S. corporation that directly or indirectly owns at least 25% by value of the shares of another corporation is treated
      as if it held its proportionate share of the assets of the other corporation and received directly its proportionate share of the income of the other corporation.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Under attribution rules, if we were a PFIC for any taxable year and had any subsidiaries or other entities in which we held a direct or indirect equity interest that are also
      PFICs, or Lower-tier PFICs, U.S. Holders would be deemed to own their proportionate share of any such Lower-tier PFICs and would be subject to U.S. federal income tax according to the rules described in the following paragraph on (i) certain
      distributions by a Lower-tier PFIC and (ii) a disposition of shares of a Lower-tier PFIC, in each case as if the U.S. Holders held such shares or equity interests directly, even if the U.S. Holders do not receive the proceeds of those distributions
      or dispositions.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">If we were a PFIC for any taxable year during which a U.S. Holder held our Ordinary Shares, an adverse tax regime would apply to the U.S. Holder&#8217;s investment in our Ordinary
      Shares. Generally, gain recognized upon a taxable disposition (including, under certain circumstances, a pledge) of Ordinary Shares by the U.S. Holder would be allocated ratably over the U.S. Holder&#8217;s holding period for such Ordinary Shares. The
      amounts allocated to the taxable year of disposition and to taxable years prior to the first taxable year in which we were a PFIC would be taxed as ordinary income. The amount allocated to each other taxable year would be subject to tax at the
      highest tax rate in effect for that taxable year for individuals or corporations, as appropriate, and an interest charge would be imposed on the resulting tax liability for each such year. Further, to the extent that any distribution received by a
      U.S. Holder on Ordinary Shares exceeded 125% of the average of the annual distributions received on such Ordinary Shares during the preceding three years or the U.S. Holder&#8217;s holding period, whichever is shorter, that distribution would be subject to
      taxation in the same manner.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">If we were a PFIC for any year during which a U.S. Holder owns Ordinary Shares, we generally would continue to be treated as a PFIC with respect to such U.S. Holder&#8217;s Ordinary
      Shares unless (a) we ceased to be a PFIC and (b) the U.S. Holder has made a deemed sale election under the PFIC rules which may result in recognition of gain (but not loss), taxable under the PFIC rules described above, without the receipt of any
      corresponding cash.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Alternatively, if we were a PFIC and if the Ordinary Shares were regularly traded on a qualified exchange, a U.S. Holder might be able to make a mark-to-market election with
      respect to our Ordinary Shares (but generally not with respect to Lower-tier PFICs, if any) that would result in tax treatment different from the general tax treatment for PFICs described above. The Ordinary Shares would be treated as regularly
      traded in any calendar year in which more than a de minimis quantity of the Ordinary Shares were traded on a qualified exchange on at least 15 days during each calendar quarter. The Nasdaq, where our Ordinary Shares are listed, is a qualified
      exchange for this purpose. If a U.S. Holder makes the mark-to-market election, the U.S. Holder generally will recognize in each year that we are a PFIC as ordinary income any excess of the fair market value of the Ordinary Shares at the end of the
      taxable year over their adjusted tax basis, and will recognize an ordinary loss in respect of any excess of the adjusted tax basis of the Ordinary Shares over their fair market value at the end of the taxable year (but only to the extent of the net
      amount of income previously included as a result of the mark-to-market election). If a U.S. Holder makes the election, the U.S. Holder&#8217;s tax basis in the Ordinary Shares will be adjusted to reflect these income or loss amounts. In addition, if a U.S.
      Holder makes the mark-to-market election, any gain that the U.S. Holder recognizes on the sale or other disposition of Ordinary Shares in a year in which we are a PFIC will be treated as ordinary income and any loss will be treated as an ordinary
      loss (but only to the extent of the net amount of income previously included as a result of the mark-to-market election). U.S. Holders should consult their tax advisers regarding the availability and advisability of making a mark-to-market election
      in their particular circumstances.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;"></div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">If we were a PFIC or, with respect to a particular U.S. Holder, were treated as a PFIC for the taxable year in which we pay a dividend or the prior taxable year, the preferential
      rates discussed above with respect to dividends paid to certain non-corporate U.S. Holders of our Ordinary Shares would not apply. In addition, if we were a PFIC for any taxable year during which a U.S. Holder owns Ordinary Shares, the U.S. Holder
      would be required to file annual reports with the IRS, subject to certain exceptions.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">U.S. Holders should consult their tax advisers regarding the potential application of the PFIC rules to their ownership in our Ordinary Shares.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Information Reporting and Backup Withholding</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Payments of distributions and sales proceeds that are made within the United States or through certain U.S. related financial intermediaries generally are subject to information
      reporting, and may be subject to backup withholding, unless (i) the U.S. Holder is a corporation or other exempt recipient or (ii) in the case of backup withholding, the U.S. Holder provides a correct taxpayer identification number and certifies that
      it is not subject to backup withholding. Backup withholding is not an additional tax. The amount of any backup withholding from a payment to a U.S. Holder will be allowed as a credit against the U.S. Holder&#8217;s U.S. federal income tax liability and may
      entitle it to a refund, provided that the required information is timely furnished to the IRS.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Information with Respect to Foreign Financial Assets</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">Certain U.S. Holders who are individuals and certain specified entities may be required to report information relating to the Ordinary Shares, unless the Ordinary Shares are held
      in an account maintained by a financial institution (in which case the account itself may be reportable if maintained by a non-U.S. financial institution). U.S. Holders should consult their tax advisors regarding their reporting obligations with
      respect to their ownership and disposition of the Ordinary Shares.&#160;</div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="LEGALMATTERS"><!--Anchor--></a>LEGAL MATTERS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">The validity of the issuance of our ordinary shares offered in this prospectus supplement and certain matters of Israeli law will be passed upon for us by Herzog, Fox &amp; Neeman,
      Tel Aviv, Israel, our Israeli counsel. Certain matters of U.S. federal and New York State law will be passed upon for us by Goodwin Procter LLP, New York, New York. B. Riley Securities, Inc. is being represented in connection with this offering by
      Duane Morris LLP, New York, New York.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="EXPERTS"><!--Anchor--></a>EXPERTS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">The financial statements incorporated in this prospectus supplement by reference to the Annual Report on Form 20-F for the year ended December 31, 2020 have been so incorporated in
      reliance on the report (which contains an explanatory paragraph relating to the Company&#8217;s ability to continue as a going concern as described in note 1b to the financial statements) of Kesselman &amp; Kesselman, Certified Public Accountants (Isr.), a
      member firm of PricewaterhouseCoopers International Limited, an independent registered public accounting firm, given on the authority of said firm as experts in auditing and accounting.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="WHEREYOUCANFINDMOREINFORM"><!--Anchor--></a>WHERE YOU CAN FIND MORE INFORMATION</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">We have filed with the U.S. Securities and Exchange Commission a registration statement (including amendments and exhibits to the registration statement) on Form F-3 under the
      Securities Act. Our SEC filings are available to the public over the Internet at the SEC&#8217;s website at <font style="font-style: italic;">http://www.sec.gov</font>. Copies of certain information filed by us with the SEC are also available on our
      website at <font style="font-style: italic;">http://www.enterabio.com</font>. Our website is not a part of this prospectus supplement and is not incorporated by reference in this prospectus supplement.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">This prospectus supplement is part of a registration statement we filed with the SEC. This prospectus supplement omits some information contained in the registration statement in
      accordance with SEC rules and regulations. You should review the information and exhibits in the registration statement for further information on us and our consolidated subsidiaries and the securities we are offering. Statements in this prospectus
      supplement concerning any document we filed as an exhibit to the registration statement or that we otherwise filed with the SEC are not intended to be comprehensive and are qualified by reference to these filings. You should review the complete
      document to evaluate these statements.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="INCORPORATIONBYREFERENCE"><!--Anchor--></a>INCORPORATION BY REFERENCE</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">The SEC allows us to incorporate by reference information into this document. This means that we can disclose important information to you by referring you to another document
      filed separately with the SEC. The information incorporated by reference is considered to be a part of this document, except for any information superseded by information that is included directly in this prospectus supplement or incorporated by
      reference subsequent to the date of this prospectus supplement.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">We incorporate by reference the following documents or information that we have filed with the SEC:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; margin-left: 18pt; line-height: 1.25;">(1) our Annual Report on <a href="https://www.sec.gov/Archives/edgar/data/1638097/000117891321001087/0001178913-21-001087-index.htm">Form 20-F</a> for the fiscal year ended
      December 31, 2020 filed on March 18, 2021; and</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; margin-left: 18pt; line-height: 1.25;">(2) our Reports on Form 6-K filed on <a href="https://www.sec.gov/Archives/edgar/data/1638097/000117891321000372/0001178913-21-000372-index.htm">February 8, 2021</a> and <a href="https://www.sec.gov/Archives/edgar/data/1638097/000117891321000999/0001178913-21-000999-index.htm">March 11, 2021</a>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">All subsequent reports that we file on Form 20-F under the Exchange Act after the date of this prospectus supplement and prior to the termination of the offering shall also be
      deemed to be incorporated by reference into this prospectus supplement and to be a part hereof from the date of filing such documents. We may also incorporate by reference any other Form 6-K that we submit to the SEC after the date of this prospectus
      supplement and prior to the termination of this offering by identifying in such Form 6-K that it is being incorporated by reference into this prospectus supplement.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">As you read the above documents, you may find inconsistencies in information from one document to another. If you find inconsistencies, you should rely on the statements made in
      this prospectus supplement or in the most recent document incorporated by reference herein.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 18pt; line-height: 1.25;">We will provide without charge to each person to whom this prospectus supplement has been delivered, upon the written or oral request of any such person to us, a copy of any or all
      of the documents referred to above that have been or may be incorporated into this prospectus supplement by reference, including exhibits to such documents. Requests for such copies should be directed to:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25;">Kiryat Hadassah<br>
      Minrav Building - Fifth Floor<br>
      Jerusalem, Israel<br>
      Tel: +972-2-532-7151</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
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    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; font-size-adjust: none; font-stretch: normal;"><b><i>PROSPECTUS</i></b></p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 14pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; font-size-adjust: none; font-stretch: normal;"><b>$100,000,000<br>
          Ordinary Shares, Debt Securities, Warrants, Rights and Units&#160;</b></p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; font-size-adjust: none; font-stretch: normal;"><img src="image00002.jpg"></p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 18pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; font-size-adjust: none; font-stretch: normal;"><b>ENTERA BIO LTD.</b></p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <div style="margin: 3pt auto; width: 25%;">
        <div style="font-size: 1pt; border-top-color: black; border-top-width: 1pt; border-top-style: solid;">&#160;</div>
      </div>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We may offer from time to time, in one or more offerings, ordinary shares, senior debt securities,
        subordinated debt securities, warrants, rights and units (collectively, the &#8220;securities&#8221;). This prospectus describes the general terms of these securities and the general manner in which these securities will be offered. We will provide the
        specific terms of these securities in supplements to this prospectus. The prospectus supplements will also describe the specific manner in which these securities will be offered and may also supplement, update or amend information contained in this
        prospectus. You should read this prospectus and any applicable prospectus supplement before you invest.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">The securities covered by this prospectus may be offered through one or more underwriters, dealers and
        agents, or directly to purchasers. The names of any underwriters, dealers or agents, if any, will be included in a supplement to this prospectus. For general information about the distribution of securities offered, please see &#8220;Plan of
        Distribution&#8221; beginning on page 15.&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">Our ordinary shares are listed on the Nasdaq Capital Market, or Nasdaq, under the symbol &#8220;ENTX&#8221;. On May
        19, 2020, the average of the bid and asked prices for our ordinary shares on Nasdaq was $3.00 per share. As of May 19, 2020, the aggregate market value of our outstanding ordinary shares held by non-affiliates was approximately $41.7 million based
        on 18,234,191 outstanding ordinary shares, of which approximately 13,921,776 ordinary shares were held by non-affiliates. We have not offered any of our ordinary shares pursuant to General Instruction I.B.5 of Form F-3 during the prior 12 calendar
        month period that ends on, and includes, the date of this prospectus.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;"> <br>
      </p>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageBreak" style="page-break-after: always;">
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      </div>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;"><br>
      </p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;"><b>Investing in the securities involves risks. You should carefully review the &#8220;Risk Factors&#8221; section set
          forth in our most recent annual report on Form 20-F, which is incorporated by reference herein, as well as in any other recently filed reports and, if any, in the relevant prospectus supplement.</b></p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;"><b>NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES COMMISSION HAS APPROVED OR
          DISAPPROVED OF THESE SECURITIES OR PASSED UPON THE ADEQUACY OR ACCURACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.</b></p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; font-size-adjust: none; font-stretch: normal;">The date of this prospectus is July 13, 2020.</p>
    </div>
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    </div>
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    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160; <br>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;"> We have not authorized any other person to provide you with information different from or in addition to
        that included in this prospectus and any prospectus supplement. We are not making an offer to sell the securities in any jurisdiction where the offer or sale is not permitted. You should not assume that the information in this prospectus or any
        prospectus supplement is accurate as of any date other than the date on the front of those documents.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">In this prospectus, the terms &#8220;Entera,&#8221; &#8220;we,&#8221; &#8220;us,&#8221; &#8220;our,&#8221; &#8220;the Company&#8221; and &#8220;our company&#8221; refer to Entera
        Bio Ltd.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td style="width: 90%;"><a href="#a_001">About This Prospectus</a></td>
            <td style="width: 10%; text-align: right;">1</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_002">Where You Can Find More Information</a></td>
            <td style="text-align: right;">1</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_003">Special Note Regarding Forward-Looking Statements</a></td>
            <td style="text-align: right;">2</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_004">Entera Bio Ltd.</a></td>
            <td style="text-align: right;">4</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_005">Risk Factors</a></td>
            <td style="text-align: right;">4</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_006">Use of Proceeds</a></td>
            <td style="text-align: right;">5</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_007">Description of Securities</a></td>
            <td style="text-align: right;">6</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_008">Plan of Distribution</a></td>
            <td style="text-align: right;">15</td>
          </tr>
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            <td><a href="#a_009">Incorporation of Certain Documents by Reference</a></td>
            <td style="text-align: right;">17</td>
          </tr>
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            <td><a href="#a_010">Service of Process and Enforcement of Judgments</a></td>
            <td style="text-align: right;">18</td>
          </tr>
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            <td><a href="#a_011">Expenses</a></td>
            <td style="text-align: right;">19</td>
          </tr>
          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_012">Legal Matters</a></td>
            <td style="text-align: right;">19</td>
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          <tr style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom;">
            <td><a href="#a_013">Experts</a></td>
            <td style="text-align: right;">19</td>
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      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; text-transform: uppercase; font-size-adjust: none; font-stretch: normal;"><a name="a_001"></a>About This Prospectus</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">This prospectus is part of a registration statement on Form F-3 that we filed with the U.S. Securities and
        Exchange Commission (the &#8220;SEC&#8221;), using a &#8220;shelf&#8221; registration process. Under this shelf process, we may, from time to time, sell the securities described in this prospectus in one or more offerings. This prospectus only provides you with a general
        description of the securities we may offer. We may also provide a prospectus supplement that will contain additional or more specific information about the terms of any offering. The prospectus supplement may also add, update or change information
        contained in this prospectus. You should carefully read both this prospectus and an applicable prospectus supplement, if any, together with additional information described under the heading &#8220;Where You Can Find More Information&#8221; before deciding to
        invest in any of the securities being offered.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">This prospectus does not contain all of the information included in the registration statement. For a more
        complete understanding of the offering of the securities, you should refer to the registration statement, including the exhibits thereto. To the extent there is a conflict between the information contained in this prospectus and the prospectus
        supplement, if any, you should rely on the information in the prospectus supplement, provided that if any statement in one of these documents is inconsistent with a statement in another document having a later date<b>&#8212;</b>for example, a document
        incorporated by reference in this prospectus or any prospectus supplement<b>&#8212;</b>the statement in the document having the later date modifies or supersedes the earlier statement.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We have filed with the U.S. Securities and Exchange Commission a registration statement (including
        amendments and exhibits to the registration statement) on Form F-3 under the Securities Act of 1933 (the &#8220;Securities Act&#8221;). This prospectus, which is part of the registration statement, does not contain all of the information set forth in the
        registration statement and the exhibits and schedules to the registration statement. For further information, we refer you to the registration statement and the exhibits and schedules filed as part of the registration statement. If a document has
        been filed as an exhibit to the registration statement, we refer you to the copy of the document that has been filed. Each statement in this prospectus relating to a document filed as an exhibit is qualified in all respects by the filed exhibit.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We are subject to the informational requirements of the Securities Exchange Act of 1934, as amended (the
        &#8220;Exchange Act&#8221;). Accordingly, we are required to file reports and other information with the SEC, including annual reports on Form 20-F and reports on Form 6-K. The SEC maintains an Internet website that contains reports and other information about
        issuers, like us, that file electronically with the SEC. The address of that website is www.sec.gov.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">As a foreign private issuer, we are exempt under the Exchange Act from, among other things, the rules
        prescribing the furnishing and content of proxy statements, and our executive officers, directors and principal shareholders are exempt from the reporting and short-swing profit recovery provisions contained in Section 16 of the Exchange Act. In
        addition, we will not be required under the Exchange Act to file periodic reports and financial statements with the SEC as frequently or as promptly as U.S. companies whose securities are registered under the Exchange Act.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 15.4pt; font-size-adjust: none; font-stretch: normal;">Various statements in this prospectus are &#8220;forward-looking statements&#8221; within the meaning of the Private
        Securities Litigation Reform Act of 1995 and other U.S. Federal securities laws. <font style="background-color: white;">In addition, historic results of scientific research and clinical and preclinical trials do not guarantee that the conclusions
          of future research or trials would not be different, and historic results referred to in this prospectus may be interpreted differently in light of additional research and clinical and preclinical trials results. Forward-looking statements
          include all statements that are not historical facts. We have based these forward-looking statements largely on our management&#8217;s current expectations and future events and financial trends that we believe may affect our financial condition,
          results of operations, business strategy and financial needs. </font>Forward-looking statements involve substantial risks and uncertainties. All statements, other than statements of historical facts, included in this prospectus and any documents
        incorporated by reference herein regarding our strategy, future operations, future financial position, projected costs, prospects, plans and objectives of management are forward-looking statements. These statements are subject to risks and
        uncertainties and are based on information currently available to our management. Words such as, but not limited to, &#8220;anticipate,&#8221; &#8220;believe,&#8221; &#8220;contemplates,&#8221; &#8220;continue,&#8221; &#8220;could,&#8221; &#8220;design,&#8221; &#8220;estimate,&#8221; &#8220;expect,&#8221; &#8220;intend,&#8221; &#8220;likely,&#8221; &#8220;may,&#8221; &#8220;ongoing,&#8221;
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        forward-looking statements may not occur and actual results could differ materially from those projected in our forward-looking statements. Meaningful factors which could cause actual results to differ include, but are not limited to:</p>
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            <td style="text-align: left;"><font style="font-family: Times New Roman, Times, Serif;">the scope, progress and costs of developing our product candidates such as EB613 for Osteoporosis and EB 612 for Hypoparathyroidism;</font></td>
          </tr>

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            <td style="text-align: left;"><font style="font-family: Times New Roman, Times, Serif;">the accuracy of our estimates regarding expenses, capital requirements, the sufficiency of our cash resources and the need for additional financing;</font></td>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td style="text-align: left;"><font style="font-family: Times New Roman, Times, Serif;">our reliance on third parties to conduct our clinical trials and on third-party suppliers to supply or produce our product candidates;</font></td>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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        are expressly qualified in their entirety by the cautionary statements contained or referred to in this section. We caution investors not to rely too heavily on the forward-looking statements we make or that are made on our behalf. Except as
        required by law, we are under no duty, and expressly disclaim any obligation, to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise. You are advised, however, to consult any
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          development and commercialization of orally delivered macromolecule therapeutics for use in areas with significant unmet medical need where adoption of injectable therapies is limited due to cost, convenience and compliance challenges for
          patients. Our current strategy for our lead product candidates is to use our technology to develop an oral formulation of human parathyroid hormone (1-34), or PTH, which has been approved in the United States in injectable form for over a decade.
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      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; font-size-adjust: none; font-stretch: normal;">Corporate Information</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">Our principal and registered office is located at Kiryat Hadassah Minrav Building - Fifth Floor,
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">Before making a decision to invest in our securities, you should carefully consider the risks described
        under &#8220;Risk Factors&#8221; in the applicable prospectus supplement and in our most recent Annual Report on Form 20-F, and in any updates to those risk factors in our reports on Form 6-K incorporated herein, together with all of the other information
        appearing or incorporated by reference in this prospectus and any applicable prospectus supplement, in light of your particular investment objectives and financial circumstances.</p>
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      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; text-transform: uppercase; font-size-adjust: none; font-stretch: normal;">Use of Proceeds</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">Unless otherwise set forth in a prospectus supplement, we currently intend to use the net proceeds of any
        offering of securities for working capital and other general corporate purposes. Accordingly, we will have significant discretion in the use of any net proceeds. We may provide additional information on the use of the net proceeds from the sale of
        the offered securities in an applicable prospectus supplement relating to the offered securities.</p>
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      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; text-transform: uppercase; font-size-adjust: none; font-stretch: normal;">Description of Securities</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;"><i>This section describes the general terms of our securities. The following description is a summary only
          and is qualified by reference to the relevant provisions of Israeli law and our restated certificate of incorporation and by-laws, copies of which are incorporated by reference in this prospectus.&#160;</i></p>
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      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; font-size-adjust: none; font-stretch: normal;">General</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We are an Israeli company incorporated with limited liability, and our affairs are governed by the
        provisions of our Articles, as amended and restated from time to time, and by the provisions of applicable Israeli law, including the Companies Law. Our number with the Israeli Registrar of Companies is 514330604. The purpose of our company appears
        in Article 3 of our Articles of Association, which is to engage in any lawful activity. In addition, our Articles of Association authorize us to donate reasonable amounts to any charitable cause. Our registered office is at Kiryat Hadassah, Minrav
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      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; font-size-adjust: none; font-stretch: normal;">Ordinary Shares</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">Our authorized share capital consists of 140,010,000 ordinary shares, par value NIS 0.0000769 per share.
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      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; font-size-adjust: none; font-stretch: normal;">Our Ordinary Shares</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We currently have only one class of shares. Subject to the rights of holders of shares with preferential
        or special rights that may be authorized in the future, holders of our ordinary shares are entitled to participate in the payment of dividends pro rata in accordance with the amounts paid-up or credited as paid-up on the par value of such ordinary
        shares at the time of payment without taking into account any premium paid thereon. In the event that we were to go into liquidation, holders of our ordinary shares are entitled to a pro rata share of surplus assets remaining over liabilities,
        subject to rights conferred on any class of shares which may be issued in the future, in accordance with the amounts paid-up or credited as paid-up on the par value of such ordinary shares, without taking into account any premium paid thereon.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">According to the Companies Law, a company may make a distribution of dividends out of its profits on the
        condition that there is no reasonable concern that the distribution may prevent the company from meeting its existing and expected obligations when they fall due. The Companies Law defines such profit as retained earnings or earnings generated in
        the last two years, whichever is greater, according to the last reviewed or audited financial statements of the company, provided that the end of the period to which the financial statements relate is not more than six months before the
        distribution. Declaration of dividends requires a resolution of our Board, and the court, if applicable and required by the Companies Law, determines that there is no reasonable concern that payment of the dividend will prevent us from satisfying
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">Payment of dividends and proceeds from the sale of the shares or interest or other payments to
        non-residents of Israel, may be subject to Israeli withholding taxes. There are currently no Israeli currency control restrictions on remittances of dividends on our ordinary shares, proceeds from the sale of the shares or interest or other
        payments to non-residents of Israel, except for shareholders who are subjects of countries that are, or have been, in a state of war with Israel.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">As permitted under the Companies Law, pursuant to our amended Articles of Association, the quorum required
        for an ordinary meeting of shareholders consists of at least two shareholders, present in person or by proxy, holding in the aggregate at least 25% of our issued shares conferring voting rights. A shareholders&#8217; meeting will be adjourned for lack of
        a quorum, after half an hour from the time set for such meeting, to the same day in the following week at the same time and place, or any time and place as the board of directors designates in a notice to the shareholders. If at such adjourned
        meeting a quorum as specified above is not present within half an hour from the time designated for holding the meeting, subject to certain exceptions, any two shareholders present in person or by proxy shall constitute a quorum.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">The Chairman of our board of directors is entitled to preside as Chairman of each shareholders&#8217; meeting.
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We are required to hold an annual meeting of our shareholders once every calendar year, but no later than
        15 months after the date of the previous annual meeting. All meetings other than the annual meeting of shareholders are referred to as special meetings. Our board of directors may call special meetings whenever it sees fit, at such time and place
        as it may determine. In addition, the Companies Law provides that the board of directors of a public company is required to convene a special meeting upon the request of:</p>
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            <td><font style="font-family: Times New Roman, Times, Serif;">one or more shareholders holding, in the aggregate: (i) five percent of the outstanding shares of the company and one percent of the voting power in the company; or (ii) five percent
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">The Companies Law enables our board of directors to fix a record date to allow us to determine the
        shareholders entitled to notice of, or to vote at, any meeting of our shareholders. Under current regulations, the record date may be not more than forty days and not less than four days prior to the date of the meeting and notice is required to be
        published at least 21 or 35 days prior to the meeting, depending on the items on the agenda. Under the Companies Law and regulations promulgated thereunder and pursuant to our amended Articles of Association, one or more shareholders holding at
        least 1% of the voting rights at a general meeting of shareholders may request that the board of directors include a matter in the agenda of a general meeting of shareholders to be convened in the future, provided that such matter is appropriate
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        approval of the shareholders of such class holding a majority of the voting rights of such class. The provisions in our Articles of Association pertaining to general meetings also apply to any special meeting of a class of shareholders. The quorum
        required for such special meeting is at least two persons who are the holders of at least 25% of the outstanding shares of that class represented in person or by proxy at such meeting. If such special meeting is adjourned due to a lack of quorum,
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        addition, under the terms of the subscription agreement entered between the Company and several investors in connection with the private placement from December 2019 to February 2020 (the &#8220;Private Placement&#8221;), each such investor has the right to
        participate, pro rata based on its respective purchase amount under the Private Placement, in any future private placement offering of the Company of more than $2,500,000 that closes within one year following the final closing of the Private
        Placement, subject to the conditions thereto.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">The ownership or voting of our ordinary shares by non-residents of Israel is not restricted in any way by
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">The debt securities will be our direct general obligations. The debt securities will be either senior debt
        securities or subordinated debt securities and may be secured or unsecured and may be convertible into other securities, including our ordinary shares. The debt securities will be issued under one or more separate indentures between our company and
        a financial institution that will act as trustee. Senior debt securities will be issued under a senior indenture. Subordinated debt securities will be issued under a subordinated indenture. Each of the senior indenture and the subordinated
        indenture is referred to individually as an indenture and collectively as the indentures. Each of the senior debt trustee and the subordinated debt trustee is referred to individually as a trustee and collectively as the trustees. The material
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            <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt;">our obligation, if any, of the Company to redeem, purchase or repay any debt securities pursuant to any mandatory redemption, sinking fund or other provisions or at
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        to pay the deferred purchase price of property or services, or as a lessee under capital leases, or as secured by a lien on any asset of ours. &#8220;Senior indebtedness&#8221; does not include the subordinated debt securities or any other obligations
        specifically designated as being subordinate in right of payment to, or pari passu with, the subordinated debt securities. In general, the holders of all senior indebtedness are first entitled to receive payment in full of such senior indebtedness
        before the holders of any of the subordinated debt securities are entitled to receive a payment on account of the principal or interest on the indebtedness evidenced by the subordinated debt securities in certain events. These events include:</p>
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            <td><font style="font-family: Times New Roman, Times, Serif;">subject to Israeli law, any insolvency or bankruptcy proceedings, or any receivership, dissolution, winding up, total or partial liquidation, reorganization or other similar
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            <td><font style="font-family: Times New Roman, Times, Serif;">(i) a default having occurred with respect to the payment of principal or interest on or other monetary amounts due and payable with respect to any senior indebtedness or (ii) an
                event of default (other than a default described in clause (i) above) having occurred with respect to any senior indebtedness that permits the holder or holders of such senior indebtedness to accelerate the maturity of such senior
                indebtedness. Such a default or event of default must have continued beyond the period of grace, if any, provided in respect of such default or event of default, and such a default or event of default shall not have been cured or waived or
                shall not have ceased to exist; and</font></td>
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            <td><font style="font-family: Times New Roman, Times, Serif;">the principal of, and accrued interest on, any series of the subordinated debt securities having been declared due and payable upon an event of default pursuant to the subordinated
                indenture. This declaration must not have been rescinded and annulled as provided in the subordinated indenture.</font></td>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We will deliver the debt securities to the trustee for authentication, and the trustee will authenticate
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    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">9</font></div>
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            <td style="width: 0.25in;">(1)</td>
            <td>default in the payment of the principal on the debt securities when it becomes due and payable at maturity or otherwise;</td>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td style="width: 0.25in;">(2)</td>
            <td>default in the payment of interest on the debt securities when it becomes due and payable, and such default continues for a period of 30 days;</td>
          </tr>

