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Capital and Financial Risk Management - Narrative (Details)
$ in Thousands
Jan. 13, 2022
shares
Dec. 31, 2022
USD ($)
shares
Aug. 19, 2022
shares
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Capital And Financial Risk Management [Line Items]            
Cash and cash equivalents   $ 149,866   $ 465,708 $ 403,881 $ 132,360
Short-term investments   200,229   0    
Investments held at fair value   251,892   $ 397,179 553,167  
Karuna, Vor and Akili            
Capital And Financial Risk Management [Line Items]            
Investments held at fair value   $ 239,000        
Karuna            
Capital And Financial Risk Management [Line Items]            
Number of associate's common stock held at fair value | shares   1,054,464        
Vor            
Capital And Financial Risk Management [Line Items]            
Number of associate's common stock held at fair value | shares   2,671,800        
Akili            
Capital And Financial Risk Management [Line Items]            
Number of shares held (in shares) | shares     12,527,477      
Number of earnout shares received from SPAC exchange (in shares) | shares 1,433,914          
Equity price risk | Karuna, Vor and Akili            
Capital And Financial Risk Management [Line Items]            
Sensitivity analysis for equity price risk, impact on pre-tax earnings, percentage   0.10        
Sensitivity analysis for equity price risk, impact on pre-tax earnings   $ 23,900        
Gelesis            
Capital And Financial Risk Management [Line Items]            
Investments in associates accounted for using equity method         $ 0  
Number of earnout shares received from SPAC exchange (in shares) | shares 4,526,622          
Gelesis and Sonde            
Capital And Financial Risk Management [Line Items]            
Investments in associates accounted for using equity method   $ 9,100