<?xml version="1.0" encoding="utf-8"?>
<xs:schema xmlns:segroplc="http://segroplc.com/xbrl/2022" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" targetNamespace="http://segroplc.com/xbrl/2022" xmlns:xs="http://www.w3.org/2001/XMLSchema">
  <xs:import schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/instance" />
  <xs:import schemaLocation="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor.xsd" namespace="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor" />
  <xs:import schemaLocation="http://www.xbrl.org/lrr/arcrole/esma-arcrole-2018-11-21.xsd" namespace="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" />
  <xs:import schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" namespace="http://xbrl.org/2005/xbrldt" />
  <xs:import schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" namespace="http://www.xbrl.org/dtr/type/numeric" />
  <xs:import schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" namespace="http://www.xbrl.org/dtr/type/non-numeric" />
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="213800xc35kgm9nfc641-2022-12-31_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="213800xc35kgm9nfc641-2022-12-31_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="213800xc35kgm9nfc641-2022-12-31_lab-en.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="213800xc35kgm9nfc641-2022-12-31_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor-lab-en.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor-gen-en.xml" xlink:type="simple" />
      <link:roleType id="Anchoring" roleURI="http://segroplc.com/xbrl/2022/roles/Anchoring">
        <link:definition>99 - Groups all anchored elements</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NotesAndMandatoryItems" roleURI="http://segroplc.com/xbrl/2022/roles/NotesAndMandatoryItems">
        <link:definition>01 - Notes and Mandatory Items</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ProfitOrLoss" roleURI="http://segroplc.com/xbrl/2022/roles/ProfitOrLoss">
        <link:definition>02 - Profit or loss</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfComprehensiveIncome" roleURI="http://segroplc.com/xbrl/2022/roles/StatementOfComprehensiveIncome">
        <link:definition>03 - Statement of comprehensive income</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfFinancialPosition" roleURI="http://segroplc.com/xbrl/2022/roles/StatementOfFinancialPosition">
        <link:definition>04 - Statement of financial position</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfChangesInEquity" roleURI="http://segroplc.com/xbrl/2022/roles/StatementOfChangesInEquity">
        <link:definition>05 - Statement of changes in equity</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfCashFlows" roleURI="http://segroplc.com/xbrl/2022/roles/StatementOfCashFlows">
        <link:definition>06 - Statement of cash flows</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfCashFlowsParenthetical" roleURI="http://segroplc.com/xbrl/2022/roles/StatementOfCashFlowsParenthetical">
        <link:definition>07 - Statement of cash flows (Parenthetical)</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="segroplc_RealisedAndUnrealisedPropertyLossGain" xbrli:balance="credit" xbrli:periodType="duration" name="RealisedAndUnrealisedPropertyLossGain" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_OtherInterestsInProperty" xbrli:balance="debit" xbrli:periodType="instant" name="OtherInterestsInProperty" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_OtherInvestments" xbrli:balance="debit" xbrli:periodType="instant" name="OtherInvestments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_OwnSharesHeld" xbrli:balance="credit" xbrli:periodType="instant" name="OwnSharesHeld" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_StatementOfFinancialPositionTable" xbrli:periodType="duration" abstract="true" name="StatementOfFinancialPositionTable" nillable="true" xmlns:q1="http://xbrl.org/2005/xbrldt" substitutionGroup="q1:hypercubeItem" type="xbrli:stringItemType" />
  <xs:element id="segroplc_StatementOfFinancialPositionLineItems" xbrli:periodType="duration" abstract="true" name="StatementOfFinancialPositionLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xs:element id="segroplc_BasicNetAssetsPerOrdinaryShare" xbrli:periodType="instant" name="BasicNetAssetsPerOrdinaryShare" nillable="true" substitutionGroup="xbrli:item" type="num:perShareItemType" />
  <xs:element id="segroplc_DilutedNetAssetsPerOrdinaryShare" xbrli:periodType="instant" name="DilutedNetAssetsPerOrdinaryShare" nillable="true" substitutionGroup="xbrli:item" type="num:perShareItemType" />
  <xs:element id="segroplc_OwnSharesHeldMember" xbrli:periodType="duration" abstract="true" name="OwnSharesHeldMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xs:element id="segroplc_TranslationHedgingAndOtherReservesMember" xbrli:periodType="duration" abstract="true" name="TranslationHedgingAndOtherReservesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xs:element