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Sequential Quarterly Product Sales - 2017 (Details) - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Jun. 30, 2018
Product sales                      
Product Sales $ 5,030 $ 4,985 $ 5,487 $ 4,882 $ 4,940 $ 4,843 $ 5,260 $ 5,025 $ 5,469 $ 5,565 $ 10,015
Actual %, quarter-on-quarter 1.00% (9.00%) 12.00% (1.00%) 2.00% (8.00%) 5.00% (8.00%) (2.00%) (10.00%)  
CER %, quarter-on-quarter 1.00% (11.00%) 12.00% (3.00%) 1.00% (6.00%) 6.00% (8.00%) (3.00%) (10.00%)  
Oncology                      
Product sales                      
Product Sales $ 1,434 $ 1,230 $ 1,120 $ 1,026 $ 993 $ 885 $ 930 $ 867 $ 848 $ 738 2,664
Actual %, quarter-on-quarter 17.00% 10.00% 9.00% 3.00% 12.00% (5.00%) 7.00% 2.00% 15.00% 3.00%  
CER %, quarter-on-quarter 17.00% 8.00% 9.00% 1.00% 11.00%   7.00% 2.00% 12.00% 3.00%  
Tagrisso                      
Product sales                      
Product Sales $ 422 $ 338 $ 304 $ 248 $ 232 $ 171 $ 147 $ 133 $ 92 $ 51 760
Actual %, quarter-on-quarter 25.00% 11.00% 23.00% 7.00% 36.00% 16.00% 11.00% 45.00% 80.00% 183.00%  
CER %, quarter-on-quarter 25.00% 10.00% 22.00% 5.00% 34.00% 19.00% 11.00% 44.00% 82.00% 200.00%  
Iressa                      
Product sales                      
Product Sales $ 143 $ 132 $ 130 $ 137 $ 137 $ 124 $ 118 $ 125 $ 135 $ 135 275
Actual %, quarter-on-quarter 8.00% 2.00% (5.00%)   10.00% 5.00% (6.00%) (7.00%)   5.00%  
CER %, quarter-on-quarter 8.00% (1.00%) (6.00%) (1.00%) 9.00% 8.00% (4.00%) (8.00%) (2.00%) 5.00%  
Lynparza                      
Product sales                      
Product Sales $ 150 $ 119 $ 100 $ 81 $ 59 $ 57 $ 62 $ 58 $ 54 $ 44 269
Actual %, quarter-on-quarter 26.00% 19.00% 23.00% 37.00% 4.00% (8.00%) 7.00% 7.00% 23.00% 22.00%  
CER %, quarter-on-quarter 26.00% 18.00% 22.00% 33.00% 2.00% (6.00%) 9.00% 7.00% 23.00% 22.00%  
Imfinzi                      
Product sales                      
Product Sales $ 122 $ 62 $ 18   $ 1           184
Actual %, quarter-on-quarter 98.00%                    
CER %, quarter-on-quarter 98.00%                    
Calquence                      
Product sales                      
Product Sales $ 12 8 3               20
Actual %, quarter-on-quarter 51.00%                    
CER %, quarter-on-quarter 50.00%                    
Faslodex                      
Product sales                      
Product Sales $ 247 $ 254 $ 238 $ 241 $ 248 $ 214 $ 222 $ 207 $ 211 $ 190 501
Actual %, quarter-on-quarter (3.00%) 7.00% (1.00%) (3.00%) 16.00% (4.00%) 7.00% (2.00%) 11.00% 3.00%  
CER %, quarter-on-quarter (2.00%) 5.00% (1.00%) (5.00%) 15.00% (3.00%) 9.00% (2.00%) 9.00% 3.00%  
