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Operating Expenses - Disclosure of other operating expense (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Operating Expenses [Abstract]      
Salaries and wages $ 41,750 $ 36,792 $ 29,403
Healthcare benefits 2,908 2,563 1,866
Payroll taxes 2,286 2,084 1,629
Share-based payment expense 14,699 13,950 10,718
Total payroll costs 61,643 55,388 43,616
Other general and administrative expenses 35,669 30,761 26,497
Other research and development expenses 116,113 81,521 61,186
Miscellaneous other operating expense 151,782 112,282 87,683
Operating income/(loss) $ 213,425 $ 167,671 $ 131,299