<SEC-DOCUMENT>0000950103-18-009753.txt : 20180817
<SEC-HEADER>0000950103-18-009753.hdr.sgml : 20180817
<ACCEPTANCE-DATETIME>20180817151224
ACCESSION NUMBER:		0000950103-18-009753
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		8
CONFORMED PERIOD OF REPORT:	20180817
FILED AS OF DATE:		20180817
DATE AS OF CHANGE:		20180817

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ASTRAZENECA PLC
		CENTRAL INDEX KEY:			0000901832
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-11960
		FILM NUMBER:		181025639

	BUSINESS ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA
		BUSINESS PHONE:		011 44 20 7304 5000

	MAIL ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ZENECA GROUP PLC
		DATE OF NAME CHANGE:	19930422
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>dp94630_6k.htm
<DESCRIPTION>FORM 6-K
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM 6-K</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SECURITIES AND EXCHANGE COMMISSION</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Washington, D.C. 20549</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Report of Foreign Issuer</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Pursuant to Rule 13a-16 or 15d-16 of</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">the Securities Exchange Act of 1934</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">For <B>August 17, 2018</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Commission File Number: 001-11960</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>AstraZeneca PLC</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">1 Francis Crick Avenue</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Cambridge Biomedical Campus</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Cambridge CB2 0AA</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">United Kingdom</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Indicate by check mark whether the registrant
files or will file annual reports under cover of Form 20-F or Form 40-F.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Form 20-F X &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Form 40-F __</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Indicate by check mark if the registrant
is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Indicate by check mark if the registrant
is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ______</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Indicate by check mark whether the registrant
by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule
12g3-2(b) under the Securities Exchange Act of 1934.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Yes __ &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;No X</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">If &ldquo;Yes&rdquo; is marked, indicate
below the file number assigned to the Registrant in connection with Rule 12g3-2(b): 82-_____________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>


<!-- Field: Page; Sequence: 1 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">EXPLANATORY NOTE</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">In connection with the issuance by AstraZeneca PLC of $850,000,000
aggregate principal amount of 3.500% Notes due 2023, $400,000,000 aggregate principal amount of Floating Rate Notes due 2023, $1,000,000,000
aggregate principal amount of 4.000% Notes due 2029 and $750,000,000 aggregate principal amount of 4.375% Notes due 2048 (collectively,
the &ldquo;Securities&rdquo;), AstraZeneca PLC is filing the following documents solely for incorporation into the Registration
Statement on Form F-3 (File No. 333-214756):</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Exhibit List</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 7%; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Exhibit No.</B></FONT></TD>
    <TD STYLE="width: 93%; border-bottom: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt"><B>&nbsp;&nbsp;&nbsp;Description</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding: 2pt"><A HREF="dp94630_0101.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt">1.1</FONT></A></TD>
    <TD STYLE="padding: 2pt"><A HREF="dp94630_0101.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt">Underwriting Agreement, dated as of August 14, 2018</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding: 2pt"><A HREF="dp94630_0102.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt">1.2</FONT></A></TD>
    <TD STYLE="padding: 2pt"><A HREF="dp94630_0102.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt">Pricing Agreement, dated as of August 14, 2018</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding: 2pt"><A HREF="dp94630_0401.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt">4.1</FONT></A></TD>
    <TD STYLE="padding: 2pt"><A HREF="dp94630_0401.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt">Officers&rsquo; Certificate of the Registrant pursuant to Section 2.08 of the Indenture setting forth the terms of the Securities, including forms of the global notes for the 3.500% Notes due 2023, the Floating Rate Notes due 2023, the 4.000% Notes due 2029 and the 4.375% Notes due 2048.</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding: 2pt"><A HREF="dp94630_0501.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt">5.1</FONT></A></TD>
    <TD STYLE="padding: 2pt"><A HREF="dp94630_0501.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt">Opinion of Freshfields Bruckhaus Deringer LLP</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding: 2pt"><A HREF="dp94630_0502.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt">5.2</FONT></A></TD>
    <TD STYLE="padding: 2pt"><A HREF="dp94630_0502.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt">Opinion of Davis Polk &amp; Wardwell London LLP</FONT></A></TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<!-- Field: Page; Sequence: 2 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2in 0pt 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2in 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2in 0pt 0; text-indent: 24pt">Pursuant to the requirements of
the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned,
thereunto duly authorized.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2in 0pt 0; text-indent: 24pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="text-indent: 24pt">&nbsp;</TD>
    <TD STYLE="text-indent: 24pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 0pt; padding-left: 0pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">ASTRAZENECA PLC&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">(Registrant)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2in 0pt 0; text-indent: 24pt">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="text-indent: 24pt">&nbsp;</TD>
    <TD STYLE="text-indent: 24pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 0pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">Date:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; padding-left: 13.5pt; text-indent: 0.65pt"><FONT STYLE="font-size: 10pt">August 17, 2018</FONT></TD>
    <TD STYLE="text-indent: 24pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Adrian Kemp </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 6%; text-indent: 24pt">&nbsp;</TD>
    <TD STYLE="width: 30%; text-indent: 24pt">&nbsp;</TD>
    <TD STYLE="width: 5%; text-indent: 24pt">&nbsp;</TD>
    <TD STYLE="width: 5%; text-indent: 24pt">&nbsp;</TD>
    <TD STYLE="width: 7%"><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
    <TD STYLE="width: 47%"><FONT STYLE="font-size: 10pt">Adrian Kemp</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 24pt">&nbsp;</TD>
    <TD STYLE="text-indent: 24pt">&nbsp;</TD>
    <TD STYLE="text-indent: 24pt">&nbsp;</TD>
    <TD STYLE="text-indent: 24pt">&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Title:</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Company Secretary</FONT></TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>





<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<!-- Field: Page; Sequence: 6; Options: Last -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <!-- Field: /Page -->



<P STYLE="margin: 0"></P>

</BODY>
</HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-1.1
<SEQUENCE>2
<FILENAME>dp94630_0101.htm
<DESCRIPTION>EXHIBIT 1.1
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 1.1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>



<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>



<P STYLE="margin: 0"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ASTRAZENECA PLC<BR>
<BR>
Debt Securities<BR>
<BR>
UNDERWRITING AGREEMENT</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">August 14, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">To the Representatives of the several Underwriters&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">named from time to time in Schedule I to
the applicable&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pricing Agreement</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Ladies and Gentlemen:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">From time to time AstraZeneca PLC, a company
organized under the laws of England (the <B>&ldquo;Company&rdquo;</B>), proposes to enter into one or more Pricing Agreements (each
a <B>&ldquo;Pricing Agreement&rdquo;</B>) substantially in the form of Annex I hereto, with such additions and deletions as the
parties thereto may determine, and subject to the terms and conditions stated herein, to issue and sell to the firms named in Schedule
I to the applicable Pricing Agreement (such firms constituting the <B>&ldquo;Underwriters&rdquo;</B> with respect to such Pricing
Agreement and the securities specified therein), certain of its debt securities (the <B>&ldquo;Securities&rdquo;</B>) specified
in Schedule II to such Pricing Agreement (with respect to such Pricing Agreement, the &ldquo;<B>Designated Securities</B>&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">The terms and rights of any particular issuance
of Designated Securities shall be as specified in the Pricing Agreement relating thereto and pursuant to the Indenture, dated as
of April 1, 2004, as supplemented from time to time (the <B>&ldquo;Indenture&rdquo;</B>), between the Company and The Bank of New
York Mellon (as successor trustee to JPMorgan Chase Bank) (the <B>&ldquo;Trustee&rdquo;</B>).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">This Agreement supersedes all prior agreements
and understanding (whether written or oral) between the Company and the Underwriters, or any Underwriter, with respect to the subject
matter hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>


<!-- Field: Page; Sequence: 1 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Particular
sales of Designated Securities may be made from time to time to the Underwriters of such Securities, for whom the firm(s) designated
as representative(s) of the Underwriters of such securities in the Pricing Agreement relating thereto will act as representatives
(the <B>&ldquo;Representatives&rdquo;</B>). The term &ldquo;Representatives&rdquo; also refers to the firm(s) acting as representative(s)
of the Underwriters and to Underwriters who act without any firm being designated as their representative. This Underwriting Agreement
shall not be construed as an obligation of the Company to sell any of the Securities or as an obligation of any of the Underwriters
to purchase the Securities. The obligation of the Company to issue and sell any of the Securities and the obligation of any of
the Underwriters to purchase any of the Securities shall be evidenced by the Pricing Agreement with respect to the Designated Securities
specified therein. Each Pricing Agreement shall specify the aggregate principal amount of such Designated Securities, the initial
public offering price of such Designated Securities, the purchase price to the Underwriters of such Designated Securities, the
names of the Underwriters of such Designated Securities, the names of the Representatives of such Underwriters and the principal
amount of such Designated Securities to be purchased by each Underwriter and shall set forth the date, time and manner of delivery
of such Designated Securities and payment therefor. The Pricing Agreement shall also specify (to the extent not set forth in the
indenture and the registration statement and prospectus with respect thereto) the terms of such Designated Securities. A Pricing
Agreement shall be in the form of an executed writing (which may be in counterparts), and may be evidenced by an exchange of telegraphic
or electronic communications or any other rapid transmission device designed to produce a written record of communications transmitted.
The obligations of the Underwriters under this Agreement and each Pricing Agreement shall be several and not joint.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company represents and warrants to, and agrees with, each of the Underwriters that:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
registration statement on Form F-3 (Registration No. 333-214756) in respect of the Securities has been filed with the Securities
and Exchange Commission (the <B>&ldquo;Commission&rdquo;</B>); such registration statement and any amendments thereto filed prior
to the date of the applicable Pricing Agreement, excluding exhibits to such registration statement, but including all documents
incorporated by reference in the prospectus contained therein, became effective on filing with the Commission in such form; the
base prospectus filed as part of such registration statement, in the form in which it has most recently been filed with the Commission
on or prior to the date of the applicable Pricing Agreement, is hereafter called the &ldquo;<B>Basic Prospectus</B>&rdquo;; any
preliminary prospectus relating to the Designated Securities (including any preliminary prospectus supplement) included in such
registration statement or filed with the Commission pursuant to Rule 424(b) of the rules and regulations of the Commission under
the Securities Act of l933, as amended (the &ldquo;<B>Act</B>&rdquo;), being hereinafter called a &ldquo;<B>Preliminary Prospectus</B>&rdquo;;
the various parts of such registration statement, including all exhibits thereto and the documents incorporated by reference in
the prospectus contained in such registration statement, at the time such parts became effective, but excluding Form T-1 and including
any prospectus supplement relating to the Designated Securities that is filed with the Commission and deemed by virtue of Rule
430B under the Act to be part of such registration statement, each as amended at the time such part of the registration statement</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 2; Options: NewSection; Value: 2 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->2<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 0pt">became effective being hereinafter
called the &ldquo;<B>Registration Statement</B>&rdquo;; &ldquo;<B>Applicable Time</B>&rdquo; is the time specified as such in the
applicable Pricing Agreement; &ldquo;<B>Effective Date</B>&rdquo; shall mean each date and time that the Registration Statement
and any post-effective amendments or amendments thereto became or becomes effective; any reference herein to the Basic Prospectus,
any Preliminary Prospectus or the Prospectus shall be deemed to refer to and include the documents incorporated by reference therein
pursuant to Item 6 of Form F-3 under the Act, as of the date of such Basic Prospectus, any Preliminary Prospectus or Prospectus,
as the case may be, and any post-effective amendments to the Registration Statement; any reference to any amendment or supplement
to the Basic Prospectus, any Preliminary Prospectus or the Prospectus shall be deemed to refer to and include any documents filed
after the date of such Basic Prospectus, any Preliminary Prospectus or Prospectus, as the case may be, under the Securities Exchange
Act of 1934, as amended (the &ldquo;<B>Exchange Act</B>&rdquo;), and incorporated by reference in such Basic Prospectus, any Preliminary
Prospectus or Prospectus, as the case may be; any reference to any amendment to the Registration Statement shall be deemed to refer
to and include any annual report of the Company filed pursuant to Section 13(a) or 15(d) of the Exchange Act after the Effective
Date of the Registration Statement that is incorporated by reference in the Registration Statement; the Basic Prospectus, as supplemented
by the prospectus supplement specifically relating to the Designated Securities filed with the Commission pursuant to Rule 424(b)
under the Act in accordance with Section 5(a) hereof, including any documents incorporated by reference therein as of the date
of such filing, is hereinafter called the &ldquo;<B>Prospectus</B>&rdquo;; and no stop order suspending the effectiveness of the
Registration Statement has been issued and no proceeding for that purpose has been initiated or threatened by the Commission and
no order preventing or suspending the use of the Basic Prospectus, any Preliminary Prospectus, the Prospectus or the Pricing Disclosure
Package (as defined below) together with any &ldquo;issuer free writing prospectus&rdquo; as defined in Rule 433 under the Act
relating to the Designated Securities (an &ldquo;<B>Issuer Free Writing Prospectus</B>&rdquo;) has been issued and no proceeding
for that purpose has been initiated or threatened by the Commission;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
documents incorporated by reference in the Pricing Disclosure Package and the Prospectus, when they became effective or were filed
with the Commission, as the case may be, conformed in all material respects to the requirements of the Act or the Exchange Act,
as applicable, and the applicable rules and regulations of the Commission thereunder, and none of such documents contained an untrue
statement of a material fact or omitted to state a material fact required to be stated therein or necessary to make the statements
therein, in the light of the circumstances under which they were made, not misleading; and any further documents so filed and incorporated
by reference in the Pricing Disclosure Package or the Prospectus or any further amendment or supplement thereto, when such documents
become effective or are filed with the Commission, as the case may be, will conform in all material respects to the requirements
of the Act or the Exchange Act, as applicable, and the rules and regulations of the Commission thereunder and will not contain
an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the
statements therein, in the light of the circumstances under which they were made, not misleading; <U>provided</U>, <U>however</U>,
that this representation and warranty shall not apply to</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 3 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->3<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 0pt">any statements or omissions made in
reliance upon and in conformity with information furnished in writing to the Company by an Underwriter of Designated Securities
through the Representatives expressly for use in the Pricing Disclosure Package or the Prospectus as amended or supplemented, as
the case may be, relating to such Securities; and no such documents will have been filed with the Commission following the Commission&rsquo;s
close of business on the business day immediately prior to the date of the applicable Pricing Agreement and prior to the execution
of the applicable Pricing Agreement, except as set forth on Schedule III to the applicable Pricing Agreement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Registration Statement and the Prospectus conform, and any further amendments or supplements to the Registration Statement and
the Prospectus will conform, in all material respects, to the requirements of the Act and the Trust Indenture Act of 1939, as amended
(the &ldquo;<B>Trust Indenture Act</B>&rdquo;), and the rules and regulations of the Commission thereunder; the Registration Statement
and any amendment thereto do not and will not, as of the applicable Effective Date, contain an untrue statement of a material fact
or omit to state a material fact required to be stated therein or necessary to make the statements therein, not misleading; and
the Prospectus and any amendment or supplement thereto do not and will not, as of its date and as of the Time of Delivery, contain
an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the
statements therein, in the light of the circumstances under which they were made not misleading; <U>provided</U>, <U>however</U>,
that this representation and warranty shall not apply to (i) any statements or omissions made in reliance upon and in conformity
with information furnished in writing to the Company by an Underwriter of Designated Securities through the Representatives expressly
for use in the Registration Statement or the Prospectus as amended or supplemented relating to such Securities or (ii) that part
of the Registration Statement which shall constitute the statement of eligibility and qualification (Form T-1) under the Trust
Indenture Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(d)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
(i) Basic Prospectus, the Preliminary Prospectus, if any, used most recently prior to the Applicable Time, as supplemented by the
final term sheet prepared and filed pursuant to Section 5(a) hereof as of the Applicable Time and listed on Schedule IV to the
applicable Pricing Agreement together with the Issuer Free Writing Prospectus listed in Schedule III (if any) to the applicable
Pricing Agreement and any other free writing prospectus that the parties hereto shall hereafter expressly agree in writing to treat
as part of the Pricing Disclosure Package (collectively, the &ldquo;<B>Pricing Disclosure Package</B>&rdquo;) and (ii) each electronic
road show, if any, when taken together as a whole with the Pricing Disclosure Package, will not include any untrue statement of
a material fact or omit to state any material fact necessary in order to make the statements therein, in the light of the circumstances
under which they were made, not misleading; and each Issuer Free Writing Prospectus listed on Schedule III (if any) to the applicable
Pricing Agreement will not conflict with the information contained in the Registration Statement, the Basic Prospectus, the Preliminary
Prospectus, if any, used most recently prior to the Applicable Time or the Prospectus; <U>provided</U>, <U>however</U>, that this
representation and warranty shall not apply to (i) any statements or omissions made in reliance upon and in conformity with information
furnished in writing to the Company by an Underwriter of Designated Securities through the Representatives expressly for use in</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 4 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->4<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 0pt">any such Issuer Free Writing Prospectus
or the Pricing Disclosure Package or (ii) that part of the Registration Statement which shall constitute the statement of eligibility
and qualification (Form T-1) under the Trust Indenture Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(e)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company is not or will not be at the time of the Pricing Agreement, an &ldquo;ineligible issuer,&rdquo; as defined in Rule 405
under the Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(f)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
consolidated financial statements (and the notes thereto) and schedules, if any, of the Company incorporated by reference in or
filed with and as a part of the Registration Statement, the Pricing Disclosure Package and the Prospectus present fairly, in all
material respects, the consolidated financial position as of the respective dates and the consolidated results of operations and
cash flows for the respective periods covered thereby of the Company in conformity with applicable generally accepted accounting
principles applied on a consistent basis throughout the periods involved;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(g)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Since
the latest date as of which information is given in the Pricing Disclosure Package, there has not been any material adverse change
in the consolidated shareholders&rsquo; equity or consolidated long-term debt of the Company and its subsidiaries taken as a whole,
or any material adverse change, or any development reasonably likely to result in a prospective material adverse change in or affecting
the financial position, shareholders&rsquo; equity or results of operations of the Company and its subsidiaries taken as a whole,
otherwise than as set forth in the Pricing Disclosure Package;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(h)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
the best of the Company&rsquo;s knowledge, after due inquiry, and other than as set forth in the Pricing Disclosure Package and
the Prospectus, there are no material legal or governmental or regulatory proceedings pending or threatened to which the Company
or any of its subsidiaries is a party or of which any property of the Company or any of its subsidiaries is the subject that are
required to be described in the Registration Statement, the Pricing Disclosure Package or the Prospectus and are not so described
and there are no statutes or regulations that are required to be described in the Registration Statement, the Pricing Disclosure
Package or the Prospectus and are not so described;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Designated Securities have been duly authorized and, when executed and authenticated in accordance with the Indenture and delivered
to and paid for by the Underwriters, will constitute valid and binding obligations of the Company entitled to the benefits provided
by the Indenture; the Indenture has been duly authorized, executed and delivered by the Company and (assuming the due authorization,
execution and delivery thereof by the Trustee), constitutes a valid and binding obligation of the Company, enforceable in accordance
with its terms, subject to the effects of applicable bankruptcy, insolvency and similar laws affecting the enforcement of creditors&rsquo;
rights generally and equitable principles of general applicability; the Indenture has been duly qualified under the Trust Indenture
Act; and the Designated Securities conform in all material respects to the description thereof contained in the Pricing Disclosure
Package and the Prospectus as amended or supplemented.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(j)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
issue and sale of the Designated Securities and the compliance by the Company with the Indenture, this Agreement and the Pricing
Agreement relating to the</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 5 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->5<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 0pt">Designated Securities and the consummation
by the Company of the transactions contemplated herein and therein will not contravene (x) any of the terms or provisions of any
indenture, mortgage, deed of trust, loan agreement or other similar agreement or instrument to which the Company is a party or
by which the Company is bound, or (y) any statute of the United Kingdom or any political subdivision thereof, or any order, rule
or regulation known to the Company of any court or of any governmental agency or body in the United States or the United Kingdom
or any political subdivision thereof, except in the case of clauses (x) and (y) above for such contraventions which would not affect
the validity or binding nature of the Designated Securities or have a material adverse effect on the financial position, shareholders&rsquo;
equity or results of operations of the Company and its consolidated subsidiaries considered as a whole;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(k)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;No
consent, approval, authorization, order, registration or qualification of or with any court or any governmental agency or body
described in (j) above is required for the issue and sale of the Designated Securities by the Company in the manner contemplated
herein or the consummation of the other transactions contemplated by this Agreement, the Pricing Agreement or the Indenture except
as may be required by the Securities or Blue Sky laws of the various states in connection with the offer and sale of the Designated
Securities;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(l)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company is not, and after giving effect to the offering and sale of the Securities and the application of the proceeds thereof
as described in the Pricing Disclosure Package and the Prospectus will not be, required to register as an &ldquo;investment company&rdquo;
as such term is defined in the Investment Company Act of 1940, as amended;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(m)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;PricewaterhouseCoopers
LLP, which has audited certain of the financial statements of the Company and its subsidiaries and the Company&rsquo;s internal
control over financial reporting as specified under the heading &ldquo;Experts&rdquo; in the Registration Statement, is an independent
registered public accounting firm with respect to the Company as required by the Act and the applicable rules and regulations of
the Commission thereunder, and KPMG LLP, which has audited certain of the financial statements of the Company and its subsidiaries
as specified under the heading &ldquo;Experts&rdquo; in the Registration Statement, was an independent registered public accounting
firm with respect to the Company as required by the Act and the applicable rules and regulations of the Commission thereunder;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(n)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company and its subsidiaries maintain &ldquo;<B>disclosure controls and procedures</B>&rdquo; (as such term is defined in Rule
13a-15(e) under the Exchange Act); such disclosure controls and procedures are effective;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(o)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
operations of the Company and its subsidiaries are and have been conducted at all times in compliance with applicable financial
recordkeeping and reporting requirements and in compliance with, in all material respects, the money laundering statutes and the
rules and regulations thereunder and any related or similar rules, regulations or guidelines, issued, administered or enforced
by any governmental agency (collectively, the &ldquo;<B>Money Laundering Laws</B>&rdquo;), insofar as they apply, and no action,
suit or proceeding by or before any court or governmental agency, authority or</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 6 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->6<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 0pt">body or any arbitrator involving the
Company or any of its subsidiaries with respect to the Money Laundering Laws is pending or, to the best knowledge of the Company,
threatened;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(p)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Neither
the Company nor any of its subsidiaries nor, to the knowledge of the Company, any director, officer, agent, employee or affiliate
of the Company or any of its subsidiaries (i) is currently the subject of any trade, economic or financial sanctions, laws, regulations,
embargoes or restrictive measures administered by the Office of Foreign Assets Control of the U.S. Treasury Department, the European
Union, the Security Council of the United Nations or Her Majesty&rsquo;s Treasury (collectively &ldquo;<B>Sanctions</B>&rdquo;),
nor (ii) has, to the knowledge of the Company, violated or is violating any Sanctions; and the Company will not use the proceeds
of the offering of the Notes, or lend, contribute or otherwise make available such proceeds to any subsidiary, joint venture partner
or other person or entity, for any purpose that would cause the Company or Underwriters to violate Sanctions; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(q)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Except
as may be determined with respect to the matters under investigation described in the Company&rsquo;s Form 6-K filed with the Commission
on July 26, 2018, and incorporated by reference into the Pricing Disclosure Package, the Company and each of its subsidiaries have
conducted their businesses in all material respects in compliance with all laws, rules, and regulations from time to time concerning
or relating to bribery or corruption, including but not limited to the U.S. Foreign Corrupt Practices Act of 1977, the U.K. Bribery
Act 2010 and all other applicable anti-bribery and corruption laws and has instituted and maintained policies and procedures designed
to promote and achieve compliance with such laws.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Upon
the execution of the Pricing Agreement applicable to any Designated Securities and authorization by the Representatives of the
release of such Designated Securities, the several Underwriters propose to offer such Designated Securities for sale upon the terms
and conditions set forth in the Prospectus as amended or supplemented.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Designated
Securities to be purchased by each Underwriter pursuant to the Pricing Agreement relating thereto, in such authorized denominations
and registered in such names as the Representatives may request upon at least forty-eight hours&rsquo; prior notice to the Company,
shall be delivered by or on behalf of the Company to the Representatives for the account of such Underwriter at the office of Davis
Polk &amp; Wardwell London LLP, 5 Aldermanbury Square, London, England, against payment by such Underwriter or on its behalf of
the purchase price therefor in same day funds, payable to the order of the Company in the funds specified in such Pricing Agreement,
all at the place and time and date specified in such Pricing Agreement or at such other place and time and date as the Representatives
and the Company may agree upon in writing, such time and date being herein called the &ldquo;<B>Time of Delivery</B>&rdquo; for
such Securities. The Securities will be delivered by the Company to the Representatives in the form of one or more global Securities,
representing all of the Securities, which will be registered in the name of a nominee for The Depository Trust Company (&ldquo;<B>DTC</B>&rdquo;)
and deposited on behalf of the Underwriters with Cede &amp; Co. as custodian for DTC, for credit to the respective participant
accounts of the Underwriters unless otherwise directed by you. Such</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>