Zoladex                      
Product sales                      
Product Sales $ 192 $ 184 $ 187 $ 185 $ 178 $ 185 $ 235 $ 199 $ 204 $ 178 376
Actual %, quarter-on-quarter 4.00% (2.00%) 1.00% 4.00% (4.00%) (21.00%) 18.00% (2.00%) 15.00% (10.00%)  
CER %, quarter-on-quarter 5.00% (4.00%) 1.00% 2.00% (5.00%) (12.00%) 11.00% (2.00%) 8.00% (8.00%)  
Casodex                      
Product sales                      
Product Sales $ 52 $ 52 $ 54 $ 51 $ 54 $ 56 $ 60 $ 62 $ 63 $ 62 104
Actual %, quarter-on-quarter   (4.00%) 6.00% (6.00%) (4.00%) (7.00%) (3.00%) (2.00%) 2.00% (2.00%)  
CER %, quarter-on-quarter (2.00%) (6.00%) 6.00% (9.00%) (3.00%) (2.00%) (2.00%) (5.00%)   (6.00%)  
Arimidex                      
Product sales                      
Product Sales $ 57 $ 54 $ 57 $ 54 $ 54 $ 52 $ 57 $ 56 $ 62 $ 57 111
Actual %, quarter-on-quarter 6.00% (5.00%) 6.00%   4.00% (9.00%) 2.00% (10.00%) 9.00% (5.00%)  
CER %, quarter-on-quarter 6.00% (7.00%) 6.00% (2.00%) 4.00% (7.00%) 5.00% (13.00%) 7.00% (5.00%)  
Oncology, Others                      
Product sales                      
Product Sales $ 37 $ 27 $ 29 $ 29 $ 30 $ 26 $ 29 $ 27 $ 27 $ 21 64
Actual %, quarter-on-quarter 37.00% (7.00%)   (3.00%) 15.00% (10.00%) 7.00%   29.00% (22.00%)  
CER %, quarter-on-quarter 50.00% (20.00%) 3.00% (3.00%) 7.00% (3.00%)   4.00% 12.00% (22.00%)  
CVRM                      
Product sales                      
Product Sales $ 1,623 $ 1,645 $ 1,939 $ 1,773 $ 1,775 $ 1,779 $ 1,811 $ 1,845 $ 2,168 $ 2,292 3,268
Actual %, quarter-on-quarter (1.00%) (15.00%) 9.00%     (2.00%) (2.00%) (15.00%) (5.00%) (7.00%)  
CER %, quarter-on-quarter   (17.00%) 9.00% (2.00%) (1.00%)   (1.00%) (15.00%) (7.00%) (7.00%)  
Brilinta                      
Product sales                      
Product Sales $ 316 $ 293 $ 299 $ 284 $ 272 $ 224 $ 236 $ 208 $ 214 $ 181 609
Actual %, quarter-on-quarter 8.00% (2.00%) 5.00% 4.00% 21.00% (5.00%) 13.00% (3.00%) 18.00% 4.00%  
CER %, quarter-on-quarter 9.00% (4.00%) 5.00% 3.00% 20.00% (4.00%) 15.00% (2.00%) 16.00% 5.00%  
Farxiga                      
Product sales                      
Product Sales $ 340 $ 299 $ 332 $ 285 $ 250 $ 207 $ 239 $ 220 $ 211 $ 165 639
Actual %, quarter-on-quarter 14.00% (10.00%) 16.00% 14.00% 21.00% (13.00%) 9.00% 4.00% 28.00% 9.00%  
CER %, quarter-on-quarter 15.00% (11.00%) 16.00% 11.00% 20.00% (13.00%) 9.00% 4.00% 26.00% 10.00%  
Onglyza                      
Product sales                      
Product Sales $ 126 $ 129 $ 180 $ 127 $ 150 $ 154 $ 149 $ 169 $ 191 $ 211 255
