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Share-based Payments - Disclosure of weighted average exercise prices for options outstanding (Details)
 12 Months Ended
Dec. 31, 2022
shares
£ / shares
Dec. 31, 2021
shares
£ / shares
Dec. 31, 2020
shares
£ / shares
Dec. 31, 2019
shares
£ / shares
Dec. 31, 2022
shares
$ / shares
Weighted Average Options Outstanding [Line Items]          
Number of share options (in shares) 17,793,881 13,414,118 10,916,086 8,472,827 17,793,881
Weighted-average exercise price (in dollars per share) | £ / shares £ 2.31 £ 2.58 £ 1.81 £ 1.16  
Weighted average remaining contractual life of outstanding share options (in years) 8 years 10 days 8 years 3 months 14 days 8 years 4 months 17 days 8 years 6 months 18 days  
Alivio          
Weighted Average Options Outstanding [Line Items]          
Number of share options (in shares)   0 3,888,168 3,698,244  
Entrega          
Weighted Average Options Outstanding [Line Items]          
Number of share options (in shares) 344,500 349,500 962,000 972,000 344,500
Weighted-average exercise price (in dollars per share) | $ / shares         $ 1.91
Weighted average remaining contractual life of outstanding share options (in years) 4 years 11 months 1 day        
Follica          
Weighted Average Options Outstanding [Line Items]          
Number of share options (in shares) 2,776,120 2,686,120 1,309,040 1,309,040 2,776,120
Weighted-average exercise price (in dollars per share) | $ / shares         $ 1.41
Weighted average remaining contractual life of outstanding share options (in years) 6 years 4 months 17 days        
Sonde          
Weighted Average Options Outstanding [Line Items]          
Number of share options (in shares) 0 2,049,004 2,192,834 1,829,004 0
Vedanta          
Weighted Average Options Outstanding [Line Items]          
Number of share options (in shares) 1,824,576 1,991,637 1,741,888 1,450,100 1,824,576
Weighted-average exercise price (in dollars per share) | $ / shares         $ 15.89
Weighted average remaining contractual life of outstanding share options (in years) 6 years 10 months 17 days