<!-- Field: Page; Sequence: 7 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->7<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 0pt">global Securities will be made available
for checking at least twenty-four hours prior to the Time of Delivery through the facilities of DTC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company agrees with each of the Underwriters of any Designated Securities:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
prepare in consultation with the Representatives the Prospectus, as amended and supplemented in relation to the applicable Designated
Securities, in a form approved by the Representatives, which approval the Representatives agree they will not unreasonably withhold,
and to file such Prospectus pursuant to Rule 424(b) under the Act not later than the Commission&rsquo;s close of business on the
second business day following the execution and delivery of the Pricing Agreement relating to the applicable Designated Securities
or, if applicable, such earlier time as may be required by Rule 424(b); to make no further amendment or any supplement to the Registration
Statement, the Pricing Disclosure Package or Prospectus (as each may have been amended or supplemented) after the date of the Pricing
Agreement relating to such Securities and prior to the Time of Delivery without prior consultation with the Representatives for
such Securities; to advise the Representatives promptly of any such amendment or supplement after such Time of Delivery and furnish
the Representatives with copies thereof; if requested by you prior to the Applicable Time, to prepare a final term sheet, containing
solely a description of the Designated Securities, in a form substantially as set forth in Schedule V to the applicable Pricing
Agreement and which shall be attached to the applicable Pricing Agreement and approved by the Representatives, and to file such
term sheet pursuant to Rule 433(d) under the Act within the time required by such Rule; to file promptly all other material required
to be filed by the Company with the Commission pursuant to Rule 433(d) under the Act; to file promptly all reports and any definitive
proxy or information statements required to be filed by the Company with the Commission pursuant to Section 13(a), 13(c), 14 or
15(d) of the Exchange Act for so long as the delivery of a prospectus (or, in lieu thereof, the notice referred to in Rule 173(a)
under the Act) is required in connection with the offering or sale of such Designated Securities, and during such same period to
advise the Representatives, promptly after the Company receives notice thereof, of the time when any amendment to the Registration
Statement has been filed or becomes effective or any supplement to the Prospectus or any amended Prospectus has been filed with
the Commission, of the issuance by the Commission of any stop order or of any order preventing or suspending the use of any prospectus
relating to the Securities, of the suspension of the qualification of such Securities for offering or sale in any jurisdiction,
of the initiation or threatening of any proceeding for any such purpose, or of any request by the Commission for the amending or
supplementing of the Registration Statement or Prospectus or for additional information; and, in the event of the issuance of any
such stop order or of any such order preventing or suspending the use of any prospectus relating to the Securities or suspending
any such qualification, to use promptly its reasonable best efforts to obtain its withdrawal;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Promptly
from time to time to use its reasonable best efforts to qualify such Securities for offering and sale under the securities laws
of such jurisdictions as the Representatives may reasonably request and to pay all expenses (including reasonable</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 8 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->8<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 0pt">fees and disbursements of counsel)
in connection with such qualification and in connection with the determination of the eligibility of such Securities for investment
under the laws of such jurisdictions as the Representatives may designate and to comply with such laws so as to permit the continuance
of sales and dealings therein in such jurisdictions for as long as may be necessary to complete the distribution of such Securities;
<U>provided</U>, <U>however</U>, that in connection therewith the Company shall not be required to qualify as a foreign corporation
or to file a general consent to service of process in any jurisdiction or to take any other action which would subject it to service
of process in suits in any jurisdiction or to subject it to taxation in any jurisdiction other than those arising out of the offering
or sale of the Designated Securities in such jurisdiction;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
furnish the Underwriters, without charge, with a copy of the Registration Statement, with copies of the Prospectus as amended or
supplemented, including the exhibits and materials, if any, incorporated by reference therein, in such quantities as the Representatives
may from time to time reasonably request, and, if the delivery of a prospectus is required (or, in lieu thereof, the notice referred
to in Rule 173(a) under the Act) at any time prior to the expiration of nine months after the time of issue of the Prospectus in
connection with the offering or sale of the Designated Securities and if at such time any event shall have occurred as a result
of which the Prospectus as then amended or supplemented would include an untrue statement of a material fact or omit to state any
material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made when
such Prospectus (or, in lieu thereof, the notice referred to in Rule 173(a) under the Act) is delivered, not misleading, or, if
for any other reason it shall be necessary during such same period to amend or supplement the Prospectus or to file under the Exchange
Act any document incorporated by reference in the Prospectus in order to comply with the Act, the Exchange Act or the Trust Indenture
Act, to notify the Representatives and upon their request to file such document and to prepare and furnish without charge to each
Underwriter and to any dealer in securities as many copies as the Representatives may from time to time reasonably request of an
amended Prospectus or a supplement to the Prospectus which will correct such statement or omission or effect such compliance; <U>provided</U>,
<U>however</U>, if any Underwriter is required to deliver a prospectus in connection with sales of any of the Designated Securities
at any time nine months or more after the time of issue of the Prospectus, upon their request but at the expense of such Underwriter,
to prepare and deliver to such Underwriter as many copies as the Representatives may request of an amended or supplemented Prospectus
complying with Section 10(a) (3) of the Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(d)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
make generally available to the Company&rsquo;s security holders and to the Representatives as soon as practicable, but in any
event not later than eighteen months after the effective date of the Registration Statement (as defined in Rule 158(c) under the
Act), an earnings statement of the Company and its subsidiaries (which need not be audited) complying with Section 11(a) of the
Act and the rules and regulations of the Commission thereunder (including, at the option of the Company, Rule 158); and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 9 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->9<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(e)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;During
the period beginning from the date of the Pricing Agreement for such Designated Securities and continuing to and including the
earlier of (i) the termination of trading restrictions for such Designated Securities, as notified to the Company by the Representatives
and (ii) the Time of Delivery for such Designated Securities, not to offer, sell, contract to sell or otherwise dispose of any
debt securities of the Company which mature more than one year after such Time of Delivery and which are denominated in U.S. dollars
and substantially similar to such Designated Securities, without the prior written consent of the Representatives, which consent
shall not be unreasonably withheld.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">6.&#9;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&#9;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each Underwriter represents
and agrees that it shall not use, refer to or distribute any &ldquo;free writing prospectus&rdquo; (as defined in Rule 405 under
the Act, a &ldquo;<B>Free Writing Prospectus</B>&rdquo;) except:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a
Free Writing Prospectus that (1) is not an Issuer Free Writing Prospectus, and (2) contains only information describing the preliminary
terms of the Securities or their offering or otherwise permitted under Rule 134 under the Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(ii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a
Free Writing Prospectus as shall be agreed in writing with the Company that is not distributed, used or referenced by such Underwriter
in a manner reasonably designed to lead to its broad unrestricted dissemination (including any electronic road show) unless the
Company consents to such dissemination and such Free Writing Prospectus is listed on Schedule VI to the applicable Pricing Agreement;
provided that an Underwriters&rsquo; internal communications with its own sales force shall not be covered by this clause (ii);
and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Notwithstanding
Section 6(a) above, the Company hereby agrees that the Underwriters may distribute to investors one or more Free Writing Prospectus
that contain only the final terms of the Securities (including, for the avoidance of doubt, in the format of Bloomberg communications)
substantially in the form set forth in Schedule V to the applicable Pricing Agreement and that such Free Writing Prospectus substantially
in the form set forth in Schedule V to the applicable Pricing Agreement will be filed by the Company in accordance with Rule 433(d)
under the Act and shall be considered an Issuer Free Writing Prospectus for purposes of this Agreement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company agrees that, unless it has obtained or will obtain the prior written consent of the Representatives, it has not made and
will not make any offer relating to the Securities that would constitute an Issuer Free Writing Prospectus or that would otherwise
constitute a &ldquo;free writing prospectus&rdquo; (as defined in Rule 405 under the Act) required to be filed by the Company with
the Commission or retained by the Company under Rule 433 under the Act, provided that the prior written consent of the parties
hereto shall be deemed to have been given in respect of the free writing prospectus included in Schedule III to the applicable
Pricing Agreement. Any such free writing prospectus consented to by the Representatives is hereinafter referred to as a &ldquo;<B>Permitted
Free Writing Prospectus</B>.&rdquo; The Company agrees that (i) it has treated and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 10 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->10<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 0pt">will treat, as the case may be, each
Permitted Free Writing Prospectus (including the final terms of the Securities as set forth in Schedule V to the applicable Pricing
Agreement) as an Issuer Free Writing Prospectus and (ii) it has complied and will comply, as the case may be, with the requirements
of Rules 164 and 433 under the Act applicable to any Permitted Free Writing Prospectus, including in respect of timely filing with
the Commission, legending and record keeping.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(d)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company agrees that if at any time following issuance of an Issuer Free Writing Prospectus any event occurred or occurs as a result
of which such Issuer Free Writing Prospectus would conflict with the information in the Registration Statement, the Pricing Disclosure
Package or the Prospectus or would include an untrue statement of a material fact or omit to state any material fact necessary
in order to make the statements therein, in the light of the circumstances then prevailing, not misleading, the Company will give
prompt notice thereof to the Representatives and, if requested by the Representatives, will prepare and furnish without charge
to each Underwriter an Issuer Free Writing Prospectus or other document which will correct such conflict, statement or omission;
<U>provided</U>, <U>however</U>, that this representation and warranty shall not apply to any statements or omissions in an Issuer
Free Writing Prospectus made in reliance upon and in conformity with information furnished in writing to the Company by an Underwriter
through the Representatives expressly for use therein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company covenants and agrees with the several Underwriters that the Company will pay or cause to be paid the following: (i) except
as provided in the proviso contained in Section 5(c) hereof, the fees, disbursements and expenses of counsel of the Company and
accountants of the Company in connection with the registration of the Designated Securities under the Act and the qualification
of any indenture related to the Designated Securities under the Trust Indenture Act and all other expenses in connection with the
preparation, printing and filing of the Registration Statement, the Basic Prospectus, any Preliminary Prospectus, the Prospectus
and amendments and supplements thereto, the Pricing Disclosure Package and any Issuer Free Writing Prospectus and the mailing and
delivering of copies thereof to the Underwriters and dealers; (ii) the cost of printing or producing any Agreement among Underwriters,
this Agreement, the Pricing Disclosure Package, any indenture related to the Designated Securities, any Blue Sky and legal investment
memoranda and any other documents in connection with the offering, purchase, sale and delivery of the Designated Securities; (iii)
all expenses in connection with the qualification of the Designated Securities for offering and sale under state securities laws
as provided in Section 5(b) hereof, including the reasonable fees, disbursements and expenses of counsel for the Underwriters in
connection with such qualification and in connection with the Blue Sky and legal investment surveys; (iv) any fees charged by securities
rating services for rating the Designated Securities; (v) any filing fees incident to any required review by the Financial Industry
Regulatory Authority of the terms of the sale of the Designated Securities; (vi) the cost of preparing the Securities and of the
delivery of the Designated Securities to the Underwriters, including any transfer or similar taxes thereon; (vii) the fees and
expenses of any Trustee and any agent of any Trustee and the fees and disbursements of counsel for any Trustee in connection with
any Indenture and the Securities; and (viii) except as provided in the proviso contained in Section 5(c) hereof all reasonable
other costs and expenses incident to the performance of their obligations hereunder which are not</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>