Actual %, quarter-on-quarter (2.00%) (28.00%) 42.00% (15.00%) (3.00%) 3.00% (12.00%) (12.00%) (9.00%) 10.00%  
CER %, quarter-on-quarter (2.00%) (29.00%) 42.00% (17.00%) (3.00%) 3.00% (11.00%) (11.00%) (11.00%) 12.00%  
Bydureon                      
Product sales                      
Product Sales $ 155 $ 139 $ 147 $ 128 $ 146 $ 153 $ 142 $ 145 $ 156 $ 135 294
Actual %, quarter-on-quarter 12.00% (5.00%) 15.00% (12.00%) (5.00%) 8.00% (2.00%) (7.00%) 16.00% (13.00%)  
CER %, quarter-on-quarter 11.00% (5.00%) 15.00% (14.00%) (5.00%) 8.00% (1.00%) (6.00%) 14.00% (16.00%)  
Byetta                      
Product sales                      
Product Sales $ 29 $ 31 $ 48 $ 39 $ 43 $ 46 $ 55 $ 61 $ 76 $ 62 60
Actual %, quarter-on-quarter (7.00%) (35.00%) 23.00% (9.00%) (7.00%) (16.00%) (10.00%) (20.00%) 23.00% (14.00%)  
CER %, quarter-on-quarter (3.00%) (38.00%) 23.00% (9.00%) (7.00%) (16.00%) (10.00%) (19.00%) 21.00% (14.00%)  
Qtern                      
Product sales                      
Product Sales     $ 5                
Crestor                      
Product sales                      
Product Sales $ 338 $ 389 $ 594 $ 580 $ 560 $ 631 $ 631 $ 688 $ 926 $ 1,156 727
Actual %, quarter-on-quarter (13.00%) (35.00%) 2.00% 4.00% (11.00%)   (8.00%) (26.00%) (20.00%) (13.00%)  
CER %, quarter-on-quarter (12.00%) (36.00%) 2.00% 2.00% (12.00%) 3.00% (7.00%) (26.00%) (21.00%) (13.00%)  
Seloken/Toprol-XL                      
Product sales                      
Product Sales $ 173 $ 200 $ 168 $ 160 $ 181 $ 186 $ 178 $ 185 $ 189 $ 185 373
Actual %, quarter-on-quarter (14.00%) 19.00% 5.00% (12.00%) (3.00%) 4.00% (4.00%) (2.00%) 2.00% 16.00%  
CER %, quarter-on-quarter (13.00%) 18.00% 4.00% (14.00%) (4.00%) 6.00% (2.00%) (2.00%)   11.00%  
Atacand                      
Product sales                      
Product Sales $ 66 $ 71 $ 73 $ 80 $ 72 $ 75 $ 81 $ 74 $ 89 $ 71 137
Actual %, quarter-on-quarter (8.00%) (3.00%) (9.00%) 11.00% (4.00%) (7.00%) 9.00% (17.00%) 25.00% (17.00%)  
CER %, quarter-on-quarter (8.00%) (3.00%) (6.00%) 8.00% (5.00%) (6.00%) 14.00% (19.00%) 22.00% (15.00%)  
CVRM, Others                      
Product sales                      
Product Sales $ 73 $ 85 $ 80 $ 80 $ 90 $ 89 $ 86 $ 84 $ 106 $ 121 158
Actual %, quarter-on-quarter (13.00%) 6.00%   (11.00%) 1.00% 3.00% 2.00% (21.00%) (12.00%) (9.00%)  
CER %, quarter-on-quarter (11.00%) 4.00% (4.00%) (12.00%) (3.00%) 12.00%   (19.00%) (11.00%) (16.00%)  
Respiratory                      
Product sales                      
Product Sales $ 1,226 $ 1,181 $ 1,334 $ 1,092 $ 1,099 $ 1,181 $ 1,210 $ 1,110 $ 1,226 $ 1,207 2,407