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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td style="width: 0.25in;">(3)</td>
            <td>default in the performance, or breach, of any covenant in the indenture (other than defaults specified in clauses (1) or (2) above) and the default or breach continues for a period of 90 consecutive days or more after written notice to us
              by the trustee or to us and the trustee by the holders of 25% or more in aggregate principal amount of the outstanding debt securities of all series affected thereby;</td>
          </tr>

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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td style="width: 0.25in;">(4)</td>
            <td>the occurrence of certain events of bankruptcy, insolvency, or similar proceedings with respect to us or any substantial part of our property; or</td>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td style="width: 0.25in;">(5)</td>
            <td>any other Events of Default that may be set forth in the applicable prospectus supplement.</td>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">If an Event of Default (other than an Event of Default specified in clause (4) above) with respect to the
        debt securities of any series then outstanding occurs and is continuing, then either the trustee or the holders of not less than 25% in principal amount of the securities of all such series then outstanding in respect of which an Event of Default
        has occurred may by notice in writing to us declare the entire principal amount of all debt securities of the affected series, and accrued interest, if any, to be due and payable immediately, and upon any such declaration the same shall become
        immediately due and payable.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">If an Event of Default described in clause (4) above occurs and is continuing, then the principal amount
        of all the debt securities then outstanding and accrued interest shall be and become due immediately and payable without any declaration, notice or other action by any holder of the debt securities or the trustee.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">The trustee will, within 90 days after the occurrence of any default actually known to it, give notice of
        the default to the holders of the debt securities of that series, unless the default was already cured or waived. Unless there is a default in paying principal or interest when due, the trustee can withhold giving notice to the holders if it
        determines in good faith that the withholding of notice is in the interest of the holders.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0in; font-size-adjust: none; font-stretch: normal;"><b>Satisfaction, Discharge and Defeasance</b></p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We may discharge our obligations under each indenture, except as to:</p>
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            <td style="width: 0.25in;"><br>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">the rights of registration of transfer and exchange of debt securities, and our right of optional redemption, if any;</font></td>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">substitution of mutilated, defaced, destroyed, lost or stolen debt securities;</font></td>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">the rights of holders of the debt securities to receive payments of principal and interest;</font></td>
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      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td style="width: 0.25in;"><br>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">the rights, obligations and immunities of the trustee; and</font></td>
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      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">the rights of the holders of the debt securities as beneficiaries with respect to the property deposited with the trustee payable to them (as described below);</font></td>
          </tr>

      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0in; font-size-adjust: none; font-stretch: normal;">when:</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="ze8e01dd56a4447df80b6949f9e956395">

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            <td style="width: 0.25in;"><br>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">either:</font></td>
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      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="z99e901c926b0425a8f03da3cd7e9054e">

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            <td style="width: 0.75in;"><br>
            </td>
            <td style="width: 0.25in;">o</td>
            <td>all debt securities of any series issued that have been authenticated and delivered have been delivered by us to the trustee for cancellation; or</td>
          </tr>

      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman', Times, serif; color: #000000; font-weight: normal; font-style: normal;">10</font></div>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="z06ab16427dea4691bc36fccfcbe92862">

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            <td style="width: 0.75in;"><br>
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            <td style="width: 0.25in;">o</td>
            <td>all the debt securities of any series issued that have not been delivered by us to the trustee for cancellation have become due and payable or will become due and payable within one year or are to be called for redemption within one year
              under arrangements satisfactory to the trustee for the giving of notice of redemption by such trustee in our name and at our expense, and we have irrevocably deposited or caused to be deposited with the trustee as trust funds the entire
              amount sufficient to pay at maturity or upon redemption all debt securities of such series not delivered to the trustee for cancellation, including principal and interest due or to become due on or prior to such date of maturity or
              redemption;</td>
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      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="zb8e82109907a481494e732c6ab678037">

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            <td style="width: 0.25in;"><br>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">we have paid or caused to be paid all other sums then due and payable under such indenture; and</font></td>
          </tr>

      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="z6cc4f7c66a6847b9b2f36674d57009e9">

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            <td style="width: 0.25in;"><br>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">we have delivered to the trustee an officers&#8217; certificate and an opinion of counsel, each stating that all conditions precedent under such indenture relating to the satisfaction and
                discharge of such indenture have been complied with.</font></td>
          </tr>

      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">In addition, unless the applicable prospectus supplement and supplemental indenture otherwise provide, we
        may elect either (i) to have our obligations under each indenture discharged with respect to the outstanding debt securities of any series (&#8220;legal defeasance&#8221;) or (ii) to be released from our obligations under each indenture with respect to certain
        covenants applicable to the outstanding debt securities of any series (&#8220;covenant defeasance&#8221;). Legal defeasance means that we will be deemed to have paid and discharged the entire indebtedness represented by the outstanding debt securities of such
        series under such indenture and covenant defeasance means that we will no longer be required to comply with the obligations with respect to such covenants (and an omission to comply with such obligations will not constitute a default or event of
        default).</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">In order to exercise legal defeasance or covenant defeasance with respect to outstanding debt securities
        of any series:</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="zc1f84d2a305446dda0b5139b273e8696">

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            <td style="width: 0.25in;"><br>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">we must irrevocably have deposited or caused to be deposited with the trustee as trust funds in trust for the purpose of making the following payments, specifically pledged as
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          </tr>

      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="zb962960cf0474e87a503ed8c1d546a8c">

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            <td style="width: 0.25in;"><br>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">money in an amount;</font></td>
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        independent public accountants, to pay and discharge, and which shall be applied by the trustee to pay and discharge, all of the principal and interest at due date or maturity or if we have made irrevocable arrangements satisfactory to the trustee
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            <td><font style="font-family: Times New Roman, Times, Serif;">we have delivered to the trustee an opinion of counsel stating that, under then applicable U.S. federal income tax law, the beneficial owners of the debt securities of that series
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            <td><font style="font-family: Times New Roman, Times, Serif;">no default relating to bankruptcy or insolvency and, in the case of a covenant defeasance, no other default has occurred and is continuing at any time;</font></td>
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            <td><font style="font-family: Times New Roman, Times, Serif;">if at such time the debt securities of such series are listed on a national securities exchange, we have delivered to the trustee an opinion of counsel to the effect that the debt
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            <td><font style="font-family: Times New Roman, Times, Serif;">we have delivered to the trustee an officers&#8217; certificate and an opinion of counsel stating that all conditions precedent with respect to the defeasance have been complied with.</font></td>
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        warrants independently or together with other securities. Warrants sold with other securities may be attached to or separate from the other securities. We will issue warrants under one or more warrant agreements between our company and a warrant
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            <td><font style="font-family: Times New Roman, Times, Serif;">the title of the warrants;</font></td>
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            <td><font style="font-family: Times New Roman, Times, Serif;">the aggregate number of warrants offered;</font></td>
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            <td><font style="font-family: Times New Roman, Times, Serif;">the designation, number and terms of the debt securities, ordinary shares or other securities purchasable upon exercise of the warrants and procedures by which those numbers may be
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            <td><font style="font-family: Times New Roman, Times, Serif;">the exercise price of the warrants;</font></td>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">the dates or periods during which the warrants are exercisable;</font></td>
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            <td><font style="font-family: Times New Roman, Times, Serif;">the designation and terms of any securities with which the warrants are issued;</font></td>
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            <td><font style="font-family: Times New Roman, Times, Serif;">if the warrants are issued as a unit with another security, the date on and after which the warrants and the other security will be separately transferable;</font></td>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">if the exercise price is not payable in U.S. dollars, the foreign currency, currency unit or composite currency in which the exercise price is denominated;</font></td>
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            <td><font style="font-family: Times New Roman, Times, Serif;">any minimum or maximum amount of warrants that may be exercised at any one time;</font></td>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">any terms relating to the modification of the warrants;</font></td>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td><font style="font-family: Times New Roman, Times, Serif;">if applicable, a discussion of the material Israeli and U.S. income tax considerations applicable to the issuance or exercise of such warrants;</font></td>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">any terms, procedures and limitations relating to the transferability, exchange or exercise of the warrants; and</font></td>
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            <td><font style="font-family: Times New Roman, Times, Serif;">any other specific terms of the warrants.</font></td>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We may issue rights to purchase any of our securities or any combination thereof. Rights may be issued
        independently or together with any other offered security and may or may not be transferable by the person purchasing or receiving the rights. The rights may be issued independently or together with any other security offered hereby and may or may
        not be transferable by the shareholder receiving the subscription rights in such offering. In connection with any rights offering to our shareholders, we may enter into a standby underwriting arrangement with one or more underwriters pursuant to
        which such underwriters will purchase any offered securities remaining unsubscribed for after such rights offering. We may also appoint a rights agent that may act solely as our agent in connection with the rights that are sold. Any such agent will
        not assume any obligation or relationship of agency or trust with any of the holders of the rights. In connection with a rights offering to our shareholders, we will distribute certificates evidencing the rights and a prospectus supplement to our
        shareholders on the record date that we set for receiving rights in such rights offering.</p>
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            <td style="width: 0.25in;">&#8226;</td>
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              <div><font style="font-family: Times New Roman, Times, Serif;">the title of such rights;</font></div>
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              <div><font style="font-family: Times New Roman, Times, Serif;">the date on which the right to exercise such rights shall commence, and the date on which such rights shall expire (subject to any extension);</font></div>
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              <div><font style="font-family: Times New Roman, Times, Serif;">if applicable, the material terms of any standby underwriting or other purchase arrangement, or any agency agreement, that we may enter into in connection with the rights
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            <td><font style="font-family: Times New Roman, Times, Serif;">any other terms of such rights, including terms, procedures and limitations relating to the exchange and exercise of such rights.</font></td>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; text-indent: 0in; font-size-adjust: none; font-stretch: normal;"><b>DESCRIPTION OF UNITS</b></p>
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        ordinary shares, debt securities, warrants, rights or any combination of such securities. Each unit will be issued so that the holder of the unit is also the holder of each security included in the unit. Thus, the holder of a unit will have the
        rights and obligations of a holder of each included security. The unit agreement under which a unit is issued may provide that the securities included in the unit may not be held or transferred separately at any time, or at any time before a
        specified date. The applicable prospectus supplement will describe:</p>
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            <td><font style="font-family: Times New Roman, Times, Serif;">the terms of the units and of the ordinary shares, debt securities, warrants and/ or rights comprising the units, including whether and under what circumstances the securities
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          </tr>

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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td><font style="font-family: Times New Roman, Times, Serif;">a description of the terms of any unit agreement governing the units; </font></td>
          </tr>

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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td><font style="font-family: Times New Roman, Times, Serif;">a description of the provisions for the payment, settlement, transfer or exchange of the units; and</font></td>
          </tr>

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            <td><font style="font-family: Times New Roman, Times, Serif;">any material provisions of the governing unit agreement that differ from those described above.</font></td>
          </tr>

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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; font-size-adjust: none; font-stretch: normal;"><font style="text-transform: uppercase;"><b>Forms of Securities</b></font></p>
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        particular investor or by one or more global securities representing the entire issuance of securities. Certificated securities in definitive form and global securities will be issued in registered form. Definitive securities name you or your
        nominee as the owner of the security, and in order to transfer or exchange these securities or to receive payments other than interest or other interim payments, you or your nominee must physically deliver the securities to the trustee, registrar,
        paying agent or other agent, as applicable. Global securities name a depositary or its nominee as the owner of the debt securities or warrants represented by these global securities. The depositary maintains a computerized system that will reflect
        each investor&#8217;s beneficial ownership of the securities through an account maintained by the investor with its broker/dealer, bank, trust company or other representative, as we explain more fully below.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">13</font></div>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; font-size-adjust: none; font-stretch: normal;"><b>Registered Global Securities</b></p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; font-size-adjust: none; font-stretch: normal;"><b>&#160;</b></p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We may issue the registered debt securities and warrants in the form of one or more fully registered
        global securities that will be deposited with a depositary or its nominee identified in the applicable prospectus supplement and registered in the name of that depositary or nominee. In those cases, one or more registered global securities will be
        issued in a denomination or aggregate denominations equal to the portion of the aggregate principal or face amount of the securities to be represented by registered global securities. Unless and until it is exchanged in whole for securities in
        definitive registered form, a registered global security may not be transferred except as a whole by and among the depositary for the registered global security, the nominees of the depositary or any successors of the depositary or those nominees.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">If not described below, any specific terms of the depositary arrangement with respect to any securities to
        be represented by a registered global security will be described in the prospectus supplement relating to those securities. We anticipate that the following provisions will apply to all depositary arrangements.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">Ownership of beneficial interests in a registered global security will be limited to persons, called
        participants, that have accounts with the depositary or persons that may hold interests through participants. Upon the issuance of a registered global security, the depositary will credit, on its book-entry registration and transfer system, the
        participants&#8217; accounts with the respective principal or face amounts of the securities beneficially owned by the participants. Any dealers, underwriters or agents participating in the distribution of the securities will designate the accounts to be
        credited. Ownership of beneficial interests in a registered global security will be shown on, and the transfer of ownership interests will be effected only through, records maintained by the depositary, with respect to interests of participants,
        and on the records of participants, with respect to interests of persons holding through participants. The laws of some states may require that some purchasers of securities take physical delivery of these securities in definitive form. These laws
        may impair your ability to own, transfer or pledge beneficial interests in registered global securities.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">So long as the depositary, or its nominee, is the registered owner of a registered global security, that
        depositary or its nominee, as the case may be, will be considered the sole owner or holder of the securities represented by the registered global security for all purposes under the applicable indenture or warrant agreement. Except as described
        below, owners of beneficial interests in a registered global security will not be entitled to have the securities represented by the registered global security registered in their names, will not receive or be entitled to receive physical delivery
        of the securities in definitive form and will not be considered the owners or holders of the securities under the applicable indenture or warrant agreement. Accordingly, each person owning a beneficial interest in a registered global security must
        rely on the procedures of the depositary for that registered global security and, if that person is not a participant, on the procedures of the participant through which the person owns its interest, to exercise any rights of a holder under the
        applicable indenture or warrant agreement. We understand that under existing industry practices, if we request any action of holders or if an owner of a beneficial interest in a registered global security desires to give or take any action that a
        holder is entitled to give or take under the applicable indenture or warrant agreement, the depositary for the registered global security would authorize the participants holding the relevant beneficial interests to give or take that action, and
        the participants would authorize beneficial owners owning through them to give or take that action or would otherwise act upon the instructions of beneficial owners holding through them.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">Principal, premium, if any, and interest payments on debt securities, and any payments to holders with
        respect to warrants, represented by a registered global security registered in the name of a depositary or its nominee will be made to the depositary or its nominee, as the case may be, as the registered owner of the registered global security.
        None of Entera, its affiliates, the trustees, the warrant agents or any other agent of us, agent of the trustees or agent of the warrant agents will have any responsibility or liability for any aspect of the records relating to payments made on
        account of beneficial ownership interests in the registered global security or for maintaining, supervising or reviewing any records relating to those beneficial ownership interests.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We expect that the depositary for any of the securities represented by a registered global security, upon
        receipt of any payment of principal, premium, interest or other distribution of underlying securities or other property to holders on that registered global security, will immediately credit participants&#8217; accounts in amounts proportionate to their
        respective beneficial interests in that registered global security as shown on the records of the depositary. We also expect that payments by participants to owners of beneficial interests in a registered global security held through participants
        will be governed by standing customer instructions and customary practices, as is now the case with the securities held for the accounts of customers in bearer form or registered in &#8220;street name,&#8221; and will be the responsibility of those
        participants.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">If the depositary for any of these securities represented by a registered global security is at any time
        unwilling or unable to continue as depositary or ceases to be a clearing agency registered under the Exchange Act, and a successor depositary registered as a clearing agency under the Exchange Act is not appointed by us within 90 days, we will
        issue securities in definitive form in exchange for the registered global security that had been held by the depositary. Any securities issued in definitive form in exchange for a registered global security will be registered in the name or names
        that the depositary gives to the relevant trustee, warrant agent or other relevant agent of ours or theirs. It is expected that the depositary&#8217;s instructions will be based upon directions received by the depositary from participants with respect to
        ownership of beneficial interests in the registered global security that had been held by the depositary.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">14</font></div>
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      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; text-transform: uppercase; font-size-adjust: none; font-stretch: normal;"><a name="a_008"></a>Plan of Distribution</p>
      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; text-transform: uppercase; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We may sell the securities in one or more of the following ways (or in any combination) from time to time:</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">through underwriters or dealers;</font></td>
          </tr>

      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="zba1e5f1ed6d24359a296bfebbe6cb80a">

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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">directly to a limited number of purchasers or to a single purchaser;</font></td>
          </tr>

      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="zb2d9e00d36db493d85aeb3c04e664fc8">

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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">in &#8220;at-the-market&#8221; offerings, within the meaning of Rule 415(a)(4) of the Securities Act, to or through a market maker or into an existing trading market on an exchange or otherwise;</font></td>
          </tr>

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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="z5b2610a78361437bbff52f9a52634c1b">

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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">through agents; or</font></td>
          </tr>

      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="z381f8792bee3436387984c25e944ffdc">

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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">through any other method permitted by applicable law and described in the applicable prospectus supplement.</font></td>
          </tr>

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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">The prospectus supplement will state the terms of the offering of the securities, including:</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td style="width: 0.25in;">&#8226;</td>
            <td><font style="font-family: Times New Roman, Times, Serif;">the name or names of any underwriters, dealers or agents;</font></td>
          </tr>