<!-- Field: Page; Sequence: 11 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->11<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">otherwise specifically provided for
in this Section. It is understood, however, that, except as provided in this Section, Section 9 and Section 13 hereof, the Underwriters
will pay all of their own costs and expenses, including the fees of their counsel, transfer taxes on the initial sale or any resale
of any of the Designated Securities by them, and any advertising expenses connected with any offers they may make.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
obligations of the Underwriters of any Designated Securities under the Pricing Agreement relating to such Designated Securities
shall be subject, in the discretion of the Representatives, to the condition that all representations and warranties and other
statements of the Company in or incorporated by reference in the Pricing Agreement relating to such Designated Securities are,
at and as of the Time of Delivery for such Designated Securities, true and correct in all material respects, the condition that
the Company shall have performed all, of its obligations hereunder theretofore to be performed, and the following additional conditions:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
final term sheet contemplated by Section 5(a) hereof in relation to the applicable Designated Securities, and any other material
required to be filed pursuant to Rule 433 under the Act in relation to the applicable Designated Securities shall have been filed
within the applicable time period prescribed for such filings by Rule 433 under the Act and the Prospectus as amended or supplemented
in relation to the applicable Designated Securities shall have been filed with the Commission pursuant to Rule 424(b) under the
Act within the applicable time period prescribed for such filing by the rules and regulations under the Act and in accordance with
Section 5(a) hereof; no stop order suspending the effectiveness of the Registration Statement has been issued and no proceeding
for that purpose has been initiated or threatened by the Commission and no order suspending or preventing the use of the Basic
Prospectus, any Preliminary Prospectus, any documents which are part of the Pricing Disclosure Package, the Prospectus or any Issuer
Free Writing Prospectus shall have been issued and no proceeding for that purpose shall have been initiated or threatened by the
Commission; and all requests for additional information on the part of the Commission shall have been complied with to the Representatives&rsquo;
reasonable satisfaction;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Simpson
Thacher &amp; Bartlett LLP, United States counsel for the Underwriters, shall have furnished to the Representatives such opinion
or opinions, dated the Time of Delivery for such Designated Securities, with respect to the validity of the Indenture, the Designated
Securities, the Registration Statement, the Pricing Disclosure Package, the Prospectus as amended or supplemented and other related
matters as the Representatives may reasonably request, and such counsel shall have received such papers and information as they
may reasonably request to enable them to pass upon such matters (such counsel being entitled to state that they have assumed that
any document referred to in their opinion and executed by the Company has been duly authorized, executed and delivered pursuant
to English law and, as to all matters of English law, their opinion is given in reliance upon, and is subject to the qualifications
set forth in, the opinion of counsel for the Company required by subsection (c) of this Section 8);</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Counsel
for the Company shall have furnished to the Representatives a written opinion, dated the Time of Delivery for such Designated Securities,
in form and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 12 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->12<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 0pt">substance reasonably satisfactory
to the Representatives (such counsel being entitled to state that such counsel has made no investigation of the laws of any country
other than England and that such counsel&rsquo;s opinion is confined to matters of English law and, as to all matters governed
by the laws of the United States and the State of New York, such opinion is given in reliance upon, and is subject to the qualifications
set forth in, the opinion required by subsection (e) of this Section 8), substantially to the effect that:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company has been duly incorporated in Great Britain under the Companies Act 1985, as amended, and is registered in England and
Wales as a public limited company, with the requisite power and authority to own its properties and assets and conduct its business
as described in the Prospectus Supplement and the Registration Statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(ii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company search revealed no order or resolution for the winding up of the Company or certain of its material subsidiaries (AstraZeneca
UK Limited and AstraZeneca Treasury Limited) and revealed no notice of appointment in respect of the Company, AstraZeneca UK Limited
or AstraZeneca Treasury Limited of a liquidator, receiver, administrative receiver or administrator and our winding up enquiry
has confirmed that no petition for the winding up of the Company, AstraZeneca UK Limited or AstraZeneca Treasury Limited has been
presented within the period covered by such enquiries;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(iii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This
Agreement and the applicable Pricing Agreement have been duly authorized, executed and delivered by the Company and the consent
to service of process contained in Section 17 of this Agreement is a valid and binding agreement of the Company;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(iv)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
issue, sale and delivery of the Designated Securities and the compliance by the Company with all of the provisions of the Indenture,
this Agreement and the Pricing Agreement relating to the Designated Securities and the consummation by the Company of the transactions
contemplated herein and therein will not contravene (x) the provisions of the Company&rsquo;s Memorandum and Articles of Association,
or (y) any law, order, rule or regulation the Company having the force of law in England and applicable to the Company;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(v)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;No
consent, license, approval or authorization of any governmental or other agency or body described in the United Kingdom is required
for the issue and sale of the Designated Securities by the Company in the manner contemplated herein or the consummation of the
other transactions contemplated by this Agreement , the Pricing Agreement or the Indenture;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(vi)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Indenture has been duly authorized, executed and delivered by the Company and constitutes a valid and binding obligation of the
Company; no taxes or recording fees are required to be paid in the United Kingdom with respect to the execution of the Indenture;
and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 13 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->13<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(vii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
statements in the Pricing Disclosure Package and the Prospectus set forth in the last sentence under the caption &ldquo;Enforceability
of Certain Civil Liabilities&rdquo; and contained under the caption &ldquo;Certain UK and US Federal Tax Considerations&mdash;United
Kingdom Taxation&rdquo; with respect to matters of English law are true and correct in all material respects.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 1in">&#9;In giving the opinion set
forth in subparagraphs (iii), (iv), (v), and (vi) of this subsection (c), such counsel may state that in the case of default by
the Company in the performance of its obligations under this Agreement or any other agreement referred to in such opinion, any
proceedings in an English court to pursue remedies would be subject to the following: (a) a judgment rendered by a court outside
the United Kingdom would not be enforced by the English courts without a retrial or re-examination if such judgment was obtained
by fraud or in a manner opposed to natural justice or if the enforcement thereof were contrary to United Kingdom public policy;
and (b) in any proceedings to enforce in an English court a foreign judgment it is open to the defendant to raise any counterclaim
which he could have brought if the action had originally been brought in England unless the subject of the counterclaim was in
issue and decided in the foreign proceedings; and in giving the opinion in subparagraph (vii) above, such counsel may assume that
the Designated Securities conform to the specimen thereof examined by such counsel.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(d)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company Secretary or General Counsel for the Company shall have furnished to the Representatives a written opinion, dated the Time
of Delivery for such Designated Securities, in form and substance reasonably satisfactory to the Representatives (such Company
Secretary or General Counsel being entitled to state that he has made no investigation of the laws of any country other than England
and that his opinion is confined to matters of English law and, as to all matters governed by the laws of the United States and
the State of New York, such opinion is given in reliance upon, and is subject to the qualifications set forth in, the opinion required
by subsection (e) of this Section 8), substantially to the effect that:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Other
than as set forth in the Pricing Disclosure Package and the Prospectus, to the best of such Company Secretary or General Counsel&rsquo;s
knowledge, after due inquiry, there are no material legal or governmental proceedings pending or threatened to which the Company
or any of its subsidiaries is a party or of which any property of the Company or any of its subsidiaries is the subject that are
required to be described in the Registration Statement, the Pricing Disclosure Package or the Prospectus and are not so described
and there are no statutes or regulations that are required to be described in the Registration Statement, the Pricing Disclosure
Package or the Prospectus and are not so described; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(ii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
issue and sale of the Designated Securities and the compliance by the Company with all of the provisions of the Indenture, this
Agreement and the Pricing Agreement relating to the Designated Securities and the consummation by the Company of the transactions
contemplated herein and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 14 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->14<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 1in; text-indent: 0pt">therein will not contravene any
of the terms or provisions of any indenture, mortgage, deed of trust, loan agreement or other similar agreement or instrument known
to such Company Secretary or General Counsel to which the Company is a party or by which the Company is bound, except for such
contraventions which would not affect the validity or binding nature of the Designated Securities or have a material adverse effect
on the financial position, shareholders&rsquo; equity or results of operations of the Company and its consolidated subsidiaries
considered as a whole.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(e)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Davis
Polk &amp; Wardwell London LLP, United States counsel for the Company, shall have furnished to the Representatives their written
opinion, dated the Time of Delivery for such Designated Securities, in form and substance reasonably satisfactory to the Representatives
(such counsel being entitled to state that they have assumed that any document referred to in their opinion and executed by the
Company has been duly authorized, executed and delivered pursuant to English law and, as to all matters governed by the laws of
England, their opinion is given in reliance upon, and is subject to the same qualifications set forth in, the opinion required
by subsection (c) of this Section&nbsp;8), substantially to the effect that:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This
Agreement and the Pricing Agreement relating to the Designated Securities have been duly authorized, executed and delivered by
the Company;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(ii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Designated Securities, when executed and authenticated in accordance with the terms of the Indenture and delivered to and paid
for by the Underwriters in accordance with the terms of this Agreement and the Pricing Agreement, will be valid and binding obligations
of the Company, enforceable in accordance with their terms, subject to applicable bankruptcy, insolvency and similar laws affecting
creditors&rsquo; rights generally and equitable principles of general applicability, and will be entitled to the benefits provided
by the Indenture, provided that such counsel expresses no opinion as to the enforceability of any waiver of rights under any usury
or stay law; the Indenture has been duly executed and delivered by the Company and assuming that the Indenture has been duly authorized,
executed and delivered by the Trustee the Indenture constitutes a valid and binding agreement of the Company, enforceable in accordance
with its terms subject to applicable bankruptcy, insolvency and similar laws affecting creditors&rsquo; rights generally and equitable
principles of general applicability; provided that such counsel expresses no opinion as to the enforceability of any waiver of
rights under any usury or stay law; the Indenture has been qualified under the Trust Indenture Act and the rules and regulations
thereunder; no taxes or recording fees are required to be paid in the United States with respect to the issuance of the Designated
Securities in the manner contemplated herein, except such as have been paid;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(iii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
statements included in the Pricing Disclosure Package and the Prospectus under the captions &ldquo;Description of Debt Securities&rdquo;
and &ldquo;Description</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 15 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->15<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 1in; text-indent: 0pt">of Notes&rdquo;, respectively, insofar
as they summarize provisions of the Indenture and the Designated Securities, fairly summarize these provisions in all material
respects;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(iv)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
statements included in the Pricing Disclosure Package and the Prospectus under the caption &ldquo;Certain UK and US Federal Tax
Considerations&mdash;United States Taxation&rdquo; (as supplemented by the statements included under the caption &ldquo;Taxation&mdash;Certain
US Federal Income Tax Considerations&rdquo;) insofar as they purport to describe provisions of U.S. federal income tax laws or
legal conclusions with respect thereto, fairly summarize such matters in all material respects;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(v)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
issue and sale of the Designated Securities and the compliance by the Company with all of the provisions of the Designated Securities,
the Indenture, this Agreement and the Pricing Agreement relating to the Designated Securities and the consummation by the Company
of the transactions herein and therein contemplated will not contravene any provision of United States federal or New York State
law that in such counsel&rsquo;s experience is normally applicable to transactions of the type contemplated by this Agreement or
the Pricing Agreement, except for such contraventions which would not affect the validity or binding nature of the Designated Securities
or have a material adverse effect on the financial position, shareholders&rsquo; equity or results of operations of the Company
and its consolidated subsidiaries considered as a whole;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(vi)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;No
consent, approval, authorization or order of, or qualification with, any governmental body or agency under the laws of the State
of New York or any federal law of the United States that in such counsel&rsquo;s experience is normally applicable to companies
such as the Company in relation to transactions of the type contemplated by this Agreement, the Pricing Agreement, the Indenture
or the Designated Securities is required for the performance by the Company of its obligations under such documents, except such
as have been obtained and such as may be required under state securities or Blue Sky laws;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(vii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company is not, and after giving effect to the offering and sale of the Securities and the application of the proceeds thereof
as described in the Prospectus will not be, required to register as an &ldquo;<B>investment company</B>&rdquo; as such term is
defined in the Investment Company Act of 1940, as amended;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(viii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
documents incorporated by reference in the Pricing Disclosure Package and Prospectus (except as to the financial statements and
supporting schedules included or incorporated by reference therein or other financial data included or incorporated by reference
therein as to which such counsel need express no opinion), when they were filed with the Commission, appeared to be appropriately
responsive in all material respects to the requirements of the Exchange Act and the applicable rules and regulations thereunder;
and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 16 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->16<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">(ix)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)
Such counsel is of the opinion that the Registration Statement as amended, at the time it became effective, the Pricing Disclosure
Package and the Prospectus as amended or supplemented and any further amendments and supplements thereto made by the Company prior
to the Time of Delivery for the Designated Securities (except as to the financial statements and supporting schedules included
or incorporated by reference therein, other financial data included or incorporated by reference therein), and except for that
part of the Registration Statement that constitutes the Statement of Eligibility and Qualification (Form T-l) of the Trustee) appear
on their face to be appropriately responsive in all material respects to the requirements of the Act and the rules and regulations
of the Commission thereunder and (2) nothing has come to such counsel&rsquo;s attention that causes them to believe that insofar
as relevant to the offering of the Designated Securities (except as to the financial statements and supporting schedules included
or incorporated by reference therein, other financial data included or incorporated by reference therein, as to which such counsel
need express no opinion, and except for that part of the Registration Statement that constitutes the Statement of Eligibility and
Qualification (Form T-1) of the Trustee), (a) the Registration Statement (including the documents incorporated by reference therein),
as of the date of the Pricing Agreement, contained any untrue statement of a material fact or omitted to state a material fact
required to be stated therein or necessary to make the statements therein not misleading, (b) the Pricing Disclosure Package, as
of the Applicable Time, contained or contains any untrue statement of a material fact or omitted or omits to state a material fact
necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading,
or (c)&nbsp;the Prospectus, as of its date and as of the Time of Delivery, contained or contains any untrue statement of a material
fact or omitted or omits to state a material fact necessary in order to make the statements therein, in the light of the circumstances
in which they were made, not misleading.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 1in">&#9;In giving the opinions set
forth in subparagraphs (viii) and (ix) of this subsection (e) such counsel may state that such opinion is based on their participation
in the preparation of the Registration Statement, the Pricing Disclosure Package and the Prospectus and a review of the contents
thereof but without independent check or verification except for the matters referred to in subparagraph (iii) of this subsection
(e). Such opinion may also state that it is confined to matters of the laws of the United States of America and the State of New
York as of the date of the opinion. Such opinion may also state that such counsel expresses no opinion or belief as to (x)&nbsp;the
statements of English law or descriptions of legislation referred to in subparagraph (vii) of paragraph (c) of this Section&nbsp;8,
(y) the conveyance of the Pricing Disclosure Package or the information contained therein to investors or (z) the due incorporation
of, and valid, binding and enforceable, execution of the Indenture by the Trustee;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(f)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;On
the date of the applicable Pricing Agreement and at the Time of Delivery for such Designated Securities, PricewaterhouseCoopers
LLP, the independent registered public accountants of the Company, and KPMG LLP, the former independent</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 17 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->17<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 0pt">registered public accountants of the
Company, each of which has certified certain of the financial statements of the Company and its consolidated subsidiaries included
or incorporated by reference in the Registration Statement as specified under the heading &ldquo;Experts&rdquo; in the Registration
Statement, shall have furnished to the Representatives a letter or letters, dated as of each such date and in form and substance
satisfactory to the Representatives, containing statements and information of the type ordinarily included in accountants&rsquo;
&ldquo;comfort letters&rdquo; to underwriters with respect to the financial statements and certain financial information contained
in the Registration Statement and the Prospectus as amended or supplemented and as to such other matters as the Representatives
may reasonably request; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">(g)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company shall have furnished or caused to be furnished to the Representatives a certificate or certificates, dated the Time of
Delivery for the Designated Securities, of officers of the Company satisfactory to the Representatives as to the accuracy of the
representations and warranties in all material respects of the Company in this Agreement and the Pricing Agreement at and as of
the Time of Delivery, as to the performance by the Company of all of its obligations hereunder to be performed prior to such Time
of Delivery, and as to the matters set forth in Sections&nbsp;8(a) and 12(i) hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)
The Company will indemnify and hold harmless each Underwriter against any losses, claims, damages or liabilities, joint or several,
to which such Underwriter may become subject, under the Act or otherwise, insofar as such losses, claims, damages or liabilities
(or actions in respect thereof) arise out of or are based upon an untrue statement or alleged untrue statement of a material fact
contained in the Registration Statement, the Basic Prospectus, any Preliminary Prospectus, the Prospectus, or any amendment or
supplement thereto, the Pricing Disclosure Package, any Issuer Free Writing Prospectus or any &ldquo;issuer information&rdquo;
filed or required to be filed pursuant to Rule 433(d) under the Act, including the information in the final term sheet filed in
accordance with Section 5(a) of this Agreement and any other prospectus relating to the Securities, or any amendment or supplement
thereto, or arise out of or are based upon the omission or alleged omission to state therein a material fact required to be stated
therein or necessary to make the statements therein not misleading, and will reimburse each Underwriter for any legal or other
expenses reasonably incurred by such Underwriter in connection with investigating or defending any such action or claim as such
expenses are incurred; <U>provided</U>, <U>however</U>, that the Company shall not be liable in any such case to the extent that
any such loss, claim, damage or liability arises out of or are based upon an untrue statement or alleged untrue statement or omission
or alleged omission made in the Registration Statement, the Basic Prospectus, any Preliminary Prospectus, the Prospectus, or any
amendment or supplement thereto, the Pricing Disclosure Package, any Issuer Free Writing Prospectus and any other prospectus relating
to the Securities, or any such amendment or supplement in reliance upon and in conformity with written information furnished to
the Company by any Underwriter of Designated Securities through the Representatives expressly for use in the Prospectus as amended
or supplemented relating to such Securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>Each
Underwriter will indemnify and hold harmless the Company against any losses, claims, damages or liabilities to which the Company
may become subject, under the Act or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 18 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->18<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 0pt">arise out of or are based upon an
untrue statement or alleged untrue statement of a material fact contained in the Registration Statement, the Basic Prospectus,
any Preliminary Prospectus, the Prospectus, or any amendment or supplement thereto, the Pricing Disclosure Package, or any Issuer
Free Writing Prospectus and any other prospectus relating to the Securities, or any amendment or supplement thereto, or arise out
of or are based upon the omission or alleged omission to state therein a material fact required to be stated therein or necessary
to make the statements therein not misleading, in each case to the extent, but only to the extent, that such untrue statement or
alleged untrue statement or omission or alleged omission was made in the Registration Statement, the Basic Prospectus, any Preliminary
Prospectus, the Prospectus, or any amendment or supplement thereto, the Pricing Disclosure Package, or any Issuer Free Writing
Prospectus and any other prospectus relating to the Securities, or any amendment or supplement in reliance upon and in conformity
with written information furnished to the Company by such Underwriter through the Representatives expressly for use therein; and
will, reimburse the Company for any legal or other expenses reasonably incurred by the Company in connection with investigating
or defending any such action or claim as such expenses are incurred.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>Promptly
after receipt by an indemnified party under subsection (a) or (b) above of notice of the commencement of any action (including
any governmental action), such indemnified party shall, if a claim in respect thereof is to be made against the indemnifying party
under such subsection, promptly notify the indemnifying party in writing of the commencement thereof; but the omission so to notify
the indemnifying party shall not relieve it from any liability which it may have to any indemnified party otherwise than under
such subsection. In case any such action shall be brought against any indemnified party and it shall notify the indemnifying party
of the commencement thereof, the indemnifying party shall be entitled to participate therein and, to the extent that it shall wish,
jointly with any other indemnifying party similarly notified, to assume the defense thereof, with counsel reasonably satisfactory
to such indemnified party (who shall not, except with the consent of the indemnified party, be counsel to the indemnifying party),
and, after notice from the indemnifying party to such indemnified party of its election so to assume the defense thereof, the indemnifying
party shall not be liable to such indemnified party under such subsection for any legal expenses of other counsel or any other
expenses, in each case subsequently incurred by such indemnified party, in connection with the defense thereof other than reasonable
costs of investigation. It is understood that the indemnifying party shall not, in connection with any action or related actions
in the same jurisdiction, be liable for the reasonable fees and expenses of more than one separate firm for all such indemnified
parties. The indemnifying party shall not be liable for any settlement of any action effected without its written consent but if
settled with such consent, the indemnifying party agrees to indemnify the indemnified party from and against any loss or liability
by reason of such settlement. Furthermore, the indemnifying party shall not, without the written consent of the indemnified party,
effect the settlement or compromise of, or consent to the entry of any judgment with respect to, any pending or threatened action
or claim in respect of which indemnification or contribution may be sought hereunder (whether or not the indemnified party is an
actual or potential party to such action or claim) unless such settlement, compromise or judgment (i) includes an unconditional
release of the indemnified party from all liability arising out of such action or claim and (ii) does not include a statement as
to, or an admission of fault, culpability or a failure to act, by or on behalf of any indemnified party.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 19 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->19<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(d)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>To
the extent that the indemnification provided for in this Section 9 is unavailable to or insufficient to hold harmless an indemnified
party under subsection (a) or (b) above in respect of any losses, claims, damages or liabilities (or actions in respect thereof)
referred to therein, then each indemnifying party shall contribute to the amount paid or payable by such indemnified party as a
result of such losses, claims, damages or liabilities (or actions in respect thereof) in such proportion as is appropriate to reflect
the relative benefits received by the Company on the one hand and the Underwriters of the Designated Securities on the other from
the offering of the Designated Securities to which loss, claim, damage or liability (or action in respect thereof) relates. If,
however, the allocation provided by the immediately preceding sentence is not permitted by applicable law or if the indemnified
party failed to give the notice required under subsection (c) above, then each indemnifying party shall contribute to such amount
paid or payable by such indemnified party in such proportion as is appropriate to reflect not only such relative benefits but also
the relative fault of the Company on the one hand and the Underwriters of the Designated Securities on the other in connection
with the statements or omissions which resulted in such losses, claims, damages or liabilities (or actions in respect thereof),
as well as any other relevant equitable considerations. The relative benefits received by the Company on the one hand and such
Underwriters on the other shall be deemed to be in the same proportion as the total net proceeds from such offering (before deducting
expenses) received by the Company bear to the total underwriting discounts and commissions received by such Underwriters, in each
case as set forth in the table on the cover page of the Prospectus as amended and supplemented. The relative fault shall be determined
by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission or alleged
omission to state a material fact relates to information supplied by the Company on the one hand or the Underwriters on the other
and the parties&rsquo; relative intent, knowledge, access to information and opportunity to correct or prevent such statement or
omission. The Company and the Underwriters agree that it would not be just and equitable if contribution pursuant to this subsection
(d) were determined by pro rata allocation (even if the Underwriters were treated as one entity for such purpose) or by any other
method of allocation which does not take account of the equitable considerations referred to above in this subsection (d). The
amount paid or payable by an indemnified party as a result of the losses, claims, damages or liabilities (or actions in respect
thereof) referred to above in this subsection (d) shall be deemed to include any legal or other expenses reasonably incurred by
such indemnified party in connection with investigating or defending any such action or claim. Notwithstanding the provisions of
this subsection (d), no Underwriter shall be required to contribute any amount in excess of the amount by which the total price
at which the applicable Designated Securities underwritten by it and distributed to the public were offered to the public exceeds
the amount of any damages which such Underwriter has otherwise been required to pay by reason of such untrue or alleged untrue
statement or omission or alleged omission. No person guilty of fraudulent misrepresentation (within the meaning of Section&nbsp;11(f)
of the Act) shall be entitled to contribution from any person who was not guilty of such fraudulent misrepresentation. The obligations
of the Underwriters of Designated Securities in this subsection (d) to contribute are several in proportion to their respective
underwriting obligations with respect to such Securities and not joint.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(e)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>The
obligations of the Company under this Section 9 shall be in addition to any liability which the Company may otherwise have and
shall extend, upon the same terms and conditions, to each person, if any, who controls any Underwriter within the meaning of the
Act</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 20 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->20<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 0pt">and to the Underwriters&rsquo; affiliates,
directors and officers; and the obligations of the Underwriters under this Section 9 shall be in addition to any liability which
the respective Underwriters may otherwise have and shall extend, upon the same terms and conditions, to each officer and director
of the Company, the duly authorized representative of the Company in the United States, and to each person, if any, who controls
the Company within the meaning of the Act or the Exchange Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">10.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)
If any Underwriter shall default in its obligation to purchase the Designated Securities which it has agreed to purchase under
the Pricing Agreement relating to such Designated Securities, the Representatives may in their discretion arrange for themselves
or another party or other parties to purchase such Designated Securities on the terms contained herein. If within thirty-six hours
after such default by any Underwriter the Representatives do not arrange for the purchase of such Designated Securities, then the
Company shall be entitled to a further period of thirty-six hours within which to procure another party or other parties reasonably
satisfactory to the Representatives to purchase such Designated Securities on such terms. In the event that, within the respective
prescribed period, the Representatives notify the Company that the Representatives have so arranged for the purchase of such Designated
Securities, or the Company notifies the Representatives that it has so arranged for the purchase of such Designated Securities,
the Representatives or the Company shall have the right to postpone the Time of Delivery for such Designated Securities for a period
of not more than seven days, in order to effect whatever changes may thereby be made necessary in the Registration Statement or
the Prospectus as amended or supplemented, or in any other documents or arrangements, and the Company agrees to file promptly any
amendments or supplements to the Registration Statement or the Prospectus which in the opinion of the Representatives may thereby
be made necessary. The term &ldquo;<B>Underwriter</B>&rdquo; as used in this Agreement shall include any person substituted under
this Section with like effect as if such person had originally been a party to the Pricing Agreement with respect to such Designated
Securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>If,
after giving effect to any arrangements for the purchase of the Designated Securities of a defaulting Underwriter or Underwriters
by the Representatives, the Company as provided in subsection (a) above, the aggregate principal amount of such Designated Securities
which remains unpurchased does not exceed one-eleventh of the aggregate principal amount of the Designated Securities, then the
Company shall have the right to require each non-defaulting Underwriter to purchase the principal amount of Designated Securities
which such Underwriter agreed to purchase under the Pricing Agreement relating to such Designated Securities and, in addition,
to require each non-defaulting Underwriter to purchase its pro rata share (based on the principal amount of Designated Securities
which such Underwriter agreed to purchase under such Pricing Agreement) of the Designated Securities of such defaulting Underwriter
or Underwriters for which such arrangements have not been made; but nothing herein shall relieve a defaulting Underwriter from
liability for its default.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>If,
after giving effect to any arrangements for the purchase of the Designated Securities of a defaulting Underwriter or Underwriters
by the Representatives and the Company as provided in subsection (a) above, the aggregate principal amount of the Designated Securities
which remains unpurchased exceeds one-eleventh of the aggregate principal amount of the Designated Securities, as referred to in
subsection (b) above, or if the Company shall not</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 21 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->21<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.5in; text-indent: 0pt">exercise the right described in
subsection (b) above to require non-defaulting Underwriters to purchase Designated Securities of a defaulting Underwriter or Underwriters,
then the Pricing Agreement relating to such Designated Securities shall thereupon terminate, without liability on the part of any
non-defaulting Underwriter or the Company, except for the indemnity and contribution agreements in Section&nbsp;9 hereof; but nothing
herein shall relieve a defaulting Underwriter from liability for its default.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">11.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
respective indemnities, agreements, representations, warranties and other statements of the Company and the several Underwriters,
as set forth in this Agreement or made by or on behalf of them, respectively, pursuant to this Agreement, shall remain in full
force and effect, regardless of any investigation (or any statement as to the results thereof) made by or on behalf of any Underwriter
or any controlling person of any Underwriter or the Company, the duly authorized representative of the Company in the United States
or any officer or director or controlling person of the Company, and shall survive delivery of and payment for the Designated Securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">12.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Any
Pricing Agreement shall be subject to termination in the absolute discretion of the Representatives, after consultation with the
Company, if, since the respective dates as of which information is given in the Pricing Disclosure Package in the case of clause
(i) below, or subsequent to the Applicable Time and prior to the Time of Delivery of the Designated Securities, in the case of
clauses (ii) through (vii) below, (i) there shall have been a material adverse change, or any development which in the reasonable
judgment of the Company will result in a material adverse change, in the business, properties or financial condition of the Company
and its consolidated subsidiaries considered as a whole, otherwise than as set forth or contemplated in the Pricing Disclosure
Package; (ii) there shall have occurred a downgrading in the rating accorded the Company&rsquo;s senior debt securities by Moody&rsquo;s
Investor Services, Inc. (&ldquo;<B>Moody&rsquo;s</B>&rdquo;) or Standard &amp; Poor&rsquo;s Corporation (&ldquo;<B>S&amp;P</B>&rdquo;)
or, in the event that the Company&rsquo;s senior debt securities are not rated by either Moody&rsquo;s or S&amp;P, by another &ldquo;<B>nationally
recognized statistical rating organization</B>&rdquo; as such term is defined by the Commission for purposes of Section 3(a)(62)
under the Exchange Act; (iii) such organization shall have publicly announced that it has under surveillance or review, or has
changed its outlook with respect to, its rating of the Securities or of any other senior debt securities or preferred stock of
or guaranteed by the Company (other than an announcement with positive implications of a possible upgrading); (iv)&nbsp;there shall
have been a change or development involving a prospective change in United States or United Kingdom taxation affecting the Designated
Securities or the imposition of exchange controls by the United States or the United Kingdom affecting the Designated Securities,
otherwise than as set forth or contemplated in the Pricing Disclosure Package; (v) trading in securities generally on the New York
Stock Exchange or the London Stock Exchange or any other exchange where the Designated Securities are listed or intended to be
listed shall have been suspended or materially limited; (vi) a general moratorium on commercial banking activities in the State
of New York shall have been declared by either Federal or New York State authorities or a general moratorium on commercial banking
activities in the United Kingdom shall have been declared by authorities in the United Kingdom; (vii) there shall have occurred
the outbreak or escalation of hostilities involving the United States or the United Kingdom or the declaration by the United States
or the United Kingdom of a national emergency or war; or (viii) there shall have occurred any change in financial markets or other</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>


<!-- Field: Page; Sequence: 22 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->22<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0in">national or international calamity
or crisis of such magnitude and severity in its effect on the financial markets, as, in any such case described in clauses (i)
through (viii) above, in the judgment of the Representatives, after consultation with the Company, to make it impracticable to
proceed with the public offering or the delivery of the Designated Securities on the terms and in the manner contemplated in the
Pricing Disclosure Package and the Prospectus, as amended or supplemented relating to such Securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">13.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;If
any Pricing Agreement shall be terminated by the Underwriters of the Designated Securities pursuant to clause (i) of Section 12
hereof or because of any failure or refusal on the part of the Company to comply with the terms or to fulfill any of the conditions
of the Pricing Agreement, or if for any reason the Company shall be unable to perform its obligations under the Pricing Agreement,
the Company will reimburse the Underwriters of such Securities for all out-of-pocket expenses (including the fees and disbursements
of counsel) reasonably incurred by the Underwriters in connection with the Designated Securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">Notwithstanding the termination of any Pricing
Agreement the provisions of Section 9, 10 and 11 hereof shall remain in effect.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">14.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In
all dealings hereunder, the Representatives of the Underwriters of Designated Securities shall act on behalf of each of such Underwriters,
and the parties hereto shall be entitled to act and rely upon any statement, request, notice or agreement on behalf of any Underwriter
made or given by such Representatives jointly or by such of the Representatives, if any, as may be designated for such purpose
in the Pricing Agreement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">All statements, requests, notices and agreements
hereunder shall be in writing, and if to the Underwriters shall be delivered or sent by mail, e-mail or facsimile transmission
as directed in the applicable Pricing Agreement; and if to the Company shall be delivered or sent by mail, e-mail or facsimile
transmission to its address set forth in the Registration Statement, Attention: Company Secretary, or such other address as the
Company shall notify in writing to the Representatives; <U>provided</U>, <U>however</U>, that any notice to an Underwriter of Designated
Securities pursuant to Section 9(c) hereof shall be delivered or sent by mail, e-mail or facsimile transmission to such Underwriter
at its address set forth in its Underwriters&rsquo; Questionnaire, or e-mail constituting such Questionnaire, which address will
be supplied to the Company by the Representatives upon request. Any such statements, requests, notices or agreements shall take
effect upon receipt thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">In accordance with the requirements of the
USA Patriot Act (Title III of Pub. L. 107-56 (signed into law October 26, 2001)), the underwriters are required to obtain, verify
and record information that identifies their respective clients, including the Company, which information may include the name
and address of their respective clients, as well as other information that will allow the underwriters to properly identify their
respective clients.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">15.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This
Agreement and each Pricing Agreement shall be binding upon, and inure solely to the benefit of, the Underwriters, the Company and,
to the extent provided in Section 9 and Section 11 hereof, the officers and directors of the Company and each person who controls
the Company or any Underwriter and their respective heirs, executors, administrators, successors and assigns, and no other person
shall acquire or have any right under or by virtue of</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>