Actual %, quarter-on-quarter 4.00% (11.00%) 22.00% (1.00%) (7.00%) (2.00%) 9.00% (9.00%) 2.00% (6.00%)  
CER %, quarter-on-quarter 4.00% (13.00%) 21.00% (3.00%) (8.00%) (1.00%) 10.00% (9.00%) 1.00% (6.00%)  
Symbicort                      
Product sales                      
Product Sales $ 672 $ 634 $ 752 $ 668 $ 706 $ 677 $ 740 $ 697 $ 803 $ 749 1,306
Actual %, quarter-on-quarter 6.00% (16.00%) 13.00% (5.00%) 4.00% (9.00%) 6.00% (13.00%) 7.00% (13.00%)  
CER %, quarter-on-quarter 6.00% (17.00%) 12.00% (7.00%) 3.00% (7.00%) 8.00% (13.00%) 6.00% (12.00%)  
Pulmicort                      
Product sales                      
Product Sales $ 287 $ 346 $ 371 $ 242 $ 226 $ 337 $ 288 $ 224 $ 239 $ 310 633
Actual %, quarter-on-quarter (17.00%) (7.00%) 53.00% 7.00% (33.00%) 17.00% 29.00% (6.00%) (23.00%) 13.00%  
CER %, quarter-on-quarter (17.00%) (8.00%) 51.00% 5.00% (33.00%) 19.00% 31.00% (6.00%) (23.00%) 14.00%  
Daliresp/Daxas                      
Product sales                      
Product Sales $ 45 $ 38 $ 53 $ 53 $ 48 $ 44 $ 41 $ 42 $ 40 $ 31 83
Actual %, quarter-on-quarter 19.00% (28.00%)   10.00% 9.00% 7.00% (2.00%) 5.00% 29.00% (3.00%)  
CER %, quarter-on-quarter 22.00% (30.00%) (2.00%) 8.00% 9.00% 10.00% (2.00%) 5.00% 29.00% (3.00%)  
Tudorza/Eklira                      
Product sales                      
Product Sales $ 39 $ 34 $ 42 $ 37 $ 34 $ 37 $ 36 $ 47 $ 48 $ 39 73
Actual %, quarter-on-quarter 15.00% (19.00%) 14.00% 9.00% (8.00%) 3.00% (23.00%) (2.00%) 23.00% (17.00%)  
CER %, quarter-on-quarter 15.00% (21.00%) 14.00% 6.00% (8.00%) 6.00% (23.00%)   21.00% (17.00%)  
Duaklir                      
Product sales                      
Product Sales $ 22 $ 28 $ 23 $ 21 $ 16 $ 19 $ 19 $ 14 $ 17 $ 13 50
Actual %, quarter-on-quarter (22.00%) 22.00% 10.00% 31.00% (16.00%)   36.00% (18.00%) 31.00% 8.00%  
CER %, quarter-on-quarter (19.00%) 17.00% 10.00% 18.00% (15.00%)   43.00% (18.00%) 31.00% 8.00%  
Bevespi                      
Product sales                      
Product Sales $ 8 $ 5 $ 8 $ 4 $ 3 $ 1 $ 3       13
Actual %, quarter-on-quarter 61.00% (38.00%) 100.00% 33.00%   (67.00%)          
CER %, quarter-on-quarter 60.00% (38.00%) 100.00% 33.00%   (50.00%)          
Respiratory, Others                      
Product sales                      
Product Sales $ 88 $ 75 $ 85 $ 67 $ 66 $ 66 $ 83 $ 86 $ 79 $ 65 163
Actual %, quarter-on-quarter 17.00% (12.00%) 27.00% 2.00%   (20.00%) (3.00%) 9.00% 22.00%    
CER %, quarter-on-quarter 16.00% (20.00%) 30.00% 4.00% (4.00%) (19.00%) 1.00% 12.00% 18.00% (3.00%)  
Other                      
Product sales                      
Product Sales $ 747 $ 929 $ 1,094 $ 991 $ 1,073 $ 998 $ 1,309 $ 1,203 $ 1,227 $ 1,328 1,676