      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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        involved in the offer or sale of the securities and any commissions paid to them. Generally, any agent will be acting on a best efforts basis for the period of its appointment.</p>
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        the terms of a distribution agreement with the underwriters or agents. Such underwriters or agents may act on an agency basis or on a principal basis. During the term of any such agreement, shares may be sold on a daily basis on any stock exchange,
        market or trading facility on which the ordinary shares are traded, in privately negotiated transactions or otherwise as agreed with the underwriters or agents. The distribution agreement will provide that any common share sold will be sold at
        negotiated prices or at prices related to the then prevailing market prices for our ordinary shares. Therefore, exact figures regarding proceeds that will be raised or commissions to be paid cannot be determined at this time and will be described
        in a prospectus supplement. Pursuant to the terms of the distribution agreement, we may also agree to sell, and the relevant underwriters or agents may agree to solicit offers to purchase, blocks of our ordinary shares or other securities. The
        terms of each such distribution agreement will be described in a prospectus supplement.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We may authorize underwriters, dealers or agents to solicit offers by certain purchasers to purchase the
        securities at the public offering price set forth in the prospectus supplement pursuant to delayed delivery contracts providing for payment and delivery on a specified date in the future. The contracts will be subject only to those conditions set
        forth in the prospectus supplement, and the prospectus supplement will set forth any commissions paid for solicitation of these contracts.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">Underwriters and agents may be entitled under agreements entered into with us to indemnification by us
        against certain civil liabilities, including liabilities under the Securities Act, or to contribution with respect to payments which the underwriters or agents may be required to make.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">The prospectus supplement may also set forth whether or not underwriters may over-allot or effect
        transactions that stabilize, maintain or otherwise affect the market price of the securities at levels above those that might otherwise prevail in the open market, including, for example, by entering stabilizing bids, effecting syndicate covering
        transactions or imposing penalty bids.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">Underwriters and agents may be customers of, engage in transactions with, or perform services for us and
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">Each series of securities will be a new issue of securities and will have no established trading market,
        other than our ordinary shares, which are listed on the Nasdaq Capital Market. Any underwriters to whom securities are sold for public offering and sale may make a market in the securities, but such underwriters will not be obligated to do so and
        may discontinue any market making at any time without notice. The securities, other than our ordinary shares, may or may not be listed on a national securities exchange.</p>
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      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; text-transform: uppercase; font-size-adjust: none; font-stretch: normal;"><a name="a_009"></a>Incorporation of Certain Documents by Reference</p>
      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; text-transform: uppercase; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">The SEC allows us to &#8220;incorporate by reference&#8221; information into this prospectus. This means that we can
        disclose important information to you by referring you to another document filed separately with the SEC. The information incorporated by reference is considered to be a part of this prospectus, except for any information superseded by information
        that is included directly in this document or incorporated by reference subsequent to the date of this document.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We incorporate by reference into this prospectus the following documents listed below, which we have
        already filed with or furnished to the SEC:</p>
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            <td style="width: 0.25in;">(1)</td>
            <td>our Annual Report on <a href="https://www.sec.gov/Archives/edgar/data/1638097/000117891320000939/zk2024188.htm">Form 20-F for the fiscal year ended December 31, 2019 filed on March 26, 2020</a>; and</td>
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            <td style="width: 0.25in;">(2)</td>
            <td>our Report on Form 6-K filed on <a style="-sec-extract: exhibit;" href="http://www.sec.gov/Archives/edgar/data/1638097/000117891320000593/zk2024074.htm">February 19, 2020</a>, <a style="-sec-extract: exhibit;" href="http://www.sec.gov/Archives/edgar/data/1638097/000117891320001565/zk2024462.htm">May 21, 2020</a> (with respect to the paragraphs entitled &#8220;EB613 Phase 2 Topline Results&#8221; in Exhibit 99.1 only), <a style="-sec-extract: exhibit;" href="http://www.sec.gov/Archives/edgar/data/1638097/000117891320001873/zk2024606.htm">June 26, 2020</a> and <a style="-sec-extract: exhibit;" href="http://www.sec.gov/Archives/edgar/data/1638097/000117891320001972/zk2024648.htm">July 7,
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            <td>our Unaudited Condensed Consolidated Interim Financial Statements for the three-month period ended March 31, 2020, which were included as <a style="-sec-extract: exhibit;" href="http://www.sec.gov/Archives/edgar/data/1638097/000117891320001565/exhibit_99-1.htm">Exhibit 99.1</a> to the Form 6-K filed on May 21, 2020; and</td>
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            <td style="width: 0.25in;">(4)</td>
            <td>our Management&#8217;s Discussion and Analysis for the three-month period ended March 31, 2020, which was included as <a style="-sec-extract: exhibit;" href="http://www.sec.gov/Archives/edgar/data/1638097/000117891320001565/exhibit_99-2.htm">Exhibit







                99.2</a> to the Form 6-K filed on May 21, 2020.</td>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">All subsequent reports that we file on Form 20-F under the Exchange Act after the date of this prospectus
        and prior to the termination of the offering shall also be deemed to be incorporated by reference into this prospectus and to be a part hereof from the date of filing such documents. We may also incorporate by reference any other Form 6-K that we
        submit to the SEC after the date of this prospectus and prior to the termination of this offering by identifying in such Form 6-K that it is being incorporated by reference into this prospectus.</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">As you read the above documents, you may find inconsistencies in information from one document to another.
        If you find inconsistencies, you should rely on the statements made in this prospectus or in the most recent document incorporated by reference herein.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We will provide without charge to each person to whom this prospectus has been delivered, upon the written
        or oral request of any such person to us, a copy of any or all of the documents referred to above that have been or may be incorporated into this prospectus by reference, including exhibits to such documents. Requests for such copies should be
        directed to:</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">Kiryat Hadassah<br>
        Minrav Building - Fifth Floor<br>
        Jerusalem, Israel<br>
        Tel: +972-2-532-7151</p>
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      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; text-transform: uppercase; font-size-adjust: none; font-stretch: normal;"><a name="a_010"></a>Service of Process and Enforcement of Judgments</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We are incorporated under the laws of the State of Israel. Service of process upon us and upon our
        directors and officers and any Israeli experts named in this prospectus, may be difficult to obtain within the United States. Furthermore, because substantially all of our assets and a significant number of our directors and officers are located
        outside the United States, any judgment obtained in the United States against us or any of our directors and officers may not be collectible within the United States.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">We have been informed by our legal counsel in Israel, Herzog Fox &amp; Neeman, that it may be difficult to
        initiate an action with respect to U.S. securities law in Israel. Israeli courts may refuse to hear a claim based on an alleged violation of U.S. securities laws reasoning that Israel is not the most appropriate forum to hear such a claim. In
        addition, even if an Israeli court agrees to hear a claim, it may determine that Israeli law and not U.S. law is applicable to the claim. If U.S. law is found to be applicable, the content of applicable U.S. law must be proved as a fact by expert
        witnesses, which can be a time-consuming and costly process. Certain matters of procedure may also be governed by Israeli law. There is little case law in Israel addressing these matters.</p>
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          </tr>

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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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            <td><font style="font-family: Times New Roman, Times, Serif;">the obligations imposed by the judgment are enforceable according to the laws of the State of Israel and according to the laws of the state in which the judgment was given and the
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      </table>
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            <td><font style="font-family: Times New Roman, Times, Serif;">the judgment was given in a state whose laws do not provide for the enforcement of judgments of Israeli courts (subject to exceptional cases);</font></td>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="z2eee9b6c986942a28238a10a5b334e34">

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            <td><font style="font-family: Times New Roman, Times, Serif;">the enforcement of the judgment is likely to prejudice the sovereignty or security of the State of Israel;</font></td>
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            <td><font style="font-family: Times New Roman, Times, Serif;">the opportunity given to the defendant to bring its arguments and evidence before the court was not reasonable in the opinion of the Israeli court;</font></td>
          </tr>

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      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="za5c0bc307d13463e9a01ac7073bf6da1">

          <tr style="vertical-align: top;">
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            <td><font style="font-family: Times New Roman, Times, Serif;">the judgment was rendered by a court not competent to render it according to the laws of private international law as they apply in Israel;</font></td>
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          <tr style="vertical-align: top;">
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            <td><font style="font-family: Times New Roman, Times, Serif;">the judgment is contradictory to another judgment that was given in the same matter between the same parties and that is still valid; or</font></td>
          </tr>

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          <tr style="vertical-align: top;">
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            <td><font style="font-family: Times New Roman, Times, Serif;">at the time the action was brought in the foreign court, a lawsuit in the same matter and between the same parties was pending before a court or tribunal in Israel.</font></td>
          </tr>

      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">If a foreign judgment is enforced by an Israeli court, it generally will be payable in Israeli currency,
        which can then be converted into non-Israeli currency and transferred out of Israel. The usual practice in an action before an Israeli court to recover an amount in a non-Israeli currency is for the Israeli court to issue a judgment for the
        equivalent amount in Israeli currency at the rate of exchange in force on the date of the judgment, but the judgment debtor may make payment in foreign currency. Pending collection, the amount of the judgment of an Israeli court stated in Israeli
        currency ordinarily will be linked to the Israeli consumer price index plus interest at the annual statutory rate set by Israeli regulations prevailing at the time. Judgment creditors must bear the risk of unfavorable exchange rates.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; text-transform: uppercase; font-size-adjust: none; font-stretch: normal;"><a name="a_011"></a>Expenses</p>
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      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">The following table sets forth the expenses (other than underwriting discounts and commissions or agency
        fees and other items constituting underwriters&#8217; or agents&#8217; compensation, if any) expected to be incurred by us in connection with a possible offering of securities registered under this registration statement.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <table cellspacing="0" cellpadding="0" id="zce0da3584127478a9369b5ecd2099fa0" style="font: 10pt/normal Times New Roman, Times, Serif; font-size-adjust: none; font-stretch: normal; width: 100%;">

          <tr style="vertical-align: bottom;">
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            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">$</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">12,980</td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
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          <tr style="vertical-align: bottom;">
            <td valign="bottom" style="font: 10pt Times New Roman,Times,serif; text-align: left; width: 88%;">FINRA filing fee</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: right; vertical-align: bottom; width: 1%;">&#160;</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom; width: 1%;">$</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; vertical-align: bottom; text-align: right; width: 9%;">15,500</td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
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            <td valign="bottom" style="font: 10pt Times New Roman,Times,serif; text-align: left; width: 88%; background-color: rgb(204, 238, 255);">Printing and engraving expenses*</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">$</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">10,000</td>
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          <tr style="vertical-align: bottom;">
            <td valign="bottom" style="font: 10pt Times New Roman,Times,serif; text-align: left; width: 88%;">Legal fees and expenses*</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: right; vertical-align: bottom; width: 1%;">&#160;</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom; width: 1%;">$</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; vertical-align: bottom; text-align: right; width: 9%;">90,000</td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
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          <tr style="vertical-align: bottom;">
            <td valign="bottom" style="font: 10pt Times New Roman,Times,serif; text-align: left; width: 88%; background-color: rgb(204, 238, 255);">Accounting fees and expenses*</td>
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            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">$</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">15,000</td>
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            <td valign="bottom" style="font: 10pt Times New Roman,Times,serif; width: 88%; padding-bottom: 2px;">Miscellaneous*</td>
            <td valign="bottom" colspan="1" style="text-align: right; font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
            <td valign="bottom" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">$</td>
            <td valign="bottom" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">50,000</td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
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          <tr style="vertical-align: bottom;">
            <td valign="bottom" style="font: 10pt Times New Roman,Times,serif; width: 88%; background-color: rgb(204, 238, 255);">Total*</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">$</td>
            <td valign="bottom" colspan="1" style="font: 10pt Times New Roman,Times,serif; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">193,480</td>
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          </tr>

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      <p style="margin-top: 0px; margin-bottom: 0px;">&#160;</p>
      <div style="width: 25%; margin-top: 3pt; margin-bottom: 3pt;">
        <div style="font-size: 1pt; border-top-color: black; border-top-width: 1pt; border-top-style: solid;">&#160;</div>
      </div>
      <table width="100%" cellspacing="0" cellpadding="0" style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;" id="zb0cf9d3528144a78a60968eedf303257">

          <tr style="vertical-align: top;">
            <td style="width: 0px;"><br>
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            <td style="width: 0.25in;">*</td>
            <td>Estimated</td>
          </tr>

      </table>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; font-size-adjust: none; font-stretch: normal;">&#160;</p>
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      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; text-transform: uppercase; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">The validity of the securities offered in respect of which this prospectus is being delivered will be
        passed upon by Herzog, Fox &amp; Neeman, Tel Aviv, Israel, our Israeli counsel. Certain matters of U.S. federal law will be passed upon for us by Davis Polk &amp; Wardwell LLP, New York, New York. Additional legal matters may be passed upon for us
        or any underwriters, dealers or agents, by counsel that we will name in the applicable prospectus supplement.</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; text-transform: uppercase; font-size-adjust: none; font-stretch: normal;"><a name="a_013"></a>Experts</p>
      <p style="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-align: center; text-transform: uppercase; font-size-adjust: none; font-stretch: normal;">&#160;</p>
      <p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0px; text-indent: 0.25in; font-size-adjust: none; font-stretch: normal;">The financial statements incorporated in this Prospectus by reference to the <a style="-sec-extract: exhibit;" href="http://www.sec.gov/Archives/edgar/data/1638097/000117891320000939/zk2024188.htm">Annual Report on Form 20-F for the year ended December 31, 2019</a> have been so incorporated in reliance on the report (which contains an
        explanatory paragraph relating to the Company&#8217;s ability to continue as a going concern as described in note 1b to the financial statements) of Kesselman &amp; Kesselman, Certified Public Accountants (Isr.), a member firm of PricewaterhouseCoopers
        International Limited, an independent registered public accounting firm, given on the authority of said firm as experts in auditing and accounting.</p>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">19</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;"><img width="210" height="135" src="image1.jpg"></div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">5,000,000 Ordinary Shares</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25;">
      <hr align="center" noshade="noshade" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Prospectus Supplement</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="line-height: 1.25;">
        <hr align="center" noshade="noshade" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">B. Riley Securities</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;">May 7, 2021</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Exhibit Index</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" id="ze481fcca08314ff4bf8dcc65f51e238b">