<!-- Field: Page; Sequence: 23 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->23<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0in">this Agreement or any such Pricing
Agreement. No purchaser of any of the Designated Securities from any Underwriter shall be deemed a successor or assign by reason
merely of such purchase.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">16.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company acknowledges and agrees that (i) the purchase and sale of any Designated Securities pursuant to this Agreement is an arm&rsquo;s-length
commercial transaction between the Company, on the one hand, and the several Underwriters, on the other, (ii) in connection therewith
and with the process leading to such transaction each Underwriter is acting solely as principal and not as an agent or fiduciary
of the Company, (iii) no Underwriter has assumed an advisory or fiduciary responsibility in favor of the Company with respect to
the offering contemplated hereby or the process leading thereto (irrespective of whether such Underwriter has advised or is currently
advising the Company on other matters) or any other obligation to the Company except the obligations expressly set forth in this
Agreement and (iv) the Company has consulted its own legal and financial advisors to the extent it deemed appropriate. The Company
agrees that it will not claim that the Underwriters, or any of them, has rendered advisory services of any nature or respect, or
owes a fiduciary or similar duty to the Company, in connection with such transaction or the process leading thereto.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">17.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company hereby appoints CT Corporation System, 111 Eighth Avenue, 13<SUP>th</SUP> Floor, New York, New York 10011 as its authorized
agent (the &ldquo;<B>Authorized Agent</B>&rdquo;) upon which process may be served in any action based on this Agreement which
may be instituted in any State or Federal court in The City, County and State of New York by any Underwriter and expressly accepts
the jurisdiction of any such court in respect of such action. Such appointment shall be irrevocable so long as any of the Designated
Securities remain outstanding unless and until a successor Authorized Agent shall be appointed and such successor shall accept
such appointment. The Company will take any and all action, including the filing of any and all documents and instruments, that
may be necessary to continue such appointment or appointments in full force and effect as aforesaid. Service of process upon the
Authorized Agent and written notice of such service to the Company (mailed or delivered as aforesaid) shall be deemed, in every
respect, effective service of process upon the Company. Notwithstanding the foregoing, any action based on this Agreement or any
Pricing Agreement may be instituted by any Underwriter against the Company in any competent court in the United Kingdom.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">18.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Time
shall be of the essence of each Pricing Agreement. As used herein, the term &ldquo;<B>business day</B>&rdquo; shall mean any day
when the Commission&rsquo;s office in Washington, D.C. is open for business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">19.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This
Agreement and each Pricing Agreement shall be governed by and construed in accordance with the laws of the State of New York.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">20.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This
Agreement and each Pricing Agreement may be executed by any one or more of the parties hereto and thereto in any number of counterparts,
each of which shall be deemed to be an original, but all such respective counterparts shall together constitute one and the same
instrument.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>


<!-- Field: Page; Sequence: 24 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->24<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="4">Very truly yours,</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 10%">&nbsp;</TD>
    <TD STYLE="width: 25%">&nbsp;</TD>
    <TD STYLE="width: 10%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="4">ASTRAZENECA PLC</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid"><U STYLE="text-decoration: none">/s/ Adrian Kemp</U></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Name:</TD>
    <TD>Adrian Kemp</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Title:</TD>
    <TD>Company Secretary</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">[<I>Signature Page to Underwriting Agreement</I>]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<!-- Field: Page; Sequence: 25; Options: NewSection -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Accepted as of the date hereof:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">CITIGROUP GLOBAL MARKETS INC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid"><U STYLE="text-decoration: none">/s/ Adam D. Bordner</U></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Name:</TD>
    <TD COLSPAN="2">Adam D. Bordner</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Title:</TD>
    <TD COLSPAN="2">Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 8%">&nbsp;</TD>
    <TD STYLE="width: 27%">&nbsp;</TD>
    <TD STYLE="width: 60%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">DEUTSCHE BANK SECURITIES INC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid"><U STYLE="text-decoration: none">/s/ Matthew J. Siracuse</U></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Name:</TD>
    <TD COLSPAN="2">Matthew J. Siracuse</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Title:</TD>
    <TD COLSPAN="2">Managing Director/Debt Syndicate</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 8%">&nbsp;</TD>
    <TD STYLE="width: 27%">&nbsp;</TD>
    <TD STYLE="width: 60%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid"><U STYLE="text-decoration: none">/s/ Timothy Azoia</U></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Name:</TD>
    <TD COLSPAN="2">Timothy Azoia</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Title:</TD>
    <TD COLSPAN="2">Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 8%">&nbsp;</TD>
    <TD STYLE="width: 27%">&nbsp;</TD>
    <TD STYLE="width: 60%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3">GOLDMAN SACHS &amp; CO. LLC</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid"><U STYLE="text-decoration: none">/s/ Adam Greene</U></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Name:</TD>
    <TD COLSPAN="2">Adam Greene</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Title:</TD>
    <TD COLSPAN="2">Managing Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 8%">&nbsp;</TD>
    <TD STYLE="width: 27%">&nbsp;</TD>
    <TD STYLE="width: 60%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3">J.P. MORGAN SECURITIES LLC</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid"><U STYLE="text-decoration: none">/s/ Som Bhattacharyya</U></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Name:</TD>
    <TD COLSPAN="2">Som Bhattacharyya</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Title:</TD>
    <TD COLSPAN="2">Executive Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 8%">&nbsp;</TD>
    <TD STYLE="width: 27%">&nbsp;</TD>
    <TD STYLE="width: 60%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">[<I>Signature Page to Underwriting Agreement</I>]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<!-- Field: Page; Sequence: 26 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: right; text-indent: 1in">ANNEX I</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: right; text-indent: 1in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>Pricing Agreement</U></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>[Name(s) of Representative(s),]&nbsp;</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">As Representatives of the several</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 92%">Underwriters named in Schedule I hereto,</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Ladies and Gentlemen:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">AstraZeneca PLC (the &ldquo;<B>Company</B>&rdquo;)
proposes, subject to the terms and conditions stated herein and in the Underwriting Agreement dated [<FONT STYLE="font-family: Symbol">&middot;</FONT>],
a copy of which is attached hereto as Annex A (the &ldquo;<B>Underwriting Agreement</B>&rdquo;), to issue and sell to the Underwriters
named in Schedule I hereto (the &ldquo;<B>Underwriters</B>&rdquo;) the Securities specified in Schedule II hereto (the &ldquo;<B>Designated
Securities</B>&rdquo;). Each of the provisions of the Underwriting Agreement is incorporated herein by reference in its entirety,
and shall be deemed to be a part of this Agreement to the same extent as if such provisions had been set forth in full herein;
and each of the representations and warranties set forth therein shall be deemed to have been made at and as of the date of this
Pricing Agreement, except that each representation and warranty which refers to the Basic Prospectus, Pricing Disclosure Package
or the Prospectus in Section 2 of the Underwriting Agreement shall be deemed to be a representation or warranty as of the date
of the Underwriting Agreement in relation to the Basic Prospectus (as defined therein) as amended or supplemented as of the date
of the Underwriting Agreement and also a representation and warranty as of the date of this Pricing Agreement in relation to the
Basic Prospectus, Pricing Disclosure Package or the Prospectus, as amended or supplemented, relating to the Designated Securities
which are the subject of this Pricing Agreement. Each reference to the Representatives herein and in the provisions of the Underwriting
Agreement so incorporated by reference shall be deemed to refer to you. Unless otherwise defined herein, terms defined in the Underwriting
Agreement are used herein as therein defined. The Representatives designated to act on behalf of the Representatives and on behalf
of each of the Underwriters of the Designated Securities pursuant to Section 14 of the Underwriting Agreement and the address of
the Representatives referred to in such Section&nbsp;14 are set forth at the end of Schedule&nbsp;II hereto. Schedule III sets
forth each Issuer Free Writing Prospectus that is part of the Pricing Disclosure Package and any additional documents incorporated
by reference that were filed with the Commission subsequent to the Commission&rsquo;s close of business on the business day immediately
prior to the date of the execution of this Pricing Agreement. Schedule IV sets forth all documents that the Company and the Representatives
agree are to be included in the Pricing Disclosure Package. The final term sheets prepared in accordance with Section 5(a) of the
Underwriting Agreement are attached hereto as Schedule V.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">The &ldquo;<B>Applicable Time</B>&rdquo; means
[&#9679;] p.m. New York time on the date hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>


<!-- Field: Page; Sequence: 27 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">An amendment of the Registration Statement,
or a supplement to the Basic Prospectus, as the case may be, relating to the Designated Securities, in the form heretofore delivered
to you is now proposed to be filed with the Commission.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">Subject to the terms and conditions set forth
herein and in the Underwriting Agreement incorporated herein by reference, the Company agrees to issue and sell to each of the
Underwriters, and each of the Underwriters agrees, severally and not jointly, to purchase from the Company, at the time and place
and at the purchase price to the Underwriters set forth in Schedule II hereto, the principal amount of Designated Securities set
forth opposite the name of such Underwriter in Schedule I hereto.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">All statements, requests, notices and agreements
hereunder shall be in writing, and if to the Underwriters shall be delivered or sent by mail, e-mail or facsimile transmission
to the Representatives to [&#9679;] and if to the Company shall be delivered or sent by mail, e-mail or facsimile transmission
to its address set forth in the Registration Statement, Attention: Company Secretary, or such other address as the Company shall
notify in writing to [&#9679;]; <U>provided</U>, <U>however</U>, that any notice to an Underwriter of Designated Securities pursuant
to Section 9(c) of the Underwriting Agreement shall be delivered or sent by mail, e-mail or facsimile transmission to such Underwriter
at its address set forth in its Underwriters&rsquo; Questionnaire, or e-mail constituting such Questionnaire, which address will
be supplied to the Company by the Representatives upon request. Any such statements, requests, notices or agreements shall take
effect upon receipt thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>


<!-- Field: Page; Sequence: 28; Options: NewSection; Value: 2 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">A-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->2<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">If the foregoing is in accordance with your
understanding, please sign and return to us <B>[One for the Issuer and [each of] the Representatives plus one for each counsel]
</B>counterparts hereof, and upon acceptance hereof by you, on behalf of each of the Underwriters, this letter and such acceptance
hereof, including the provisions of the Underwriting Agreement incorporated herein by reference, shall constitute a binding agreement
between each of the Underwriters and the Company. It is understood that your acceptance of this letter on behalf of each of the
Underwriters is or will be pursuant to the authority set forth in a form of Agreement among Underwriters, the form of which shall
be submitted to the Company for examination upon request, but without warranty on the part of the Representatives as to the authority
of the signers thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 1in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-indent: 0in">Very truly yours,</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in; width: 50%">&nbsp;</TD>
    <TD STYLE="text-indent: 0in; width: 18%">&nbsp;</TD>
    <TD STYLE="text-indent: 0in; width: 16%">&nbsp;</TD>
    <TD STYLE="text-indent: 0in; width: 16%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-indent: 0in">ASTRAZENECA PLC</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in; width: 50%">&nbsp;</TD>
    <TD STYLE="text-indent: 0in; width: 4%">By:</TD>
    <TD STYLE="text-indent: 0in; width: 30%; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="text-indent: 0in; width: 16%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">Name:</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">Title:</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">[<I>Signature Page to Pricing Agreement</I>]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;&nbsp;</P>

<!-- Field: Page; Sequence: 29 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">A-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->3<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Accepted as of the date hereof:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">CITIGROUP GLOBAL MARKETS INC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%">By:</TD>
    <TD STYLE="width: 45%; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="width: 50%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Name:&nbsp;&nbsp;&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Title:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">DEUTSCHE BANK SECURITIES INC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; width: 45%">&nbsp;</TD>
    <TD STYLE="width: 50%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Name:</TD>
    <TD>&nbsp;&nbsp;&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Title:</TD>
    <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; width: 45%">&nbsp;</TD>
    <TD STYLE="width: 50%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Name:&nbsp;&nbsp;&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Title:</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">GOLDMAN SACHS &amp; CO. LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; width: 45%">&nbsp;</TD>
    <TD STYLE="width: 50%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Name:&nbsp;&nbsp;&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Title:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">J.P. MORGAN SECURITIES LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; width: 45%">&nbsp;</TD>
    <TD STYLE="width: 50%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Name:</TD>
    <TD>&nbsp;&nbsp;&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Title:</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">[<I>Signature Page to Pricing Agreement</I>]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<!-- Field: Page; Sequence: 30 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD STYLE="width: 100%; font-size: 11pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">A-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->4<!-- Field: /Sequence --></FONT></TD></TR></TABLE><P STYLE="margin: 0pt"></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Schedule I</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: top; width: 86%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 14%; padding-right: 2pt; padding-left: 2pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Principal
Amount of Designated Securities to be Purchased</B></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><B>[Name(s) of Representative(s)]</B>&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">$</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><B>[Names of other Underwriters]</B>&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; padding-right: 2pt; padding-left: 2pt">
</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 0.5in">&#9;Total&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; border-bottom: Black 1.5pt double">$</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">&nbsp;</TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 31; Options: NewSection -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE II</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Title of Designated Securities:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[___%] [Floating Rate] [Zero Coupon] [Notes]<BR>
[Debentures] due</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Aggregate principal amount</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">[$]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Price to Public:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">% of the principal amount of the Designated Securities,<BR>
plus accrued interest from ____________ to __________<BR>
[and accrued amortization, if any, from __________ to _________________]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Purchase Price by Underwriters:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">% of the principal amount of the Designated Securities,<BR>
plus accrued interest from ____________ to __________<BR>
[and accrued amortization, if any, from __________ to _________________]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Expenses:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Specified funds for payment of purchase price:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[New York] Clearing House funds</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Indenture:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">Indenture dated as of April 1, 2004, between the Company
and The Bank of New York Mellon, as successor Trustee to JPMorgan Chase Bank</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Maturity:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Interest Rate:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[___%] [Zero Coupon] [See Floating Rate Provisions]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 32 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Interest Payment Date:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[months and dates]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Redemption Provisions:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[No provisions for redemption]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[The Designated Securities may be redeemed, otherwise
than through the sinking fund, in whole or in part at the option of the Company, in the amount of [$]_________ or an integral multiple
thereof,</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[on or after __________, ____________ at the following
redemption prices (expressed in percentages of principal amount). If [redeemed on or before _______, ____ %, and if] redeemed during
the 12- month period beginning _____________,</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="width: 50%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 47%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">Year</P></TD>
    <TD STYLE="width: 53%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">Redemption
Price</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
</TABLE><BR STYLE="clear: both">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">and thereafter at 100% of their principal amount,
together in each case with accrued interest to the redemption date.]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[on any interest payment date falling in or after
______, __, at the election of the Company, at a redemption price equal to the principal amount thereof, plus accrued interest
to the date of redemption].</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[Other possible redemption provisions, such as mandatory
redemption upon occurrence of certain events or redemption for changes in tax law]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[Restriction on refunding]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Sinking Fund Provisions:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[No sinking fund provisions]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[The Designated Securities are entitled to the benefit
of a sinking fund to retire [$]__________ principal amount of Designated Securities on ____________ in each of the years _____
through _____ at 100% of their principal amount plus accrued interest] [, together with [cumulative] [noncumulative] redemptions
at the option of the Company to retire an additional [$]_________ principal amount of Designated Securities in the years _____
through _____ at 100% of their principal amount plus accrued interest].</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 33; Options: NewSection; Value: 2 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">II-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->2<!-- Field: /Sequence --></FONT></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[If Securities are extendable debt Securities, insert
---]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Extendable provisions:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">Securities are repayable on ________, ___ [insert
day and years], at the option of the holder, at their principal amount with accrued interest. Initial annual interest rate will
be ___%, and thereafter annual interest rate will be adjusted on __________, __ and ______, __ to a rate not less than ___% of
the effective annual interest rate on U.S. Treasury obligations with ____-year maturities as of the [insert date 15 days prior
to maturity date] prior to such [insert maturity date].]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">[If Securities are Floating Rate debt Securities insert
---]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Floating Rate provisions:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">Initial annual interest rate will
be ___% through ___[and thereafter will be adjusted [monthly] [on each _________, _________, ________ and __________] [to an annual
rate of ____% above the average rate for ____-year [month] [securities] [certificates of deposit] issued by ________ and ________
[insert names of banks].] [and the annual interest rate [thereafter] [from _________ through _________] will be the interest yield
equivalent of the weekly average per annum market discount rate for ____-month Treasury bills plus ___% of Interest Differential
(the excess, if any, of (i) then currently weekly average per annum secondary market yield for ___-month certificates of deposit
over (ii) then current interest yield equivalent of the weekly average per annum market discount rate for ___-month Treasury bills);
[from _________ and thereafter the rate will be the then current interest yield equivalent plus ___% of Interest Differential].]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Defeasance provisions:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Time of Delivery:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Closing Location for Delivery of Securities:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Names and addresses of Representatives:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">Designated Representatives:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">Address for Notices, etc.:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 34 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">II-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->3<!-- Field: /Sequence --></FONT></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>[Other Terms]</B>*</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>

<!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin-top: 3pt; margin-bottom: 3pt"><DIV STYLE="font-size: 1pt; border-top: Black 1pt solid; width: 25%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">* &nbsp;&nbsp;&nbsp;A
description of particular tax, accounting or other unusual features (such as the addition of event risk language) of the Securities
should be set forth, or referenced to an attached and accompanying description, if necessary to ensure agreement as to the terms
of the Securities to be purchased and sold. Such a description might appropriately be in the form in which such features will
be described in the Prospectus Supplement for the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 35 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">II-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->4<!-- Field: /Sequence --></FONT></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE III</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in"><B>Issuer Free Writing Prospectus:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">(a) Issuer Free Writing Prospectus,
if any:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">1.</TD><TD>[Electronic road show]</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">(b) Additional Documents Incorporated
by Reference, if any:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 36; Options: NewSection -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE IV</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Pricing Disclosure Package:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


<!-- Field: Page; Sequence: 37 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE V</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Final Term Sheets</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


<!-- Field: Page; Sequence: 38; Options: Last -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->



</BODY>
</HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-1.2
<SEQUENCE>3
<FILENAME>dp94630_0102.htm
<DESCRIPTION>EXHIBIT 1.2
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 1.2</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>Pricing Agreement</U></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 4in; text-align: right">August 14,
2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: 4in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">Citigroup Global Markets Inc.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.65in; text-indent: 0pt">388 Greenwich Street&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.65in; text-indent: 0pt">New York, New York 10013&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">Deutsche Bank Securities Inc.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.65in; text-indent: 0pt">60 Wall Street&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.65in; text-indent: 0pt">New York, New York 10005</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">Goldman Sachs &amp; Co. LLC&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.65in; text-indent: 0pt">200 West Street&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.65in; text-indent: 0pt">New York, New York 10282</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">J.P. Morgan Securities LLC&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.65in; text-indent: 0pt">383 Madison Avenue&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 0.65in; text-indent: 0pt">New York, New York 10179&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in"><BR>
Ladies and Gentlemen:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">AstraZeneca PLC (the &ldquo;<B>Company</B>&rdquo;)
proposes, subject to the terms and conditions stated herein and in the Underwriting Agreement dated August <FONT STYLE="font-family: Symbol">14</FONT>,
2018, a copy of which is attached hereto as Annex A (the &ldquo;<B>Underwriting Agreement</B>&rdquo;), to issue and sell to the
Underwriters named in Schedule I hereto (the &ldquo;<B>Underwriters</B>&rdquo;) the Securities specified in Schedule II hereto
(the &ldquo;<B>Designated Securities</B>&rdquo;). Each of the provisions of the Underwriting Agreement is incorporated herein by
reference in its entirety, and shall be deemed to be a part of this Agreement to the same extent as if such provisions had been
set forth in full herein; and each of the representations and warranties set forth therein shall be deemed to have been made at
and as of the date of this Pricing Agreement, except that each representation and warranty which refers to the Basic Prospectus,
Pricing Disclosure Package or the Prospectus in Section 2 of the Underwriting Agreement shall be deemed to be a representation
or warranty as of the date of the Underwriting Agreement in relation to the Basic Prospectus (as defined therein) as amended or
supplemented as of the date of the Underwriting Agreement and also a representation and warranty as of the date of this Pricing
Agreement in relation to the Basic Prospectus, Pricing Disclosure Package or the Prospectus, as amended or supplemented, relating
to the Designated Securities which are the subject of this Pricing Agreement. Each reference to the Representatives herein and
in the provisions of the Underwriting Agreement so incorporated by reference shall be deemed to refer to you. Unless otherwise
defined herein, terms defined in the Underwriting Agreement are used herein as therein defined. The Representatives designated
to act on behalf of the Representatives and on behalf of each of the Underwriters of the Designated Securities pursuant to Section
14 of the Underwriting Agreement and the address of the Representatives referred to in such Section 14 are set forth at the end
of Schedule&nbsp;II hereto. Schedule III sets</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>


