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Operating Expenses - Disclosure of payroll costs (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Disclosure of information of employees [Line Items] |  |  |
Aggregate payroll costs | $ 61,643 | $ 55,388 | $ 43,616
General and administrative |  |  |
Disclosure of information of employees [Line Items] |  |  |
Aggregate payroll costs | 25,322 | 26,438 | 22,943
Research and development |  |  |
Disclosure of information of employees [Line Items] |  |  |
Aggregate payroll costs | 36,321 | 28,950 | 20,674
Total |  |  |
Disclosure of information of employees [Line Items] |  |  |
Aggregate payroll costs | $ 61,643 | $ 55,388 | $ 43,616

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