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            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Exhibit No.</div>
          </td>
          <td style="width: 82.43%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Document</div>
            <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 17.57%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif;"><a href="exhibit_1-2.htm">1.2</a></div>
          </td>
          <td style="width: 82.43%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;"><a href="exhibit_1-2.htm">Sales Agreement, dated as of May 7, 2021
                between Entera Bio Ltd. and B. Riley Securities, Inc</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 17.57%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif;"><a href="exhibit_5-1.htm">5.1</a></div>
          </td>
          <td style="width: 82.43%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;"><a href="exhibit_5-1.htm">Opinion of Herzog Fox &amp; Neeman, Israeli
                counsel to the Registrant, as to the validity of the Shares.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 17.57%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif;"><a href="exhibit_5-1.htm">23.1</a></div>
          </td>
          <td style="width: 82.43%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;"><a href="exhibit_5-1.htm">Consent of Herzog Fox &amp; Neeman (included in
                Exhibit 5.1).</a></div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">_______________</div>
    <div style="line-height: 1.25;">* To be filed, if necessary, by amendment or as an exhibit to a report filed or submitted pursuant to Section 13(a) or 15(d) of the U.S. Securities Exchange Act of 1934, as amended, and incorporated by reference.</div>
    <div style="line-height: 1.25;"> <br>
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<DOCUMENT>
<TYPE>EX-1.2
<SEQUENCE>2
<FILENAME>exhibit_1-2.htm
<DESCRIPTION>EXHIBIT 1.2
<TEXT>
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    <div style="text-align: right;"> <u><font style="font-weight: bold;">Exhibit 1.2<br>
        </font></u></div>
    <div><u><font style="font-weight: bold;"> </font></u><br>
    </div>
    <div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">ENTERA BIO LTD.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: center; line-height: 1.25;">Ordinary Shares</div>
      <div style="text-align: center; line-height: 1.25;">(par value NIS 0.0000769 per share)<br>
          <br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">At Market Issuance Sales Agreement</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;May 7, 2021</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="line-height: 1.25;">B. Riley Securities, Inc.</div>
      <div style="line-height: 1.25;">299 Park Avenue, 21<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">st</sup> Floor</div>
      <div style="line-height: 1.25;">New York, NY 10171</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Ladies and Gentlemen:</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Entera Bio Ltd., an Israeli company (the &#8220;<u>Company</u>&#8221;), confirms its agreement (this &#8220;<u>Agreement</u>&#8221;) with B. Riley Securities, Inc. (the &#8220;<u>Agent</u>&#8221;) as follows:</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">1.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Issuance and Sale of Shares</u>. The Company agrees that, from time to time during the term of this Agreement, on the terms and
        subject to the conditions set forth herein, it may issue and sell through or to the Agent, as sales agent or principal, shares (the &#8220;<u>Placement Shares</u>&#8221;);<font style="font-style: italic;">&#160;</font>of the Company&#8217;s ordinary shares, par value NIS 0.0000769 per share (the &#8220;<u>Ordinary Shares</u>&#8221;); <font style="font-style: italic;">provided however, </font>that in no event shall the Company issue or sell through the Agent such number of
        Placement Shares that (a) exceeds the number of shares or dollar amount of Ordinary Shares registered on the effective Registration Statement (as defined below) pursuant to which the offering is being made or (b) exceeds the number of shares or
        dollar amount registered on the Prospectus (as defined below) (the lesser of (a) or (b) the &#8220;<u>Maximum Amount</u>&#8221;) and <font style="font-style: italic;">provided further, however,</font> that in no event shall the aggregate number of Placement Shares sold pursuant to this Agreement exceed the number of authorized but unissued Ordinary Shares.
        The issuance and sale of Placement Shares through the Agent will be effected pursuant to the Registration Statement (as defined below), although nothing in this Agreement shall be construed as requiring the Company to use the Registration Statement
        to issue any Placement Shares.</div>
      <div style="line-height: 1.25">&#160;</div>
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      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company has filed, in accordance with the provisions of the Securities Act of 1933, as amended and the rules
        and regulations thereunder (the &#8220;<u>Securities Act</u>&#8221;), with the Securities and Exchange Commission (the &#8220;Commission&#8221;), a registration statement on Form F-3 (File
        No. 333-239843), including a base prospectus, relating certain securities including the Placement Shares to be issued from time to time by the Company, and which incorporates by reference documents that the Company has filed or will file in
        accordance with the provisions of the Securities Exchange Act of 1934, as amended and the rules and regulations thereunder (the &#8220;<u>Exchange Act</u>&#8221;). The Company
        has prepared or will prepare a prospectus or prospectus supplement to the base prospectus included as part of such registration statement specifically relating to the Placement Shares (the &#8220;<u>Prospectus Supplement</u>&#8221;). The Company will furnish to the Agent, for use by the Agent, copies of the base prospectus included as part of such registration statement, as supplemented by the Prospectus
        Supplement, relating to the Placement Shares. Except where the context otherwise requires, such registration statement, and any post-effective amendment thereto, including all documents filed as part thereof or incorporated by reference therein,
        and including any information contained in a Prospectus (as defined below) subsequently filed with the Commission pursuant to Rule 424(b) under the Securities Act or deemed to be a part of such registration statement pursuant to Rule&#160;430B of the
        Securities Act, or any subsequent registration statement on Form F-3 filed pursuant to Rule 415(a)(6) under the Securities Act by the Company to cover any Placement Shares, is herein called the &#8220;<u>Registration Statement</u>.&#8221; The base prospectus, including all documents incorporated or deemed incorporated therein by reference to the extent such information has not been superseded or modified in accordance
        with Rule 412 under the Securities Act (as qualified by Rule 430B(g) of the Securities Act), included in the Registration Statement, as it may be supplemented by the Prospectus Supplement, in the form in which such base prospectus and/or Prospectus
        Supplement have most recently been filed by the Company with the Commission pursuant to Rule 424(b) under the Securities Act is herein called the &#8220;<u>Prospectus</u>.&#8221;
        Any reference herein to the Registration Statement, the Prospectus or any amendment or supplement thereto shall be deemed to refer to and include the documents incorporated by reference therein, and any reference herein to the terms &#8220;amend,&#8221;
        &#8220;amendment&#8221; or &#8220;supplement&#8221; with respect to the Registration Statement or the Prospectus shall be deemed to refer to and include the filing after the execution hereof of any document with the Commission incorporated by reference therein (the &#8220;<u>Incorporated Documents</u>&#8221;).</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">For purposes of this Agreement, all references to the Registration Statement, the Prospectus or to any amendment or
        supplement thereto shall be deemed to include the most recent copy filed with the Commission pursuant to its Electronic Data Gathering Analysis and Retrieval System, or if applicable, the Interactive Data Electronic Application system when used by
        the Commission (collectively, &#8220;<u>EDGAR</u>&#8221;).</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">2.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Placements</u>. Each time that the Company wishes to issue and sell Placement Shares hereunder (each, a &#8220;<u>Placement</u>&#8221;), it will notify the Agent by electronic mail (or other method mutually agreed to in writing by the parties) of the number of Placement Shares, the time period during which
          sales are requested to be made, any limitation on the number of Placement Shares that may be sold in any one day and any minimum price below which sales may not be made (a &#8220;<u>Placement Notice</u>&#8221;), the form of which is attached hereto as <u>Schedule 1</u>. The Placement Notice shall originate from any of the
          individuals from the Company set forth on <u>Schedule 3</u> (with a copy to each of the other individuals from the Company listed on such schedule), and shall be
          addressed to each of the individuals from the Agent set forth on <u>Schedule 3,</u> as such <u>Schedule 3</u> may be amended from time to time. The Placement Notice shall be effective immediately upon receipt by the Agent unless and until (i) the Agent declines to accept the terms contained therein for any reason, in
          its sole discretion, (ii) the entire amount of the Placement Shares thereunder has been sold, (iii) the Company suspends or terminates the Placement Notice, which suspension and termination rights may be exercised by the Company in its sole
          discretion, or (iv) this Agreement has been terminated under the provisions of <u>Section 13</u>. The amount of any discount, commission or other compensation to
          be paid by the Company to the Agent in connection with the sale of the Placement Shares shall be calculated in accordance with the terms set forth in <u>Schedule 2</u>.&#160;
          It is expressly acknowledged and agreed that neither the Company nor the Agent will have any obligation whatsoever with respect to a Placement or any Placement Shares unless and until the Company delivers a Placement Notice to the Agent and the
          Agent does not decline such Placement Notice pursuant to the terms set forth above, and then only upon the terms specified therein and herein. In the event of a conflict between the terms of <u>Sections 2</u> or <u>3</u> of this Agreement and the terms of a Placement Notice, the terms of the Placement Notice will
          control.</div>
      <div style="line-height: 1.25">&#160;</div>
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        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; font-weight: normal; font-style: normal;" id="DSPFPageNumber">2</font></div>
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      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">3.&#160;&#160;&#160;&#160;&#160; &#160; &#160;&#160; <u>Sale of Placement Shares by the Agent</u>.&#160; Subject to the terms and conditions of this Agreement, for the period specified in a
          Placement Notice, the Agent will use its commercially reasonable efforts consistent with its normal trading and sales practices and applicable state and federal laws, rules and regulations and the rules of the Nasdaq Capital Market (the &#8220;<u>Exchange</u>&#8221;), to sell the Placement Shares up to the amount specified in, and otherwise in accordance with the terms of, such Placement Notice. The Agent will
          provide written confirmation to the Company no later than the opening of the Trading Day (as defined below) immediately following the Trading Day on which it has made sales of Placement Shares hereunder setting forth the number of Placement
          Shares sold on such day, the compensation payable by the Company to the Agent pursuant to <u>Section 2</u> with respect to such sales, and the Net Proceeds (as
          defined below) payable to the Company, with an itemization of the deductions made by the Agent (as set forth in <u>Section 5(b))</u> from the gross proceeds that
          it receives from such sales. Subject to the terms of a Placement Notice, the Agent may sell Placement Shares by any method permitted by law deemed to be an &#8220;at the market offering&#8221; as defined in Rule 415 of the Securities Act. &#8220;<u>Trading Day</u>&#8221; means any day on which shares of Ordinary Shares are purchased and sold on the Exchange.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.3pt; margin-left: 0.7pt; line-height: 1.25;">4.&#160;&#160;&#160; &#160; &#160;&#160;&#160;&#160; <u>Suspension of Sales</u>. The Company or the Agent may, upon notice to the other party in writing (including by email correspondence to
          each of the individuals of the other party set forth on <u>Schedule 3</u>, if receipt of such correspondence is actually acknowledged by any of the individuals
          to whom the notice is sent, other than via auto-reply) or by telephone (confirmed immediately by verifiable facsimile transmission or email correspondence to each of the individuals of the other party set forth on <u>Schedule </u>3), suspend any sale of Placement Shares (a &#8220;<u>Suspension</u>&#8221;); <font style="font-style: italic;">provided, however</font>, that such suspension shall not affect or impair any party&#8217;s obligations with respect to any Placement Shares sold hereunder
          prior to the receipt of such notice. While a Suspension is in effect, any obligation under <u>Sections 7(k)</u>, <u>7(l)</u>, and <u>7(m)</u> with respect to the delivery of certificates, opinions, or comfort letters to the Agent,
          shall be waived. Each of the parties agrees that no such notice under this <u>Section 4</u> shall be effective against any other party unless it is made to one
          of the individuals named on <u>Schedule 3</u> hereto, as such Schedule may be amended from time to time.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 35.3pt; margin-left: 0.7pt; line-height: 1.25;">5.&#160;&#160; &#160; &#160;&#160;&#160;&#160;&#160; <u>Sale and Delivery to the Agent; Settlement</u>.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">a.&#160;&#160;&#160;&#160;&#160; &#160; &#160;&#160; <u>Sale of Placement Shares</u>. On the basis of the representations and warranties herein contained and subject to the terms and conditions herein set forth, upon
          the Agent&#8217;s acceptance of the terms of a Placement Notice, and unless the sale of the Placement Shares described therein has been declined, suspended, or otherwise terminated in accordance with the terms of this Agreement, the Agent, for the
          period specified in the Placement Notice, will use its commercially reasonable efforts consistent with its normal trading and sales practices and applicable state and federal laws, rules and regulations and the rules of the Exchange to sell such
          Placement Shares up to the amount specified in, and otherwise in accordance with the terms of, such Placement Notice. The Company acknowledges and agrees that (i) there can be no assurance that the Agent will be successful in selling Placement
          Shares, (ii) the Agent will incur no liability or obligation to the Company or any other person or entity if it does not sell Placement Shares for any reason other than a failure by the Agent to use its commercially reasonable efforts consistent
          with its normal trading and sales practices and applicable state and federal laws, rules and regulations and the rules of the Exchange to sell such Placement Shares as required under this Agreement and (iii) the Agent shall be under no obligation
          to purchase Placement Shares on a principal basis pursuant to this Agreement, except as otherwise agreed by the Agent and the Company.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">3</font></div>
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      </div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">b.&#160;&#160; &#160;&#160; &#160;&#160;&#160;&#160;&#160; <u>Settlement of Placement Shares</u>. Unless otherwise specified in the applicable Placement Notice, settlement for sales of Placement Shares will occur on the
          second&#160;(2<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup>) Trading Day (or such earlier day as is industry practice for regular-way trading) following the date on which such sales are made (each, a &#8220;<u>Settlement
              Date</u>&#8221;). The Agent shall notify the Company of each sale of Placement Shares no later than opening day following the Trading Day that the Agent sold Placement Shares. The amount of proceeds to be delivered to the Company on a
          Settlement Date against receipt of the Placement Shares sold (the &#8220;<u>Net Proceeds</u>&#8221;) will be equal to the aggregate sales price received by the Agent, after
          deduction for (i) the Agent&#8217;s commission, discount or other compensation for such sales payable by the Company pursuant to Section 2 hereof, and (ii) any transaction fees imposed by any governmental or self-regulatory organization in respect of
          such sales.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">c.&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160; <u>Delivery of Placement Shares</u>. On or before each Settlement Date, the Company will, or will cause its transfer agent to, electronically transfer the Placement
          Shares being sold by crediting the Agent&#8217;s or its designee&#8217;s account (provided the Agent shall have given the Company written notice of such designee and such designee&#8217;s account information at least one Trading Day prior to the Settlement Date)
          at The Depository Trust Company through its Deposit and Withdrawal at Custodian System or by such other means of delivery as may be mutually agreed upon by the parties hereto which in all cases shall be freely tradable, transferable, registered
          shares in good deliverable form. On each Settlement Date, the Agent will deliver the related Net Proceeds in same day funds to an account designated by the Company on, or prior to, the Settlement Date. The Company agrees that if the Company, or
          its transfer agent (if applicable), defaults in its obligation to deliver Placement Shares on a Settlement Date through no fault of the Agent, then in addition to and in no way limiting the rights and obligations set forth in <u>Section 11(a)</u> hereto, it will (i) hold the Agent harmless against any loss, claim, damage, or reasonable, documented expense (including reasonable and
          documented legal fees and expenses), as incurred, arising out of or in connection with such default by the Company or its transfer agent (if applicable) and (ii)&#160;pay to the Agent (without duplication) any commission, discount, or other
          compensation to which it would otherwise have been entitled absent such default.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">d.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Limitations on Offering Size</u>. Under no circumstances shall the Company cause or request the offer or sale of any Placement Shares if, after giving effect to
          the sale of such Placement Shares, the aggregate number of Placement Shares sold pursuant to this Agreement would exceed the lesser of (A) together with all sales of Placement Shares under this Agreement, the Maximum Amount, (B) the amount
          available for offer and sale under the currently effective Registration Statement and (C) the amount authorized from time to time to be issued and sold under this Agreement by the Company&#8217;s board of directors, a duly authorized committee thereof
          or a duly authorized executive committee, and notified to the Agent in writing.&#160; Under no circumstances shall the Company cause or request the offer or sale of any Placement Shares pursuant to this Agreement at a price lower than the minimum
          price authorized from time to time by the Company&#8217;s board of directors, a duly authorized committee thereof or a duly authorized executive committee, and notified to the Agent in writing.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">4</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
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      </div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">6.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Representations and Warranties of the Company</u>. Except as disclosed in the Registration Statement or Prospectus (including the
          Incorporated Documents), the Company represents and warrants to, and agrees with the Agent that as of the date of this Agreement and as of each Applicable Time (as defined below), unless such representation, warranty or agreement specifies a
          different date or time:</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">a.&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160; <u>Registration Statement and Prospectus</u>. The transactions contemplated by this Agreement meet the requirements for and comply with the conditions for the use of
          Form&#160;F&#8209;3 under the Securities Act. The Registration Statement has been filed with the Commission and has been declared effective under the Securities Act. The Prospectus Supplement will name the Agent as the agent in the section entitled &#8220;Plan of
          Distribution.&#8221; The Company has not received, and has no notice of, any order of the Commission preventing or suspending the use of the Registration Statement, or threatening or instituting proceedings for that purpose. The Registration Statement
          and the offer and sale of Placement Shares as contemplated hereby meet the requirements of Rule 415 under the Securities Act and comply in all material respects with said Rule. Any statutes, regulations, contracts or other documents that are
          required to be described in the Registration Statement or the Prospectus or to be filed as exhibits to the Registration Statement have been so described or filed, as applicable. Copies of the Registration Statement, the Prospectus, and any such
          amendments or supplements and all documents incorporated by reference therein that were filed with the Commission on or prior to the date of this Agreement have been delivered, or are available through EDGAR, to the Agent and its counsel. The
          Company has not distributed and, prior to the later to occur of each Settlement Date and completion of the distribution of the Placement Shares, will not distribute any offering material in connection with the offering or sale of the Placement
          Shares other than the Registration Statement and the Prospectus and any Issuer Free Writing Prospectus (as defined below) to which the Agent has consented, which consent will not be unreasonably withheld or delayed, or that is required by
          applicable law or the listing maintenance requirements of the Exchange. The Ordinary Shares are currently quoted on the Exchange under the trading symbol &#8220;ENTX&#8221;. The Company has not, in the 12&#160;months preceding the date hereof, received notice
          from the Exchange to the effect that the Company is not in compliance with the listing or maintenance requirements of the Exchange. To the Company&#8217;s knowledge, it is in compliance with all such listing and maintenance requirements.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">b.&#160; &#160; &#160;&#160;&#160;&#160;&#160;&#160; <u>No Misstatement or Omission</u>. At each Settlement Date, the Registration Statement and the Prospectus, as of such date, will conform in all material respects
          with the requirements of the Securities Act. The Registration Statement, when it became or becomes effective, did not, and will not, contain an untrue statement of a material fact or omit to state a material fact required to be stated therein or
          necessary to make the statements therein not misleading. The Prospectus and any amendment and supplement thereto, on the date thereof and at each Applicable Time (defined below), did not or will not include an untrue statement of a material fact
          or omit to state a material fact necessary to make the statements therein, in light of the circumstances under which they were made, not misleading. The documents incorporated by reference in the Prospectus or any Prospectus Supplement did not,
          and any further documents filed and incorporated by reference therein will not, when filed with the Commission, contain an untrue statement of a material fact or omit to state a material fact required to be stated in such document or necessary to
          make the statements in such document, in light of the circumstances under which they were made, not misleading. The foregoing shall not apply to statements in, or omissions from, any such document made in reliance upon, and in conformity with,
          information furnished to the Company by the Agent specifically for use in the preparation thereof.</div>
      <div style="line-height: 1.25">&#160;</div>
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        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">5</font></div>
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      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">c.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Conformity with Securities Act and Exchange Act</u>. The Registration Statement, the Prospectus, any Issuer Free Writing Prospectus or any amendment or supplement
          thereto, and the Incorporated Documents, when such documents were or are filed with the Commission under the Securities Act or the Exchange Act or became or become effective under the Securities Act, as the case may be, conformed or will conform
          in all material respects with the requirements of the Securities Act and the Exchange Act, as applicable.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">d.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Financial Information</u>. The consolidated financial statements of the Company included or incorporated by reference in the Registration Statement and the
          Prospectus, together with the related notes and schedules, present fairly, in all material respects, the consolidated financial position of the Company and the Subsidiaries (as defined below) as of the dates indicated and the consolidated results
          of operations, cash flows and changes in stockholders&#8217; equity of the Company and the Subsidiaries for the periods specified (subject, in the case of unaudited statements, to normal year-end audit adjustments which will not be material, either
          individually or in the aggregate) and have been prepared in compliance with the published requirements of the Securities Act and Exchange Act, as applicable, and in conformity with International Financial Reporting Standards (&#8220;<u>IFRS</u>&#8221;) applied on a consistent basis (except (i) for such adjustments to accounting standards and practices as are noted therein and (ii) in the case of
          unaudited interim statements, to the extent they may exclude footnotes or may be condensed or summary statements) during the periods involved; the other financial and statistical data with respect to the Company and the Subsidiaries contained or
          incorporated by reference in the Registration Statement and the Prospectus, are accurately and fairly presented and prepared on a basis consistent with the financial statements and books and records of the Company; there are no financial
          statements (historical or pro forma) that are required to be included or incorporated by reference in the Registration Statement, or the Prospectus that are not included or incorporated by reference as required; the Company and the Subsidiaries
          do not have any material liabilities or obligations, direct or contingent (including any off balance sheet obligations), not described in the Registration Statement, and the Prospectus which are required to be described in the Registration
          Statement or Prospectus; and all disclosures contained or incorporated by reference in the Registration Statement and the Prospectus, if any, regarding &#8220;non--GAAP financial measures&#8221; (as such term is defined by the rules and regulations of the
          Commission) comply in all material respects with Regulation G of the Exchange Act and Item 10 of Regulation S-K under the Securities Act, to the extent applicable.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">e.&#160;&#160; &#160; &#160;&#160; &#160;&#160;&#160; <u>Conformity with EDGAR Filing</u>. The Prospectus delivered to the Agent for use in connection with the sale of the Placement Shares pursuant to this Agreement will
          be identical to the versions of the Prospectus created to be transmitted to the Commission for filing via EDGAR, except to the extent permitted by Regulation S-T.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">6</font></div>
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      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">f.&#160;&#160;&#160;&#160;&#160; &#160; &#160;&#160; <u>Organization</u>. (i) The Company and any subsidiary that is a significant subsidiary (as such term is defined in Rule 1-02 of Regulation S-X promulgated by the
          Commission) (each, a &#8220;<u>Subsidiary</u>,&#8221; collectively, the &#8220;<u>Subsidiaries</u>&#8221;),
          are duly organized and validly existing under the laws of Israel or under the laws of their jurisdictions, respectively, and have all requisite power and authority to carry on their businesses as are currently being conducted as described in the
          Prospectus, and to own, lease and operate their respective properties. Each of the Company and the Subsidiaries is duly qualified as a foreign entity to transact business and is in good standing in each jurisdiction in which such qualification is
          required, whether by reason of the ownership or leasing of property or the conduct of business, except where the failure, individually or in the aggregate, to be so qualified or in good standing or have such power or authority would not,
          individually or in the aggregate, have a material adverse effect on (i) the assets, properties, condition, financial or otherwise or in the results of operations, business affairs or business prospects of the Company and its Subsidiaries taken as
          a whole, (ii) the transactions contemplated hereby or (iii) the ability of the Company to perform its obligations under this Agreement (collectively, a &#8220;<u>Material
              Adverse Effect</u>&#8221;); and to the Company&#8217;s knowledge, no proceeding has been instituted revoking, limiting, or curtailing, or seeking to revoke, limit or curtail, such power and authority or qualification. The Company is not designated
          as a &#8220;breaching company&#8221; (within the meaning of the Israeli Companies Law, 5759-1999, the &#8220;<u>Companies Law</u>&#8221;) by the Registrar of Companies of the State of
          Israel (the &#8220;<u>Israeli Registrar</u>&#8221;). The certificate of incorporation and articles of association and other organizational documents of the Company comply
          with the requirements of applicable law of its jurisdiction of incorporation and are in full force and effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">g.&#160;&#160;&#160;&#160; &#160; &#160; &#160;&#160; <u></u><u>Subsidiaries</u>.&#160; The Company owns directly or indirectly, all of the equity interests of the Subsidiaries free and clear of any lien, charge,
          security interest, encumbrance, right of first refusal or other restriction, and all the equity interests of the Subsidiaries are validly issued and are fully paid, nonassessable and free of preemptive and similar rights.&#160; The Company does not
          own or control, directly or indirectly, any corporation, association or other entity other than the subsidiaries listed in Exhibit 8.1 to the Company&#8217;s Annual Report on Form 20-F for the most recently ended fiscal year and other than (i) those
          subsidiaries not required to be listed on Exhibit 21.1 by Item 601 of Regulation S-K under the Exchange Act and (ii) those subsidiaries formed since the last day of the most recently ended fiscal year.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">h.&#160;&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160; <u>No Violation or Default</u>. Neither the Company nor any Subsidiary is (i)&#160;in violation of its charter or by-laws or similar organizational documents; (ii) in
          default, and no event has occurred that, with notice or lapse of time or both, would constitute such a default, in the due performance or observance of any term, covenant or condition contained in any indenture, mortgage, deed of trust, loan
          agreement or other similar agreement or instrument to which the Company or any Subsidiary is a party or by which the Company or any Subsidiary is bound or to which any of the property or assets of the Company or any Subsidiary is subject; or
          (iii) in violation of any law or statute or any judgment, order, rule or regulation of any court or arbitrator or governmental or regulatory authority, except, in the case of each of clauses (ii) and (iii) above, for any such violation or default
          that would not, individually or in the aggregate, have a Material Adverse Effect. To the Company&#8217;s knowledge, no other party under any material contract or other agreement to which it or any Subsidiary is a party is in default in any respect
          thereunder where such default would have a Material Adverse Effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">7</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
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      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">i.&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; &#160; <u>No Material Adverse Effect</u>. Since the date of the most recent financial statements of the Company included or incorporated by reference in the Registration
          Statement and Prospectus, except in each case as otherwise disclosed in the Registration Statement and Prospectus, there has not been (i) any Material Adverse Effect, or any development that would result in a Material Adverse Effect, (ii) any
          transaction which is material to the Company and the Subsidiaries taken as a whole, (iii) any obligation or liability, direct or contingent (including any off-balance sheet obligations), incurred by the Company or the Subsidiaries, which is
          material to the Company and the Subsidiaries taken as a whole, (iv) any material change in the capital stock (other than (A) the grant of additional options under the Company&#8217;s existing stock option plans, (B) changes in the number of outstanding
          Ordinary Shares of the Company due to the issuance of shares upon the exercise or conversion of securities exercisable for, or convertible into, Ordinary Shares outstanding on the date hereof, (C) as a result of the issuance of Placement Shares,
          (D) any repurchases of capital stock of the Company, (E) as described in a proxy statement filed on Schedule 14A or a Registration Statement on Form S-4, or (F)&#160;otherwise publicly announced) or outstanding long-term indebtedness of the Company or
          the Subsidiaries or (v) any dividend or distribution of any kind declared, paid or made on the capital stock of the Company or any Subsidiary, other than in each case above in the ordinary course of business or as otherwise disclosed in the
          Registration Statement or Prospectus (including any document incorporated by reference therein).</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">j.&#160;&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160; <u>Capitalization</u>. The issued and outstanding shares of capital stock of the Company have been validly issued, are fully paid and non-assessable and, other than
          as disclosed in the Registration Statement or the Prospectus, are not subject to any preemptive rights, rights of first refusal or similar rights. The Company has an authorized, issued and outstanding capitalization as set forth in the
          Registration Statement and the Prospectus as of the dates referred to therein (other than (i) the grant of additional options under the Company&#8217;s existing stock option plans, (ii) changes in the number of outstanding Ordinary Shares of the
          Company due to the issuance of shares upon the exercise or conversion of securities exercisable for, or convertible into, Ordinary Shares outstanding on the date hereof, (iii) as a result of the issuance of Placement Shares, or (iv) any
          repurchases of capital stock of the Company) and such authorized capital stock conforms to the description thereof set forth in the Registration Statement and the Prospectus. The description of the Ordinary Shares in the Registration Statement
          and the Prospectus is complete and accurate in all material respects. Except as disclosed or incorporated by reference in or contemplated by the Registration Statement or the Prospectus, the Company did not have outstanding any options to
          purchase, or any rights or warrants to subscribe for, or any securities or obligations convertible into, or exchangeable for, or any contracts or commitments to issue or sell, any shares of capital stock or other securities.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">k.&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160;&#160; <u>F-3 Eligibility</u>.&#160; At the time the Registration Statement was or will be declared effective, and at the time the Company&#8217;s most recent Annual Report on Form
          20-F was filed with the Commission, the Company met or will meet the then applicable requirements for the use of Form F-3 under the Securities Act, including, but not limited to, General Instruction I.B.1 of Form F-3, if applicable. The Company
          is not a shell company (as defined in Rule 405 under the Securities Act) and has not been a shell company for at least 12 calendar months previously and if it has been a shell company at any time previously, has filed current Form 10 information
          (as defined in General Instruction I.B.5 of Form F-3) with the Commission at least 12 calendar months previously reflecting its status as an entity that is not a shell company.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></div>
      <div style="line-height: 1.25">&#160;<br>
        <hr align="left" noshade="noshade" style="background-color: #000000; border: 0px; height: 1px; width: 2in; margin-left: 0pt; margin-right: auto; color: #000000;">
        <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup> Updated to reflect that the Company is subject to I.B.1, rather than I.B.5.</div>
        <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><br>
        </div>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">8</font></div>
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      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">l.&#160; &#160; &#160; &#160;&#160;&#160;&#160;&#160; <u>Authorization; Enforceability</u>. The Company has full legal right, power and authority to enter into this Agreement and perform the transactions contemplated
          hereby. This Agreement has been duly authorized, executed and delivered by the Company and is a legal, valid and binding agreement of the Company enforceable against the Company in accordance with its terms, except to the extent that (i)
          enforceability may be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors&#8217; rights generally and by general equitable principles and (ii) the indemnification and contribution provisions of <u>Section 11</u> hereof may be limited by federal or state securities laws and public policy considerations in respect thereof.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">m.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Authorization of Placement Shares</u>. The Placement Shares, when issued and delivered pursuant to the terms approved by the board of directors of the Company or a
          duly authorized committee thereof, or a duly authorized executive committee, against payment therefor as provided herein, will be duly and validly authorized and issued and fully paid and nonassessable, free and clear of any pledge, lien,
          encumbrance, security interest or other claim (other than any pledge, lien, encumbrance, security interest or other claim arising from an act or omission of the Agent or a purchaser), including any statutory or contractual preemptive rights,
          resale rights, rights of first refusal or other similar rights, and will be registered pursuant to Section 12 of the Exchange Act. The Placement Shares, when issued, will conform in all material respects to the description thereof set forth in or
          incorporated into the Prospectus.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">n.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>No Consents Required</u>. No consent, approval, authorization, order, registration or qualification of or with any court or arbitrator or any governmental or
          regulatory authority is required for the execution, delivery and performance by the Company of this Agreement, and the issuance and sale by the Company of the Placement Shares as contemplated hereby, except for such consents, approvals,
          authorizations, orders and registrations or qualifications (i) as may be required under applicable state securities laws or by the by-laws and rules of the Financial Industry Regulatory Authority (&#8220;<u>FINRA</u>&#8221;) or the Exchange, including any notices that may be required by the Exchange, or formal filings and reports with the Israel Innovation Authority (formerly the Office of the Chief Scientist)
          of the Israeli Ministry of Economy and Industry, and certain post-closing filings to be filed with the Israeli Registrar of Companies, in connection with the sale of the Placement Shares by the Agent, (ii) as may be required under the Securities
          Act and (iii) as have been previously obtained by the Company.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">o.&#160;&#160;&#160; &#160; &#160;&#160;&#160;&#160; <u>No Preferential Rights</u>. (i) No person, as such term is defined in Rule 1-02 of Regulation S-X promulgated under the Securities Act (each, a &#8220;<u>Person</u>&#8221;), has the right, contractual or otherwise, to cause the Company to issue or sell to such Person any Ordinary Shares or shares of any other capital
          stock or other securities of the Company (other than upon the exercise of options or warrants to purchase Ordinary Shares or upon the exercise of options that may be granted from time to time under the Company&#8217;s stock option plan), (ii) no Person
          has any preemptive rights, rights of first refusal, or any other rights (whether pursuant to a &#8220;poison pill&#8221; provision or otherwise) to purchase any Ordinary Shares or shares of any other capital stock or other securities of the Company from the
          Company which have not been duly waived with respect to the offering contemplated hereby, (iii) no Person has the right to act as an underwriter or as a financial advisor to the Company in connection with the offer and sale of the Ordinary
          Shares, and (iv) no Person has the right, contractual or otherwise, to require the Company to register under the Securities Act any Ordinary Shares or shares of any other capital stock or other securities of the Company, or to include any such
          shares or other securities in the Registration Statement or the offering contemplated thereby, whether as a result of the filing or effectiveness of the Registration Statement or the sale of the Placement Shares as contemplated thereby or
          otherwise, except in each case for such rights as have been waived on or prior to the date hereof or as may described in the Prospectus, including the documents incorporated therein by reference.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">9</font></div>
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      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">p.&#160;&#160; &#160; &#160;&#160;&#160;&#160;&#160; <u>Independent Public Accountant</u>. &#160;Kesselman &amp; Kesselman, a member firm of PricewaterhouseCoopers International Limited (the &#8220;<u>Accountant</u>&#8221;), whose report on the consolidated financial statements of the Company is filed with the Commission as part of the Company&#8217;s most recent Annual Report on Form 20-F filed
          with the Commission and incorporated into the Registration Statement, are and, during the periods covered by their report, were independent public accountants within the meaning of the Securities Act and the Public Company Accounting Oversight
          Board (United States).</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">q.&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <u>Enforceability of Agreements</u>. All agreements between the Company and third parties expressly referenced in the Prospectus, other than such agreements that have
          expired by their terms or whose termination is disclosed in documents filed by the Company on EDGAR, are legal, valid and binding obligations of the Company and, to the Company&#8217;s knowledge, enforceable in accordance with their respective terms,
          except to the extent that (i)&#160;enforceability may be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors&#8217; rights generally and by general equitable principles and (ii) the indemnification provisions of
          certain agreements may be limited by federal or state securities laws or public policy considerations in respect thereof, and except for any unenforceability that, individually or in the aggregate, would not have a Material Adverse Effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; margin-right: 3.6pt; line-height: 1.25;">r.&#160;&#160;&#160;&#160;&#160;&#160; &#160; &#160; <u>No Litigation</u>. There are no legal, governmental or regulatory actions, suits or proceedings pending, nor, to the Company&#8217;s
          knowledge, any legal, governmental or regulatory investigations, including any proceeding before the United States Food and Drug Administration of the U.S. Department of Health and Human Services (the &#8220;<u>FDA</u>&#8221;) or comparable federal, state, local or foreign governmental authorities (it being understood that the interaction between the Company and the FDA and such comparable governmental authorities
          relating to the clinical development and product approval process shall not be deemed proceedings for purposes of this representation), to which the Company or a Subsidiary is a party or to which any property of the Company or any Subsidiary is
          the subject that, individually or in the aggregate, if determined adversely to the Company or any Subsidiary, would have a Material Adverse Effect or materially and adversely affect the ability of the Company to perform its obligations under this
          Agreement; to the Company&#8217;s knowledge, no such actions, suits or proceedings are threatened or contemplated in writing by any governmental or regulatory authority or threatened in writing by others that, individually or in the aggregate, if
          determined adversely to the Company or any Subsidiary, would have a Material Adverse Effect; and there are no current or pending legal, governmental or regulatory actions, suits, proceedings or, to the Company&#8217;s knowledge, investigations that are
          required under the Securities Act to be described in the Prospectus that are not described in the Prospectus (including any Incorporated Document).&#160; The Company is in compliance with all applicable federal, state, local and foreign laws,
          regulations, orders and decrees governing its business as enforced by the FDA, or any other federal, state or foreign agencies or bodies engaged in the regulation of medical devices, except where noncompliance would not, singularly or in the
          aggregate, reasonably be expected to have a Material Adverse Effect. All preclinical and clinical studies conducted by or on behalf of the Company to support clearance for commercialization of the Company&#8217;s products have been conducted by the
          Company, or to the Company&#8217;s knowledge by third parties, in compliance with all applicable federal, state or foreign laws, rules, orders and regulations, except for such failure or failures to be in compliance as would not reasonably be expected
          to have, singularly or in the aggregate, a Material Adverse Effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">10</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
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      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">s.&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160;&#160; <u>Licenses and Permits</u>. The Company and the Subsidiaries possess or have obtained, all licenses, certificates, consents, orders, approvals, permits and other
          authorizations issued by, and have made all declarations and filings with, the appropriate federal, state, local or foreign governmental or regulatory authorities that are necessary for the ownership or lease of their respective properties or the
          conduct of their respective businesses as currently conducted, as described in the Registration Statement and the Prospectus (the &#8220;<u>Permits</u>&#8221;), except where
          the failure to possess, obtain or make the same would not, individually or in the aggregate, have a Material Adverse Effect. Neither the Company nor any Subsidiary has received written notice of any proceeding relating to revocation or
          modification of any such Permit or has any reason to believe that such Permit will not be renewed in the ordinary course, except where the failure to obtain any such renewal would not, individually or in the aggregate, have a Material Adverse
          Effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">t.&#160;&#160;&#160;&#160; &#160; &#160;&#160;&#160; <u>No Material Defaults</u>. Neither the Company nor any Subsidiary has defaulted on any installment on indebtedness for borrowed money or on any rental on one or
          more long-term leases, which defaults, individually or in the aggregate, would have a Material Adverse Effect. The Company has not filed a report pursuant to Section 13(a) or 15(d) of the Exchange Act since the filing of its last Annual Report on
          Form 20-F, indicating that it (i) has failed to pay any dividend or sinking fund installment on preferred stock or (ii) has defaulted on any installment on indebtedness for borrowed money or on any rental on one or more long-term leases, which
          defaults, individually or in the aggregate, would have a Material Adverse Effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">u.&#160;&#160;&#160; &#160; &#160;&#160;&#160;&#160; <u>Certain Market Activities</u>. Neither the Company, nor any Subsidiary, nor, to the knowledge of the Company, any of their respective directors, officers or
          controlling persons has taken, directly or indirectly, any action designed, or that has constituted or would cause or result in, under the Exchange Act or otherwise, the stabilization or manipulation of the price of any security of the Company to
          facilitate the sale or resale of the Placement Shares.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">v.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <u>Broker/Dealer Relationships</u>. Neither the Company nor any Subsidiary or any related entities (i) is required to register as a &#8220;broker&#8221; or &#8220;dealer&#8221; in accordance
          with the provisions of the Exchange Act or (ii) directly or indirectly through one or more intermediaries, controls or is a &#8220;person associated with a member&#8221; or &#8220;associated person of a member&#8221; (within the meaning set forth in the FINRA Manual).</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">w.&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160; <u>No Reliance</u>. The Company has not relied upon the Agent or legal counsel for the Agent for any legal, tax or accounting advice in connection with the offering
          and sale of the Placement Shares.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">11</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
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      <div>
        <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">x.&#160;&#160;&#160; &#160; &#160;&#160;&#160;&#160; <u>Taxes</u>. The Company and the Subsidiaries have filed all federal, state, local and foreign tax returns which have been required to be filed and paid all taxes
            shown thereon through the date hereof, to the extent that such taxes have become due and are not being contested in good faith, except where the failure to do so would not have a Material Adverse Effect. Except as otherwise disclosed in or
            contemplated by the Registration Statement or the Prospectus, no tax deficiency has been determined adversely to the Company or any Subsidiary which has had, or would have, individually or in the aggregate, a Material Adverse Effect. The
            Company has no knowledge of any federal, state or other governmental tax deficiency, penalty or assessment which has been or might be asserted or threatened against it which would have a Material Adverse Effect.</div>