<!-- Field: Page; Sequence: 1 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">forth each Issuer Free Writing Prospectus
that is part of the Pricing Disclosure Package and any additional documents incorporated by reference that were filed with the
Commission subsequent to the Commission&rsquo;s close of business on the business day immediately prior to the date of the execution
of this Pricing Agreement. Schedule IV sets forth all documents that the Company and the Representatives agree are to be included
in the Pricing Disclosure Package. The final term sheets prepared in accordance with Section 5(a) of the Underwriting Agreement
are attached hereto as Schedule V.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">The &ldquo;<B>Applicable Time</B>&rdquo; means
6:00 p.m. New York time on the date hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">An amendment of the Registration Statement,
or a supplement to the Basic Prospectus, as the case may be, relating to the Designated Securities, in the form heretofore delivered
to you is now proposed to be filed with the Commission.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">Subject to the terms and conditions set forth
herein and in the Underwriting Agreement incorporated herein by reference, the Company agrees to issue and sell to each of the
Underwriters, and each of the Underwriters agrees, severally and not jointly, to purchase from the Company, at the time and place
and at the purchase price to the Underwriters set forth in Schedule II hereto, the principal amount of Designated Securities set
forth opposite the name of such Underwriter in Schedule I hereto.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">All statements, requests, notices and agreements
hereunder shall be in writing, and if to the Underwriters shall be delivered or sent by mail, e-mail or facsimile transmission
to (i) Citigroup Global Markets Inc., 388 Greenwich Street, New York, New York 10013, Attention: General Counsel, Fax: +1 (646)
291-1469; (ii) Deutsche Bank Securities Inc., 60 Wall Street, New York, New York 10005, Attention: Debt Capital Markets Syndicate,
Fax: +1 (212) 297-2202, with a copy to General Counsel, Fax: +1 (646) 374-107; (iii) Goldman Sachs &amp; Co. LLC, 200 West Street,
New York, New York 10282, Attention: Registration Department; and (iv) J.P. Morgan Securities LLC, 383 Madison Avenue, New York,
New York 10179, Attention: Investment Grade Syndicate Desk, Fax: +1 (212) 834-6081; and if to the Company shall be delivered or
sent by mail, e-mail or facsimile transmission to its address set forth in the Registration Statement, Attention: Company Secretary,
or such other address as the Company shall notify in writing to the Representatives at their respective foregoing addresses; <U>provided</U>,
<U>however</U>, that any notice to an Underwriter of Designated Securities pursuant to Section 9(c) of the Underwriting Agreement
shall be delivered or sent by mail, e-mail or facsimile transmission to such Underwriter at its address set forth in its Underwriters&rsquo;
Questionnaire, or e-mail constituting such Questionnaire, which address will be supplied to the Company by the Representatives
upon request. Any such statements, requests, notices or agreements shall take effect upon receipt thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;&nbsp;</P>


<!-- Field: Page; Sequence: 2 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">If the foregoing is in accordance with your
understanding, please sign and return to us five counterparts hereof, and upon acceptance hereof by you, on behalf of each of the
Underwriters, this letter and such acceptance hereof, including the provisions of the Underwriting Agreement incorporated herein
by reference, shall constitute a binding agreement between each of the Underwriters and the Company. It is understood that your
acceptance of this letter on behalf of each of the Underwriters is or will be pursuant to the authority set forth in a form of
Agreement among Underwriters, the form of which shall be submitted to the Company for examination upon request, but without warranty
on the part of the Representatives as to the authority of the signers thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt"><I></I></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>


<!-- Field: Page; Sequence: 3 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="width: 50%; text-indent: 0in">Very truly yours,</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">ASTRAZENECA PLC</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="width: 5%; text-indent: 0in">By:</TD>
    <TD STYLE="width: 27%; text-indent: 0in; border-bottom: Black 1pt solid">/s/ Adrian Kemp</TD>
    <TD STYLE="width: 18%; text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">Name:Adrian Kemp</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">Title: Company Secretary</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt"><I>[Signature Page to Pricing Agreement]</I></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>
<!-- Field: Page; Sequence: 4 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Accepted as of the date hereof:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">CITIGROUP GLOBAL MARKETS INC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">By:</TD>
    <TD COLSPAN="2" STYLE="text-indent: 0in; border-bottom: Black 1pt solid">/s/ Adam D. Bordner</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in; width: 5%">&nbsp;</TD>
    <TD STYLE="text-indent: 0in; width: 6%">Name:</TD>
    <TD STYLE="text-indent: 0in; width: 39%">Adam D. Bordner&nbsp;&nbsp;</TD>
    <TD STYLE="text-indent: 0in; width: 50%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">Title:</TD>
    <TD STYLE="text-indent: 0in">Director</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">DEUTSCHE BANK SECURITIES INC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">By:</TD>
    <TD COLSPAN="2" STYLE="text-indent: 0in; border-bottom: Black 1pt solid">/s/ Matthew J. Siracuse</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in; width: 5%">&nbsp;</TD>
    <TD STYLE="text-indent: 0in; width: 6%">Name:</TD>
    <TD STYLE="text-indent: 0in; width: 39%">Matthew J. Siracuse</TD>
    <TD STYLE="text-indent: 0in; width: 50%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">Title:</TD>
    <TD STYLE="text-indent: 0in">Managing Director/Debt Syndicate</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">By:</TD>
    <TD COLSPAN="2" STYLE="text-indent: 0in; border-bottom: Black 1pt solid">/s/ Timothy Azoia</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in; width: 5%">&nbsp;</TD>
    <TD STYLE="text-indent: 0in; width: 6%">Name:</TD>
    <TD STYLE="text-indent: 0in; width: 39%">Timothy Azoia</TD>
    <TD STYLE="text-indent: 0in; width: 50%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">Title:</TD>
    <TD STYLE="text-indent: 0in">Director</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">GOLDMAN SACHS &amp; CO. LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">By:</TD>
    <TD COLSPAN="2" STYLE="text-indent: 0in; border-bottom: Black 1pt solid">/s/ Adam Greene</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in; width: 5%">&nbsp;</TD>
    <TD STYLE="text-indent: 0in; width: 6%">Name:</TD>
    <TD STYLE="text-indent: 0in; width: 39%">Adam Greene</TD>
    <TD STYLE="text-indent: 0in; width: 50%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">Title:</TD>
    <TD STYLE="text-indent: 0in">Managing Director</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">J.P. MORGAN SECURITIES LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">By:</TD>
    <TD COLSPAN="2" STYLE="text-indent: 0in; border-bottom: Black 1pt solid">/s/ Som Bhattacharyya</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in; width: 5%">&nbsp;</TD>
    <TD STYLE="text-indent: 0in; width: 6%">Name:&nbsp;&nbsp;&nbsp;</TD>
    <TD STYLE="text-indent: 0in; width: 39%">Som Bhattacharyya</TD>
    <TD STYLE="text-indent: 0in; width: 50%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0in">&nbsp;</TD>
    <TD STYLE="text-indent: 0in">Title:</TD>
    <TD STYLE="text-indent: 0in">Executive Director</TD>
    <TD STYLE="text-indent: 0in">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt"><I>[Signature Page to Pricing Agreement]</I></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<!-- Field: Page; Sequence: 5 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE I</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD><TD STYLE="padding-bottom: 2pt; padding-top: 2pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: center; border-bottom: Black 1pt solid; padding-top: 2pt; padding-bottom: 2pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Principal
Amount of Designated Securities to be Purchased</B></P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center; border-bottom: Black 1pt solid; padding-top: 10pt; padding-bottom: 2pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><BR>Underwriter</B></P> </TD><TD STYLE="padding-bottom: 2pt; padding-top: 10pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: center; border-bottom: Black 1pt solid; padding-top: 10pt; padding-bottom: 2pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>3.500%
Notes due 2023</B></P></TD><TD STYLE="padding-bottom: 2pt; padding-top: 10pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: center; border-bottom: Black 1pt solid; padding-top: 10pt; padding-bottom: 2pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Floating</B><BR>
<B>Rate Notes due 2023</B></P></TD><TD STYLE="padding-bottom: 2pt; padding-top: 10pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: center; border-bottom: Black 1pt solid; padding-top: 10pt; padding-bottom: 2pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>4.000%
Notes due 2029</B></P></TD><TD STYLE="padding-bottom: 2pt; padding-top: 10pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: center; border-bottom: Black 1pt solid; padding-top: 10pt; padding-bottom: 2pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>4.375%
Notes due 2048</B></P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 40%; text-align: left; padding-top: 2pt; padding-bottom: 2pt">Citigroup Global Markets Inc.&#9;</TD><TD STYLE="width: 3%; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="width: 10%; text-align: right; padding-top: 2pt; padding-bottom: 2pt">212,500,000</TD><TD STYLE="width: 1%; text-align: left; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD><TD STYLE="width: 3%; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="width: 10%; text-align: right; padding-top: 2pt; padding-bottom: 2pt">100,000,000</TD><TD STYLE="width: 1%; text-align: left; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD><TD STYLE="width: 3%; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="width: 10%; text-align: right; padding-top: 2pt; padding-bottom: 2pt">250,000,000</TD><TD STYLE="width: 1%; text-align: left; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD><TD STYLE="width: 3%; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="width: 10%; text-align: right; padding-top: 2pt; padding-bottom: 2pt">187,500,000</TD><TD STYLE="width: 1%; text-align: left; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">Deutsche Bank Securities Inc.&#9;</TD><TD STYLE="padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="text-align: right; padding-top: 2pt; padding-bottom: 2pt">212,500,000</TD><TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD><TD STYLE="padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="text-align: right; padding-top: 2pt; padding-bottom: 2pt">100,000,000</TD><TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD><TD STYLE="padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="text-align: right; padding-top: 2pt; padding-bottom: 2pt">250,000,000</TD><TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD><TD STYLE="padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="text-align: right; padding-top: 2pt; padding-bottom: 2pt">187,500,000</TD><TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">Goldman Sachs &amp; Co. LLC&#9;</TD><TD STYLE="padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="text-align: right; padding-top: 2pt; padding-bottom: 2pt">212,500,000</TD><TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD><TD STYLE="padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="text-align: right; padding-top: 2pt; padding-bottom: 2pt">100,000,000</TD><TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD><TD STYLE="padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="text-align: right; padding-top: 2pt; padding-bottom: 2pt">250,000,000</TD><TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD><TD STYLE="padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="text-align: right; padding-top: 2pt; padding-bottom: 2pt">187,500,000</TD><TD STYLE="text-align: left; padding-top: 2pt; padding-bottom: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left; padding-bottom: 2pt; padding-top: 2pt">J.P. Morgan Securities LLC&#9;</TD><TD STYLE="padding-bottom: 2pt; padding-top: 2pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right; padding-top: 2pt; padding-bottom: 2pt">212,500,000</TD><TD STYLE="padding-bottom: 2pt; text-align: left; padding-top: 2pt">&nbsp;</TD><TD STYLE="padding-bottom: 2pt; padding-top: 2pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right; padding-top: 2pt; padding-bottom: 2pt">100,000,000</TD><TD STYLE="padding-bottom: 2pt; text-align: left; padding-top: 2pt">&nbsp;</TD><TD STYLE="padding-bottom: 2pt; padding-top: 2pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right; padding-top: 2pt; padding-bottom: 2pt">250,000,000</TD><TD STYLE="padding-bottom: 2pt; text-align: left; padding-top: 2pt">&nbsp;</TD><TD STYLE="padding-bottom: 2pt; padding-top: 2pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right; padding-top: 2pt; padding-bottom: 2pt">187,500,000</TD><TD STYLE="padding-bottom: 2pt; text-align: left; padding-top: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="padding-bottom: 2pt; padding-left: 0.5in; padding-top: 2pt">Total&#9;</TD><TD STYLE="padding-bottom: 2pt; padding-top: 2pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right; padding-top: 2pt; padding-bottom: 2pt">850,000,000</TD><TD STYLE="padding-bottom: 2pt; text-align: left; padding-top: 2pt">&nbsp;</TD><TD STYLE="padding-bottom: 2pt; padding-top: 2pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right; padding-top: 2pt; padding-bottom: 2pt">400,000,000</TD><TD STYLE="padding-bottom: 2pt; text-align: left; padding-top: 2pt">&nbsp;</TD><TD STYLE="padding-bottom: 2pt; padding-top: 2pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right; padding-top: 2pt; padding-bottom: 2pt">1,000,000,000</TD><TD STYLE="padding-bottom: 2pt; text-align: left; padding-top: 2pt">&nbsp;</TD><TD STYLE="padding-bottom: 2pt; padding-top: 2pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left; padding-top: 2pt; padding-bottom: 2pt">$</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right; padding-top: 2pt; padding-bottom: 2pt">750,000,000</TD><TD STYLE="padding-bottom: 2pt; text-align: left; padding-top: 2pt">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


<!-- Field: Page; Sequence: 6 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE II</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Title of Designated Securities:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">$850,000,000 3.500% Fixed Rate Notes due 2023 (the
&ldquo;<B>2023 Notes</B>&rdquo;).&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">$400,000,000 Floating Rate Notes due 2023 (the &ldquo;<B>Floating
Rate Notes</B>&rdquo;).&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">$1,000,000,000 4.000% Fixed Rate Notes due 2029 (the
&ldquo;<B>2029 Notes</B>&rdquo;).&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">$750,000,000 4.375% Fixed Rate Notes due 2048 (the
&ldquo;<B>2048 Notes</B>&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">The 2023 Notes, the 2029 Notes and the 2048 Notes
are collectively referred to herein as the &ldquo;Fixed Rate Notes&rdquo;.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">The Floating Rate Notes are referred to herein as
the &ldquo;Floating Rate Notes&rdquo;.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">The Fixed Rate Notes and the Floating Rate Notes are
collectively referred to herein as the &ldquo;Designated Securities&rdquo;.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Aggregate Principal Amount:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">$850,000,000 for the 2023 Notes.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">$400,000,000 for the Floating Rate Notes.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">$1,000,000,000 for the 2029 Notes.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">$750,000,000 for the 2048 Notes.<BR>
</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Price to Public:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">99.673% of the principal amount of the 2023 Notes,
plus accrued interest, if any, from August 17, 2018 (for the 2023 Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">100.000% of the principal amount of the Floating Rate
Notes, plus accrued interest, if any, from August 17, 2018 (for the Floating Rate Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">99.590% of the principal amount of the 2029 Notes,
plus accrued interest, if any, from August 17, 2018 (for the 2029 Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">98.944% of the principal amount of the 2048 Notes,
plus accrued interest, if any, from August 17, 2018 (for the 2048 Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Purchase Price by Underwriters:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">99.448% of the principal amount of the 2023 Notes,
plus accrued interest, if any, from August 17, 2018 (for the 2023 Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">99.775% of the principal amount of the Floating Rate
Notes, plus accrued interest, if any, from August 17, 2018 (for the Floating Rate Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">99.265% of the principal amount of the 2029 Notes,
plus accrued interest, if any, from August 17, 2018 (for the 2029 Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 7 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">98.294% of the principal amount of the 2048 Notes,
plus accrued interest, if any, from August 17, 2018 (for the 2048 Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Specified Funds for Payment of Purchase
Price:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">New York Clearing House funds.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Indenture:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">Indenture, dated as of April 1, 2004, between the
Company and The Bank of New York Mellon, as successor Trustee to JPMorgan Chase Bank, as supplemented from time to time.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Maturity Dates:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">The stated maturity of the principal of the 2023
Notes will be August 17, 2023.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">The stated maturity of the principal of the Floating
Rate Notes will be August 17, 2023.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">The stated maturity of the principal of the 2029
Notes will be January 17, 2029.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">The stated maturity of the principal of the 2048 Notes
will be August 17, 2048.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Interest Rates:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">The 2023 Notes will bear interest from August 17,
2018 at a fixed rate of 3.500% per annum, payable semi-annually.<BR>
<BR>
<FONT STYLE="background-color: white">The interest rate for the Floating Rate Notes for the first interest period will be LIBOR
(as defined herein) as determined on August 15, 2018 plus the Spread (as defined below). Thereafter, the interest rate for any
Floating Rate Interest Period (as defined below) will be LIBOR as determined on the applicable Interest Determination Date (as
defined below) plus the Spread.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">The 2029 Notes will bear interest from August 17,
2018 at a fixed rate of 4.000% per annum, payable semi-annually.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">The 2048 Notes will bear interest from August 17,
2018 at a fixed rate of 4.375% per annum, payable semi-annually.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 8 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Interest Payment Dates:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">Interest on the 2023 Notes will be paid semi-annually
in arrears on February 17 and August 17 of each year, commencing February 17, 2019.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">Interest on the Floating Rate Notes will be paid quarterly
in arrears on February 17, May 17, August 17 and November 17 of each year, commencing November 17, 2018.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">Interest on the 2029 Notes will be paid semi-annually
in arrears on January 17 and July 17 of each year, commencing January 17, 2019.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">Interest on the 2048 Notes will be paid semi-annually
in arrears on February 17 and August 17 of each year, commencing February 17, 2019.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Redemption Provisions:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">The Company may redeem the Fixed
Rate Notes of each series, in whole or in part, from time to time as follows: (i) prior to the Par Call Date (as defined herein),
at a redemption price equal to the greater of (A) 100% of the principal amount of the Fixed Rate Notes to be redeemed, and (B)
as determined by the Quotation Agent (as defined in the <FONT STYLE="background-color: white">supplement to the Prospectus relating
to the Designated Securities dated August 14, 2018 (the &ldquo;<B>Prospectus Supplement</B>&rdquo;</FONT>), the sum of the present
values of the remaining scheduled payments of principal and interest on the Fixed Rate Notes to be redeemed (assuming for this
purpose that such series of Fixed Rate Notes matured on the applicable Par Call Date and not including any portion of such payments
of interest accrued as of the date of redemption) discounted to the date of redemption on a semiannual basis (assuming a 360-day
year consisting of twelve 30-day months) at the treasury rate plus the Make-Whole Spread (as defined herein), and (ii) on or after
the Par Call Date, at a redemption price equal to 100% of the principal amount of the Fixed Rate Notes to be redeemed, plus, in
each case, accrued interest thereon to but excluding the date of redemption.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">Subject to the optional tax redemption
described below, the Company may not redeem the Floating Rate Notes prior to maturity.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">In the event of various tax law
changes and other limited circumstances that require the Company to pay additional amounts as described in the Prospectus Supplement,
the Company may redeem in whole, but not in part, any series of the Notes prior to maturity at a redemption price equal to 100%
of their principal amount plus accrued interest thereon to but excluding the date of redemption.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Par Call Dates:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">2023 Notes: July 17, 2023.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">2029 Notes: October 17, 2028.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">2048 Notes: February 17, 2048.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Make-Whole Spreads:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">2023 Notes: 15 basis points.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 9 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">2029 Notes: 20 basis points.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">2048 Notes: 25 basis points.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white"><B>Spread: </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white">Floating Rate
Notes: 66.5 basis points.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white"><B>Interest
Reset Dates: </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white">Interest on
the Floating Rate Notes will have Interest Reset Dates of February 17, May 17, August 17 and November 17, of each year, commencing
November 17, 2018.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white"><B>Interest
Periods: </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white">The first interest
period for the Floating Rate Notes will be the period from and including the original issue date to but excluding the immediately
succeeding Interest Reset Date. Thereafter, the interest periods for the Floating Rate Notes will be the periods from and including
an Interest Reset Date to but excluding the immediately succeeding Interest Reset Date (together with the first interest period,
each a &ldquo;<B>Floating Rate Interest Period</B>&rdquo;). However, the final Floating Rate Interest Period will be the period
from and including the Interest Reset Date immediately preceding the maturity date to the maturity date.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white"><B>Interest
Determination Date:</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white">The calculation
agent in respect of the Floating Rate Notes, will determine LIBOR (as defined below) for each Floating Rate Interest Period on
the second London business day prior to the first day of such Floating Rate Interest Period (an &ldquo;<B>Interest Determination
Date</B>&rdquo;). LIBOR for the first Floating Rate Interest Period will be determined on August 15, 2018. </FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white"><B>LIBOR:</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white">LIBOR means,
with respect to any Interest Determination Date, the offered rate for deposits of US dollars having a maturity of three months
that appears on the Bloomberg Screen BBAL display page, or any successor page, on Bloomberg or any successor service (or any such
other service(s) as may be nominated by ICE Benchmark Administration Limited (&ldquo;<B>IBA</B>&rdquo;) or its successor or such
other entity assuming the responsibility of IBA or its successor in calculating the London Interbank Offered Rate in the event
IBA or its successor no longer does so) (the &ldquo;<B>Designated LIBOR Page</B>&rdquo;).</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white">If no rate appears
on the Designated LIBOR Page, LIBOR will be determined for such Interest Determination Date on the basis of the rates at approximately
11:00 a.m., London time, on such Interest Determination Date at which deposits in US dollars are offered to prime banks in the
London inter-bank market by four major banks in such market selected by the calculation agent, after consultation with us, for
a term of three months and in a principal amount equal to an amount that in the judgment of the calculation agent is representative
for a single transaction in US dollars in such market at such time (a &ldquo;<B>Representative Amount</B>&rdquo;). The calculation
agent will request the principal London office of each of such banks to provide a quotation of its rate. If at least two such quotations
are provided, LIBOR for such Floating Rate Interest Period will be the arithmetic mean (rounded, if necessary, to the nearest one-hundred-thousandth
of a percentage </FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 10 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white">point, with
five-millionths of a percentage point rounded upwards) of such quotations. If fewer than two such quotations are provided, LIBOR
for such Floating Rate Interest Period will be the arithmetic mean (rounded, if necessary, to the nearest one-hundred-thousandth
of a percentage point, with five millionths of a percentage point rounded upwards) of the rates quoted at approximately 11:00 a.m.
in the City of New York on such Interest Determination Date by three major banks in New York City, selected by the calculation
agent, after consultation with us, for loans in US dollars to leading European banks, for a term of three months and in a Representative
Amount; provided, however, that if the banks so selected are not quoting as mentioned above, LIBOR on the Interest Determination
Date will be LIBOR in effect with respect to the immediately preceding Interest Determination Date, or in the case of the initial
Interest Determination Date, the First Interest Rate.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white">Notwithstanding
the above, if the Company determines on or prior to the relevant Interest Determination Date, after consultation with an independent
financial advisor selected by the Company in its sole discretion, that LIBOR has ceased to be calculated or administered or is
no longer viewed as an acceptable benchmark rate in accordance with accepted market practice for debt obligations such as the Floating
Rate Notes, then the Company will appoint in our sole discretion an independent financial advisor (the &ldquo;IFA&rdquo;) to determine
whether there is a substitute or successor base rate to LIBOR that is consistent with accepted market practice for debt obligations
such as the Floating Rate Notes (the &ldquo;Alternative Rate&rdquo;). If the IFA determines that there is an Alternative Rate,
for each future Interest Determination Date, the calculation agent shall use such Alternative Rate as a substitute for LIBOR in
calculating the interest rate on the Floating Rate Notes. As part of such substitution, the calculation agent will make such adjustments
to the Alternative Rate or the Spread thereon, as well as the business day convention, Interest Determination Dates, Interest Reset
Dates and related provisions and definitions (&ldquo;Adjustments&rdquo;), in each case that are consistent with accepted market
practice for the use of such Alternative Rate, all as determined and directed by the IFA; provided, however, that the calculation
agent shall not be required to implement any such Adjustments that affects its own rights, duties or immunities under the Indenture,
the Calculation Agency Agreement or otherwise. If the IFA determines that there is no such Alternative Rate as provided above,
LIBOR will be equal to the rate of interest in effect with respect to the immediately preceding Interest Determination Date or,
in the case of the initial Interest Determination Date, the rate of interest will be equal to the First Interest Rate.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="background-color: white">The interest
rate on the Floating Rate Notes will in no event be higher than the maximum rate permitted by law.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Sinking Fund Provisions:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><FONT STYLE="font-size: 10pt">No sinking fund provisio</FONT>ns.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><B>Defeasance Provisions:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">The Designated Securities are entitled
to full defeasance and discharge under certain conditions as set forth in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><B>Time of Delivery of the Designated Securities:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">August 17, 2018.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 11 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><B>Closing Location for Delivery of the Designated
Securities:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">The offices of Davis Polk &amp; Wardwell London LLP,
5 Aldermanbury Square, London EC2V 7HR England.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in"><B>Address of the Company For Notice Purposes:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">AstraZeneca PLC<BR>
1 Francis Crick Avenue&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in">Cambridge Biomedical Campus&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in">Cambridge CB2 0AA<BR>
England, United Kingdom&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in">Attention: Company Secretary</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Names and Addresses of the Representatives
For Notice Purposes:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">Citigroup Global Markets Inc.<BR>
c/o Citigroup Global Markets Inc.<BR>
388 Greenwich Street<BR>
New York, New York 10013<BR>
Attention: General Counsel<BR>
Fax: +1 (646) 291-1469</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">Deutsche Bank Securities Inc.<BR>
c/o Deutsche Bank Securities Inc.<BR>
60 Wall Street<BR>
New York, New York 10005<BR>
Attention: Debt Capital Markets Syndicate<BR>
Fax: +1 (212) 297-2202<BR>
With a copy to General Counsel<BR>
Fax: +1 (646) 374-1071</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">Goldman Sachs &amp; Co. LLC<BR>
c/o Goldman Sachs &amp; Co. LLC<BR>
200 West Street<BR>
New York, New York 10282<BR>
Attention: Registration Department</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">J.P. Morgan Securities LLC<BR>
c/o J.P. Morgan Securities LLC<BR>
383 Madison Avenue<BR>
New York, New York 10179<BR>
Attention: Investment Grade Syndicate Desk<BR>
Telephone Collect at: +1 (212) 834-4533</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 12 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE III</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in"><B>Issuer Free Writing Prospectus:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">Final Term Sheet dated August 14,
2018 containing the final terms of the Designated Securities as set forth in Schedule V hereto.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">Free Writing Prospectus dated August
14, 2018 entitled &ldquo;Fixed-Income Investor Update &ndash; August 2018&rdquo;.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>


