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Investments held at fair value - Narrative (Details)
$ in Thousands
 2 Months Ended 5 Months Ended 12 Months Ended
Aug. 22, 2022
shares
May 25, 2022
USD ($)
shares
Jan. 13, 2022
USD ($)
shares
Nov. 10, 2021
shares
Nov. 09, 2021
USD ($)
shares
May 25, 2021
USD ($)
shares
May 24, 2021
Feb. 10, 2021
shares
Feb. 09, 2021
USD ($)
shares
Jan. 08, 2021
USD ($)
shares
Aug. 26, 2020
USD ($)
shares
Jun. 30, 2020
USD ($)
shares
May 26, 2020
USD ($)
shares
Apr. 30, 2020
USD ($)
shares
Apr. 01, 2020
USD ($)
shares
Feb. 12, 2020
USD ($)
shares
Jan. 22, 2020
USD ($)
shares
Sep. 30, 2022
USD ($)
Dec. 31, 2022
USD ($)
shares
Dec. 31, 2022
USD ($)
shares
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Aug. 19, 2022
shares
Aug. 08, 2022
shares
Dec. 30, 2021
USD ($)
Investments held at fair value [Line Items]                                                  
Cash purchase of Vor preferred shares                                       $ 5,000 $ 500 $ 1,150      
Share of losses recorded against Long Term Interests (LTIs)                                         73,703        
Sale of investments held at fair value                                       118,710 218,125 350,586      
Realized loss on sale of investments                                       29,303 20,925 54,976      
Cash Investment (Akili)                                       0 0 10,000      
Loss – change in fair value through profit and loss                                       (32,060) 179,271        
Gain on deconsolidation of subsidiary                                       27,251 0 0      
Gelesis                                                  
Investments held at fair value [Line Items]                                                  
Share of losses recorded against Long Term Interests (LTIs)                                         73,700 23,000      
Gelesis Earn out shares received in SPAC exchange     $ 14,214                                            
Gains (losses) on change in fair value of equity investments                                       (4,400) 34,600 7,100      
Number of earnout shares received from SPAC exchange (in shares) | shares     4,526,622                                            
CapStar Special Purpose Acquisition Corp                                                  
Investments held at fair value [Line Items]                                                  
Gelesis Earn out shares received in SPAC exchange                                     $ 100 100          
Gains (losses) on earn-out shares at fair value through profit or loss                                       $ (14,100)          
Vor                                                  
Investments held at fair value [Line Items]                                                  
Cash purchase of Vor preferred shares                   $ 500   $ 500       $ 700         500        
Acquisition of equity instruments in other entities | shares                   961,538   961,538                          
Share price of investee shares (in dollars per share)                 18.00                                
Proportion of ownership interest in investee               8.60%                                  
Sale of equity instruments in other entities (in shares) | shares                                     535,400 535,400          
Proceeds from sale of equity investment                                     $ (3,300)            
Gains (losses) on change in fair value of equity investments                                       $ 16,200 3,900 19,100      
Karuna                                                  
Investments held at fair value [Line Items]                                                  
Proportion of ownership interest in investee       5.60%       8.20%                       3.10%          
Gains (losses) on change in fair value of equity investments                                       $ 135,000 110,000 191,200      
Sale of investments held at fair value         $ 100,100       $ 118,000                 $ 115,500              
Realized loss on sale of investments                                   $ 29,300   29,303          
Akili                                                  
Investments held at fair value [Line Items]                                                  
Acquisition of equity instruments in other entities | shares 500,000                                                
Number of shares held (in shares) | shares                                             12,527,477    
Proportion of ownership interest in investee 14.70%         27.50% 41.90%                                    
Gelesis Earn out shares received in SPAC exchange                                     $ 1,000 1,000          
Gains (losses) on change in fair value of equity investments                                       (131,400) $ 32,200 14,400      
Cash Investment (Akili)                                       5,000          
Number of earnout shares received from SPAC exchange (in shares) | shares     1,433,914                                            
resTORbio                                                  
Investments held at fair value [Line Items]                                                  
Sale of investments held at fair value                           $ 3,000                      
Realized loss on sale of investments                                           200      
Loss – change in fair value through profit and loss                                           100      
Sonde                                                  
Investments held at fair value [Line Items]                                                  
Gains (losses) on change in fair value of equity investments                                       $ 200          
Fair value of equity investment   $ 11,200                                              
Sonde | One Unnamed Investor                                                  
Investments held at fair value [Line Items]                                                  
Cash purchase of Vor preferred shares   $ 3,500                                              
Acquisition of equity instruments in other entities | shares   1,125,401                                              
Acquisition of equity instruments in other entities, discount rate   20.00%                                              
Capstar                                                  
Investments held at fair value [Line Items]                                                  
SPAC exchange, PIPE transaction, amount                                                 $ 15,000
Business combination, investment in common share     $ 5,000                                            
Series A-2 preferred | Vor                                                  
Investments held at fair value [Line Items]                                                  
Acquisition of equity instruments in other entities | shares                               1,625,000                  
Common | Vor                                                  
Investments held at fair value [Line Items]                                                  
Number of shares issued by investee (in shares) | shares                 9,828,017                                
Number of shares held (in shares) | shares               3,207,200                                  
Common | Karuna                                                  
Investments held at fair value [Line Items]                                                  
Number of shares held (in shares) | shares       1,656,564       2,406,564                                  
Sale of equity instruments in other entities (in shares) | shares         750,000       1,000,000   1,333,333   555,500       2,100,000             125,000  
Sale of investments held at fair value                     $ 101,600   $ 45,000       $ 200,900                
Realized loss on sale of investments                                           $ 54,800      
Exercise of call options, maximum number of common stocks to be purchased (in shares) | shares                                               477,100  
Common | resTORbio                                                  
Investments held at fair value [Line Items]                                                  
Sale of equity instruments in other entities (in shares) | shares                           2,119,696                      
Series 3 growth preferred stock | Gelesis                                                  
Investments held at fair value [Line Items]                                                  
Cash purchase of Vor preferred shares                             $ 10,000                    
Acquisition of equity instruments in other entities | shares                             579,038                    
Series D | Akili                                                  
Investments held at fair value [Line Items]                                                  
Number of shares issued by investee (in shares) | shares           13,053,508                                      
Proceeds from the issuance of shares and subsidiary preferred shares           $ 110,000