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Share-based Payments - Disclosure of stock option activity (Details) | 12 Months Ended
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Dec. 31, 2022 shares £ / shares | Dec. 31, 2021 shares £ / shares | Dec. 31, 2020 shares £ / shares | Dec. 31, 2019 shares £ / shares
Disclosure of share capital, reserves and other equity interest [Abstract] |  |  |  |
Outstanding at beginning of period (in shares) | shares | 13,414,118 | 10,916,086 | 8,472,827 |
Granted (in shares) | shares | 8,881,000 | 5,424,000 | 4,076,982 |
Exercised (in shares) | shares | (577,022) | (2,238,187) | (514,410) |
Forfeited and expired (in shares) | shares | (3,924,215) | (687,781) | (1,119,313) |
Options exercisable (in shares) | shares | 6,185,216 | 4,773,873 | 5,447,405 |
Outstanding at end of period (in shares) | shares | 17,793,881 | 13,414,118 | 10,916,086 | 8,472,827
Weighted-average exercise price, beginning of year (in GBP per share) | £ 2.58 | £ 1.81 | £ 1.16 |
Weighted average exercise price, options granted (in GBP per share) | 2.04 | 3.34 | 3.14 |
Weighted average exercise price, options exercised (in GBP per share) | 0.50 | 0.70 | 1.52 |
Weighted average exercise price, options forfeited and expired (in GBP per share) | 2.89 | 2.53 | 1.88 |
Weighted average exercise price of, options exercisable (in GBP per share) | 2.03 | 1.42 | 0.98 |
Weighted-average exercise price, end of year (in GBP per share) | £ 2.31 | £ 2.58 | £ 1.81 | £ 1.16
Weighted average remaining contractual life of outstanding share options (in years) | 8 years 10 days | 8 years 3 months 14 days | 8 years 4 months 17 days | 8 years 6 months 18 days
Weighted average remaining contractual life of options excisable (in years) | 6 years 2 months 15 days | 6 years 6 months | 7 years 5 months 15 days |
Weighted average stock price of share options exercised in share-based payment arrangement (in GBP per share) | £ 2.43 | £ 3.63 | £ 2.88 |

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