id="segroplc_OwnSharesAcquired" xbrli:balance="debit" xbrli:periodType="duration" name="OwnSharesAcquired" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_MovementInNonControllingInterest" xbrli:balance="credit" xbrli:periodType="duration" name="MovementInNonControllingInterest" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_CashFlowFromCostOfEarlyCloseOutOfInterestRateDerivativesAndNewInterestRateDerivativesTransacted" xbrli:balance="credit" xbrli:periodType="duration" name="CashFlowFromCostOfEarlyCloseOutOfInterestRateDerivativesAndNewInterestRateDerivativesTransacted" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_AcquisitionOfOtherInterestInPropertyClassifiedAsInvestingActivities" xbrli:balance="credit" xbrli:periodType="duration" name="AcquisitionOfOtherInterestInPropertyClassifiedAsInvestingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_PurchaseOfPlantAndEquipmentAndIntangiblesClassifiedAsInvestingActivities" xbrli:balance="credit" xbrli:periodType="duration" name="PurchaseOfPlantAndEquipmentAndIntangiblesClassifiedAsInvestingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_AcquisitionOfOtherInvestmentsClassifiedAsInvestingActivities" xbrli:balance="credit" xbrli:periodType="duration" name="AcquisitionOfOtherInvestmentsClassifiedAsInvestingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_LoanAdvancesPaidToSubsidiaryUndertakingsClassifiedAsInvestingActivities" xbrli:balance="credit" xbrli:periodType="duration" name="LoanAdvancesPaidToSubsidiaryUndertakingsClassifiedAsInvestingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_InvestmentAndLoansToJointVenturesAndAssociatesClassifiedAsInvestingActivities" xbrli:balance="credit" xbrli:periodType="duration" name="InvestmentAndLoansToJointVenturesAndAssociatesClassifiedAsInvestingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_DivestmentFromAndRepaymentOfLoansByJointVenturesAndAssociatesClassifiedAsInvestingActivities" xbrli:balance="debit" xbrli:periodType="duration" name="DivestmentFromAndRepaymentOfLoansByJointVenturesAndAssociatesClassifiedAsInvestingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_CashFlowsFromTheSettlementOfForeignExchangeDerivativesClassifiedAsFinancingActivities" xbrli:balance="debit" xbrli:periodType="duration" name="CashFlowsFromTheSettlementOfForeignExchangeDerivativesClassifiedAsFinancingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_CashFlowsFromThePurchaseOfNonControllingInterestClassifiedAsFinancingActivities" xbrli:balance="credit" xbrli:periodType="duration" name="CashFlowsFromThePurchaseOfNonControllingInterestClassifiedAsFinancingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_TotalAcqusitionsAndAdditionsToInvestmentPropertyWithinCashAndNonCashMovements" xbrli:balance="credit" xbrli:periodType="duration" name="TotalAcqusitionsAndAdditionsToInvestmentPropertyWithinCashAndNonCashMovements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_InterestCapitalisedWithinCashAndNonCashMovements" xbrli:balance="credit" xbrli:periodType="duration" name="InterestCapitalisedWithinCashAndNonCashMovements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_NetMovementInCapitalAccrualsAndPrepaymentsWithinCashAndNonCashMovements" xbrli:balance="credit" xbrli:periodType="duration" name="NetMovementInCapitalAccrualsAndPrepaymentsWithinCashAndNonCashMovements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_OtherNonCashMovements" xbrli:balance="credit" xbrli:periodType="duration" name="OtherNonCashMovements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="segroplc_DescriptionOfAccountingPolicyForTransactionsEliminatedOnConsolidation" xbrli:periodType="duration" name="DescriptionOfAccountingPolicyForTransactionsEliminatedOnConsolidation" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DescriptionOfAccountingPolicyForConsolidationOfForeignEntities" xbrli:periodType="duration" name="DescriptionOfAccountingPolicyForConsolidationOfForeignEntities" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DescriptionOfAccountingPolicyForOtherInterestInProperty" xbrli:periodType="duration" name="DescriptionOfAccountingPolicyForOtherInterestInProperty" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DescriptionOfAccountingPolicyForTradingProperties" xbrli:periodType="duration" name="DescriptionOfAccountingPolicyForTradingProperties" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DescriptionOfAccountingPolicyForPropertyAcquisitionsAndDisposals" xbrli:periodType="duration" name="DescriptionOfAccountingPolicyForPropertyAcquisitionsAndDisposals" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DisclosureOfAdjustedProfit" xbrli:periodType="duration" name="DisclosureOfAdjustedProfit" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DisclosureOfRealisedAndUnrealisedPropertyGain" xbrli:periodType="duration" name="DisclosureOfRealisedAndUnrealisedPropertyGain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DisclosureOfEarningsAndNetAssetsPerShare" xbrli:periodType="duration" name="DisclosureOfEarningsAndNetAssetsPerShare" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DisclosureOfNetAssetsPerShareNAV" xbrli:periodType="duration" name="DisclosureOfNetAssetsPerShareNAV" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DisclosureOfTradingProperties" xbrli:periodType="duration" name="DisclosureOfTradingProperties" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DisclosureOfFinancialInstrumentsAndFairValues" xbrli:periodType="duration" name="DisclosureOfFinancialInstrumentsAndFairValues" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DisclosureOfForeignCurrencyRiskManagement" xbrli:periodType="duration" name="DisclosureOfForeignCurrencyRiskManagement" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DisclosureOfInterestRateRiskManagement" xbrli:periodType="duration" name="DisclosureOfInterestRateRiskManagement" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DisclosureOfShareCapitalAndShareBasedPayments" xbrli:periodType="duration" name="DisclosureOfShareCapitalAndShareBasedPayments" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="segroplc_DisclosureOfPropertyValuationTechniquesSustainabilityAndClimateChangeConsiderationsAndRelatedQuantitativeInformation" xbrli:periodType="duration" name="DisclosureOfPropertyValuationTechniquesSustainabilityAndClimateChangeConsiderationsAndRelatedQuantitativeInformation" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
</xs:schema>