      </div>
      <div><br>
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      <div style="text-align: justify; text-indent: 72pt; margin-right: 3.6pt; line-height: 1.25;">y.&#160;&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160; <u>Title to Real and Personal Property.</u> The Company and the Subsidiaries have good and valid title in fee simple to all items of real
          property and good and valid title to all personal property described in the Registration Statement or Prospectus as being owned by them that are material to the businesses of the Company or such Subsidiary, in each case free and clear of all
          liens, encumbrances and claims, except those that (i) do not materially interfere with the use made and proposed to be made of such property by the Company and the Subsidiaries or (ii) would not, individually or in the aggregate, have a Material
          Adverse Effect. Any real property described in the Registration Statement or Prospectus as being leased by the Company and the Subsidiaries is held by them under valid, existing and enforceable leases, except those that (A) do not materially
          interfere with the use made or proposed to be made of such property by the Company or the Subsidiaries or (B) would not, individually or in the aggregate, have a Material Adverse Effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; margin-right: 3.6pt; line-height: 1.25;">z.&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; &#160; <u>Intellectual Property.</u>&#160;Except as described in the Registration Statement or Prospectus, the Company and the Subsidiary own or
          possess adequate enforceable rights to use all patents, patent applications, trademarks (both registered and unregistered), trade names, trademark registrations, service marks, service mark registrations, Internet domain name registrations,
          copyrights, copyright registrations, licenses and know-how (including trade secrets and other unpatented and/or unpatentable proprietary or confidential information, systems or procedures) (collectively, the &#8220;<u>Intellectual Property</u>&#8221;), necessary for the conduct of their respective businesses as conducted as of the date hereof, except to the extent that the failure to own or possess adequate
          rights to use such Intellectual Property would not, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect. The Company and the Subsidiaries have not received any written notice of any claim of infringement or
          conflict which asserted Intellectual Property rights of others, which infringement or conflict, if the subject of an unfavorable decision, would result in a Material Adverse Effect. There are no pending, or to the Company&#8217;s knowledge, threatened
          judicial proceedings or interference proceedings challenging the Company&#8217;s or any Subsidiary&#8217;s rights in or to or the validity of the scope of any of the Company&#8217;s or its Subsidiaries&#8217; patents, patent applications or proprietary information. To
          the Company&#8217;s knowledge, no other entity or individual has any right or claim in any of the Company&#8217;s or any of its Subsidiary&#8217;s patents, patent applications or any patent to be issued therefrom by virtue of any contract, license or other
          agreement entered into between such entity or individual and the Company or any Subsidiary or by any non-contractual obligation, other than by written licenses granted by the Company or any Subsidiary. The Company has not received any written
          notice of any claim challenging the rights of the Company or its Subsidiaries in or to any Intellectual Property owned, licensed or optioned by the Company or any Subsidiary which claim, if the subject of an unfavorable decision, would result in
          a Material Adverse Effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">12</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
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      <div style="text-align: justify; text-indent: 72pt; margin-right: 3.6pt; line-height: 1.25;">aa.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Compliance with Applicable Laws</u>. The Company and the Subsidiaries: (A) are and at all times have been in material compliance with
          all statutes, rules and regulations applicable to the ownership, testing, development, manufacture, packaging, processing, use, distribution, marketing, labeling, promotion, sale, offer for sale, storage, import, export or disposal of any product
          under development, manufactured or distributed by the Company or the Subsidiaries (&#8220;<u>Applicable Laws</u>&#8221;), (b) have not received any Form 483 from the FDA,
          notice of adverse finding, warning letter, or other written correspondence or notice from the FDA, the European Medicines Agency (the &#8220;<u>EMA</u>&#8221;), or any other
          federal, state, local or foreign governmental or regulatory authority alleging or asserting material noncompliance with any Applicable Laws or any licenses, certificates, approvals, clearances, authorizations, permits and supplements or
          amendments thereto required by any such Applicable Laws (&#8220;<u>Authorizations</u>&#8221;), which would, individually or in the aggregate, result in a Material Adverse
          Effect; (C) possess all material Authorizations necessary for its operations as currently conducted and such Authorizations are valid and in full force and effect and neither the Company nor the Subsidiaries is in material violation of any term
          of any such Authorizations; (D) have not received written notice of any claim, action, suit, proceeding, hearing, enforcement, investigation, arbitration or other action from the FDA, the EMA, or any other federal, state, local or foreign
          governmental or regulatory authority or third party alleging that any Company product, operation or activity is in material violation of any Applicable Laws or Authorizations; (E) have not received written notice that the FDA, EMA, or any other
          federal, state, local or foreign governmental or regulatory authority has taken, is taking or intends to take action to limit, suspend, modify or revoke any material Authorizations; and (F) have filed, obtained, maintained or submitted all
          reports, documents, forms, notices, applications, records, claims, submissions and supplements or amendments as required by any Applicable Laws or Authorizations except where the failure to file such reports, documents, forms, notices,
          applications, records, claims, submissions and supplements or amendments would not result in a Material Adverse Effect, and that all such reports, documents, forms, notices, applications, records, claims, submissions and supplements or amendments
          were materially complete and correct on the date filed (or were corrected or supplemented by a subsequent submission). <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">2</sup></div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; margin-right: 3.6pt; line-height: 1.25;">bb.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Clinical Studies</u>. The preclinical studies and clinical trials conducted by the Company or on behalf of the Company were, and, if
          still pending are, to the Company&#8217;s knowledge, being conducted in all material respects in compliance with all Applicable Laws and in accordance with experimental protocols, procedures and controls generally used by qualified experts in the
          preclinical study and clinical trials of new drugs and biologics as applied to comparable products to those being developed by the Company; the descriptions of the results of such preclinical studies and clinical trials contained in the
          Registration Statement and the Prospectus are accurate and complete in all material respects; and the Company has not received any written notices or correspondence from the FDA, the EMA, or any other domestic or foreign governmental agency
          requiring the termination, suspension or modification of any preclinical studies or clinical trials conducted by or on behalf of the Company that are described in the Registration Statement and the Prospectus or the results of which are referred
          to in the Registration Statement and the Prospectus.</div>
      <div style="line-height: 1.25">&#160;<br>
        <hr align="left" noshade="noshade" style="background-color: #000000; border: 0px; height: 1px; width: 2in; margin-left: 0pt; margin-right: auto; color: #000000;">
        <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">2</sup> Please let us know the reason for the strike of the compliance program rep &#8211; does the Company not
          have a compliance program in place or is there just an objection to making the rep?</div>
        <div style="text-align: justify; line-height: 1.25;">&#160;</div>
      </div>
      <div style="line-height: 1.25"> </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">13</font></div>
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      </div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">cc.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Environmental Laws</u>. The Company and the Subsidiaries (i) are in compliance with any and all applicable federal, state, local and foreign laws, rules,
          regulations, decisions and orders relating to the protection of human health and safety, the environment or hazardous or toxic substances or wastes, pollutants or contaminants (collectively, &#8220;<u>Environmental Laws</u>&#8221;); (ii)&#160;have received and are in compliance with all permits, licenses or other approvals required of them under applicable Environmental Laws to conduct their respective businesses as
          described in the Registration Statement and the Prospectus; and (iii) have not received notice of any actual or potential liability for the investigation or remediation of any disposal or release of hazardous or toxic substances or wastes,
          pollutants or contaminants, except, in the case of any of clauses (i), (ii) or (iii) above, for any such failure to comply or failure to receive required permits, licenses, other approvals or liability as would not, individually or in the
          aggregate, have a Material Adverse Effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">dd.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Disclosure Controls</u>. The Company maintains a system of internal accounting controls sufficient to provide reasonable assurance that (i) transactions are
          executed in accordance with management&#8217;s general or specific authorizations; (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with IFRS and to maintain asset accountability; (iii) access to
          assets is permitted only in accordance with management&#8217;s general or specific authorization; and (iv) the recorded accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is taken with respect
          to any differences. The Company is not aware of any material weaknesses in its internal control over financial reporting (other than as set forth in the Registration Statement or the Prospectus). Since the date of the latest audited financial
          statements of the Company included in the Prospectus, there has been no change in the Company&#8217;s internal control over financial reporting that has materially affected, or is reasonably likely to materially affect, the Company&#8217;s internal control
          over financial reporting (other than as set forth in the Registration Statement or the Prospectus). The Company has established disclosure controls and procedures (as defined in Exchange Act Rules 13a-15 and 15d-15) that comply with the
          requirements of the Exchange Act. The Company&#8217;s certifying officers have evaluated the effectiveness of the Company&#8217;s controls and procedures as of a date within 90 days prior to the filing date of the Form 20-F for the fiscal year most recently
          ended (such date, the &#8220;<u>Evaluation Date</u>&#8221;). The Company presented in its Form&#160;20-F for the fiscal year most recently ended the conclusions of the certifying
          officers about the effectiveness of the disclosure controls and procedures based on their evaluations as of the most recent Evaluation Date, and the &#8220;disclosure controls and procedures&#8221; are effective.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">ee.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Sarbanes-Oxley Act</u>. There is and has been no failure on the part of the Company or, to the knowledge of the Company, any of the Company&#8217;s directors or
          officers, in their capacities as such, to comply in all material respects with any applicable provisions of the Sarbanes-Oxley Act of 2002 (the &#8220;<u>Sarbanes-Oxley Act</u>&#8221;)
          and the rules and regulations promulgated thereunder. Each of the principal executive officer and the principal financial officer of the Company (or each former principal executive officer of the Company and each former principal financial
          officer of the Company as applicable) has made all certifications required by Sections 302 and 906 of the Sarbanes-Oxley Act with respect to all reports, schedules, forms, statements and other documents required to be filed by it or furnished by
          it to the Commission during the past 12 months. For purposes of the preceding sentence, &#8220;principal executive officer&#8221; and &#8220;principal financial officer&#8221; shall have the meanings given to such terms in the Exchange Act Rules 13a-15 and 15d-15.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">14</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
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      </div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">ff.&#160;&#160;&#160;&#160;&#160; &#160; &#160;&#160; <u>Finder&#8217;s Fees</u>. Neither the Company nor any Subsidiary has incurred any liability for any finder&#8217;s fees, brokerage commissions or similar payments in connection
          with the transactions herein contemplated, except as may otherwise exist with respect to the Agent pursuant to this Agreement.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">gg.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Labor Disputes</u>. No labor disturbance by or dispute with employees of the Company or any Subsidiary exists or, to the knowledge of the Company, is threatened
          which would result in a Material Adverse Effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">hh.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Investment Company Act</u>. Neither the Company nor any Subsidiary is or, after giving effect to the offering and sale of the Placement Shares, will be required to
          register as an &#8220;investment company&#8221; or an entity &#8220;controlled&#8221; by an &#8220;investment company,&#8221; as such terms are defined in the Investment Company Act of 1940, as amended (the &#8220;<u>Investment Company Act</u>&#8221;).</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">ii.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Operations</u>. The operations of the Company and the Subsidiaries are and have been conducted at all times in compliance with applicable financial record keeping
          and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, the money laundering statutes of all jurisdictions to which the Company or the Subsidiaries are subject, the rules and regulations thereunder
          and any related or similar rules, regulations or guidelines, issued, administered or enforced by any governmental agency having jurisdiction over the Company (collectively, the &#8220;<u>Money Laundering Laws</u>&#8221;), except where the failure to be in such compliance would not result in a Material Adverse Effect; and no action, suit or proceeding by or before any court or governmental agency, authority or body
          or any arbitrator involving the Company or any Subsidiary with respect to the Money Laundering Laws is pending or, to the knowledge of the Company, threatened.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">jj.&#160;&#160;&#160; &#160; &#160;&#160;&#160;&#160; <u>Off-Balance Sheet Arrangements</u>. There are no transactions, arrangements and other relationships between and/or among the Company, and/or, to the knowledge of
          the Company, any of its affiliates and any unconsolidated entity, including, but not limited to, any structured finance, special purpose or limited purpose entity (each, an &#8220;<u>Off Balance Sheet Transaction</u>&#8221;) that would affect materially the Company&#8217;s liquidity or the availability of or requirements for its capital resources, including those Off Balance Sheet Transactions described in the
          Commission&#8217;s Statement about Management&#8217;s Discussion and Analysis of Financial Conditions and Results of Operations (Release Nos. 33-8056; 34-45321; FR-61), required to be described in the Registration Statement or the Prospectus which have not
          been described as required.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">kk.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Underwriter Agreements</u>. Other than with respect to this agreement, the Company is not a party to any agreement with an agent or underwriter for any other &#8220;at
          the market&#8221; or continuous equity transaction.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">ll.&#160;&#160;&#160;&#160; &#160; &#160;&#160;&#160; <u>Forward-Looking Statements</u>. No forward-looking statement (within the meaning of Section 27A of the Securities Act and Section 21E of the Exchange Act) (a&#160;&#8220;<u>Forward-Looking Statement</u>&#8221;) contained in the Registration Statement and the Prospectus has been made or reaffirmed without a reasonable basis or has been
          disclosed other than in good faith.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">mm.&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Margin Rules</u>. Neither the issuance, sale and delivery of the Placement Shares nor the application of the proceeds thereof by the Company as described in the
          Registration Statement and the Prospectus will violate Regulation T, U or X of the Board of Governors of the Federal Reserve System.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">15</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">nn.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Insurance</u>. The Company and the Subsidiaries carry, or are covered by, insurance in such amounts and covering such risks as the Company and the Subsidiaries
          reasonably believe are adequate for the conduct of their business.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">oo.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>No Improper Practices</u>. (i) Neither the Company nor, to the Company&#8217;s knowledge, the Subsidiaries, nor to the Company&#8217;s knowledge, any of their respective
          executive officers has, in the past five years, made any unlawful contributions to any candidate for any political office (or failed fully to disclose any contribution in violation of law) or made any contribution or other payment to any official
          of, or candidate for, any federal, state, municipal, or foreign office or other person charged with similar public or quasi-public duty in violation of any law or of the character required to be disclosed in the Prospectus; (ii) no relationship,
          direct or indirect, exists between or among the Company or, to the Company&#8217;s knowledge, the Subsidiaries or any affiliate of any of them, on the one hand, and the directors, officers and stockholders of the Company or, to the Company&#8217;s knowledge,
          the Subsidiaries, on the other hand, that is required by the Securities Act to be described in the Registration Statement and the Prospectus that is not so described; (iii) no relationship, direct or indirect, exists between or among the Company
          or the Subsidiaries or any affiliate of them, on the one hand, and the directors, officers, stockholders or directors of the Company or, to the Company&#8217;s knowledge, the Subsidiaries, on the other hand, that is required by the rules of FINRA to be
          described in the Registration Statement and the Prospectus that is not so described; (iv) there are no material outstanding loans or advances or material guarantees of indebtedness by the Company or, to the Company&#8217;s knowledge, the Subsidiaries
          to or for the benefit of any of their respective officers or directors or any of the members of the families of any of them; and (v) the Company has not offered, or caused any placement agent to offer, Ordinary Shares to any person with the
          intent to influence unlawfully (A) a customer or supplier of the Company or the Subsidiaries to alter the customer&#8217;s or supplier&#8217;s level or type of business with the Company or the Subsidiaries or (B) a trade journalist or publication to write or
          publish favorable information about the Company or the Subsidiaries or any of their respective products or services, and, (vi) neither the Company nor the Subsidiaries nor, to the Company&#8217;s knowledge, any employee or agent of the Company or the
          Subsidiaries has made any payment of funds of the Company or the Subsidiaries or received or retained any funds in violation of any law, rule or regulation (including, without limitation, the Foreign Corrupt Practices Act of 1977), which payment,
          receipt or retention of funds is of a character required to be disclosed in the Registration Statement or the Prospectus.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">pp.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Status Under the Securities Act</u>. The Company was not and is not an ineligible issuer as defined in Rule 405 under the Securities Act at the times specified in
          Rules&#160;164 and 433 under the Securities Act in connection with the offering of the Placement Shares.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">qq.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>No Misstatement or Omission in an Issuer Free Writing Prospectus</u>. Each Issuer Free Writing Prospectus, as of its issue date and as of each Applicable Time (as
          defined in <u>Section 25</u> below), did not, does not and will not, through the completion of the Placement or Placements for which such Issuer Free Writing
          Prospectus is issued, include any information that conflicted, conflicts or will conflict with the information contained in the Registration Statement or the Prospectus, including any incorporated document deemed to be a part thereof that has not
          been superseded or modified. The foregoing sentence does not apply to statements in or omissions from any Issuer Free Writing Prospectus based upon and in conformity with written information furnished to the Company by the Agent specifically for
          use therein.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">16</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
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      </div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">rr.&#160;&#160; &#160; &#160;&#160;&#160;&#160;&#160; <u>No Conflicts</u>. Neither the execution of this Agreement, nor the issuance, offering or sale of the Placement Shares, nor the consummation of any of the
          transactions contemplated herein, nor the compliance by the Company with the terms and provisions hereof will conflict with, or will result in a breach of, any of the terms and provisions of, or has constituted or will constitute a default under,
          or has resulted in or will result in the creation or imposition of any lien, charge or encumbrance upon any property or assets of the Company pursuant to the terms of any contract or other agreement to which the Company may be bound or to which
          any of the property or assets of the Company is subject, except (i)&#160;such conflicts, breaches or defaults as may have been waived and (ii) such conflicts, breaches and defaults that would not have a Material Adverse Effect; nor will such action
          result (x) in any violation of the provisions of the organizational or governing documents of the Company, or (y)&#160;in any material violation of the provisions of any statute or any order, rule or regulation applicable to the Company or of any
          court or of any federal, state or other regulatory authority or other government body having jurisdiction over the Company, except where such violation would not have a Material Adverse Effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; margin-right: 3.6pt; line-height: 1.25;">ss.&#160;&#160;&#160;&#160; &#160; &#160;&#160;&#160; <u>OFAC</u>.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 104.4pt; margin-left: 3.6pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Neither the Company nor any Subsidiary (collectively, the &#8220;<u>Entity</u>&#8221;) nor, to the Company&#8217;s knowledge, any director, officer,
          employee, agent, affiliate or representative of the Entity, is a government, individual, or entity (in this paragraph (uu), &#8220;<u>Person</u>&#8221;) that is, or is owned
          or controlled by a Person that is:</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 108pt; margin-left: 36pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the subject of any sanctions administered or enforced by the U.S. Department of Treasury&#8217;s Office of Foreign Assets Control (&#8220;<u>OFAC</u>&#8221;), the
          United Nations Security Council (&#8220;<u>UNSC</u>&#8221;), the European Union (&#8220;<u>EU</u>&#8221;),
          Her Majesty&#8217;s Treasury (&#8220;<u>HMT</u>&#8221;), or other relevant sanctions authority (collectively, &#8220;<u>Sanctions</u>&#8221;), nor</div>
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      <div style="text-align: justify; text-indent: 108pt; margin-left: 36pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;located, organized or resident in a country or territory that is the subject of Sanctions.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 108.9pt; margin-left: 3.6pt; line-height: 1.25;">(ii)&#160;&#160;&#160;&#160;&#160;&#160; The Entity will not, directly or indirectly, knowingly use the proceeds of the offering, or lend, contribute or otherwise make available such proceeds to any subsidiary, joint venture partner or other Person:</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 108pt; margin-left: 36pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;to fund or facilitate any activities or business of or with any Person or in any country or territory that, at the time of such funding or facilitation, is the subject of Sanctions; or</div>
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      <div style="text-align: justify; text-indent: 108pt; margin-left: 36pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;in any other manner that will result in a violation of Sanctions by any Person (including any Person participating in the offering, whether as underwriter, advisor, investor or otherwise).</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 108.9pt; margin-left: 3.6pt; line-height: 1.25;">(iii)&#160;&#160;&#160;&#160;&#160; The Entity represents and covenants that, except as detailed in the Registration Statement and the Prospectus, for the past 5 years, it has not knowingly engaged in and is not now knowingly engaged in any dealing or
          transactions with any Person, or in any country or territory, that at the time of the dealing or transaction is or was the subject of Sanctions.</div>
      <div style="line-height: 1.25">&#160;</div>
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      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">tt.&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160; <u>Taxes</u>. No Israeli stamp or other Israeli issuance or transfer taxes or similar Israeli issuance or transfer duties and assuming that the Agent is not otherwise
          subject to taxation in Israel due to Israeli tax residence, the existence of a permanent establishment in Israel, a fixed place of business in Israel or any business activity of Agent in Israel, no capital gains, income, withholding or other
          taxes are payable in Israel by or on behalf of Agent in connection with the sale and delivery by the Company of the Placement Shares to or for the account of Agent or the sale and delivery by Agent of the Placement Shares to the purchasers
          thereof.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">uu.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>IT Systems</u>. (i)(x) To the knowledge of Company, there has been no security breach or other compromise of any Company&#8217;s information technology and computer
          systems, networks, hardware, software, data (including the data of their respective customers, employees, suppliers, vendors and any third party data maintained by or on behalf of them), equipment or technology (collectively, &#8220;<u>IT Systems and Data</u>&#8221;) and (y) the Company has not been notified of, and have no knowledge of any event or condition that would reasonably be expected to result
          in, any security breach or other compromise to their IT Systems and Data; (ii) the Company is presently in material compliance with all applicable laws or statutes and all judgments, orders, rules and regulations of any court or arbitrator or
          governmental or regulatory authority, internal policies and contractual obligations relating to the privacy and security of IT Systems and Data and to the protection of such IT Systems and Data from unauthorized use, access, misappropriation or
          modification, except as would not, in the case of this clause (ii), individually or in the aggregate, have a Material Adverse Effect; and (iii) the Company has implemented backup and disaster recovery technology consistent with industry standards
          and practices.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">vv.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>PFIC Status</u>. The Company was not a &#8220;passive foreign investment company&#8221; (&#8220;<u>PFIC</u>&#8221;)
          as defined in Section 1297 of the U.S. Internal Revenue Code of 1986, as amended, for the taxable year ended December 31, 2020 and, based on certain estimates of the Company&#8217;s gross income and the value of its assets, the intended use of proceeds
          from the offering and sale of the Placement Shares and the nature of the Company&#8217;s business, the Company does not expect to be classified as a PFIC for the taxable year ending December 31, 2021.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">ww.&#160;&#160;&#160;&#160;&#160;&#160; <u>CFC Status</u>. The Company was not a &#8220;controlled foreign corporation&#8221; (&#8220;<u>CFC</u>&#8221;)
          as defined in the U.S. Internal Revenue Code of 1986, as amended, for the taxable year ended December 31, 2020 and, based on the Company&#8217;s expectations with respect to its shareholders, the Company does not expect to be classified as a CFC for
          the taxable year ending December 31, 2021.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">xx.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Validity of Choice of Law</u>. The choice of the laws of the State of New York as the governing law of this Agreement is a valid choice of law under the laws of
          Israel and will be honored by courts in Israel. The Company has the power to submit, and pursuant to this Agreement, has legally, validly, effectively and irrevocably submitted, to the personal jurisdiction of each the State of New York and
          United States Federal court sitting in New York County (each, a &#8220;New York Court&#8221;) and has validly and irrevocably waived any objection to the laying of venue of any suit, action or proceeding brought in any such court; and the Company has the
          power to designate, appoint and empower, and pursuant to this Agreement, has legally, validly, effectively and irrevocably designated, appointed and empowered, an authorized agent for service of process in any action arising out of or relating to
          this Agreement, or the offering of the Placement Shares in any New York Court, and service of process effected on such authorized agent will be effective to confer valid personal jurisdiction over the Company as provided in this Agreement.</div>
      <div style="line-height: 1.25">&#160;</div>
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        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">18</font></div>
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      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Any certificate signed by an officer of the Company and delivered to the Agent or to counsel for the Agent pursuant
        to or in connection with this Agreement shall be deemed to be a representation and warranty by the Company, as applicable, to the Agent as to the matters set forth therein.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.3pt; margin-left: 0.7pt; line-height: 1.25;">7.&#160;&#160;&#160; &#160; &#160;&#160;&#160;&#160; <u>Covenants of the Company</u>.&#160; The Company covenants and agrees with the Agent that:</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">a.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Registration Statement Amendments</u>. After the date of this Agreement and during any period in which a prospectus relating to any Placement Shares is required to
          be delivered by the Agent under the Securities Act (including in circumstances where such requirement may be satisfied pursuant to Rule 172 under the Securities Act) (the &#8220;<u>Prospectus Delivery Period</u>&#8221;) (i) the Company will notify the Agent promptly of the time when any subsequent amendment to the Registration Statement, other than documents incorporated by reference or amendments not related
          to any Placement, has been filed with the Commission and/or has become effective or any subsequent supplement to the Prospectus has been filed and of any request by the Commission for any amendment or supplement to the Registration Statement or
          Prospectus related to the Placement or for additional information related to the Placement, (ii) the Company will prepare and file with the Commission, promptly upon the Agent&#8217;s request, any amendments or supplements to the Registration Statement
          or Prospectus that, upon the advice of the Company&#8217;s legal counsel, may be necessary or advisable in connection with the distribution of the Placement Shares by the Agent (<font style="font-style: italic;">provided, however</font>, that the failure of the Agent to make such request shall not relieve the Company of any obligation or liability hereunder, or affect the Agent&#8217;s right to rely on the representations and
          warranties made by the Company in this Agreement and provided, further, that the only remedy the Agent shall have with respect to the failure to make such filing shall be to cease making sales under this Agreement until such amendment or
          supplement is filed); (iii) the Company will not file any amendment or supplement to the Registration Statement or Prospectus relating to the Placement Shares or a security convertible into the Placement Shares (other than an Incorporated
          Document) unless a copy thereof has been submitted to the Agent within a reasonable period of time before the filing and the Agent has not reasonably objected thereto (<font style="font-style: italic;">provided, however</font>, that (A) the failure of the Agent to make such objection shall not relieve the Company of any obligation or liability hereunder, or affect the Agent&#8217;s right to rely on the representations and
          warranties made by the Company in this Agreement and (B) the Company has no obligation to provide the Agent any advance copy of such filing or to provide the Agent an opportunity to object to such filing if the filing does not name the Agent or
          does not relate to the transaction herein provided; and provided, further, that the only remedy the Agent shall have with respect to the failure by the Company to obtain such consent shall be to cease making sales under this Agreement) and the
          Company will furnish to the Agent at the time of filing thereof a copy of any document that upon filing is deemed to be incorporated by reference into the Registration Statement or Prospectus, except for those documents available via EDGAR; and
          (iv) the Company will cause each amendment or supplement to the Prospectus to be filed with the Commission as required pursuant to the applicable paragraph of Rule 424(b) of the Securities Act or, in the case of any document to be incorporated
          therein by reference, to be filed with the Commission as required pursuant to the Exchange Act, within the time period prescribed (the determination to file or not file any amendment or supplement with the Commission under this <u>Section 7(a)</u>, based on the Company&#8217;s reasonable opinion or reasonable objections, shall be made exclusively by the Company).</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">19</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
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      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">b.&#160;&#160;&#160;&#160;&#160;&#160; &#160; &#160; <u>Notice of Commission Stop Orders</u>. The Company will advise the Agent, promptly after it receives notice or obtains knowledge thereof, of the issuance or
          threatened issuance by the Commission of any stop order suspending the effectiveness of the Registration Statement, of the suspension of the qualification of the Placement Shares for offering or sale in any jurisdiction, or of the initiation or
          threatening of any proceeding for any such purpose; and it will use its commercially reasonable efforts to prevent the issuance of any stop order or to obtain its withdrawal if such a stop order should be issued. The Company will advise the Agent
          promptly after it receives any request by the Commission for any amendments to the Registration Statement or any amendment or supplements to the Prospectus or any Issuer Free Writing Prospectus or for additional information related to the
          offering of the Placement Shares or for additional information related to the Registration Statement, the Prospectus or any Issuer Free Writing Prospectus.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">c.&#160; &#160;&#160;&#160;&#160;&#160;&#160; &#160; <u>Delivery of Prospectus; Subsequent Changes</u>. During the Prospectus Delivery Period, the Company will comply with all requirements imposed upon it by the
          Securities Act, as from time to time in force, and to file on or before their respective due dates all reports and any definitive proxy or information statements required to be filed by the Company with the Commission pursuant to Sections 13(a),
          13(c), 14, 15(d) or any other provision of or under the Exchange Act. If the Company has omitted any information from the Registration Statement pursuant to Rule 430A under the Securities Act, it will use its commercially reasonable efforts to
          comply with the provisions of and make all requisite filings with the Commission pursuant to said Rule 430A and to notify the Agent promptly of all such filings. If during the Prospectus Delivery Period any event occurs as a result of which the
          Prospectus as then amended or supplemented would include an untrue statement of a material fact or omit to state a material fact necessary to make the statements therein, in the light of the circumstances then existing, not misleading, or if
          during such Prospectus Delivery Period it is necessary to amend or supplement the Registration Statement or Prospectus to comply with the Securities Act, the Company will promptly notify the Agent to suspend the offering of Placement Shares
          during such period and the Company will promptly amend or supplement the Registration Statement or Prospectus (at the expense of the Company) so as to correct such statement or omission or effect such compliance; <font style="font-style: italic;">provided, however</font>, that the Company may delay the filing of any amendment or supplement, if in the judgment of the Company, it is in the best interest of the Company.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">d.&#160;&#160;&#160;&#160; &#160; &#160;&#160;&#160; <u>Listing of Placement Shares</u>. During the Prospectus Delivery Period, the Company will use its commercially reasonable efforts to cause the Placement Shares to
          be listed on the Exchange and to qualify the Placement Shares for sale under the securities laws of such jurisdictions in the United States as the Agent reasonably designates and to continue such qualifications in effect so long as required for
          the distribution of the Placement Shares; <font style="font-style: italic;">provided, however</font>, that the Company shall not be required in connection therewith to qualify as a
          foreign corporation or dealer in securities, file a general consent to service of process, or subject itself to taxation in any jurisdiction if it is not otherwise so subject.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">20</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">e.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Delivery of Registration Statement and Prospectus</u>.&#160; The Company will furnish to the Agent and its counsel (at the reasonable expense of the Company) copies of
          the Registration Statement, the Prospectus (including all documents incorporated by reference therein) and all amendments and supplements to the Registration Statement or Prospectus that are filed with the Commission during the Prospectus
          Delivery Period (including all documents filed with the Commission during such period that are deemed to be incorporated by reference therein), in each case as soon as reasonably practicable and in such quantities as the Agent may from time to
          time reasonably request and, at the Agent&#8217;s request, will also furnish copies of the Prospectus to each exchange or market on which sales of the Placement Shares may be made; <font style="font-style: italic;">provided, however</font>, that the Company shall not be required to furnish any document (other than the Prospectus) to the Agent to the extent such document is available on EDGAR.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">f.&#160;&#160;&#160;&#160;&#160;&#160; &#160; &#160; &#160; <u>Use of Proceeds</u>. The Company will use the Net Proceeds as described in the Prospectus in the section entitled &#8220;Use of Proceeds.&#8221;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">g.&#160;&#160;&#160;&#160;&#160; &#160; &#160;&#160; <u>Notice of Other Sales</u>. Without the prior written consent of the Agent, the Company will not, directly or indirectly, offer to sell, sell, contract to sell,
          grant any option to sell or otherwise dispose of any Ordinary Shares (other than the Placement Shares offered pursuant to this Agreement) or securities convertible into or exchangeable for Ordinary Shares, warrants or any rights to purchase or
          acquire, Ordinary Shares during the period beginning on the date on which any Placement Notice is delivered to the Agent hereunder and ending on the third (3rd) Trading Day immediately following the final Settlement Date with respect to Placement
          Shares sold pursuant to such Placement Notice (or, if the Placement Notice has been terminated or suspended prior to the sale of all Placement Shares covered by a Placement Notice, the date of such suspension or termination); and will not
          directly or indirectly enter into in any other &#8220;at the market&#8221; or continuous equity transaction offer to sell, sell, contract to sell, grant any option to sell or otherwise dispose of any Ordinary Shares (other than the Placement Shares offered
          pursuant to this Agreement) or securities convertible into or exchangeable for Ordinary Shares, warrants or any rights to purchase or acquire, Ordinary Shares prior to the termination of this Agreement; <font style="font-style: italic;">provided, however</font>, that such restrictions will not apply in connection with the Company&#8217;s issuance or sale of (i) Ordinary Shares, options to purchase Ordinary Shares or Ordinary
          Shares issuable upon the exercise of options, pursuant to any stock option, or benefits plan, stock ownership plan or dividend reinvestment plan (but not Ordinary Shares subject to a waiver to exceed plan limits in its dividend reinvestment plan)
          of the Company whether now in effect or hereafter implemented; (ii) Ordinary Shares issuable upon conversion of securities or the exercise of warrants, options or other rights in effect or outstanding, and disclosed in filings by the Company
          available on EDGAR or otherwise in writing to the Agent, (iii)&#160;Ordinary Shares, or securities convertible into or exercisable for Ordinary Shares, offered and sold in a privately negotiated transaction to vendors, customers, strategic partners or
          potential strategic partners or other investors conducted in a manner so as not to be integrated with the offering of Ordinary Shares hereby and (iv) Ordinary Shares in connection with any acquisition, strategic investment or other similar
          transaction (including any joint venture, strategic alliance or partnership).</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">h.&#160; &#160;&#160; &#160;&#160;&#160;&#160;&#160;&#160; <u>Change of Circumstances</u>. The Company will, at any time during the pendency of a Placement Notice advise the Agent promptly after it shall have received notice
          or obtained knowledge thereof, of any information or fact that would alter or affect in any material respect any opinion, certificate, letter or other document required to be provided to the Agent pursuant to this Agreement.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">21</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
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      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">i.&#160;&#160;&#160;&#160; &#160; &#160;&#160;&#160; <u>Due Diligence Cooperation</u>. During the term of this Agreement, the Company will cooperate with any reasonable due diligence review conducted by the Agent or its
          representatives in connection with the transactions contemplated hereby, including, without limitation, providing information and making available documents and senior corporate officers, during regular business hours and at the Company&#8217;s
          principal offices, as the Agent may reasonably request.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">j.&#160;&#160;&#160;&#160;&#160; &#160; &#160; &#160;&#160; <u>Required Filings Relating to Placement of Placement Shares</u>. The Company agrees that on such dates as the Securities Act shall require, the Company will (i)
          file a prospectus supplement with the Commission under the applicable paragraph of Rule 424(b) under the Securities Act (each and every date a filing under Rule 424(b) is made, a &#8220;<u>Filing Date</u>&#8221;), which prospectus supplement will set forth, within the relevant period, the amount of Placement Shares sold through the Agent, the Net Proceeds to the Company and the compensation payable by the
          Company to the Agent with respect to such Placement Shares, and (ii) deliver such number of copies of each such prospectus supplement to each exchange or market on which such sales were effected as may be required by the rules or regulations of
          such exchange or market.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">k.&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; &#160; <u>Representation Dates; Certificate</u>. Each time during the term of this Agreement that the Company:</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; amends
          or supplements (other than a prospectus supplement relating solely to an offering of securities other than the Placement Shares) the Registration Statement or the Prospectus relating to the Placement Shares by means of a post-effective amendment,
          sticker, or supplement but not by means of incorporation of documents by reference into the Registration Statement or the Prospectus relating to the Placement Shares;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;files
          an annual report on Form 20-F under the Exchange Act (including any Form 20-F/A containing amended audited financial information or a material amendment to the previously filed Form 20-F);</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;">(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; files
          a report on Form 6-K containing interim financial statements under the Exchange Act; or</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;">(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; files
          a report on Form 6-K containing amended financial information (other than information &#8220;furnished&#8221; pursuant to Form 6-K or to provide disclosure pursuant to Form 6-K relating to the reclassification of certain properties as discontinued operations
          in accordance with Statement of Financial Accounting Standards No. 144) under the Exchange Act;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; line-height: 1.25;">(Each date of filing of one or more of the documents referred to in clauses (i) through (iv) shall be a &#8220;<u>Representation Date</u>.&#8221;)</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; line-height: 1.25;">the Company shall furnish the Agent (but in the case of clause (iv) above only if the Agent reasonably determines that the information
        contained in such Form 6-K is material) with a certificate, in the form attached hereto as <u>Exhibit 7(k)</u>. The requirement to provide a certificate under this
        <u>Section 7(k)</u> shall be waived for any Representation Date occurring at a time at which no Placement Notice is pending, which waiver shall continue until the
        earlier to occur of the date the Company delivers a Placement Notice hereunder (which for such calendar quarter shall be considered a Representation Date) and the next occurring Representation Date on which the Company files its annual report on
        Form 20-F. Notwithstanding the foregoing, (i) upon the delivery of the first Placement Notice hereunder and (ii) if the Company subsequently decides to sell Placement Shares following a Representation Date when the Company relied on such waiver and
        did not provide the Agent with a certificate under this <u>Section 7(k)</u>, then before the Agent sells any Placement Shares, the Company shall provide the Agent
        with a certificate, in the form attached hereto as <u>Exhibit 7(k)</u>, dated the date of the Placement Notice.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">22</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
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      </div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">l.&#160;&#160;&#160;&#160; &#160; &#160;&#160;&#160;&#160; <u>Legal Opinion</u>. Upon execution of this Agreement, on or prior to the date of the first Placement Notice given hereunder the Company shall cause to be furnished
          to the Agent a written opinion and a negative assurance letter to the extent applicable, of (a) Goodwin Procter LLP, special counsel to the Company, (b) Herzog Fox &amp; Neeman, Israeli legal counsel for the Company, and, (c) Ehrlich &amp;
          Fenster LTD, patent counsel for the Company (collectively, &#8220;<u>Company Counsel</u>&#8221;) each in form and substance reasonably satisfactory to the Agent. Thereafter,
          within five (5) Trading Days of each Representation Date with respect to which the Company is obligated to deliver a certificate in the form attached hereto as Exhibit 7(k) for which no waiver is applicable, the Company shall cause to be
          furnished to the Agent a&#160;negative assurance letter of Company Counsel in form and substance reasonably satisfactory to the Agent; provided that, in lieu of such negative assurance for subsequent periodic filings under the Exchange Act, counsel
          may furnish the Agent with a letter (a&#160;&#8220;<u>Reliance Letter</u>&#8221;) to the effect that the Agent may rely on the negative assurance letter previously delivered under
          this Section 7(l) to the same extent as if it were dated the date of such letter (except that statements in such prior letter shall be deemed to relate to the Registration Statement and the Prospectus as amended or supplemented as of the date of
          the Reliance Letter).</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">m.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Comfort Letter</u>. On or prior to the date of the first Placement Notice given hereunder and within five (5) Trading Days after each subsequent Representation
          Date, other than pursuant to Section 7(k)(iii), the Company shall cause its independent accountants to furnish the Agent letters (the &#8220;<u>Comfort Letters</u>&#8221;),
          dated the date the Comfort Letter is delivered, which shall meet the requirements set forth in this <u>Section 7(m)</u>. The Comfort Letter from the Company&#8217;s
          independent accountants shall be in a form and substance reasonably satisfactory to the Agent, (i) confirming that they are an independent public accounting firm within the meaning of the Securities Act and the Public Company Accounting Oversight
          Board (the &#8220;<u>PCAOB</u>&#8221;), (ii) stating, as of such date, the conclusions and findings of such firm with respect to the financial information and other matters
