FORM 8.3

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the “Code”)

1.

KEY INFORMATION

(a)

Identity of the person whose positions/dealings are being disclosed:

Wellington Management Company, LLP

(b)

Owner or controller of interests and short positions disclosed, if different from 1(a): The naming of nominee or vehicle companies is insufficient

(c)

Name of offeror/offeree in relation to whose relevant securities this form relates: Use a separate form for each offeror/offeree

AstraZeneca PLC

(d)

If an exempt fund manager connected with an offeror/offeree, state this and specify identity of offeror/offeree:

(e)

Date position held/dealing undertaken:

19 May 2014

(f)

Has the discloser previously disclosed, or are they today disclosing, under the Code in respect of any other party to this offer?

YES

2.

POSITIONS OF THE PERSON MAKING THE DISCLOSURE

(a)

Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security:

Ordinary Shares (GB0009895292) and ADRs (US0463531089)

Interests

Short Positions

Number

%

Number

%

(1)

Relevant securities owned and/or controlled:

64,375,741 shares

5.10 %

(2)

Derivatives (other than options):

(3)

Options and agreements to purchase/sell:

Total

64,375,741 shares

5.10 %

(b)

Rights to subscribe for new securities (including directors’ and other executive options)

Class of relevant security in relation to which subscription right exists:

Details, including nature of the rights concerned and relevant percentages:

3.

DEALINGS

(a)

Purchases and sales

Class of relevant security

Purchase/sale

Number of securities

Price per unit

Ordinary Shares (GB0009895292)

Purchase

831,145 shares

42.0329 GBP

Ordinary Shares (GB0009895292)

Purchase

263,820 shares

42.0350 GBP

Ordinary Shares (GB0009895292)

Purchase

206,754 shares

42.5500 GBP

Ordinary Shares (GB0009895292)

Purchase

63,568 shares

42.6826 GBP

Ordinary Shares (GB0009895292)

Purchase

16,613 shares

42.8750 GBP

Ordinary Shares (GB0009895292)

Purchase

3,507 shares

42.9027 GBP

ADRs (US0463531089)

Purchase

3,900 Depository Receipts (representing 3,900 shares on a converted basis)

71.0959 USD

(b)

Derivatives transactions (other than options)

Class of relevant security

Product description e.g. CFD

Nature of dealing e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

(c)

Options transactions in respect of existing securities

(i)

Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type e.g. American, European etc.

Expiry date

Option money paid/ received per unit

(ii)

Exercising

Class of relevant security

Product description e.g. call option

Number of securities

Exercise price per unit

(d)

Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing e.g. subscription, conversion

Details

Price per unit (if applicable)

4.		OTHER INFORMATION
(a)		Indemnity and other dealing arrangements
Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer: If there are no such agreements, arrangements or understandings, state “none”
None
(b)		Agreements, arrangements or understandings relating to options or derivatives
Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to: (i) the voting rights of any relevant securities under any option; or (ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced: If there are no such agreements, arrangements or understandings, state “none”
None
(c)		Attachments
Is a Supplemental Form 8 attached?				NO
Date of disclosure				20 May 2014
Contact name				John D. Norberg
Telephone number				617-790-7265

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel at monitoring@disclosure.org.uk. The Panel’s Market Surveillance Unit is available for consultation in relation to the Code’s dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel?s website at www.thetakeoverpanel.org.uk.