<!-- Field: Page; Sequence: 13 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE IV</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Pricing Disclosure Package:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">Preliminary Prospectus dated and
filed with the Commission on August 14, 2018, together with the Issuer Free Writing Prospectus listed on Schedule III hereto</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>


<!-- Field: Page; Sequence: 14 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE V</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>


<!-- Field: Page; Sequence: 15; Options: Last -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->



<P STYLE="margin: 0"></P>

</BODY>
</HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.1
<SEQUENCE>4
<FILENAME>dp94630_0401.htm
<DESCRIPTION>EXHIBIT 4.1
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 4.1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ASTRAZENECA PLC</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">OFFICERS&rsquo; CERTIFICATE</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In connection with the issuance of the
3.500% Notes due 2023 (the &ldquo;<B>2023 Notes</B>&rdquo;), the Floating Rate Notes due 2023 (the &ldquo;<B>Floating Rate Notes</B>&rdquo;),
the 4.000% Notes due 2029 (the &ldquo;<B>2029 Notes</B>&rdquo;) and the 4.375% Notes due 2048 (the &ldquo;<B>2048 Notes</B>&rdquo;,
together with the 2023 Notes and the 2029 Notes, the &ldquo;<B>Fixed Rate Notes</B>&rdquo;, and collectively with the Floating
Rate Notes, the &ldquo;<B>Notes</B>&rdquo; or the &ldquo;<B>Securities</B>&rdquo;) of AstraZeneca PLC (the &ldquo;<B>Issuer</B>&rdquo;)
pursuant to the Indenture, dated as of April 1, 2004 (the &ldquo;<B>Indenture</B>&rdquo;), between the Issuer and The Bank of New
York Mellon as successor Trustee (section references herein being to the Indenture), and pursuant to the authorization of the Board
of Directors of the Issuer at its meetings held on May 17, 2018 and May 18, 2018 and the authorisation of the Issuer&rsquo;s Issuance
Committee by written resolution dated July 13, 2018, the undersigned hereby confirms that, to the extent not otherwise provided
for in the Indenture, the following forms, terms and conditions of the Notes were established as required pursuant to Section 2.01
and Section 2.08 of the Indenture:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 35%; font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Title of Notes&#9;</TD>
    <TD STYLE="width: 65%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">3.500% Notes due 2023&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">Floating Rate Notes due 2023&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">4.000% Notes due 2029&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">4.375% Notes due 2048&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Initial Aggregate Principal Amount of Notes&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>2023 Notes</I>: US$850,000,000&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>Floating Rate Notes</I>: US$400,000,000&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>2029 Notes</I>: US$1,000,000,000&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>2048 Notes</I>: US$750,000,000&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Price to Public&#9;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt"><I>2023 Notes</I>: 99.673% of the Principal Amount per 2023 Note, plus accrued interest, if any, from August 17, 2018</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>Floating Rate Notes:</I> 100.000% of the
Principal Amount per Floating Rate Note, plus accrued interest, if any, from August 17, 2018&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>2029 Notes</I>: 99.590% of the Principal
Amount per 2029 Note, plus accrued interest, if any, from August 17, 2018&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt"><I>2048 Notes</I>: 98.944% of the Principal Amount per 2048 Note, plus accrued interest, if any, from August 17, 2018</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Issue Date&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>2023 Notes</I>: August 17, 2018&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>Floating Rate Notes</I>: August 17, 2018&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>2029 Notes</I>: August 17, 2018&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>2048 Notes</I>: August 17, 2018&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Form of Notes&#9;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">The Notes will be issued in the form of global notes that will be deposited with The Depository Trust Company, New York, New York (&ldquo;<B>DTC</B>&rdquo;) on the closing date. Seven global notes will be issued to DTC, which will be executed and delivered in substantially the form of Notes set forth in Exhibits A, B, C and D hereto.&nbsp;&nbsp;In certain circumstances described in the Indenture, Notes may be issued in definitive form.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Maturity&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>2023 Notes</I>: August 17, 2023&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>Floating Rate Notes</I>: August 17, 2023&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>2029 Notes</I>: January 17, 2029&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>2048 Notes</I>: August 17, 2048&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 1 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->1<!-- Field: /Sequence --></FONT></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 35%; font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Interest Rate for Fixed Rate Notes&#9;</TD>
    <TD STYLE="width: 65%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>2023 Notes</I>: 3.500% per annum, accruing from
        August 17, 2018</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>2029 Notes</I>: 4.000% per annum, accruing from
        August 17, 2018</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>2048 Notes</I>: 4.375% per annum, accruing from August
17, 2018&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Interest Periods for Fixed Rate Notes&#9;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">The first interest period for the Fixed Rate Notes will be the period from and including the original issue date to but excluding the first Fixed Rate Interest Payment Date (as defined below). Thereafter, the interest periods for the Fixed Rate Notes will be the periods from and including the Fixed Rate Interest Payment Dates to but excluding the immediately succeeding Fixed Rate Interest Payment Date (together with the first interest period, each a &ldquo;<B>Fixed Rate Interest Period</B>&rdquo;). The final Fixed Rate Interest Period will be the period from and including the Fixed Rate Interest Payment Date immediately preceding the maturity date to the maturity date, or the redemption date.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Interest Rate for Floating Rate Notes&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">The interest rate for the Floating Rate Notes for
        the first interest period will be LIBOR (as defined below) as determined on August 15, 2018 plus the Spread (as defined below).
        Thereafter, the interest rate for any Floating Rate Interest Period (as defined below) will be LIBOR as determined on the applicable
        Interest Determination Date (as defined below) plus the Spread.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&ldquo;<B>LIBOR</B>&rdquo; means, with respect to
        any Interest Determination Date, the offered rate for deposits of US dollars having a maturity of three months that appears on
        the Bloomberg Screen BBAL display page, or any successor page, on Bloomberg or any successor service (or any such other service(s)
        as may be nominated by ICE Benchmark Administration Limited (&ldquo;<B>IBA</B>&rdquo;) or its successor or such other entity assuming
        the responsibility of IBA or its successor in calculating the London Interbank Offered Rate in the event IBA or its successor no
        longer does so) (the &ldquo;<B>Designated LIBOR Page</B>&rdquo;).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">If no rate appears on the Designated LIBOR Page, LIBOR
will be determined for such Interest Determination Date on the basis of the rates at approximately 11:00 a.m., London time, on
such Interest Determination Date at which deposits in US dollars are offered to prime banks in the London inter-bank market by
four major banks in such market selected by the calculation agent, after consultation with the Issuer, for a term of three months
and in a principal amount equal to an amount that in the judgment of the calculation agent is representative for a single transaction
in US dollars in such market at such time (a &ldquo;<B>Representative Amount</B>&rdquo;). The calculation agent will request the
principal London office of each of such banks to provide a quotation of its rate. If at least two such quotations are provided,
LIBOR for such Floating Rate Interest Period will be the arithmetic mean (rounded, if necessary, to the nearest one-hundred-thousandth
of a percentage point, with five-millionths of a percentage point rounded upwards) of such quotations. If fewer than two such
quotations are provided, LIBOR for such Floating Rate Interest Period will be the arithmetic mean (rounded, if necessary, to the
nearest one-hundred-thousandth of a percentage point, with five millionths of a percentage point rounded upwards) of the rates
quoted at approximately 11:00 a.m. in the City of New York on such Interest Determination Date by&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 2 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->2<!-- Field: /Sequence --></FONT></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 35%; font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="width: 65%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">three major banks in New York City, selected by the
        calculation agent, after consultation with the Issuer, for loans in US dollars to leading European banks, for a term of three months
        and in a Representative Amount; provided, however, that if the banks so selected are not quoting as mentioned above, <FONT STYLE="background-color: white">LIBOR
        on the Interest Determination Date will be LIBOR in effect with respect to the immediately preceding Interest Determination Date,
        or in the case of the initial Interest Determination Date, the First Interest Rate</FONT>.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">Notwithstanding the above, if the Issuer determines
        on or prior to the relevant Interest Determination Date, after consultation with an&nbsp;independent financial advisor selected
        by the Issuer in its sole discretion, that LIBOR has ceased to be calculated or administered or is no longer viewed as an acceptable
        benchmark rate in accordance with accepted market practice for debt obligations such as the Floating Rate Notes, then the Issuer
        will appoint in its sole discretion an independent financial advisor (the &ldquo;<B>IFA</B>&rdquo;) to determine whether there
        is a substitute or successor base rate to LIBOR that is consistent with accepted market practice for debt obligations such as the
        Floating Rate Notes (the &ldquo;<B>Alternative Rate</B>&rdquo;). If the IFA determines that there is an Alternative Rate, for each
        future Interest Determination Date, the calculation agent shall use such Alternative Rate as a substitute for LIBOR in calculating
        the interest rate on the Floating Rate Notes. As part of such substitution, the calculation agent will make such adjustments to
        the Alternative Rate or the Spread thereon, as well as the business day convention, Interest Determination Dates, Interest Reset
        Dates and related provisions and definitions (&ldquo;<B>Adjustments</B>&rdquo;), in each case that are consistent with accepted
        market practice for the use of such Alternative Rate, all as determined and directed by the IFA; provided, however, that the calculation
        agent shall not be required to implement any such Adjustments that affects its own rights, duties or immunities under the Indenture,
        the Calculation Agency Agreement or otherwise. If the IFA determines that there is no such Alternative Rate as provided above,
        LIBOR will be equal to the rate of interest in effect with respect to the immediately preceding Interest Determination Date or,
        in the case of the initial Interest Determination Date, the rate of interest will be equal to the First Interest Rate.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">The interest rate on the Floating Rate Notes will
        in no event be higher than the maximum rate permitted by law.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&ldquo;<B>Spread</B>&rdquo; means 66.5 basis points.&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Interest Determination Dates for Floating Rate Notes&#9;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">Interest on the Floating Rate Notes will be determined two London business days prior to each Interest Reset Date. LIBOR for the first Floating Rate Interest Period was determined on August 15, 2018.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Interest Reset Dates for Floating Rate Notes&#9;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">Interest on the Floating Rate Notes will have Interest Reset Dates of February 17, May 17, August 17 and November 17 of each year, commencing November 17, 2018.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Interest Periods for Floating Rate Notes&#9;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">The first interest period for the Floating Rate Notes will be the period from and including the original issue date to but excluding the immediately succeeding Interest Reset Date. Thereafter, the interest periods for the Floating Rate Notes will be the periods</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 3 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->3<!-- Field: /Sequence --></FONT></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 35%; font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="width: 65%; font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">from and including an Interest Reset Date to but excluding the immediately succeeding Interest Reset Date (together with the first interest period, each a &ldquo;<B>Floating Rate Interest Period</B>&rdquo;). However, the final Floating Rate Interest Period will be the period from and including the Interest Reset Date immediately preceding the maturity date to the maturity date or the redemption date.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Interest Payment Dates&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>Fixed Rate Notes</I>: Interest on the 2023 Notes
        shall be payable semi-annually in arrears on February 17 and August 17, commencing February 17, 2019 (each, a &ldquo;<B>2023 Fixed
        Rate Interest Payment Date</B>&rdquo;).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">Interest on the 2029 Notes shall be payable semi-annually
        in arrears on January 17 and July 17, commencing January 17, 2019 (each, a &ldquo;<B>2029 Fixed Rate Interest Payment Date</B>&rdquo;).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">Interest on the 2048 Notes shall be payable semi-annually
in arrears on February 17 and August 17, commencing February 17, 2019 (each, a &ldquo;<B>2048 Fixed Rate Interest Payment Date</B>&rdquo;,
and together with each 2023 Fixed Rate Interest Payment Date and 2029 Fixed Rate Interest Payment Date, each a &ldquo;<B>Fixed
Rate Interest Payment Date</B>&rdquo;).&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">Notwithstanding the above, if a Fixed Rate Interest
        Payment Date would fall on a day that is not a business day (as defined below), the Fixed Rate Interest Payment Date will be postponed
        to the next succeeding day that is a business day, but no additional interest shall be paid unless the issuer fails to make payment
        on such date.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><I>Floating Rate Notes:</I> Interest on the Floating
        Rate Notes will be paid quarterly in arrears on February 17, May 17, August 17 and November 17 of each year, commencing November
        17, 2018 (each, a &ldquo;<B>Floating Rate Interest Payment Date</B>&rdquo;).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">Notwithstanding the above, if a Floating Rate Interest
Payment Date would fall on a day that is not a business day, the Floating Rate Interest Payment Date will be postponed to the
next succeeding day that is a business day, except that if the business day falls in the next succeeding calendar month, the applicable
Floating Rate Interest Payment Date will be the immediately preceding business day. In each such case, except for the Floating
Rate Interest Payment Date falling on the maturity date, the Floating Rate Interest Periods and the Interest Reset Dates will
be adjusted accordingly to calculate the amount of interest payable on the Floating Rate Notes.&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Regular Record Dates for Interest&#9;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">Interest shall be paid to the holder in whose name the Notes are registered at the close of business on the 15th calendar day preceding each Fixed Rate Interest Payment Date or Floating Rate Interest Payment Date, as the case may be, whether or not such day is a business day.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Business day&#9;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">Any day which is not, in London, England or New York, New York, or the place of payment of amounts payable in respect of the Notes, a Saturday, a Sunday, a legal holiday or a day on which banking institutions are authorized or obligated by law, regulation or executive order to close.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 4 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->4<!-- Field: /Sequence --></FONT></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 35%; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">London business day&#9;</TD>
    <TD STYLE="width: 65%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">A day on which dealings in deposits in U.S. dollars are transacted in the London interbank market.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Place of Payment, Registration of Transfer and Exchange, Paying Agent, Calculation Agent&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt"><P STYLE="margin-top: 0; margin-bottom: 0">The Bank
of New York Mellon<BR> 240 Greenwich Street<BR> New York, NY 10286</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Trustee&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">The Bank of New York Mellon</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Notice and Demands to Issuer&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">1 Francis Crick Avenue&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">Cambridge Biomedical Campus&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt">Cambridge CB2 0AA<BR>
England, United Kingdom<BR>
Attn: The Company Secretary&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Redemption Provisions:</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Optional Tax Redemption for any series of Notes&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">Optional, in whole but not in part, at the option of the Issuer, at any time in accordance with the terms set forth in the relevant form of Notes set forth in Exhibits A, B, C and D hereto. The Issuer may not otherwise redeem the Floating Rate Notes prior to maturity.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Optional Redemption for any series of Fixed Rate Notes&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">Optional, in whole or in part, from time to time as follows: (i) prior to the Par Call Date (as set forth below), at a redemption price equal to the greater of (A) 100% of the principal amount of the Fixed Rate Notes to be redeemed, and (B) as determined by the Quotation Agent (as defined below), the sum of the present values of the remaining scheduled payments of principal and interest on the Fixed Rate Notes to be redeemed (assuming for this purpose that such series of Notes matured on the applicable Par Call Date and not including any portion of such payments of interest accrued as of the date of redemption) discounted to the date of redemption on a semiannual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate plus the Make Whole Spread (as set forth below) and (ii) on or after the Par Call Date, at a redemption price equal to 100% of the principal amount of the Fixed Rate Notes to be redeemed, plus, in each case, accrued interest thereon to but excluding the date of redemption.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&ldquo;<B>Treasury Rate</B>&rdquo; means, with respect to any redemption date, the rate per annum equal to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such redemption date.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&ldquo;<B>Comparable Treasury Issue</B>&rdquo; means the United States Treasury security selected by the Quotation Agent as having a maturity comparable to the remaining term of the applicable series of Notes to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining term of such series of Notes (assuming for this purpose that such series of Fixed Rate Notes matured on the applicable Par Call Date).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&ldquo;<B>Comparable Treasury Price</B>&rdquo; means, with respect to any</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 5 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->5<!-- Field: /Sequence --></FONT></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 35%; padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="width: 65%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">redemption date, (i) the average, as determined by the Quotation Agent, of the Reference Treasury Dealer Quotations for such redemption date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, or (ii) if the Quotation Agent obtains fewer than three such Reference Treasury Dealer Quotations, the average of all such Quotations.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&ldquo;<B>Quotation Agent</B>&rdquo; means the Reference Treasury Dealer appointed by the Issuer.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&ldquo;<B>Reference Treasury Dealer</B>&rdquo; means (i) each of Citigroup Global Markets Inc., Deutsche Bank Securities Inc., Goldman Sachs &amp; Co. LLC and J.P. Morgan Securities LLC, and their respective successors or affiliates; <I>provided</I>, <I>however</I>, that if the foregoing shall cease to be a primary U.S. Government securities dealer in New York City (a &ldquo;<B>Primary Treasury Dealer</B>&rdquo;), the Issuer shall substitute therefor another Primary Treasury Dealer; and (ii) any other Primary Treasury Dealer selected by the Issuer.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&ldquo;<B>Reference Treasury Dealer Quotations</B>&rdquo; means, with respect to each Reference Treasury Dealer and any redemption date, the average, as determined by the Quotation Agent, of the bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted in writing to the trustee by such Reference Treasury Dealer at 5:00 p.m., New York City time, on the third business day preceding such redemption date.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&ldquo;<B>Make-Whole Spread</B>&rdquo; means, with respect to, (i) the 2023 Notes, 15 basis points, (ii) the 2029 Notes, 20 basis points and (iii) the 2048 Notes, 25 basis points.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&ldquo;<B>Par Call Date</B>&rdquo; means, with respect to, (i) the 2023 Notes, July 17, 2023, (ii) the 2029 Notes, October 17, 2028 and (iii) the 2048 Notes, February 17, 2048.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Redemption Notices&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">Notice of any redemption will be given to DTC at least 15 days but not more than 30 days prior to the redemption date to the Holders.&nbsp;&nbsp;Unless the Issuer defaults in payment of the Redemption Price, on and after the redemption date, interest will cease to accrue on the Notes or portions thereof called for redemption.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Defeasance and Discharge of the Notes (Section 9.03)&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">Applicable.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Sinking Fund&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">None.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Additional Amounts&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">Pursuant to the relevant form of Notes set forth in Exhibits A, B, C and D hereto, the Issuer may, subject to certain exceptions, be obligated to pay additional amounts.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">Other Terms of the Notes&#9;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">The other terms of the Notes shall be substantially as set forth in the Indenture, the relevant form of Notes attached hereto as Exhibits A, B, C and D, the Prospectus dated November 22, 2016 (the &ldquo;<B>Prospectus</B>&rdquo;) relating to the Notes and the Prospectus Supplement dated August 14, 2018 to the Prospectus.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 20pt; text-indent: -20pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">&nbsp;</TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 6 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->6<!-- Field: /Sequence --></FONT></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Each of the undersigned hereby certifies
that:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;He
has read the provisions of the Indenture setting forth covenants and conditions to the Trustee&rsquo;s authentication and delivery
of the Securities and the definitions in the Indenture relating thereto.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;He
has examined the resolutions of the Board of Directors and the Issuance Committee of the Issuer adopted prior to the date hereof
relating to the authorization, issuance, authentication and delivery of the Securities, such other corporate records of the Issuer,
as applicable, and such other documents deemed necessary as a basis for the opinion hereinafter expressed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In
his opinion, such examination is sufficient to enable him to express an informed opinion as to whether or not the covenants and
conditions referred to above have been complied with.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;He
is of the opinion that the covenants and conditions referred to above have been complied with.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 7 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->7<!-- Field: /Sequence --></FONT></P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">IN WITNESS WHEREOF, each of the undersigned
has hereunto signed his name.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Dated: August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid">/s/ Marc Dunoyer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 16%">Name:</TD>
    <TD STYLE="width: 84%">Marc Dunoyer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>Title:</TD>
    <TD>Chief Financial Officer</TD></TR>
</TABLE><BR STYLE="clear: both">

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid">/s/ Adrian Kemp</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 16%">Name:</TD>
    <TD STYLE="width: 84%">Adrian Kemp</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>Title:</TD>
    <TD>Company Secretary</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">[<I>Signature Page to Officers&rsquo; Certificate
Pursuant to the Indenture</I>]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<!-- Field: Page; Sequence: 8; Options: NewSection -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Exhibit A</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>