          ordinarily covered by accountants&#8217; &#8220;comfort letters&#8221; to underwriters in connection with registered public offerings (the first such letter, the &#8220;<u>Initial Comfort
              Letter</u>&#8221;) and (iii)&#160;updating the Initial Comfort Letter with any information that would have been included in the Initial Comfort Letter had it been given on such date and modified as necessary to relate to the Registration
          Statement and the Prospectus, as amended and supplemented to the date of such letter.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">n.&#160;&#160;&#160;&#160;&#160;&#160; &#160; &#160; <u>Market Activities</u>. The Company will not, directly or indirectly, (i) take any action designed to cause or result in, or that constitutes or would constitute,
          the stabilization or manipulation of the price of any security of the Company to facilitate the sale or resale of Ordinary Shares or (ii) sell, bid for, or purchase Ordinary Shares in violation of Regulation M, or pay anyone any compensation for
          soliciting purchases of the Placement Shares other than the Agent.</div>
      <div style="line-height: 1.25">&#160;</div>
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      </div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">o.&#160;&#160;&#160; &#160; &#160;&#160;&#160;&#160; <u>Investment Company Act</u>. The Company will conduct its affairs in such a manner so as to reasonably ensure that neither it nor the Subsidiaries will be or
          become, at any time prior to the termination of this Agreement, an &#8220;investment company,&#8221; as such term is defined in the Investment Company Act.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">p.&#160;&#160;&#160;&#160;&#160;&#160; &#160; &#160; <u>No Offer to Sell</u>. Other than an Issuer Free Writing Prospectus approved in advance by the Company and the Agent in its capacity as agent hereunder pursuant to
          <u>Section 23</u>, the Company (including its agents and representatives) will not make, use, prepare, authorize, approve or refer to any written communication
          (as defined in Rule 405), required to be filed with the Commission, that constitutes an offer to sell or solicitation of an offer to buy Placement Shares hereunder.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">q.&#160;&#160;&#160;&#160; &#160; &#160;&#160;&#160; <u>Sarbanes-Oxley Act</u>. The Company will maintain and keep accurate books and records reflecting its assets and maintain internal accounting controls in a manner
          designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with IFRS and including those policies and procedures that (i) pertain to
          the maintenance of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of the assets of the Company, (ii) provide reasonable assurance that transactions are recorded as necessary to permit the
          preparation of the Company&#8217;s consolidated financial statements in accordance with IFRS, (iii) that receipts and expenditures of the Company are being made only in accordance with management&#8217;s and the Company&#8217;s directors&#8217; authorization, and (iv)
          provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the Company&#8217;s assets that could have a material effect on its financial statements. The Company will maintain disclosure
          controls and procedures that comply with the requirements of the Exchange Act.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">8.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Representations and Covenants of the Agent</u>. The Agent represents and warrants that it is duly registered as a broker-dealer under FINRA, the Exchange Act and
          the applicable statutes and regulations of each state in which the Placement Shares will be offered and sold, except such states in which the Agent is exempt from registration or such registration is not otherwise required. The Agent shall
          continue, for the term of this Agreement, to be duly registered as a broker-dealer under FINRA, the Exchange Act and the applicable statutes and regulations of each state in which the Placement Shares will be offered and sold, except such states
          in which it is exempt from registration or such registration is not otherwise required, during the term of this Agreement.&#160; The Agent shall comply with all applicable law and regulations in connection with the transactions contemplated by this
          Agreement, including the issuance and sale through the Agent of the Placement Shares. Other than an Issuer Free Writing Prospectus approved in advance by the Company and the Agent in its capacity as agent hereunder pursuant to <u>Section 23</u>, the Agent (including its agents and representatives, other than the Agent in its capacity as such) will not make, use, prepare, authorize, approve
          or refer to any written communication (as defined in Rule 405), required to be filed with the Commission, that constitutes an offer to sell or solicitation of an offer to buy Placement Shares hereunder.</div>
      <div style="line-height: 1.25">&#160;</div>
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        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">24</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
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      </div>
      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">9.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Payment of Expenses</u>. The Company will pay all expenses incident to the performance of its obligations under this Agreement, including (i) the preparation,
          filing, including any fees required by the Commission, and printing of the Registration Statement (including financial statements and exhibits) as originally filed and of each amendment and supplement thereto and each Free Writing Prospectus, in
          such number as the Agent shall deem reasonably necessary, (ii) the printing and delivery to the Agent of this Agreement and such other documents as may be required in connection with the offering, purchase, sale, issuance or delivery of the
          Placement Shares, (iii) the preparation, issuance and delivery of the certificates, if any, for the Placement Shares to the Agent, including any stock or other transfer taxes and any capital duties, stamp duties or other duties or taxes payable
          upon the sale, issuance or delivery of the Placement Shares to the Agent, (iv) the fees and disbursements of the counsel, accountants and other advisors to the Company, (v) the reasonable and documented out-of-pocket fees and disbursements of
          counsel to the Agent incurred in connection with (a) entering into the transactions contemplated by this Agreement in an amount not to exceed $50,000 in the aggregate, and (b) ongoing diligence arising from the transactions contemplated by this
          Agreement in an amount not to exceed $2,500 in the aggregate per calendar quarter; (vi) the fees and expenses of the transfer agent and registrar for the Ordinary Shares, (vii) the filing fees incident to any review by FINRA of the terms of the
          sale of the Placement Shares, and (viii) the fees and expenses incurred in connection with the listing of the Placement Shares on the Exchange.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">10.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Conditions to the Agent&#8217;s Obligations</u>. The obligations of the Agent hereunder with respect to a Placement will be subject to the
          continuing accuracy and completeness of the representations and warranties made by the Company herein (other than those representations and warranties made as of a specified date or time), to the due performance in all material respects by the
          Company of its obligations hereunder, to the completion by the Agent of a due diligence review satisfactory to it in its reasonable judgment, and to the continuing reasonable satisfaction (or waiver by the Agent in its sole discretion) of the
          following additional conditions:</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">a.&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; &#160; <u>Registration Statement Effective</u>. The Registration Statement shall remain effective and shall be available for the sale of all Placement Shares contemplated to
          be issued by any Placement Notice.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">b.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>No Material Notices</u>. None of the following events shall have occurred and be continuing: (i) receipt by the Company of any request for additional information
          from the Commission or any other federal or state governmental authority during the period of effectiveness of the Registration Statement, the response to which would require any post&#8209;effective amendments or supplements to the Registration
          Statement or the Prospectus; (ii)&#160;the issuance by the Commission or any other federal or state governmental authority of any stop order suspending the effectiveness of the Registration Statement or receipt by the Company of notification of the
          initiation of any proceedings for that purpose; (iii) receipt by the Company of any notification with respect to the suspension of the qualification or exemption from qualification of any of the Placement Shares for sale in any jurisdiction or
          receipt by the Company of notification of the initiation of, or a threat to initiate, any proceeding for such purpose; or (iv) the occurrence of any event that makes any material statement made in the Registration Statement or the Prospectus or
          any material Incorporated Document untrue in any material respect or that requires the making of any changes in the Registration Statement, the Prospectus or any material Incorporated Document so that, in the case of the Registration Statement,
          it will not contain any materially untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein not misleading and, that in the case of the Prospectus or any
          material Incorporated Document, it will not contain any materially untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances
          under which they were made, not misleading.</div>
      <div style="line-height: 1.25">&#160;</div>
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        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">25</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
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      </div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">c.&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160;&#160; <u>No Misstatement or Material Omission</u>. The Agent shall not have advised the Company that the Registration Statement or Prospectus, or any amendment or
          supplement thereto, contains an untrue statement of fact that in the Agent&#8217;s reasonable opinion is material, or omits to state a fact that in the Agent&#8217;s reasonable opinion is material and is required to be stated therein or is necessary to make
          the statements therein not misleading.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">d.&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160; <u>Material Changes</u>. Except as contemplated in the Prospectus, or disclosed in the Company&#8217;s reports filed with the Commission, there shall not have been any
          Material Adverse Effect, or any development that would cause a Material Adverse Effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">e.&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160; <u>Company Counsel Legal Opinion</u>. The Agent shall have received the opinion and negative assurance letter of Company Counsel required to be delivered pursuant to
          <u>Section&#160;7(l)</u> on or before the date on which such delivery of such opinion and negative assurance letter are required pursuant to <u>Section 7(l)</u>.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">f.&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160;&#160; <u>Agent Counsel Legal Opinion</u>. Agent shall have received from Duane Morris LLP, counsel for the Agent, such opinion or opinions, on or before the date on which
          the delivery of the Company Counsel legal opinion is required pursuant to <u>Section 7(l)</u>, with respect to such matters as the Agent may reasonably require,
          and the Company shall have furnished to such counsel such documents as they request for enabling them to pass upon such matters.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">g.&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160; <u>Comfort Letter</u>. The Agent shall have received the Comfort Letter required to be delivered pursuant <u>Section 7(m)</u> on or before the date on which such delivery of such letter is required pursuant to <u>Section 7(m)</u>.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">h.&#160;&#160; &#160;&#160; &#160;&#160;&#160;&#160;&#160; <u>Representation Certificate</u>. The Agent shall have received the certificate required to be delivered pursuant to <u>Section 7(k)</u> on or before the date on which delivery of such certificate is required pursuant to <u>Section 7(k)</u>.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">i.&#160;&#160;&#160; &#160; &#160; &#160;&#160;&#160;&#160; <u>Secretary&#8217;s Certificate</u>. On or prior to the first Representation Date, the Agent shall have received a certificate, signed on behalf of the Company by its
          corporate Secretary, in form and substance satisfactory to the Agent and its counsel.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">j.&#160;&#160;&#160;&#160;&#160; &#160; &#160; &#160;&#160; <u>No Suspension</u>. Trading in the Ordinary Shares shall not have been suspended on the Exchange and the Ordinary Shares shall not have been delisted from the
          Exchange.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">k.&#160;&#160;&#160;&#160; &#160; &#160;&#160;&#160; <u>Other Materials</u>. On each date on which the Company is required to deliver a certificate pursuant to <u>Section 7(k)</u>, the Company shall have furnished to the Agent such appropriate further information, certificates and documents as the Agent may reasonably request and which are usually and customarily
          furnished by an issuer of securities in connection with a securities offering of the type contemplated hereby. All such opinions, certificates, letters and other documents will be in compliance with the provisions hereof.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">l.&#160;&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160; <u>Securities Act Filings Made</u>. All filings with the Commission required by Rule 424 under the Securities Act to have been filed prior to the issuance of any
          Placement Notice hereunder shall have been made within the applicable time period prescribed for such filing by Rule 424.</div>
      <div style="line-height: 1.25">&#160;</div>
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        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">26</font></div>
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      </div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">m.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Approval for Listing</u>. The Placement Shares shall either have been approved for listing on the Exchange, subject only to notice of issuance, or the Company
          shall have filed an application for listing of the Placement Shares on the Exchange at, or prior to, the issuance of any Placement Notice.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">n.&#160;&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160; <u>No Termination Event</u>. There shall not have occurred any event that would permit the Agent to terminate this Agreement pursuant to <u>Section 13(a)</u>.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">11.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Indemnification and Contribution</u>.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Company Indemnification</u>. The Company agrees to indemnify and hold harmless the Agent, its partners, members, directors, officers, employees and agents and each
          person, if any, who controls the Agent within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act as follows:</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;against
          any and all loss, liability, claim, damage and expense whatsoever, as incurred, joint or several, arising out of or based upon any untrue statement or alleged untrue statement of a material fact contained in the Registration Statement (or any
          amendment thereto), or the omission or alleged omission therefrom of a material fact required to be stated therein or necessary to make the statements therein not misleading, or arising out of any untrue statement or alleged untrue statement of a
          material fact included in any related Issuer Free Writing Prospectus or the Prospectus (or any amendment or supplement thereto), or the omission or alleged omission therefrom of a material fact necessary in order to make the statements therein,
          in the light of the circumstances under which they were made, not misleading;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;against
          any and all loss, liability, claim, damage and expense whatsoever, as incurred, joint or several, to the extent of the aggregate amount paid in settlement of any litigation, or any investigation or proceeding by any governmental agency or body,
          commenced or threatened, or of any claim whatsoever based upon any such untrue statement or omission, or any such alleged untrue statement or omission; provided that (subject to <u>Section&#160;11(d)</u> below) any such settlement is effected with the written consent of the Company, which consent shall not unreasonably be delayed or withheld; and</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;">(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;against
          any and all expense whatsoever, as incurred (including the reasonable and documented out-of-pocket fees and disbursements of counsel), reasonably incurred in investigating, preparing or defending against any litigation, or any investigation or
          proceeding by any governmental agency or body, commenced or threatened, or any claim whatsoever based upon any such untrue statement or omission, or any such alleged untrue statement or omission, to the extent that any such expense is not paid
          under (i) or (ii) above,</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; line-height: 1.25;"><font style="font-style: italic;">provided, however</font>, that this
        indemnity agreement shall not apply to any loss, liability, claim, damage or expense to the extent arising out of any untrue statement or omission or alleged untrue statement or omission made solely in reliance upon and in conformity with written
        information furnished to the Company by the Agent expressly for use in the Registration Statement (or any amendment thereto), or in any related Issuer Free Writing Prospectus or the Prospectus (or any amendment or supplement thereto).</div>
      <div style="line-height: 1.25">&#160;</div>
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      </div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Indemnification by the Agent</u>. The Agent agrees to indemnify and hold harmless the Company and its directors and officers, and each person, if any, who (i)
          controls the Company within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act or (ii) is controlled by or is under common control with the Company against any and all loss, liability, claim, damage and expense
          described in the indemnity contained in <u>Section 11(a)</u>, as incurred, but only with respect to untrue statements or omissions, or alleged untrue statements
          or omissions, made in the Registration Statement (or any amendments thereto) or in any related Issuer Free Writing Prospectus or the Prospectus (or any amendment or supplement thereto) in reliance upon and in conformity with information relating
          to the Agent and furnished to the Company in writing by the Agent expressly for use therein.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Procedure</u>. Any party that proposes to assert the right to be indemnified under this <u>Section 11</u> will, promptly after receipt of notice of commencement of any action against such party in respect of which a claim is to be made against an indemnifying party or parties under this <u>Section 11</u>, notify each such indemnifying party of the commencement of such action, enclosing a copy of all papers served, but the omission so to notify such indemnifying party
          will not relieve the indemnifying party from (i) any liability that it might have to any indemnified party otherwise than under this <u>Section 11</u> and (ii)
          any liability that it may have to any indemnified party under the foregoing provisions of this <u>Section 11</u> unless, and only to the extent that, such
          omission results in the forfeiture of substantive rights or defenses by the indemnifying party. If any such action is brought against any indemnified party and it notifies the indemnifying party of its commencement, the indemnifying party will be
          entitled to participate in and, to the extent that it elects by delivering written notice to the indemnified party promptly after receiving notice of the commencement of the action from the indemnified party, jointly with any other indemnifying
          party similarly notified, to assume the defense of the action, with counsel reasonably satisfactory to the indemnified party, and after notice from the indemnifying party to the indemnified party of its election to assume the defense, the
          indemnifying party will not be liable to the indemnified party for any legal or other expenses except as provided below and except for the reasonable costs of investigation subsequently incurred by the indemnified party in connection with the
          defense. The indemnified party will have the right to employ its own counsel in any such action, but the fees, expenses and other charges of such counsel will be at the expense of such indemnified party unless (1) the employment of counsel by the
          indemnified party has been authorized in writing by the indemnifying party, (2) the indemnified party has reasonably concluded (based on advice of counsel) that there may be legal defenses available to it or other indemnified parties that are
          different from or in addition to those available to the indemnifying party, (3) a conflict or potential conflict of interest exists (based on advice of counsel to the indemnified party) between the indemnified party and the indemnifying party (in
          which case the indemnifying party will not have the right to direct the defense of such action on behalf of the indemnified party) or (4) the indemnifying party has not in fact employed counsel to assume the defense of such action within a
          reasonable time after receiving notice of the commencement of the action, in each of which cases the reasonable and documented out-of-pocket fees, disbursements and other charges of counsel will be at the expense of the indemnifying party or
          parties. It is understood that the indemnifying party or parties shall not, in connection with any proceeding or related proceedings in the same jurisdiction, be liable for the reasonable and documented out-of-pocket fees, disbursements and other
          charges of more than one separate firm admitted to practice in such jurisdiction at any one time for all such indemnified party or parties. All such reasonable and documented out-of-pocket fees, disbursements and other charges will be reimbursed
          by the indemnifying party promptly after the indemnifying party receives a written invoice relating to fees, disbursements and other charges in reasonable detail. An indemnifying party will not, in any event, be liable for any settlement of any
          action or claim effected without its written consent. No indemnifying party shall, without the prior written consent of each indemnified party, settle or compromise or consent to the entry of any judgment in any pending or threatened claim,
          action or proceeding relating to the matters contemplated by this <u>Section 11</u> (whether or not any indemnified party is a party thereto), unless such
          settlement, compromise or consent (1) includes an unconditional release of each indemnified party from all liability arising out of such litigation, investigation, proceeding or claim and (2) does not include a statement as to or an admission of
          fault, culpability or a failure to act by or on behalf of any indemnified party.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">28</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Contribution</u>. In order to provide for just and equitable contribution in circumstances in which the indemnification provided for in the foregoing paragraphs of
          this <u>Section 11</u> is applicable in accordance with its terms but for any reason is held to be unavailable from the Company or the Agent, the Company and the
          Agent will contribute to the total losses, claims, liabilities, expenses and damages (including any investigative, legal and other expenses reasonably incurred in connection with, and any amount paid in settlement of, any action, suit or
          proceeding or any claim asserted, but after deducting any contribution received by the Company from persons other than the Agent, such as persons who control the Company within the meaning of the Securities Act or the Exchange Act, officers of
          the Company who signed the Registration Statement and directors of the Company, who also may be liable for contribution) to which the Company and the Agent may be subject in such proportion as shall be appropriate to reflect the relative benefits
          received by the Company on the one hand and the Agent on the other hand. The relative benefits received by the Company on the one hand and the Agent on the other hand shall be deemed to be in the same proportion as the total Net Proceeds from the
          sale of the Placement Shares (before deducting expenses) received by the Company bear to the total compensation received by the Agent (before deducting expenses) from the sale of Placement Shares on behalf of the Company. If, but only if, the
          allocation provided by the foregoing sentence is not permitted by applicable law, the allocation of contribution shall be made in such proportion as is appropriate to reflect not only the relative benefits referred to in the foregoing sentence
          but also the relative fault of the Company, on the one hand, and the Agent, on the other hand, with respect to the statements or omission that resulted in such loss, claim, liability, expense or damage, or action in respect thereof, as well as
          any other relevant equitable considerations with respect to such offering.&#160; Such relative fault shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or omission or alleged
          omission to state a material fact relates to information supplied by the Company or the Agent, the intent of the parties and their relative knowledge, access to information and opportunity to correct or prevent such statement or omission. The
          Company and the Agent agree that it would not be just and equitable if contributions pursuant to this <u>Section 11(d)</u> were to be determined by pro rata
          allocation or by any other method of allocation that does not take into account the equitable considerations referred to herein. The amount paid or payable by an indemnified party as a result of the loss, claim, liability, expense, or damage, or
          action in respect thereof, referred to above in this <u>Section 11(d)</u> shall be deemed to include, for the purpose of this <u>Section 11(d)</u>, any legal or other expenses reasonably incurred by such indemnified party in connection with investigating or defending any such action or claim to the extent
          consistent with <u>Section 11(c)</u> hereof. Notwithstanding the foregoing provisions of this <u>Section 11(d)</u>, the Agent shall not be required to contribute any amount in excess of the commissions received by it under this Agreement and no person found guilty of fraudulent misrepresentation (within the meaning
          of Section 11(f) of the Securities Act) will be entitled to contribution from any person who was not guilty of such fraudulent misrepresentation. For purposes of this <u>Section
              11(d)</u>, any person who controls a party to this Agreement within the meaning of the Securities Act or the Exchange Act, and any officers, directors, partners, employees or agents of the Agent, will have the same rights to
          contribution as that party, and each officer who signed the Registration Statement and director of the Company will have the same rights to contribution as the Company, subject in each case to the provisions hereof. Any party entitled to
          contribution, promptly after receipt of notice of commencement of any action against such party in respect of which a claim for contribution may be made under this <u>Section
              11(d)</u>, will notify any such party or parties from whom contribution may be sought, but the omission to so notify will not relieve that party or parties from whom contribution may be sought from any other obligation it or they may
          have under this <u>Section 11(d)</u> except to the extent that the failure to so notify such other party materially prejudiced the substantive rights or defenses
          of the party from whom contribution is sought. Except for a settlement entered into pursuant to the last sentence of <u>Section 11(c)</u> hereof, no party will
          be liable for contribution with respect to any action or claim settled without its written consent if such consent is required pursuant to <u>Section 11(c)</u>
          hereof.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">29</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">12.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Representations and Agreements to Survive Delivery</u>. The indemnity and contribution agreements contained in Section 11 of this
          Agreement and all representations and warranties of the Company herein or in certificates delivered pursuant hereto shall survive, as of their respective dates, regardless of (i) any investigation made by or on behalf of the Agent, any
          controlling persons, or the Company (or any of their respective officers, directors or controlling persons), (ii) delivery and acceptance of the Placement Shares and payment therefor or (iii) any termination of this Agreement.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 35.3pt; margin-left: 0.7pt; line-height: 1.25;">13.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Termination</u>.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">a.&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; &#160; The
          Agent may terminate this Agreement, by notice to the Company, as hereinafter specified at any time (1) if there has been, since the time of execution of this Agreement or since the date as of which information is given in the Prospectus, any
          Material Adverse Effect, or any development that would have a Material Adverse Effect that, in the sole judgment of the Agent, is material and adverse and makes it impractical or inadvisable to market the Placement Shares or to enforce contracts
          for the sale of the Placement Shares, (2) if there has occurred any material adverse change in the financial markets in the United States or the international financial markets, any outbreak of hostilities or escalation thereof or other calamity
          or crisis or any change or development involving a prospective change in national or international political, financial or economic conditions, in each case the effect of which is such as to make it, in the judgment of the Agent, impracticable or
          inadvisable to market the Placement Shares or to enforce contracts for the sale of the Placement Shares, (3) if trading in the Ordinary Shares has been suspended or limited by the Commission or the Exchange, or if trading generally on the
          Exchange has been suspended or limited, or minimum prices for trading have been fixed on the Exchange, (4) if any suspension of trading of any securities of the Company on any exchange or in the over-the-counter market shall have occurred and be
          continuing, (5) if a major disruption of securities settlements or clearance services in the United States shall have occurred and be continuing, or (6)&#160;if a banking moratorium has been declared by either U.S. Federal or New York authorities. Any
          such termination shall be without liability of any party to any other party except that the provisions of <u>Section</u> 9 (Payment of Expenses), <u>Section 11</u> (Indemnification and Contribution), <u>Section 12</u>
          (Representations and Agreements to Survive Delivery), <u>Section 18</u> (Governing Law and Time; Waiver of Jury Trial) and <u>Section 19</u> (Consent to Jurisdiction) hereof shall remain in full force and effect notwithstanding such termination. If the Agent elects to terminate this Agreement as provided in this
          Section 13(a), the Agent shall provide the required notice as specified in Section 14 (Notices).</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">30</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">b.&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160; The
          Company shall have the right, by giving five (5) days&#8217; notice as hereinafter specified to terminate this Agreement in its sole discretion at any time after the date of this Agreement. Any such termination shall be without liability of any party
          to any other party except that the provisions of <u>Section 9</u> (Payment of Expenses), <u>Section 11</u> (Indemnification and Contribution), <u>Section 12</u> (Representations and Agreements to Survive Delivery), <u>Section 18</u> (Governing Law and Time; Waiver of Jury Trial) and <u>Section 19</u>
          (Consent to Jurisdiction) hereof shall remain in full force and effect notwithstanding such termination.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">c.&#160;&#160;&#160;&#160; &#160; &#160;&#160;&#160; The
          Agent shall have the right, by giving five (5) days&#8217; notice as hereinafter specified to terminate this Agreement in its sole discretion at any time after the date of this Agreement. Any such termination shall be without liability of any party to
          any other party except that the provisions of <u>Section 9</u> (Payment of Expenses), <u>Section&#160;11</u> (Indemnification and Contribution), <u>Section 12</u> (Representations and Agreements to Survive Delivery), <u>Section 18</u> (Governing Law and Time; Waiver of Jury Trial) and <u>Section 19</u>
          (Consent to Jurisdiction) hereof shall remain in full force and effect notwithstanding such termination.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">d.&#160;&#160; &#160;&#160; &#160;&#160;&#160;&#160;&#160; Unless
          earlier terminated pursuant to this <u>Section 13</u>, this Agreement shall automatically terminate upon the issuance and sale of all of the Placement Shares
          through the Agent on the terms and subject to the conditions set forth herein except that the provisions of <u>Section 9</u> (Payment of Expenses), <u>Section 11</u> (Indemnification and Contribution), <u>Section 12</u>
          (Representations and Agreements to Survive Delivery), <u>Section 18</u> (Governing Law and Time; Waiver of Jury Trial) and <u>Section 19</u> (Consent to Jurisdiction) hereof shall remain in full force and effect notwithstanding such termination.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">e.&#160;&#160;&#160;&#160; &#160; &#160;&#160;&#160; This
          Agreement shall remain in full force and effect unless terminated pursuant to <u>Sections 13(a)</u>, <u>(b</u>), <u>(c</u>), or <u>(d)</u> above
          or otherwise by mutual agreement of the parties; <font style="font-style: italic;">provided, however</font>, that any such termination by mutual agreement shall in all cases be
          deemed to provide that <u>Section 9</u> (Payment of Expenses), <u>Section 11</u>
          (Indemnification and Contribution), <u>Section 12</u> (Representations and Agreements to Survive Delivery), <u>Section 18</u> (Governing Law and Time; Waiver of Jury Trial) and <u>Section 19</u> (Consent to Jurisdiction) shall remain
          in full force and effect. Upon termination of this Agreement, the Company shall not have any liability to the Agent for any discount, commission or other compensation with respect to any Placement Shares not otherwise sold by the Agent under this
          Agreement.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">f.&#160; &#160;&#160; &#160;&#160;&#160;&#160;&#160;&#160; Any
          termination of this Agreement shall be effective on the date specified in such notice of termination; <font style="font-style: italic;">provided, however</font>, that such
          termination shall not be effective until the close of business on the date of receipt of such notice by the Agent or the Company, as the case may be. If such termination shall occur prior to the Settlement Date for any sale of Placement Shares,
          such Placement Shares shall settle in accordance with the provisions of this Agreement.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">31</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">14.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Notices</u>. All notices or other communications required or permitted to be given by any party to any other party pursuant to the terms
          of this Agreement shall be in writing, unless otherwise specified, and if sent to the Agent, shall be delivered to:</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="margin-left: 72pt; line-height: 1.25;">B. Riley Securities, Inc.</div>
      <div style="margin-left: 72pt; line-height: 1.25;">299 Park Avenue, 7<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> Floor</div>
      <div style="margin-left: 72pt; line-height: 1.25;">New York, NY 10171</div>
      <div style="margin-left: 72pt; line-height: 1.25;">Attention:&#160;&#160;&#160; General
          Counsel<br>
          Telephone:&#160;&#160; (212) 457-9947</div>
      <div style="margin-left: 72pt; line-height: 1.25;">Email:&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;atmdesk@brileyfin.com</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="line-height: 1.25;">with a copy to:</div>
      <div style="margin-left: 72pt; line-height: 1.25;"><br>
        Duane Morris LLP</div>
      <div style="margin-left: 72pt; line-height: 1.25;">1540 Broadway</div>
      <div style="margin-left: 72pt; line-height: 1.25;">New York, NY 10036</div>
      <div style="margin-left: 72pt; line-height: 1.25;">Attention:&#160;&#160;&#160; James
          T. Seery</div>
      <div style="margin-left: 72pt; line-height: 1.25;">Telephone:&#160;&#160; (973)
          424-2088</div>
      <div style="margin-left: 72pt; line-height: 1.25;">Email:&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;jtseery@duanemorris.com</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="line-height: 1.25;">and if to the Company, shall be delivered to:</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 72pt; line-height: 1.25;">Entera Bio Ltd.</div>
      <div style="margin-left: 72pt; line-height: 1.25;">Kiryat Hadassah</div>
      <div style="margin-left: 72pt; line-height: 1.25;">Minrav Building - Fifth Floor</div>
      <div style="margin-left: 72pt; line-height: 1.25;">Jerusalem, Israel<br>
        Attention:&#160;&#160;&#160; Chief Financial Officer<br>
        Telephone:&#160;&#160; 781-266-7514</div>
      <div style="margin-left: 72pt; line-height: 1.25;">Email:&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Ramesh@enterabio.com</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">with a copy to:</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 72pt; line-height: 1.25;">Goodwin Procter LLP</div>
      <div style="margin-left: 72pt; line-height: 1.25;">100 Northern Ave.</div>
      <div style="margin-left: 72pt; line-height: 1.25;">Boston, MA 02210<br>
        Attention:&#160;&#160;&#160; John Egan<br>
        Telephone:&#160;&#160; (617) 570-1514</div>
      <div style="margin-left: 72pt; line-height: 1.25;">Email:&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;JEgan@goodwinlaw.com</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">Each party to this Agreement may change such address for notices by sending to the parties to this Agreement written notice of a new
        address for such purpose. Each such notice or other communication shall be deemed given (i) when delivered personally, by email, or by verifiable facsimile transmission on or before 4:30 p.m., New York City time, on a Business Day or, if such day
        is not a Business Day, on the next succeeding Business Day, (ii) on the next Business Day after timely delivery to a nationally-recognized overnight courier and (iii) on the Business Day actually received if deposited in the U.S. mail (certified or
        registered mail, return receipt requested, postage prepaid). For purposes of this Agreement, &#8220;<u>Business Day</u>&#8221; shall mean any day on which the Exchange and
        commercial banks in the City of New York are open for business.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">32</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">15.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Successors and Assigns</u>. This Agreement shall inure to the benefit of and be binding upon the Company and the Agent and their
          respective successors and the affiliates, controlling persons, officers and directors referred to in <u>Section 11</u> hereof. References to any of the parties
          contained in this Agreement shall be deemed to include the successors and permitted assigns of such party. Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective
          successors and permitted assigns any rights, remedies, obligations or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement. Neither the Company nor the Agent may assign its rights or obligations under
          this Agreement without the prior written consent of the other party.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">16.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Adjustments for Stock Splits</u>. The parties acknowledge and agree that all share&#8209;related numbers contained in this Agreement shall be
          adjusted to take into account any share consolidation, bonus shares, stock split, stock dividend, corporate domestication or similar event effected with respect to the Placement Shares.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">17.&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Entire Agreement; Amendment; Severability</u>. This Agreement (including all schedules and exhibits attached hereto and Placement
          Notices issued pursuant hereto) constitutes the entire agreement and supersedes all other prior and contemporaneous agreements and undertakings, both written and oral, among the parties hereto with regard to the subject matter hereof. Neither
          this Agreement nor any term hereof may be amended except pursuant to a written instrument executed by the Company and the Agent. In the event that any one or more of the provisions contained herein, or the application thereof in any circumstance,
          is held invalid, illegal or unenforceable as written by a court of competent jurisdiction, then such provision shall be given full force and effect to the fullest possible extent that it is valid, legal and enforceable, and the remainder of the
          terms and provisions herein shall be construed as if such invalid, illegal or unenforceable term or provision was not contained herein, but only to the extent that giving effect to such provision and the remainder of the terms and provisions
          hereof shall be in accordance with the intent of the parties as reflected in this Agreement.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">18.&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>GOVERNING LAW AND TIME; WAIVER OF JURY TRIAL</u>. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE
          STATE OF NEW YORK WITHOUT REGARD TO THE PRINCIPLES OF CONFLICTS OF LAWS. SPECIFIED TIMES OF DAY REFER TO NEW YORK CITY TIME. THE COMPANY AND THE AGENT EACH HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL
          RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">33</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">19.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>CONSENT TO JURISDICTION</u>. EACH PARTY HEREBY IRREVOCABLY SUBMITS TO THE NON-EXCLUSIVE JURISDICTION OF THE STATE AND FEDERAL COURTS
          SITTING IN THE CITY OF NEW YORK, BOROUGH OF MANHATTAN, FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION WITH ANY TRANSACTION CONTEMPLATED HEREBY, AND HEREBY IRREVOCABLY WAIVES, AND AGREES NOT TO ASSERT IN ANY SUIT, ACTION OR
          PROCEEDING, ANY CLAIM THAT IT IS NOT PERSONALLY SUBJECT TO THE JURISDICTION OF ANY SUCH COURT, THAT SUCH SUIT, ACTION OR PROCEEDING IS BROUGHT IN AN INCONVENIENT FORUM OR THAT THE VENUE OF SUCH SUIT, ACTION OR PROCEEDING IS IMPROPER. EACH PARTY
          HEREBY IRREVOCABLY WAIVES PERSONAL SERVICE OF PROCESS AND CONSENTS TO PROCESS BEING SERVED IN ANY SUCH SUIT, ACTION OR PROCEEDING BY MAILING A COPY THEREOF (CERTIFIED OR REGISTERED MAIL, RETURN RECEIPT REQUESTED) TO SUCH PARTY AT THE ADDRESS IN
          EFFECT FOR NOTICES TO IT UNDER THIS AGREEMENT AND AGREES THAT SUCH SERVICE SHALL CONSTITUTE GOOD AND SUFFICIENT SERVICE OF PROCESS AND NOTICE THEREOF. NOTHING CONTAINED HEREIN SHALL BE DEEMED TO LIMIT IN ANY WAY ANY RIGHT TO SERVE PROCESS IN ANY
          MANNER PERMITTED BY LAW.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">20.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Appointment of Agent for Service</u>. The Company hereby irrevocably appoints Entera Bio Ltd., 37 Walnut Street, Suite 300, Wellesley
          Hills, MA 02481 as its agent for service of process in any suit, action or proceeding described in Section 18 and agrees that service of process in any suit, action or proceeding may be made upon it at the office of such agent. The Company
          waives, to the fullest extent permitted by law, any other requirements of or objections to personal jurisdiction with respect thereto. The Company represents and warrants that such agent has agreed to act as the Company&#8217;s agent for service of
          process, and the Company agrees to take any and all action, including the filing of any and all documents and instruments, that may be necessary to continue such appointment in full force and effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">21.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Use of Information</u>. The Agent may not use any information gained in connection with this Agreement and the transactions contemplated
          by this Agreement, including due diligence, to advise any party with respect to transactions not expressly approved by the Company.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">22.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Counterparts</u>. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of
          which together shall constitute one and the same instrument. Delivery of an executed Agreement by one party to the other may be made by facsimile transmission or email of a .pdf attachment.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">23.&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <u>Effect of Headings</u>.&#160; The section, Schedule and Exhibit headings herein are for convenience only and shall not affect the
          construction hereof.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">24.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Permitted Free Writing Prospectuses</u>. The Company represents, warrants and agrees that, unless it obtains the prior consent of the
          Agent, and the Agent represents, warrants and agrees that, unless it obtains the prior consent of the Company, it has not made and will not make any offer relating to the Placement Shares that would constitute an Issuer Free Writing Prospectus,
          or that would otherwise constitute a &#8220;free writing prospectus,&#8221; as defined in Rule 405, required to be filed with the Commission. Any such free writing prospectus consented to by the Agent or by the Company, as the case may be, is hereinafter
          referred to as a &#8220;Permitted Free Writing Prospectus.&#8221; The Company represents and warrants that it has treated and agrees that it will treat each Permitted Free Writing Prospectus as an &#8220;issuer free writing prospectus,&#8221; as defined in Rule 433, and
          has complied and will comply with the requirements of Rule 433 applicable to any Permitted Free Writing Prospectus, including timely filing with the Commission where required, legending and record keeping. For the purposes of clarity, the parties
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          relationship between the Company or any of its respective affiliates, stockholders (or other equity holders), creditors or employees or any other party, on the one hand, and the Agent, on the other hand, has been or will be created in respect of
          any of the transactions contemplated by this Agreement, irrespective of whether or not the Agent has advised or is advising the Company on other matters, and the Agent has no obligation to the Company with respect to the transactions contemplated
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      <div style="text-align: center; line-height: 1.25;">[Remainder of the page intentionally left blank]</div>
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    <div>
      <div style="text-align: justify; line-height: 1.25;">If the foregoing correctly sets forth the understanding between the Company and the Agent, please so indicate in the space provided
        below for that purpose, whereupon this letter shall constitute a binding agreement between the Company and the Agent.</div>
      <div style="line-height: 1.25">&#160;</div>
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          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="vertical-align: top;" colspan="2">
              <div style="line-height: 1.25;">Very truly yours,</div>
            </td>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="vertical-align: top;" colspan="2" rowspan="1">&#160;</td>
            <td style="width: 20%; vertical-align: top;" rowspan="1">&#160;</td>
          </tr>
          <tr>
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              <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold; margin-left: 9pt;">ENTERA BIO LTD.</div>
            </td>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="vertical-align: top;" colspan="2" rowspan="1">&#160;</td>
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          </tr>
          <tr>
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            <td style="width: 5%; vertical-align: top; padding-bottom: 2px;">
              <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; margin-left: 9pt;">By:</div>
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            <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="line-height: 1.25;">/S/ Spiros Jamas</div>
            </td>
            <td style="width: 20%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 25%; vertical-align: top;">
              <div style="margin-right: 9pt; line-height: 1.25;">Name: Spiros Jamas</div>
            </td>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 25%; vertical-align: top;">
              <div style="margin-right: 9pt; line-height: 1.25;">Title:&#160; CEO</div>
            </td>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
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          <tr>
            <td style="width: 50%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 5%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 25%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 20%; vertical-align: top;" rowspan="1">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="vertical-align: top;" colspan="2">
              <div style="line-height: 1.25; font-weight: bold;">ACCEPTED as of the date first-above written:</div>
            </td>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 25%; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
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            <td style="vertical-align: top;" colspan="2">
              <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold; margin-left: 9pt;">B. RILEY SECURITIES, INC.</div>
            </td>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 25%; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 5%; vertical-align: top; padding-bottom: 2px;">
              <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; margin-left: 9pt;">By:</div>
            </td>
            <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="line-height: 1.25;">/S/ Patrice McNicoll</div>
            </td>
            <td style="width: 20%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 25%; vertical-align: top;">
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            </td>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 25%; vertical-align: top;">
              <div style="line-height: 1.25;">Title:&#160; Co-Head of Investment Banking</div>
            </td>
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          </tr>

