<SEC-DOCUMENT>0000935836-25-000684.txt : 20251114
<SEC-HEADER>0000935836-25-000684.hdr.sgml : 20251114
<ACCEPTANCE-DATETIME>20251114132922
ACCESSION NUMBER:		0000935836-25-000684
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251114
DATE AS OF CHANGE:		20251114

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MDxHealth SA
		CENTRAL INDEX KEY:			0001872529
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				000000000
		STATE OF INCORPORATION:			C9

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-93034
		FILM NUMBER:		251484030

	BUSINESS ADDRESS:	
		STREET 1:		CAP BUSINESS CENTER
		STREET 2:		RUE D'ABHOOZ, 31, B-4040
		CITY:			HERSTAL
		STATE:			C9
		ZIP:			00000
		BUSINESS PHONE:		949-271-9221

	MAIL ADDRESS:	
		STREET 1:		CAP BUSINESS CENTER
		STREET 2:		RUE D'ABHOOZ, 31, B-4040
		CITY:			HERSTAL
		STATE:			C9
		ZIP:			00000

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MDx Health SA
		DATE OF NAME CHANGE:	20210713

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LYTTON LAURENCE W
		CENTRAL INDEX KEY:			0001105806
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	MAIL ADDRESS:	
		STREET 1:		467 CENTRAL PARK WEST
		CITY:			NY
		STATE:			NY
		ZIP:			10025
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0000935836-25-000142</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: LYTTON LAURENCE W -->
          <cik>0001105806</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>2</amendmentNo>
      <securitiesClassTitle>Ordinary Shares</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>09/30/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001872529</issuerCik>
        <issuerName>MDxHealth SA</issuerName>
        <issuerCusip>B5950S113</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>CAP BUSINESS CENTER</com:street1>
          <com:street2>RUE D'ABHOOZ, 31, B-4040</com:street2>
          <com:city>HERSTAL</com:city>
          <com:stateOrCountry>C9</com:stateOrCountry>
          <com:zipCode>00000</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>LYTTON LAURENCE W</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>3149548.00</soleVotingPower>
        <sharedVotingPower>13738.00</sharedVotingPower>
        <soleDispositivePower>3149548.00</soleDispositivePower>
        <sharedDispositivePower>13738.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3163286.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>6.4</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>Percentage calculated based on 49,497,334 Ordinary Shares outstanding as of December 31, 2024, as reported in the Form 20-F filed by the Issuer for the fiscal year ended December 31, 2024.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>MDxHealth SA</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>CAP BUSINESS CENTER RUE D'ABHOOZ, 31, B-4040 HERSTAL, BELGIUM 00000</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Laurence W. Lytton</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>467 Central Park West
New York, NY 10025</principalBusinessOfficeOrResidenceAddress>
        <citizenship>USA</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>3,163,286</amountBeneficiallyOwned>
        <classPercent>6.4%</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>3,149,548</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>13,738</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>3,149,548</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>13,738</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>LYTTON LAURENCE W</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Laurence W. Lytton</signature>
        <title>Reporting person</title>
        <date>11/14/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