<!-- Field: Page; Sequence: 9 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>THIS SECURITY IS A GLOBAL REGISTERED SECURITY WITHIN THE
MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY
MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE
REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED
IN THE INDENTURE.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ASTRAZENECA PLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">3.500% Notes due 2023</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 52%; text-align: left">No. 001</TD>
    <TD STYLE="width: 48%; text-align: right">$500,000,000</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">CUSIP No. 046353AR9</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">ISIN No. US046353AR96</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">ASTRAZENECA PLC, a public limited company
incorporated under the laws of England and Wales (herein called the &ldquo;Issuer&rdquo;, which term includes any successor Person
under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &amp; Co., or registered assigns,
the principal sum of Five Hundred Million Dollars on August 17, 2023 and to pay interest thereon from August 17, 2018 or from the
most recent Interest Payment Date (as defined below) to which interest has been paid or duly provided for, semiannually in arrears
on February 17 and August 17 in each year, commencing February 17, 2019 (each, an &ldquo;Interest Payment Date&rdquo;), at the
rate of 3.500% per annum, until the principal hereof is paid or made available for payment. The interest so payable, and punctually
paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name
this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date (as defined
below) for such interest which shall be the 15<SUP>th</SUP> calendar day preceding such Interest Payment Date (whether or not such
day is a Business Day (as defined below)), as the case may be. Any such interest not so punctually paid or duly provided for will
forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this
Security (or one or more Predecessor Securities) is registered at the close of business on a subsequent record date (the &ldquo;Special
Record Date&rdquo;) for the payment of such defaulted interest to be fixed by the Trustee (which shall not be less than five Business
Days prior to the date of payment of such defaulted interest), notice whereof shall be given to Holders of Securities of this series
not less than 15 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with
the requirements of any securities exchange on which the Securities of this series may</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 10 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">be listed, and upon such notice as may be
required by such exchange, all as more fully provided in said Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Issuer maintained for that purpose in
New York City, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts; <U>provided</U>, <U>however</U>, that at the option of the Issuer payment of interest may be made by
check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Unless the certificate of authentication
hereon has been executed by the Trustee by manual signature of an authorized signatory, this Security shall not be entitled to
any benefit under the Indenture or be valid or obligatory for any purpose.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 11 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">IN WITNESS WHEREOF, the Issuer has caused
this instrument to be duly executed manually or in facsimile.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated: August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">ASTRAZENECA PLC</FONT></TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
</TABLE><BR STYLE="clear: both">


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 14%; padding-left: 0pt; text-indent: 0pt">By:</TD>
    <TD STYLE="width: 86%; border-bottom: Black 1pt solid; padding-left: 0pt; text-indent: 0pt">/s/ Marc Dunoyer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">Name:&#9;Marc Dunoyer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">Title:&#9;Chief Financial Officer</TD></TR>
</TABLE><BR STYLE="clear: both">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 14%; padding-left: 0pt; text-indent: 0pt">By:</TD>
    <TD STYLE="width: 86%; border-bottom: Black 1pt solid; padding-left: 0pt; text-indent: 0pt">/s/ Adrian Kemp</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">Name: Adrian Kemp</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">Title:&#9;Company Secretary</TD></TR>
</TABLE><BR STYLE="clear: both">

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt"><I>[Signature page to Global Note]</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<!-- Field: Page; Sequence: 12 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This is one of the Securities of the series
designated herein and referred to in the within-mentioned Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated: August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>


<P STYLE="margin: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0.25in; text-indent: -0.25in"><FONT STYLE="font-size: 10pt; text-transform: uppercase">The Bank of New York</FONT> <FONT STYLE="font-size: 10pt">MELLON</FONT><BR>
<FONT STYLE="font-size: 10pt"><I>As Trustee</I></FONT></TD></TR>
</TABLE>

<BR STYLE="clear: both">
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid">L. O&rsquo;Brien</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="width: 14%">&nbsp;</TD>
    <TD STYLE="width: 85%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt"><I>[Signature page to Global Note]</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">&nbsp;</P>



<!-- Field: Page; Sequence: 13 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This Security is one of a duly authorized
issue of securities of the Issuer (herein called the &ldquo;Securities&rdquo;), issued and to be issued in one or more series under
an Indenture, dated as of April 1, 2004 (herein called the &ldquo;Indenture&rdquo; which term shall have the meaning assigned to
it in such instrument), among the Issuer and The Bank of New York Mellon (formerly known as The Bank of New York), as successor
Trustee (herein called the &ldquo;Trustee&rdquo;, which term includes any other successor trustee under the Indenture) to JPMorgan
Chase Bank, and reference is hereby made to the Indenture and to the Officers&rsquo; Certificate delivered pursuant to Section
2.08 of the Indenture with respect to this security for a statement of the respective rights, limitations of rights, duties and
immunities thereunder of the Issuer, the Trustee and the Holders of the Securities and of the terms upon which the Securities are,
and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited
in aggregate principal amount to U.S.$850,000,000.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Securities of this series are subject
to redemption, as a whole or in part, from time to time, at the election of the Issuer, upon not less than 15 nor more than 30
days&rsquo; notice, as follows: (i) prior to July 17, 2023 (the &ldquo;Par Call Date&rdquo;), at a Redemption Price equal to the
greater of (A) 100% of the principal amount of the Securities to be redeemed, and (B) as determined by the Quotation Agent (as
defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (assuming for
this purpose that such series of Notes matured on the Par Call Date and not including any portion of such payments of interest
accrued as of the date of redemption) discounted to the date of redemption on a semiannual basis (assuming a 360-day year consisting
of twelve 30-day months) at the Treasury Rate plus 15 basis points, and (ii) on or after the Par Call Date, at a redemption price
equal to 100% of the principal amount of the Securities to be redeemed; plus, in each of cases (A) and (B) above, accrued interest
thereon to but excluding the date of redemption.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Business Day&rdquo; means any day which is not, in
London, England or New York, New York, or the place of payment of amounts payable in respect of the Securities, a Saturday, a Sunday,
a legal holiday or a day on which banking institutions are authorized or obligated by law, regulation or executive order to close.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Comparable Treasury Issue&rdquo; means the United
States Treasury security selected by the Quotation Agent as having a maturity comparable to the remaining term of the Securities
to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing
new issues of corporate debt securities of comparable maturity to the remaining term of such Securities (assuming for this purpose
that such Securities matured on the Par Call Date).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 14 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Comparable Treasury Price&rdquo; means, with respect
to any redemption date, (i) the average, as determined by the Quotation Agent, of the Reference Treasury Dealer Quotations for
such redemption date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, or (ii) if the Quotation
Agent obtains fewer than three such Reference Treasury Dealer Quotations, the average of all such Quotations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Quotation Agent&rdquo; means the Reference Treasury
Dealer appointed by the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Reference Treasury Dealer&rdquo; means (i) Citigroup
Global Markets Inc., Deutsche Bank Securities Inc., Goldman Sachs &amp; Co. LLC and J.P. Morgan Securities LLC, and their respective
successors; <I>provided, however</I>, that if the foregoing shall cease to be a primary U.S. Government securities dealer in New
York City (a &ldquo;Primary Treasury Dealer&rdquo;), the Issuer shall substitute therefor another Primary Treasury Dealer; and
(ii) any other Primary Treasury Dealer selected by the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Reference Treasury Dealer Quotations&rdquo; means,
with respect to each Reference Treasury Dealer and any redemption date, the average, as determined by the Quotation Agent, of the
bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted
in writing to the Trustee by such Reference Treasury Dealer at 5:00 p.m., New York City time, on the third Business Day preceding
such redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Treasury Rate&rdquo; means, with respect to any redemption
date, the rate per annum equal to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price
for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for
such redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Indenture contains provisions to the
effect that, in the event of various tax law changes and other limited circumstances that require the Issuer to pay Additional
Amounts (as defined below), the Issuer may redeem the Securities of a series, in whole but not in part, at a price equal to 100%
of the principal amount of the Securities plus accrued interest thereon to but excluding the date of redemption, which provisions
apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In the event of redemption of this Security
in part only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in
the name of the Holder hereof upon the cancellation hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 15 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Indenture contains provisions for defeasance
at any time of the entire indebtedness on this Security upon compliance by the Issuer with certain conditions set forth thereon,
which provisions apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any amounts to be paid by the Issuer under
this Security of principal, premium and interest in respect of this Security will be paid without deduction or withholding for,
any and all present and future taxes, levies, duties, assessments, imposts or other governmental charges of whatever nature imposed,
assessed, levied or collected by or for the account of the government of any jurisdiction in which the Issuer is resident for tax
purposes or any political subdivision or taxing authority of such jurisdiction, unless such withholding or deduction is required
by law. If such deduction or withholding is at any time required, the Issuer will (subject to compliance by the Holder of this
Security with any relevant administrative requirements) pay such additional amounts (&ldquo;Additional Amounts&rdquo;) as will
result in the receipt of such amounts as would have been received by the Holder had no such withholding or deduction been required,
provided that the Issuer will not have to pay Additional Amounts if:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for the Holder&rsquo;s
(or certain related parties&rsquo;) connection to the jurisdiction in which the Issuer is resident for tax purposes, other than
by merely holding this Security or by receiving principal, premium, if any, or interest, if any, on this Security, or enforcing
this Security. These connections include where the Holder or related party:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been a domiciliary, national or resident of such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been engaged in a trade or business in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>has or had a permanent establishment in such jurisdiction; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been physically present in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(ii)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for presentation
of this Security for payment, if presentation is required, more than 30 days after this Security became due or payment was provided
for;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iii)&nbsp;&nbsp;&nbsp;the tax, levy, impost or other governmental charge is an estate, inheritance, gift, sale, transfer, personal property or similar
tax, levy, impost or other governmental charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 16 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iv)&nbsp;&nbsp;&nbsp;&nbsp;the tax, levy, impost or other governmental charge is payable in a manner that does not involve deduction or withholding from payments
on or in respect of this Security;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(v)&nbsp;&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed or withheld but for the failure of the Holder or beneficial
owner, upon a reasonable request, addressed to the Holder, to comply with any certification, identification or other reporting
requirement concerning the Holder&rsquo;s or the beneficial owner&rsquo;s nationality, residence, identity or connection with any
jurisdiction in which the Issuer is resident for tax purposes, if compliance is required by any treaty, statute, regulation or
administrative practice of such jurisdiction as a condition to relief or exemption from such tax, levy, impost or other governmental
charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vi)&nbsp;&nbsp;
the tax, levy, impost or other governmental charge is required by Sections 1471 through 1474 of the Internal Revenue Code of 1986,
as amended (&ldquo;FATCA&rdquo;), any current or future U.S. Treasury Regulations or rulings promulgated thereunder, any intergovernmental
agreement between the United States and any other jurisdiction to implement FATCA (an &ldquo;IGA&rdquo;), any law, regulation or
other official guidance enacted in any jurisdiction implementing FATCA or an IGA, or any agreement with the U.S. Internal Revenue
Service under or with respect to FATCA; or</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vii) any combination of the taxes referred
to in (i) through (vi) above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, no payments of Additional
Amounts will be made with respect to any payment on this Security if the Holder of this Security is a fiduciary, partnership or
a person other than the sole beneficial owner of any payment, and, by the laws of the jurisdiction in which the Issuer is resident
for tax purposes, that payment would be required for tax purposes to be included in income of a beneficiary or settlor with respect
to the fiduciary, a member of that partnership or a beneficial owner who would not have been entitled to the Additional Amounts
had that beneficiary, settlor, partner or member owner been the Holder of this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Issuer will remit the full amount of
any taxes withheld to the applicable taxing authorities in accordance with the applicable law. The Issuer will also provide the
Trustee with documentation reasonably satisfactory to the Trustee evidencing the payment of any taxes in respect of which the Issuer
has paid Additional Amounts. The Issuer will provide copies of such documentation to the Holder of this Security upon request.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any reference in the Indenture or this
Security to principal, premium or interest in respect of this Security will be deemed also to refer to any Additional Amounts that
may be payable with respect to such principal, premium or interest under the obligations referred to herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 17 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Issuer and the rights of the
Holders of the Securities of each series to be affected under the Indenture at any time by the Issuer and the Trustee with the
consent of the Holders of a majority in principal amount of the Securities at the time Outstanding of each series to be affected.
The Indenture also contains provisions permitting the Holders of specified percentages in principle amount of the Securities of
each series at the time Outstanding, on behalf of the Holders of all Securities of such series to waive compliance by the Issuer
with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent
or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security
and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation
of such consent or waiver is made upon this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">As set forth in, and subject to, the provisions
of the Indenture, no Holder of any Security of this series will have any right to institute any proceeding with respect to the
Indenture, this Security or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice
of a continuing Event of Default with respect to the Securities of this series, the Holders of not less than 25% in principal amount
of the Outstanding Securities of this series shall have made written request, and offered reasonable indemnity, to the Trustee
to institute such proceeding as trustee, and the Trustee shall not have received from the Holders of a majority in principal of
the Outstanding Securities of this series a direction inconsistent with such request and shall have failed to institute such proceeding
within 60 days; <U>provided</U>, <U>however</U>, that such limitations do not apply to a suit instituted by the Holder hereof for
the enforcement of payment of the principal (and premium, if any) or any interest on this Security on or after the respective due
dates expressed herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No reference herein to the Indenture and
no provision of this Security or of the Indenture shall alter or impair the obligation of the Issuer, which is absolute and unconditional,
to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency,
herein prescribed or to convert this Security as provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000 in excess thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No service charge shall be made for any
such registration of transfer or exchange, but the Issuer or the Trustee may require payment of a sum sufficient to cover any tax
or other governmental charge payable in connection therewith.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 18 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Prior to due presentation of this Security
for registration of transfer, the Issuer, the Trustee and any agent of the Issuer or the Trustee may treat the Person in whose
name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither of
the Issuer nor the Trustee nor any such agent shall be affected by notice to the contrary.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>This Security shall be governed by and
construed in accordance with the laws of the State of New York.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Unless otherwise defined herein, all terms
used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 19 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE OF PRINCIPAL AMOUNT</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The initial principal amount of this Security
shall be $500,000,000. The following decreases/increases in the principal amount of this Security have been made:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 26%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Date
        of Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Decrease
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Increase
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 22%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Total
        Principal Amount Following such Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 18%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Notation
        Made by or on Behalf of Trustee</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 20 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>THIS SECURITY IS A GLOBAL REGISTERED SECURITY WITHIN THE
MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY
MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE
REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED
IN THE INDENTURE.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ASTRAZENECA PLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">3.500% Notes due 2023</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 54%; font-size: 10pt; text-align: left">No. 002</TD>
    <TD STYLE="width: 46%; font-size: 10pt; text-align: right">$350,000,000</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">CUSIP No. 046353AR9</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">ISIN No. US046353AR96</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">ASTRAZENECA PLC, a public limited company
incorporated under the laws of England and Wales (herein called the &ldquo;Issuer&rdquo;, which term includes any successor Person
under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &amp; Co., or registered assigns,
the principal sum of Three Hundred And Fifty Million Dollars on August 17, 2023 and to pay interest thereon from August 17, 2018
or from the most recent Interest Payment Date (as defined below) to which interest has been paid or duly provided for, semiannually
in arrears on February 17 and August 17 in each year, commencing February 17, 2019 (each, an &ldquo;Interest Payment Date&rdquo;),
at the rate of 3.500% per annum, until the principal hereof is paid or made available for payment. The interest so payable, and
punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in
whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date
(as defined below) for such interest which shall be the 15<SUP>th</SUP> calendar day preceding such Interest Payment Date (whether
or not such day is a Business Day (as defined below)), as the case may be. Any such interest not so punctually paid or duly provided
for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose
name this Security (or one or more Predecessor Securities) is registered at the close of business on a subsequent record date (the
&ldquo;Special Record Date&rdquo;) for the payment of such defaulted interest to be fixed by the Trustee (which shall not be less
than five Business Days prior to the date of payment of such defaulted interest), notice whereof shall be given to Holders of Securities
of this series not less than 15 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent
with the requirements of any securities exchange on which the Securities of this series may</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>

<!-- Field: Page; Sequence: 21 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">be listed, and upon such notice as
may be required by such exchange, all as more fully provided in said Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Issuer maintained for that purpose in
New York City, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts; <U>provided</U>, <U>however</U>, that at the option of the Issuer payment of interest may be made by
check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Unless the certificate of authentication
hereon has been executed by the Trustee by manual signature of an authorized signatory, this Security shall not be entitled to
any benefit under the Indenture or be valid or obligatory for any purpose.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 22 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">IN WITNESS WHEREOF, the Issuer has caused
this instrument to be duly executed manually or in facsimile.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated: August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">ASTRAZENECA PLC</FONT></TD></TR>
</TABLE><BR STYLE="clear: both">


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>


<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 14%; padding-left: 0pt; text-indent: 0pt">By:</TD>
    <TD STYLE="width: 86%; border-bottom: Black 1pt solid; padding-left: 0pt; text-indent: 0pt">/s/ Marc Dunoyer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">Name:&#9;Marc Dunoyer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">Title:&#9;Chief Financial Officer</TD></TR>
</TABLE><BR STYLE="clear: both">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 14%; padding-left: 0pt; text-indent: 0pt">By:</TD>
    <TD STYLE="width: 86%; border-bottom: Black 1pt solid; padding-left: 0pt; text-indent: 0pt">/s/ Adrian Kemp</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">Name: Adrian Kemp</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; text-indent: 0pt">Title:&#9;Company Secretary</TD></TR>
</TABLE><BR STYLE="clear: both">

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt"><I>[Signature page to Global Note]</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>
<!-- Field: Page; Sequence: 23 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This is one of the Securities of the series
designated herein and referred to in the within-mentioned Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated: August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0.25in; text-indent: -0.25in"><FONT STYLE="font-size: 10pt; text-transform: uppercase">The Bank of New York</FONT> <FONT STYLE="font-size: 10pt">MELLON</FONT><BR>
<FONT STYLE="font-size: 10pt"><I>As Trustee</I></FONT></TD></TR>
</TABLE><BR STYLE="clear: both">


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>



<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid">L. O&rsquo;Brien</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="width: 14%">&nbsp;</TD>
    <TD STYLE="width: 85%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0"></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt"><I>[Signature page to Global Note]</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">&nbsp;</P>


<!-- Field: Page; Sequence: 24 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">This Security is one of a duly authorized
issue of securities of the Issuer (herein called the &ldquo;Securities&rdquo;), issued and to be issued in one or more series under
an Indenture, dated as of April 1, 2004 (herein called the &ldquo;Indenture&rdquo; which term shall have the meaning assigned to
it in such instrument), among the Issuer and The Bank of New York Mellon (formerly known as The Bank of New York), as successor
Trustee (herein called the &ldquo;Trustee&rdquo;, which term includes any other successor trustee under the Indenture) to JPMorgan
Chase Bank, and reference is hereby made to the Indenture and to the Officers&rsquo; Certificate delivered pursuant to Section
2.08 of the Indenture with respect to this security for a statement of the respective rights, limitations of rights, duties and
immunities thereunder of the Issuer, the Trustee and the Holders of the Securities and of the terms upon which the Securities are,
and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited
in aggregate principal amount to U.S.$850,000,000.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Securities of this series are subject
to redemption, as a whole or in part, from time to time, at the election of the Issuer, upon not less than 15 nor more than 30
days&rsquo; notice, as follows: (i) prior to July 17, 2023 (the &ldquo;Par Call Date&rdquo;), at a Redemption Price equal to the
greater of (A) 100% of the principal amount of the Securities to be redeemed, and (B) as determined by the Quotation Agent (as
defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (assuming for
this purpose that such series of Notes matured on the Par Call Date and not including any portion of such payments of interest
accrued as of the date of redemption) discounted to the date of redemption on a semiannual basis (assuming a 360-day year consisting
of twelve 30-day months) at the Treasury Rate plus 15 basis points, and (ii) on or after the Par Call Date, at a redemption price
equal to 100% of the principal amount of the Securities to be redeemed; plus, in each of cases (A) and (B) above, accrued interest
thereon to but excluding the date of redemption.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Business Day&rdquo; means any day which is not, in
London, England or New York, New York, or the place of payment of amounts payable in respect of the Securities, a Saturday, a Sunday,
a legal holiday or a day on which banking institutions are authorized or obligated by law, regulation or executive order to close.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Comparable Treasury Issue&rdquo; means the United
States Treasury security selected by the Quotation Agent as having a maturity comparable to the remaining term of the Securities
to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing
new issues of corporate debt securities of comparable maturity to the remaining term of such Securities (assuming for this purpose
that such Securities matured on the Par Call Date).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Comparable Treasury Price&rdquo; means, with respect
to any redemption date, (i) the average, as determined by the Quotation Agent, of the Reference Treasury Dealer Quotations for
such redemption date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, or (ii) if the Quotation
Agent obtains fewer than three such Reference Treasury Dealer Quotations, the average of all such Quotations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Quotation Agent&rdquo; means the Reference Treasury
Dealer appointed by the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 25 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Reference Treasury Dealer&rdquo; means (i) Citigroup
Global Markets Inc., Deutsche Bank Securities Inc., Goldman Sachs &amp; Co. LLC and J.P. Morgan Securities LLC, and their respective
successors; <I>provided, however</I>, that if the foregoing shall cease to be a primary U.S. Government securities dealer in New
York City (a &ldquo;Primary Treasury Dealer&rdquo;), the Issuer shall substitute therefor another Primary Treasury Dealer; and
(ii) any other Primary Treasury Dealer selected by the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Reference Treasury Dealer Quotations&rdquo; means,
with respect to each Reference Treasury Dealer and any redemption date, the average, as determined by the Quotation Agent, of the
bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted
in writing to the Trustee by such Reference Treasury Dealer at 5:00 p.m., New York City time, on the third Business Day preceding
such redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Treasury Rate&rdquo; means, with respect to any redemption
date, the rate per annum equal to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price
for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for
such redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture contains provisions to the
effect that, in the event of various tax law changes and other limited circumstances that require the Issuer to pay Additional
Amounts (as defined below), the Issuer may redeem the Securities of a series, in whole but not in part, at a price equal to 100%
of the principal amount of the Securities plus accrued interest thereon to but excluding the date of redemption, which provisions
apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">In the event of redemption of this Security
in part only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in
the name of the Holder hereof upon the cancellation hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture contains provisions for defeasance
at any time of the entire indebtedness on this Security upon compliance by the Issuer with certain conditions set forth thereon,
which provisions apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">Any amounts to be paid by the Issuer under
this Security of principal, premium and interest in respect of this Security will be paid without deduction or withholding for,
any and all present and future taxes, levies, duties, assessments, imposts or other governmental charges of whatever nature imposed,
assessed, levied or collected by or for the account of the government of any jurisdiction in which the Issuer is resident for tax
purposes or any political subdivision or taxing authority of such jurisdiction, unless such withholding or deduction is required
by law. If such deduction or withholding is at any time required, the Issuer will (subject to compliance by the Holder of this
Security with any relevant administrative requirements) pay such additional</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 26 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">amounts (&ldquo;Additional Amounts&rdquo;)
as will result in the receipt of such amounts as would have been received by the Holder had no such withholding or deduction been
required, provided that the Issuer will not have to pay Additional Amounts if:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(i)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for the Holder&rsquo;s
(or certain related parties&rsquo;) connection to the jurisdiction in which the Issuer is resident for tax purposes, other than
by merely holding this Security or by receiving principal, premium, if any, or interest, if any, on this Security, or enforcing
this Security. These connections include where the Holder or related party:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been a domiciliary, national or resident of such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been engaged in a trade or business in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>has or had a permanent establishment in such jurisdiction; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been physically present in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(ii)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for presentation
of this Security for payment, if presentation is required, more than 30 days after this Security became due or payment was provided
for;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iii)&nbsp;&nbsp;the tax, levy, impost or other governmental charge is an estate, inheritance, gift, sale, transfer, personal property or similar
tax, levy, impost or other governmental charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iv)&nbsp;&nbsp;the tax, levy, impost or other governmental charge is payable in a manner that does not involve deduction or withholding from payments
on or in respect of this Security;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(v)&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed or withheld but for the failure of the Holder or beneficial
owner, upon a reasonable request, addressed to the Holder, to comply with any certification, identification or other reporting
requirement concerning the Holder&rsquo;s or the beneficial owner&rsquo;s nationality, residence, identity or connection with any
jurisdiction in which the Issuer is resident for tax purposes, if compliance is required by any treaty, statute, regulation or
administrative practice of such jurisdiction as a condition to relief or exemption from such tax, levy, impost or other governmental
charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vi)&nbsp;&nbsp;the tax, levy, impost or other governmental charge is required by Sections 1471 through 1474 of the Internal Revenue Code of 1986,
as amended (&ldquo;FATCA&rdquo;), any current or future U.S. Treasury Regulations or rulings promulgated thereunder, any intergovernmental
agreement between the United States and any other jurisdiction to implement FATCA (an &ldquo;IGA&rdquo;), any law, regulation or
other official guidance enacted in any jurisdiction implementing FATCA or an IGA, or any agreement with the U.S. Internal Revenue
Service under or with respect to FATCA; or</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vii) any combination of the taxes referred
to in (i) through (vi) above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, no payments of Additional
Amounts will be made with respect to any payment on this Security if the Holder of this Security is a fiduciary, partnership or
a person other than the sole beneficial owner of any payment, and, by the laws of the jurisdiction in which the Issuer is resident
for tax purposes, that payment would be required for tax purposes to be included in</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 27 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">income of a beneficiary or settlor with
respect to the fiduciary, a member of that partnership or a beneficial owner who would not have been entitled to the Additional
Amounts had that beneficiary, settlor, partner or member owner been the Holder of this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Issuer will remit the full amount of
any taxes withheld to the applicable taxing authorities in accordance with the applicable law. The Issuer will also provide the
Trustee with documentation reasonably satisfactory to the Trustee evidencing the payment of any taxes in respect of which the Issuer
has paid Additional Amounts. The Issuer will provide copies of such documentation to the Holder of this Security upon request.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any reference in the Indenture or this
Security to principal, premium or interest in respect of this Security will be deemed also to refer to any Additional Amounts that
may be payable with respect to such principal, premium or interest under the obligations referred to herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Issuer and the rights of the
Holders of the Securities of each series to be affected under the Indenture at any time by the Issuer and the Trustee with the
consent of the Holders of a majority in principal amount of the Securities at the time Outstanding of each series to be affected.
The Indenture also contains provisions permitting the Holders of specified percentages in principle amount of the Securities of
each series at the time Outstanding, on behalf of the Holders of all Securities of such series to waive compliance by the Issuer
with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent
or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security
and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation
of such consent or waiver is made upon this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As set forth in, and subject to, the provisions
of the Indenture, no Holder of any Security of this series will have any right to institute any proceeding with respect to the
Indenture, this Security or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice
of a continuing Event of Default with respect to the Securities of this series, the Holders of not less than 25% in principal amount
of the Outstanding Securities of this series shall have made written request, and offered reasonable indemnity, to the Trustee
to institute such proceeding as trustee, and the Trustee shall not have received from the Holders of a majority in principal of
the Outstanding Securities of this series a direction inconsistent with such request and shall have failed to institute such proceeding
within 60 days; <U>provided</U>, <U>however</U>, that such limitations do not apply to a suit instituted by the Holder hereof for
the enforcement of payment of the principal (and premium, if any) or any interest on this Security on or after the respective due
dates expressed herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No reference herein to the Indenture and
no provision of this Security or of the Indenture shall alter or impair the obligation of the Issuer, which is absolute and unconditional,
to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency,
herein prescribed or to convert this Security as provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000 in excess thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 28 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No service charge shall be made for any
such registration of transfer or exchange, but the Issuer or the Trustee may require payment of a sum sufficient to cover any tax
or other governmental charge payable in connection therewith.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Prior to due presentation of this Security
for registration of transfer, the Issuer, the Trustee and any agent of the Issuer or the Trustee may treat the Person in whose
name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither of
the Issuer nor the Trustee nor any such agent shall be affected by notice to the contrary.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>This Security shall be governed by and
construed in accordance with the laws of the State of New York.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Unless otherwise defined herein, all terms
used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 29 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE OF PRINCIPAL AMOUNT</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The initial principal amount of this Security
shall be $350,000,000. The following decreases/increases in the principal amount of this Security have been made:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 26%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Date
        of Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Decrease
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Increase
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 22%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Total
        Principal Amount Following such Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 18%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Notation
        Made by or on Behalf of Trustee</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 30 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Exhibit B</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>