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      <div style="line-height: 1.25; font-weight: bold;">SCHEDULE 1</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="line-height: 1.25; text-align: center;">
        <hr align="center" style="height: 1px; width: 15%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;">&#160;</div>
      <div style="text-align: center; line-height: 1.25;">FORM OF PLACEMENT NOTICE</div>
      <div style="line-height: 1.25; text-align: center;">&#160; <br>
        <hr align="center" style="height: 1px; width: 15%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
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            <tr>
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                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">From:</div>
              </td>
              <td style="width: 88%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Entera Bio Ltd.</div>
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;"> <br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 12%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">To:</div>
              </td>
              <td style="width: 88%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">B. Riley Securities, Inc.<br>
                  <br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 12%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Attention:</div>
              </td>
              <td style="width: 88%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">[&#8226;]</div>
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;"> <br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 12%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Subject:</div>
              </td>
              <td style="width: 88%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">At Market Issuance--Placement Notice</div>
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            </tr>

        </table>
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      <div style="margin-left: 36pt; line-height: 1.25;">Ladies and Gentlemen:</div>
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      <div style="line-height: 1.25">&#160;</div>
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      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-weight: bold;">SCHEDULE 2</div>
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      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Compensation</div>
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      <hr align="center" style="height: 1px; width: 15%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;">
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      </div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company shall pay to the Agent in cash, upon each sale of Placement Shares pursuant to this Agreement, an
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      <div style="line-height: 1.25; font-weight: bold;">SCHEDULE 3</div>
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      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">
        <hr align="center" style="height: 1px; width: 15%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">
        <hr align="center" style="height: 1px; width: 15%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
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          <tr>
            <td style="width: 12%; vertical-align: top;">
              <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;"><u>The Company</u></div>
            </td>
            <td style="width: 88%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">&#160;</td>
            <td style="width: 88%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Spiros Jamas</div>
            </td>
            <td style="width: 88%; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">spiros@enterabio.com</div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">&#160;</td>
            <td style="width: 88%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Ramesh Ratan</div>
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            <td style="width: 88%; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">ramesh@enterabio.com</div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">&#160;</td>
            <td style="width: 88%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">
              <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;"><u>B. Riley Securities</u></div>
            </td>
            <td style="width: 88%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">&#160;</td>
            <td style="width: 88%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Matthew Feinberg</div>
            </td>
            <td style="width: 88%; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman', Times, serif;"><u>mfeinberg@brileyfin.com</u></div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">&#160;</td>
            <td style="width: 88%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Patrice McNicoll</div>
            </td>
            <td style="width: 88%; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman', Times, serif;"><u>pmcnicoll@brileyfin.com </u></div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">&#160;</td>
            <td style="width: 88%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Keith Pompliano</div>
            </td>
            <td style="width: 88%; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman', Times, serif;"><u>kpompliano@brileyfin.com</u></div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">&#160;</td>
            <td style="width: 88%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Scott Ammaturo</div>
            </td>
            <td style="width: 88%; vertical-align: top;">
              <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman', Times, serif;"><u>sammaturo@brileyfin.com</u></div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">with a copy to <u>atmdesk@brileyfin.com</u></div>
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        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">40</font></div>
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      <div><br>
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"><u>EXHIBIT 7(k)</u></div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"><br>
        Form of Representation Date Certificate</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"> <br>
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">___________, 20___</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 32.4pt; line-height: 1.25;">This Representation Date Certificate (this &#8220;<u>Certificate</u>&#8221;) is executed and delivered in connection with <u>Section 7(k)</u> of the At Market Issuance Sales Agreement (the &#8220;<u>Agreement</u>&#8221;), dated [&#8226;], 2021, and entered into between Entera Bio Ltd. (the &#8220;<u>Company</u>&#8221;)
        and B. Riley Securities, Inc. All capitalized terms used but not defined herein shall have the meanings given to such terms in the Agreement.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company hereby certifies as follows:</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">1.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;As of the date of this Certificate (i) the Registration Statement does not contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary in order to make the
          statements therein not misleading and (ii) neither the Registration Statement nor the Prospectus contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary in order to make the
          statements therein, in light of the circumstances under which they were made, not misleading and (iii) no event has occurred as a result of which it is necessary to amend or supplement the Prospectus in order to make the statements therein not
          untrue or misleading for this paragraph 1 to remain true.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">2.&#160;&#160; &#160; &#160;&#160;&#160;&#160;&#160; Each of the representations and warranties of the Company contained in the Agreement were, when originally made, and are, as of the date of this Certificate, true and correct in all material respects.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">3.&#160; &#160; &#160;&#160;&#160;&#160;&#160;&#160; Except as waived by the Agent in writing, each of the covenants required to be performed by the Company in the Agreement on or prior to the date of the Agreement, this Representation Date, and each such other date prior to
          the date hereof as set forth in the Agreement, has been duly, timely and fully performed in all material respects and each condition required to be complied with by the Company on or prior to the date of the Agreement, this Representation Date,
          and each such other date prior to the date hereof as set forth in the Agreement has been duly, timely and fully complied with in all material respects.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">4.&#160;&#160;&#160;&#160;&#160;&#160; &#160; &#160; Subsequent to the date of the most recent financial statements in the Prospectus, and except as described in the Prospectus, including Incorporated Documents, there has been no Material Adverse Effect.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">5.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;No stop order suspending the effectiveness of the Registration Statement or of any part thereof has been issued, and no proceedings for that purpose have been instituted or are pending or threatened by any securities or
          other governmental authority (including, without limitation, the Commission).</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">41</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: justify; text-indent: 35.1pt; margin-left: 0.9pt; line-height: 1.25;">6.&#160;&#160; &#160; &#160;&#160;&#160;&#160;&#160; No order suspending the effectiveness of the Registration Statement or the qualification or registration of the Placement Shares under the securities or Blue Sky laws of any jurisdiction are in effect and no
        proceeding for such purpose is pending before, or threatened, to the Company&#8217;s knowledge or in writing by, any securities or other governmental authority (including, without limitation, the Commission).</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The undersigned has executed this Representation Date Certificate as of the date first written above.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="line-height: 1.25">
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            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="vertical-align: top;" colspan="2">
                <div style="line-height: 1.25; font-weight: bold;">ENTERA BIO LTD.</div>
                <div style="line-height: 1.25; font-weight: bold;"> <br>
                </div>
              </td>
              <td style="width: 23%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
              <td style="width: 4%; vertical-align: top; padding-bottom: 2px;">
                <div style="line-height: 1.25;">By:</div>
              </td>
              <td style="width: 23%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 23%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;" rowspan="1">&#160;</td>
              <td style="width: 4%; vertical-align: top;" rowspan="1">&#160;</td>
              <td style="width: 23%; vertical-align: top;" rowspan="1">&#160;</td>
              <td style="width: 23%; vertical-align: top;" rowspan="1">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
              <td style="width: 4%; vertical-align: top; padding-bottom: 2px;">
                <div style="margin-right: 18pt; line-height: 1.25;">Name:</div>
              </td>
              <td style="width: 23%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 23%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;" rowspan="1">&#160;</td>
              <td style="width: 4%; vertical-align: top;" rowspan="1">&#160;</td>
              <td style="width: 23%; vertical-align: top;" rowspan="1">&#160;</td>
              <td style="width: 23%; vertical-align: top;" rowspan="1">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
              <td style="width: 4%; vertical-align: top; padding-bottom: 2px;">
                <div style="margin-right: 18pt; line-height: 1.25;">Title:</div>
              </td>
              <td style="width: 23%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 23%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            </tr>

