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Capital and Financial Risk Management - Narrative (Details) $ in Thousands | Jan. 13, 2022 shares | Dec. 31, 2022 USD ($) shares | Aug. 19, 2022 shares | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
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Capital And Financial Risk Management [Line Items] |  |  |  |  |  |
Cash and cash equivalents |  | $ 149,866 |  | $ 465,708 | $ 403,881 | $ 132,360
Short-term investments |  | 200,229 |  | 0 |  |
Investments held at fair value |  | 251,892 |  | $ 397,179 | 553,167 |
Karuna, Vor and Akili |  |  |  |  |  |
Capital And Financial Risk Management [Line Items] |  |  |  |  |  |
Investments held at fair value |  | $ 239,000 |  |  |  |
Karuna |  |  |  |  |  |
Capital And Financial Risk Management [Line Items] |  |  |  |  |  |
Number of associate's common stock held at fair value | shares |  | 1,054,464 |  |  |  |
Vor |  |  |  |  |  |
Capital And Financial Risk Management [Line Items] |  |  |  |  |  |
Number of associate's common stock held at fair value | shares |  | 2,671,800 |  |  |  |
Akili |  |  |  |  |  |
Capital And Financial Risk Management [Line Items] |  |  |  |  |  |
Number of shares held (in shares) | shares |  |  | 12,527,477 |  |  |
Number of earnout shares received from SPAC exchange (in shares) | shares | 1,433,914 |  |  |  |  |
Equity price risk | Karuna, Vor and Akili |  |  |  |  |  |
Capital And Financial Risk Management [Line Items] |  |  |  |  |  |
Sensitivity analysis for equity price risk, impact on pre-tax earnings, percentage |  | 0.10 |  |  |  |
Sensitivity analysis for equity price risk, impact on pre-tax earnings |  | $ 23,900 |  |  |  |
Gelesis |  |  |  |  |  |
Capital And Financial Risk Management [Line Items] |  |  |  |  |  |
Investments in associates accounted for using equity method |  |  |  |  | $ 0 |
Number of earnout shares received from SPAC exchange (in shares) | shares | 4,526,622 |  |  |  |  |
Gelesis and Sonde |  |  |  |  |  |
Capital And Financial Risk Management [Line Items] |  |  |  |  |  |
Investments in associates accounted for using equity method |  | $ 9,100 |  |  |  |

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