Actual %, quarter-on-quarter (20.00%) (15.00%) 10.00% (8.00%) 8.00% (24.00%) 9.00% (2.00%) (8.00%) (24.00%)  
CER %, quarter-on-quarter (20.00%) (16.00%) 10.00% (9.00%) 7.00% (22.00%) 10.00% (3.00%) (9.00%) (22.00%)  
Nexium                      
Product sales                      
Product Sales $ 442 $ 448 $ 427 $ 469 $ 595 $ 461 $ 491 $ 516 $ 562 $ 463 890
Actual %, quarter-on-quarter (1.00%) 5.00% (9.00%) (21.00%) 29.00% (6.00%) (5.00%) (8.00%) 21.00% (18.00%)  
CER %, quarter-on-quarter (1.00%) 3.00% (9.00%) (22.00%) 28.00% (4.00%) (4.00%) (9.00%) 20.00% (18.00%)  
Synagis                      
Product sales                      
Product Sales $ 26 $ 224 $ 234 $ 153 $ 70 $ 230 $ 302 $ 104 $ 27 $ 244 250
Actual %, quarter-on-quarter (89.00%) (4.00%) 53.00%   (70.00%) (24.00%)     (89.00%) (11.00%)  
CER %, quarter-on-quarter (88.00%) (4.00%) 53.00%   (70.00%) (24.00%)     (89.00%) (11.00%)  
Losec/Prilosec                      
Product sales                      
Product Sales $ 76 $ 69 $ 69 $ 66 $ 68 $ 68 $ 59 $ 72 $ 70 $ 75 145
Actual %, quarter-on-quarter 10.00%   5.00% (3.00%)   15.00% (18.00%) 3.00% (7.00%) (3.00%)  
CER %, quarter-on-quarter 11.00% (4.00%) 5.00% (6.00%) (3.00%) 18.00% (17.00%) 4.00% (9.00%) (4.00%)  
Seroquel XR                      
Product sales                      
Product Sales $ 76 $ 53 $ 108 $ 62 $ 95 $ 67 $ 118 $ 190 $ 225 $ 202 129
Actual %, quarter-on-quarter 44.00% (51.00%) 74.00% (35.00%) 42.00% (43.00%) (38.00%) (16.00%) 11.00% (16.00%)  
CER %, quarter-on-quarter 42.00% (51.00%) 66.00% (36.00%) 38.00% (42.00%) (37.00%) (16.00%) 11.00% (16.00%)  
Movantik/Moventig                      
Product sales                      
Product Sales $ 24 $ 28 $ 30 $ 30 $ 32 $ 30 $ 26 $ 25 $ 23 $ 17 52
Actual %, quarter-on-quarter (14.00%) (7.00%)   (6.00%) 7.00% 15.00% 4.00% 9.00% 35.00% 13.00%  
CER %, quarter-on-quarter (14.00%) (7.00%)   (6.00%) 7.00% 15.00% 4.00% 9.00% 35.00% 13.00%  
FluMist/Fluenz                      
Product sales                      
Product Sales     $ 58 $ 20     $ 67 $ 26 $ 6 $ 5  
Actual %, quarter-on-quarter     190.00%           20.00% (97.00%)  
CER %, quarter-on-quarter     175.00%           20.00% (97.00%)  
Other, Others                      
Product sales                      
Product Sales $ 103 $ 107 $ 168 $ 191 $ 213 $ 142 $ 246 $ 270 $ 314 $ 322 $ 210
Actual %, quarter-on-quarter (4.00%) (36.00%) (12.00%) (10.00%) 50.00% (42.00%) (9.00%) (14.00%) (2.00%) (15.00%)  
CER %, quarter-on-quarter (5.00%) (37.00%) (12.00%) (11.00%) 51.00% (41.00%) (8.00%) (16.00%) (4.00%) (7.00%)