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Operating Expenses (Tables) | 12 Months Ended
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Dec. 31, 2022
Operating Expenses [Abstract] |
Disclosure of total operating expense | Total operating expenses were as follows:
For the years ending December 31, | 2022 $000s | 2021 $000s | 2020 $000s
General and administrative | 60,991 |  | 57,199 |  | 49,440 |
Research and development | 152,433 |  | 110,471 |  | 81,859 |
Total operating expenses | 213,425 |  | 167,671 |  | 131,299 |
Disclosure of information about employees | The average number of persons employed by the Group during the year, analyzed by category, was as follows:
For the years ending December 31, | 2022 | 2021 | 2020
General and administrative | 57 |  | 52 |  | 43 |
Research and development | 144 |  | 119 |  | 95 |
Total | 201 |  | 171 |  | 138 |
Disclosure of payroll costs | The aggregate payroll costs of these persons were as follows:
| 2022 $000s | 2021 $000s | 2020 $000s
For the years ending December 31,
General and administrative | 25,322 |  | 26,438 |  | 22,943 |
Research and development | 36,321 |  | 28,950 |  | 20,674 |
Total | 61,643 |  | 55,388 |  | 43,616 |
Disclosure of other operating expense | Detailed operating expenses were as follows:
| 2022 $000s | 2021 $000s | 2020 $000s
For the years ending December 31,
Salaries and wages | 41,750 |  | 36,792 |  | 29,403 |
Healthcare benefits | 2,908 |  | 2,563 |  | 1,866 |
Payroll taxes | 2,286 |  | 2,084 |  | 1,629 |
Share-based payments | 14,699 |  | 13,950 |  | 10,718 |
Total payroll costs | 61,643 |  | 55,388 |  | 43,616 |
Other general and administrative expenses | 35,669 |  | 30,761 |  | 26,497 |
Other research and development expenses | 116,113 |  | 81,521 |  | 61,186 |
Total other operating expenses | 151,782 |  | 112,282 |  | 87,683 |
Total operating expenses | 213,425 |  | 167,671 |  | 131,299 |
Disclosure of auditors' remuneration | Auditor's remuneration:
For the years ending December 31, | 2022 $000s | 2021 $000s | 2020 $000s
Audit of these financial statements | 1,716 |  | 1,183 |  | 1,145 |
Audit of the financial statements of subsidiaries | 132 |  | 312 |  | 291 |
Audit of the financial statements of associate** | 814 |  | 571 |  | 350 |
Audit-related assurance services* | 1,157 |  | 1,868 |  | 490 |
Non-audit related services | — |  | — |  | 173 |
Total | 3,819 |  | 3,934 |  | 2,449 |
* 2021 – $468.2 thousand represents prepaid expenses related to an expected initial public offering of a subsidiary. ** Audit fees of $720.0 thousand, $500.0 thousand and $350.0 thousand in respect of financial statements of associates for the years ended December 31, 2022, 2021, and 2020 respectively, are not included within the consolidated financial statements. Fees related to the audit of the financial statements of associates have been disclosed in respect of 2022, 2021, and 2020 as these fees went towards supporting the audit opinion on the Group accounts. Such amounts were not previously disclosed in the 2020 financial statements. Please refer to Note 8 for further disclosures related to share-based payments and Note 24 for management’s remuneration disclosures.

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