13. Additional information: |
OrbiMed Advisors LLC and OrbiMed Capital LLC (together, "OrbiMed") are affiliated investment advisers registered with the U.S. Securities and Exchange Commission. OrbiMed acts as investment manager or investment adviser for the funds and accounts listed in Item 4, which beneficially own the shares that are the subject of this notification. This filing (the "New Filing") is being submitted to correct the TR-1 submitted on October 28, 2016 (the "Prior Filing"), as it has been determined that the Prior Filing was filed mistakenly due to a calculation error. The Prior Filing inadvertently identified the 23,000,000 shares referenced in Item 8.A as constituting 3.49% of the voting rights related to the issuer's issued share capital. In fact, the 23,000,000 shares constituted only 1.18% of such voting rights. As a result, no TR-1 filing was actually required, but OrbiMed considers it appropriate to update the market in this way. OrbiMed is submitting the New Filing, with the corrected percentages in the relevant parts of Item 8, to correct the Prior Filing as of the date thereof. |