Exhibit 15.1

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CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

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We consent to the incorporation by reference in Registration Statement Nos. 333-283361, 333-275886, 333-268756, 333-260500, 333-249416, 333-231765, 333-225263, 333-218160, 333-215783, 333-211834, 333-208697 and 333-204567, on Form S-8 of our report dated March 23, 2023 (March 28, 2024 as to the effects of the discontinued operations described in Note 5) relating to the financial statements of Galapagos NV appearing in this Annual Report on Form 20-F for the year ended December 31, 2024.

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/s/ Deloitte Bedrijfsrevisoren/Réviseurs d’Entreprises BV/SRL | ​
Zaventem, Belgium | ​
March 27, 2025 | ​

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