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Taxation - Disclosure of reconciliation of effective tax rate (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Reconciliation of Effective Tax Rate [Table]      
US federal statutory rate $ (19,486) $ (12,380) $ 3,984
US federal statutory rate 21.00% 21.00% 21.00%
Effects of state tax rate in U.S. $ (8,043) $ (4,484) $ 1,844
Effects of state tax rate in U.S. 8.67% 7.61% 9.72%
R&D and orphan drug tax credits $ (6,876) $ (5,056) $ (5,642)
R&D and orphan drug tax credits 7.41% 8.58% (29.74%)
Non deductible share based payment expenses $ 788 $ 555 $ 327
Non deductible share based payment expenses (0.85%) (0.94%) 1.73%
Finance income/(costs) – fair value accounting $ (28,783) $ (2,017) $ 919
Finance income/(costs) – fair value accounting 31.02% 3.42% 4.84%
Loss with respect to associate for which no deferred tax asset is recognized $ 1,413 $ 11,542 $ 0
Loss with respect to associate for which no deferred tax asset is recognized (1.52%) (19.58%) 0.00%
Change in blended state rate impact due to state apportionment change $ (8,856) $ 0 $ 0
Change in blended state rate impact due to state apportionment change 9.54% 0.00% 0.00%
Transaction Costs $ 0 $ 309 $ 361
Transaction Costs 0.00% (0.52%) 1.91%
Interest Expense $ 69 $ 217 $ (2,258)
Interest Expense (0.07%) (0.37%) (11.91%)
Executive Compensation $ 300 $ 746 $ 827
Executive Compensation (0.32%) (1.27%) 4.36%
Recognition of deferred tax assets and tax benefits not previously recognized $ (184) $ (414) $ 0
Recognition of deferred tax assets and tax benefits not previously recognized 0.20% 0.70% 0.00%
Current year losses for which no deferred tax asset is recognized $ 17,287 $ 14,375 $ 13,948
Current year losses for which no deferred tax asset is recognized (18.63%) (24.38%) 73.53%
Sonde Deconsolidation $ (3,572) $ 0 $ 0
Sonde Deconsolidation 3.85% 0.00% 0.00%
Other $ 224 $ 363 $ 91
Other (0.25%) (0.62%) 0.48%
Income tax expense/(benefit) $ (55,719) $ 3,756 $ 14,401
Average effective tax rate 60.05% (6.37%) 75.92%