        </table>
      </div>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">42</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
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      <div style="text-align: center; line-height: 1.25; font-weight: bold;"><u>EXHIBIT 23</u></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Permitted Issuer Free Writing Prospectuses</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">None.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
  </div>
  <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">43</font></div>
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    <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber"> </font></div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>exhibit_5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
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  <div>
    <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;">
    <div style="text-align: right;">
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><u><font style="font-weight: bold;">Exhibit 5.1 and 23.1</font></u></div>
    </div>
    <div> <br>
    </div>
    <div style="text-align: center;"> <img src="image2.jpg"> </div>
    <div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">May 7, 2021</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;">To:</div>
        <div style="line-height: 1.25;">Entera Bio Ltd.</div>
        <div style="line-height: 1.25;">Kiryat Hadassah, Minrav Building - Fifth Floor</div>
        <div style="line-height: 1.25;">Jerusalem</div>
        <div style="line-height: 1.25;"><u>Israel</u></div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Re: <u><font style="font-weight: bold;">Prospectus Supplement</font></u></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;"><br>
        Ladies and Gentlemen:</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; text-indent: 36pt;">We have acted as Israeli counsel to Entera Bio Ltd., an Israeli company (the &#8220;<u>Company</u>&#8221;) in connection with the At
        Market Sales Issuance Agreement, dated as of May <u>7,</u> 2021 (the &#8220;<u>Sales Agreement</u>&#8221;), entered into by and between the Company and B. Riley Securities, Inc. (the &#8220;<u>Agent</u>&#8221;) pursuant to which the
        Company has agreed to offer and sell ordinary shares, par value NIS 0.0000769 of the Company (&#8220;<u>Ordinary Shares</u>" or &#8220;<u>Shares</u>&#8221;) in an aggregate amount of up to 5,000,000 Ordinary Shares pursuant to that certain
        Prospectus (as defined below) (the &#8220;<u>ATM Shares</u>&#8221;). The ATM Shares will be issued pursuant to the registration statement on Form F-3 filed by the Company with the United States Securities and Exchange Commission (the &#8220;<u>SEC</u>&#8221;)
        on July 13, 2020 (the &#8220;<u>Registration Statement</u>&#8221;) and the prospectus supplement dated on or around the date hereof (the &#8220;<u>Prospectus</u>&#8221;), covering the ATM Shares.<font style="font-style: italic;">&#160;</font></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; text-indent: 36pt;">This opinion letter is rendered pursuant to Item 9 of Form F-3 promulgated by the SEC and Items 601(b)(5) of Regulation S-K under the
        Securities Act, in connection with the filing of the Registration Statement.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; text-indent: 36pt;">In connection herewith, we have examined the originals, photocopies or copies, certified or otherwise identified to our satisfaction,
        of: (i) a copy of the Registration Statement and the related prospectus contained therein covering the ATM Shares, to which this opinion letter is attached as an exhibit; (ii) a copy of the articles of association of the Company, as amended and
        restated and currently in effect (the &#8220;<u>Articles</u>&#8221;); (iii) minutes of a meeting or written resolutions of the board of directors of the Company (the &#8220;<u>Board</u>&#8221;) at which the filing of the Registration Statement,
        the execution of the Sales Agreement and the actions to be taken in connection therewith were approved, and (iv) such other documents, corporate records, agreements, certificates and other instruments, and have made inquiries with such officers and
        representatives of the Company, as we have deemed necessary or advisable for the purpose of rendering this opinion.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; text-indent: 36pt;">In such examination, we have assumed the genuineness of all signatures, the legal capacity of all natural persons, the authenticity of
        all documents submitted to us as originals, the conformity to original documents of all documents submitted to us as certified, confirmed as photostatic copies and the authenticity of the originals of such latter documents. As to all questions of
        fact material to these opinions that have not been independently established, we have relied upon certificates or comparable documents of officers and representatives of the Company.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; text-indent: 36pt;">We have also assumed the truth of all facts communicated to us by the Company and that all minutes of meetings of the Board that have
        been provided to us are true and accurate and have been properly prepared in accordance with the Articles and all applicable laws. We have assumed, that at the time of the execution and delivery of the Sales Agreement and as long as such Sales
        Agreement remains effective, between the Company and the Agent pursuant to which any of the ATM Shares which may be issued will be a valid and legally binding obligation of the Agent, enforceable against the Agent in accordance with its terms. We
        have further assumed that at the time of the issuance and sale of any of the ATM Shares, the terms of the ATM Shares, and their issuance and sale, will have been established so as not to violate any applicable law or result in a default under or
        breach of any agreement or instrument binding upon the Company and so as to comply with any requirement or restriction imposed by any court or governmental body having jurisdiction over the Company. We have further assumed that in no event shall
        the Company issue or sell through the Agent such number of ATM Shares that (a) exceeds the number of shares or dollar amount of Ordinary Shares registered on the Registration Statement pursuant to which the sale of the ATM Shares is being made or
        (b) exceeds the number of shares or dollar amount registered on the Prospectus.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; text-indent: 36pt;">Based upon and subject to the foregoing, we are of the opinion that with respect to the ATM Shares, that upon payment to the Company
        of the consideration for the ATM Shares in such amount as has been authorized and approved by the Board, or in amount as may be authorized and approved by the Board or a pricing committee of the Board from time to time in accordance with Israeli
        law, the ATM Shares, when issued and sold under the Sales Agreement as described in the Registration Statement and Prospectus, will be duly authorized, validly issued, fully paid and non-assessable.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; text-indent: 36pt;">You have informed us that you intend to issue the ATM Shares, from time to time on a delayed or continuous basis, and this opinion is
        limited to the laws, including the rules and regulations, as in effect on the date hereof. We understand that prior to issuing any ATM Shares, you will afford us an opportunity to review the corporate approval documents and operative documents
        pursuant to which such ATM Shares are to be issued (including the authorizing resolutions) and we will file such supplement or amendment to this opinion (if any) as we may reasonably consider necessary or appropriate by reason of the terms of such
        ATM Shares.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; text-indent: 36pt;">With respect to our opinion as to the ATM Shares, including any Ordinary Shares issued upon exercise or conversion of any ATM Shares,
        we have assumed that, at the time of issuance and sale and to the extent any such issuance would exceed the maximum share capital of the Company currently authorized, the number of Ordinary Shares that the Company is authorized to issue shall have
        been increased in accordance with the Articles and as described in the Registration Statement and pursuant to the Prospectus, such that a sufficient number of Ordinary Shares are authorized and available for issuance under the Articles, as then in
        effect.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; text-indent: 36pt;">We consent to the filing of this opinion as an exhibit to the Registration Statement. In giving this consent, we do not thereby admit
        that we are within the category of persons whose consent is required under Section 7 of the Securities Act, the rules and regulations of the SEC promulgated thereunder or Item 509 of the SEC&#8217;s Regulation S-K under the Securities Act.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; text-indent: 36pt;">Members of our firm are admitted to the Bar in the State of Israel, and we do not express any opinion as to the laws of any other
        jurisdiction. This opinion is limited to the matters stated herein and limited to Israeli law, and no opinion is implied or may be inferred beyond the matters expressly stated.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; text-indent: 36pt;">This opinion letter is rendered as of the date hereof and we disclaim any obligation to advise you of facts, circumstances, events or
        developments that may be brought to our attention after the date hereof that may alter, affect or modify the opinions expressed herein.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
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          <tr>
            <td colspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 50%; vertical-align: top;">
              <div style="line-height: 1.25;">Very truly yours,</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="line-height: 1.25;"><u>/s/Herzog Fox &amp; Neeman</u></div>
              <div style="line-height: 1.25;">Herzog Fox &amp; Neeman</div>
            </td>
          </tr>

      </table>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
