<?xml version="1.0" encoding="utf-8" standalone="no"?>
<?taxonomy-version 1.0.0.0?>
<?taxonomy-date 2023-04-11?>
<!--This is a generated XML file-->
<xs:schema targetNamespace="https://home.photocure.com" xmlns:photocure="https://home.photocure.com" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xs="http://www.w3.org/2001/XMLSchema">
  <xs:import namespace="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor" schemaLocation="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor.xsd" />
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xs:annotation>
    <xs:appinfo>
      <link:roleType roleURI="https://home.photocure.com/role/ProfitLoss" id="ProfitLoss">
        <link:definition>ProfitLoss</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="https://home.photocure.com/role/BalanceSheet" id="BalanceSheet">
        <link:definition>BalanceSheet</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="https://home.photocure.com/role/CashFlow" id="CashFlow">
        <link:definition>CashFlow</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="https://home.photocure.com/role/ChangeEquity" id="ChangeEquity">
        <link:definition>ChangeEquity</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="https://home.photocure.com/role/Generalinformationaboutfinancialstatements" id="Generalinformationaboutfinancialstatements">
        <link:definition>Generalinformationaboutfinancialstatements</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="https://home.photocure.com/role/Anchoring" id="Anchoring">
        <link:definition>Anchoring</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="https://home.photocure.com/role/ChangeEquityA" id="ChangeEquityA">
        <link:definition>ChangeEquity a</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:linkbaseRef xlink:href="5967007LIEEXZXG8OW35-2022-12-31_def.xml" xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" />
      <link:linkbaseRef xlink:href="5967007LIEEXZXG8OW35-2022-12-31_cal.xml" xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" />
      <link:linkbaseRef xlink:href="5967007LIEEXZXG8OW35-2022-12-31_pre.xml" xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" />
      <link:linkbaseRef xlink:href="5967007LIEEXZXG8OW35-2022-12-31_lab-en.xml" xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" />
      <link:linkbaseRef xlink:href="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor-lab-en.xml" xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" />
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="photocure_SigningFeesAndMilestoneRevenues" name="SigningFeesAndMilestoneRevenues" abstract="false" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xs:element id="photocure_GrossProfitAbstract" name="GrossProfitAbstract" abstract="true" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xs:element id="photocure_Indirectmanufacturingexpenses" name="Indirectmanufacturingexpenses" abstract="false" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xs:element id="photocure_OtherOperatingIncomeExpenseAbstract" name="OtherOperatingIncomeExpenseAbstract" abstract="true" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xs:element id="photocure_ProfitLossFromOperatingActivitiesAbstract" name="ProfitLossFromOperatingActivitiesAbstract" abstract="true" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xs:element id="photocure_FinanceIncomeCostAbstract" name="FinanceIncomeCostAbstract" abstract="true" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xs:element id="photocure_ProfitLossBeforeTaxAbstract" name="ProfitLossBeforeTaxAbstract" abstract="true" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xs:element id="photocure_CustomerRelations" name="CustomerRelations" abstract="false" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xs:element id="photocure_OtherPaidInCapital" name="OtherPaidInCapital" abstract="false" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xs:element id="photocure_Longtermborrowings" name="Longtermborrowings" abstract="false" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xs:element id="photocure_Settlementemployeebenefits" name="Settlementemployeebenefits" abstract="false" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xs:element id="photocure_Earnoutliability" name="Earnoutliability" abstract="false" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xs:element id="photocure_IncreaseDecreaseThroughTransactionsWithOwnersEquityAbstract" name="IncreaseDecreaseThroughTransactionsWithOwnersEquityAbstract" abstract="true" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
</xs:schema>