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Share-based Payments - Disclosure of weighted average exercise prices for options granted (Details)
 12 Months Ended
Dec. 31, 2022
£ / shares
Dec. 31, 2022
$ / shares
Dec. 31, 2021
£ / shares
Dec. 31, 2021
$ / shares
Dec. 31, 2020
£ / shares
Dec. 31, 2020
$ / shares
Weighted Average Options granted [Line Items]            
Weighted average exercise price (in dollars per share) | £ / shares £ 2.04   £ 3.34   £ 3.14  
Alivio            
Weighted Average Options granted [Line Items]            
Weighted average exercise price (in dollars per share)   $ 0   $ 0   $ 0.47
Entrega            
Weighted Average Options granted [Line Items]            
Weighted average exercise price (in dollars per share)   0.02   0   0
Follica            
Weighted Average Options granted [Line Items]            
Weighted average exercise price (in dollars per share)   1.86   1.86   0
Sonde            
Weighted Average Options granted [Line Items]            
Weighted average exercise price (in dollars per share)   0   0   0.18
Vedanta            
Weighted Average Options granted [Line Items]            
Weighted average exercise price (in dollars per share)   $ 14.94   $ 19.69   $ 19.59