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Taxation - Disclosure of reconciliation of effective tax rate (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Reconciliation of Effective Tax Rate [Table] |  |  |
US federal statutory rate | $ (19,486) | $ (12,380) | $ 3,984
US federal statutory rate | 21.00% | 21.00% | 21.00%
Effects of state tax rate in U.S. | $ (8,043) | $ (4,484) | $ 1,844
Effects of state tax rate in U.S. | 8.67% | 7.61% | 9.72%
R&D and orphan drug tax credits | $ (6,876) | $ (5,056) | $ (5,642)
R&D and orphan drug tax credits | 7.41% | 8.58% | (29.74%)
Non deductible share based payment expenses | $ 788 | $ 555 | $ 327
Non deductible share based payment expenses | (0.85%) | (0.94%) | 1.73%
Finance income/(costs) – fair value accounting | $ (28,783) | $ (2,017) | $ 919
Finance income/(costs) – fair value accounting | 31.02% | 3.42% | 4.84%
Loss with respect to associate for which no deferred tax asset is recognized | $ 1,413 | $ 11,542 | $ 0
Loss with respect to associate for which no deferred tax asset is recognized | (1.52%) | (19.58%) | 0.00%
Change in blended state rate impact due to state apportionment change | $ (8,856) | $ 0 | $ 0
Change in blended state rate impact due to state apportionment change | 9.54% | 0.00% | 0.00%
Transaction Costs | $ 0 | $ 309 | $ 361
Transaction Costs | 0.00% | (0.52%) | 1.91%
Interest Expense | $ 69 | $ 217 | $ (2,258)
Interest Expense | (0.07%) | (0.37%) | (11.91%)
Executive Compensation | $ 300 | $ 746 | $ 827
Executive Compensation | (0.32%) | (1.27%) | 4.36%
Recognition of deferred tax assets and tax benefits not previously recognized | $ (184) | $ (414) | $ 0
Recognition of deferred tax assets and tax benefits not previously recognized | 0.20% | 0.70% | 0.00%
Current year losses for which no deferred tax asset is recognized | $ 17,287 | $ 14,375 | $ 13,948
Current year losses for which no deferred tax asset is recognized | (18.63%) | (24.38%) | 73.53%
Sonde Deconsolidation | $ (3,572) | $ 0 | $ 0
Sonde Deconsolidation | 3.85% | 0.00% | 0.00%
Other | $ 224 | $ 363 | $ 91
Other | (0.25%) | (0.62%) | 0.48%
Income tax expense/(benefit) | $ (55,719) | $ 3,756 | $ 14,401
Average effective tax rate | 60.05% | (6.37%) | 75.92%

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