<!-- Field: Page; Sequence: 31 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>THIS SECURITY IS A GLOBAL REGISTERED SECURITY WITHIN THE
MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY
MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE
REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED
IN THE INDENTURE.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ASTRAZENECA PLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Floating Rate Notes due 2023</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 79%; font-size: 10pt; text-align: left">No. 001&nbsp;&nbsp;</TD>
    <TD STYLE="width: 21%; font-size: 10pt; text-align: right">$400,000,000 </TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">CUSIP No. 046353AS7</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">ISIN No. US046353AS79</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">ASTRAZENECA PLC, a public limited company
incorporated under the laws of England and Wales (herein called the &ldquo;Issuer&rdquo;, which term includes any successor Person
under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &amp; Co., or registered assigns,
the principal sum of Four Hundred Million Dollars on August 17, 2023 and to pay interest thereon from August 17, 2018 or from the
most recent Interest Payment Date (as defined below) to which interest has been paid or duly provided for, quarterly in arrears
on February 17, May 17, August 17 and November 17 in each year, commencing November 17, 2018 (each, an &ldquo;Interest Payment
Date&rdquo;), at the rate per annum determined in accordance with the provisions set forth on the reverse side hereof, until the
principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided for, on any
Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on the Regular Record Date (as defined below) for such interest which shall
be the 15<SUP>th</SUP> calendar day preceding such Interest Payment Date (whether or not such day is a Business Day (as defined
below)), as the case may be. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to
the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on a subsequent record date (the &ldquo;Special Record Date&rdquo;) for the
payment of such defaulted interest to be fixed by the Trustee (which shall not be less than five Business Days prior to the date
of payment of such defaulted interest), notice whereof shall be given to Holders of Securities of this series not less than 15
days prior to such Special Record Date, or</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 32 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">be paid at any time in any other lawful
manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed,
and upon such notice as may be required by such exchange, all as more fully provided in said Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Issuer maintained for that purpose in
New York City, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts; <U>provided</U>, <U>however</U>, that at the option of the Issuer payment of interest may be made by
check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Unless the certificate of authentication
hereon has been executed by the Trustee by manual signature of an authorized signatory, this Security shall not be entitled to
any benefit under the Indenture or be valid or obligatory for any purpose.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 33 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">IN WITNESS WHEREOF, the Issuer has caused
this instrument to be duly executed manually or in facsimile.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated: August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">ASTRAZENECA PLC</FONT></TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
</TABLE><BR STYLE="clear: both">


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: top; width: 16%; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">By:</TD>
    <TD STYLE="vertical-align: top; width: 83%; border-bottom: Black 1pt solid; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">/s/ Marc Dunoyer</TD>
    <TD STYLE="width: 1%; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">Name:&#9;Marc Dunoyer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">Title:&#9;Chief Financial Officer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>


<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: top; width: 16%; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">By:</TD>
    <TD STYLE="vertical-align: top; width: 83%; border-bottom: Black 1pt solid; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">/s/ Adrian Kemp</TD>
    <TD STYLE="width: 1%; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">Name:&#9;Adrian Kemp</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">Title:&#9;Company Secretary</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">&nbsp;</TD></TR>
</TABLE><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center"><I>[Signature page to Floating Rate Global Note]</I></P>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>

<!-- Field: Page; Sequence: 34 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This is one of the Securities of the series
designated herein and referred to in the within-mentioned Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated:&#9;August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; width: 3%; padding-left: 0.25in; text-indent: -0.25in"><FONT STYLE="font-size: 10pt; text-transform: uppercase">The Bank of New York</FONT> <FONT STYLE="font-size: 10pt">MELLON</FONT><BR>
<FONT STYLE="font-size: 10pt"><I>As Trustee</I></FONT></TD></TR>
</TABLE><BR STYLE="clear: both">


<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>




<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid">L. O&rsquo;Brien</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="width: 14%">&nbsp;</TD>
    <TD STYLE="width: 85%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>


<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center"><I>[Signature page to Floating Rate Global Note]</I></P>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P>
<!-- Field: Page; Sequence: 35 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">This Security is one of a duly authorized
issue of securities of the Issuer (herein called the &ldquo;Securities&rdquo;), issued and to be issued in one or more series under
an Indenture, dated as of April 1, 2004 (herein called the &ldquo;Indenture&rdquo; which term shall have the meaning assigned to
it in such instrument), among the Issuer and The Bank of New York Mellon (formerly known as The Bank of New York), as successor
Trustee (herein called the &ldquo;Trustee&rdquo;, which term includes any other successor trustee under the Indenture) to JPMorgan
Chase Bank, and reference is hereby made to the Indenture and to the Officers&rsquo; Certificate delivered pursuant to Section
2.08 of the Indenture with respect to this security for a statement of the respective rights, limitations of rights, duties and
immunities thereunder of the Issuer, the Trustee and the Holders of the Securities and of the terms upon which the Securities are,
and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited
in aggregate principal amount to U.S.$400,000,000.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">Interest on the Securities is payable quarterly
in arrears on February 17, May 17, August 17 and November 17 of each year, commencing November 17, 2018. However, if an Interest
Payment Date would fall on a day that is not a Business Day, the Interest Payment Date will be postponed to the next succeeding
day that is a Business Day, except that if the Business Day falls in the next succeeding calendar month, the applicable Interest
Payment Date will be the immediately preceding Business Day. In each such case, except for the Interest Payment Date falling on
the maturity date, the Interest Periods (as defined below) and the Interest Reset Dates will be adjusted accordingly to calculate
the amount of interest payable on the Securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">&ldquo;Business Day&rdquo; means any day
which is not, in London, England or New York, New York, or the place of payment of amounts payable in respect of the Securities,
a Saturday, a Sunday, a legal holiday or a day on which banking institutions are authorized or obligated by law, regulation or
executive order to close.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">A &ldquo;London Business Day&rdquo; means
a day on which dealings in deposits in U.S. dollars are transacted in the London interbank market.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The interest rate for the Securities for
the first Interest Period (as defined below) will be LIBOR (as defined below) as determined on August 15, 2018 plus the Spread.
Thereafter, the interest rate for each Interest Period other than the first Interest Period will be LIBOR as determined on the
applicable Interest Determination Date (as defined below) plus the Spread, in each case calculated on the basis of a 360-day year
and the actual number of days elapsed. The Spread is 66.5 basis points.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The interest rate will be reset on February
17, May 17, August 17 and November 17 of each year, commencing November 17, 2018 (each, an &ldquo;Interest Reset Date&rdquo;).
However, if any Interest Reset Date would otherwise be a day that is not a Business Day, that Interest Reset Date will be postponed
to the next succeeding day that is a Business Day, except that if the Business Day falls in the next succeeding calendar month,
the applicable Interest Reset Date will be the immediately preceding Business Day.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The first interest period will be the period
from and including the original issue date to but excluding the immediately succeeding Interest Reset Date. Thereafter, the interest
periods will be the periods from and including an Interest Reset Date to but excluding the immediately succeeding Interest Reset
Date (together with the first interest period, each an &ldquo;Interest Period&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 36 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">However, the final Interest Period will be the period from and
including the Interest Reset Date immediately preceding the maturity date to the maturity date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Bank of New York Mellon, or its successor
appointed by the Issuer, will act as calculation agent (the &ldquo;Calculation Agent&rdquo;). The Calculation Agent in respect
of this Security, will determine LIBOR (as defined below) for each Interest Period on the second London Business Day prior to the
first day of such Interest Period (an &ldquo;Interest Determination Date&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">&ldquo;LIBOR&rdquo; means, with respect
to any Interest Determination Date, the offered rate for deposits of U.S. dollars having a maturity of three months that appears
on the Bloomberg Screen BBAL display page, or any successor page, on Bloomberg or any successor service (or any such other service(s)
as may be nominated by ICE Benchmark Administration Limited (&ldquo;IBA&rdquo;) or its successor or such other entity assuming
the responsibility of IBA or its successor in calculating the London Interbank Offered Rate in the event IBA or its successor no
longer does so) (the &ldquo;Designated LIBOR Page&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">If no rate appears on the Designated LIBOR
Page, LIBOR will be determined for such Interest Determination Date on the basis of the rates at approximately 11:00 a.m., London
time, on such Interest Determination Date at which deposits in U.S. dollars are offered to prime banks in the London inter-bank
market by four major banks in such market selected by the Calculation Agent, after consultation with the Issuer, for a term of
three months and in a principal amount equal to an amount that in the judgment of the Calculation Agent is representative for a
single transaction in U.S. dollars in such market at such time (a &ldquo;Representative Amount&rdquo;). The Calculation Agent will
request the principal London office of each of such banks to provide a quotation of its rate. If at least two such quotations are
provided, LIBOR for such Interest Period will be the arithmetic mean (rounded, if necessary, to the nearest one-hundred-thousandth
of a percentage point, with five-millionths of a percentage point rounded upwards) of such quotations. If fewer than two such quotations
are provided, LIBOR for such Interest Period will be the arithmetic mean (rounded, if necessary, to the nearest one-hundred-thousandth
of a percentage point, with five millionths of a percentage point rounded upwards) of the rates quoted at approximately 11:00 a.m.
in the City of New York on such Interest Determination Date by three major banks in New York City, selected by the Calculation
Agent, after consultation with the Issuer, for loans in U.S. dollars to leading European banks, for a term of three months and
in a Representative Amount; provided, however, that if the banks so selected are not quoting as mentioned above, LIBOR on the Interest
Determination Date will be LIBOR in effect with respect to the immediately preceding Interest Determination Date, or in the case
of the initial Interest Determination Date, the first Interest Rate.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">Notwithstanding the above, if the Issuer
determines on or prior to the relevant Interest Determination Date, after consultation with an independent financial advisor selected
by the Issuer in its sole discretion, that LIBOR has ceased to be calculated or administered or is no longer viewed as an acceptable
benchmark rate in accordance with accepted market practice for debt obligations such as the Securities, then the Issuer will appoint
in its sole discretion an independent financial advisor (the &ldquo;IFA&rdquo;) to determine whether there is a substitute or successor
base rate to LIBOR that is consistent with accepted market practice for debt obligations such as the Securities (the &ldquo;Alternative
Rate&rdquo;). If the IFA determines that there is an Alternative Rate, for each future Interest Determination Date, the Calculation
Agent shall use such Alternative Rate as a substitute for LIBOR in calculating the interest rate on the Securities. As part of
such</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 37 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">substitution, the Calculation Agent will
make such adjustments to the Alternative Rate or the Spread thereon, as well as the business day convention, Interest Determination
Dates, Interest Reset Dates and related provisions and definitions (&ldquo;Adjustments&rdquo;), in each case that are consistent
with accepted market practice for the use of such Alternative Rate, all as determined and directed by the IFA; provided, however,
that the Calculation Agent shall not be required to implement any such Adjustments that affects its own rights, duties or immunities
under the Indenture, the Calculation Agency Agreement or otherwise. If the IFA determines that there is no such Alternative Rate
as provided above, LIBOR will be equal to the rate of interest in effect with respect to the immediately preceding Interest Determination
Date or, in the case of the initial Interest Determination Date, the rate of interest will be equal to the first Interest Rate.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The interest rate on the Securities will
in no event be higher than the maximum rate permitted by law.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture contains provisions to the
effect that, in the event of various tax law changes and other limited circumstances that require the Issuer to pay Additional
Amounts (as defined below), the Issuer may redeem the Securities of a series, in whole but not in part, at a price equal to 100%
of the principal amount of the Securities plus accrued interest thereon to but excluding the date of redemption, which provisions
apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">Subject to the immediately preceding paragraph,
the Securities are not subject to redemption.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture contains provisions for defeasance
at any time of the entire indebtedness on this Security upon compliance by the Issuer with certain conditions set forth thereon,
which provisions apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Any amounts to be paid by the Issuer under
this Security of principal, premium and interest in respect of this Security will be paid without deduction or withholding for,
any and all present and future taxes, levies, duties, assessments, imposts or other governmental charges of whatever nature imposed,
assessed, levied or collected by or for the account of the government of any jurisdiction in which the Issuer is resident for tax
purposes or any political subdivision or taxing authority of such jurisdiction, unless such withholding or deduction is required
by law. If such deduction or withholding is at any time required, the Issuer will (subject to compliance by the Holder of this
Security with any relevant administrative requirements) pay such additional amounts (&ldquo;Additional Amounts&rdquo;) as will
result in the receipt of such amounts as would have been received by the Holder had no such withholding or deduction been required,
provided that the Issuer will not have to pay Additional Amounts if:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(i)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for the Holder&rsquo;s
(or certain related parties&rsquo;) connection to the jurisdiction in which the Issuer is resident for tax purposes, other than
by merely holding this Security or by receiving principal, premium, if any, or interest, if any, on this Security, or enforcing
this Security. These connections include where the Holder or related party:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 38 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been a domiciliary, national or resident of such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been engaged in a trade or business in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>has or had a permanent establishment in such jurisdiction; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been physically present in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(ii)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for presentation
of this Security for payment, if presentation is required, more than 30 days after this Security became due or payment was provided
for;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iii)&nbsp;&nbsp;the tax, levy, impost or other governmental charge is an estate, inheritance, gift, sale, transfer, personal property or similar
tax, levy, impost or other governmental charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iv)&nbsp;&nbsp;the tax, levy, impost or other governmental charge is payable in a manner that does not involve deduction or withholding from payments
on or in respect of this Security;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(v)&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed or withheld but for the failure of the Holder or beneficial
owner, upon a reasonable request, addressed to the Holder, to comply with any certification, identification or other reporting
requirement concerning the Holder&rsquo;s or the beneficial owner&rsquo;s nationality, residence, identity or connection with any
jurisdiction in which the Issuer is resident for tax purposes, if compliance is required by any treaty, statute, regulation or
administrative practice of such jurisdiction as a condition to relief or exemption from such tax, levy, impost or other governmental
charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vi)&nbsp;
the tax, levy, impost or other governmental charge is required by Sections 1471 through 1474 of the Internal Revenue Code of 1986,
as amended (&ldquo;FATCA&rdquo;), any current or future U.S. Treasury Regulations or rulings promulgated thereunder, any intergovernmental
agreement between the United States and any other jurisdiction to implement FATCA (an &ldquo;IGA&rdquo;), any law, regulation or
other official guidance enacted in any jurisdiction implementing FATCA or an IGA, or any agreement with the U.S. Internal Revenue
Service under or with respect to FATCA; or</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vii) any combination of the taxes referred
to in (i) through (vi) above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In addition, no payments of Additional Amounts
will be made with respect to any payment on this Security if the Holder of this Security is a fiduciary, partnership or a person
other than the sole beneficial owner of any payment, and, by the laws of the jurisdiction in which the Issuer is resident for tax
purposes, that payment would be required for tax purposes to be included in income of a beneficiary or settlor with respect to
the fiduciary, a member of that partnership or a beneficial owner who would not have been entitled to the Additional Amounts had
that beneficiary, settlor, partner or member owner been the Holder of this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Issuer will remit the full amount of
any taxes withheld to the applicable taxing authorities in accordance with the applicable law. The Issuer will also provide the
Trustee with documentation reasonably satisfactory to the Trustee evidencing the payment of any taxes in respect of which the Issuer
has paid Additional Amounts. The Issuer will provide copies of such documentation to the Holder of this Security upon request.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 39 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Any reference in the Indenture or this Security
to principal, premium or interest in respect of this Security will be deemed also to refer to any Additional Amounts that may be
payable with respect to such principal, premium or interest under the obligations referred to herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Issuer and the rights of the
Holders of the Securities of each series to be affected under the Indenture at any time by the Issuer and the Trustee with the
consent of the Holders of a majority in principal amount of the Securities at the time Outstanding of each series to be affected.
The Indenture also contains provisions permitting the Holders of specified percentages in principle amount of the Securities of
each series at the time Outstanding, on behalf of the Holders of all Securities of such series to waive compliance by the Issuer
with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent
or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security
and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation
of such consent or waiver is made upon this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">As set forth in, and subject to, the provisions
of the Indenture, no Holder of any Security of this series will have any right to institute any proceeding with respect to the
Indenture, this Security or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice
of a continuing Event of Default with respect to the Securities of this series, the Holders of not less than 25% in principal amount
of the Outstanding Securities of this series shall have made written request, and offered reasonable indemnity, to the Trustee
to institute such proceeding as trustee, and the Trustee shall not have received from the Holders of a majority in principal of
the Outstanding Securities of this series a direction inconsistent with such request and shall have failed to institute such proceeding
within 60 days; <U>provided</U>, <U>however</U>, that such limitations do not apply to a suit instituted by the Holder hereof for
the enforcement of payment of the principal (and premium, if any) or any interest on this Security on or after the respective due
dates expressed herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No reference herein to the Indenture and
no provision of this Security or of the Indenture shall alter or impair the obligation of the Issuer, which is absolute and unconditional,
to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency,
herein prescribed or to convert this Security as provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000 in excess thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No service charge shall be made for any
such registration of transfer or exchange, but the Issuer or the Trustee may require payment of a sum sufficient to cover any tax
or other governmental charge payable in connection therewith.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Prior to due presentation of this Security
for registration of transfer, the Issuer, the Trustee and any agent of the Issuer or the Trustee may treat the Person in whose
name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither of
the Issuer nor the Trustee nor any such agent shall be affected by notice to the contrary.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 40 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>This Security shall be governed by and
construed in accordance with the laws of the State of New York.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Unless otherwise defined herein, all terms
used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 41 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE OF PRINCIPAL AMOUNT</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The initial principal amount of this Security
shall be $400,000,000. The following decreases/increases in the principal amount of this Security have been made:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 26%; padding-right: 2pt; padding-left: 2pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Date
        of Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Decrease
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Increase
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 22%; padding-right: 2pt; padding-left: 2pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Total
        Principal Amount Following such Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 18%; padding-right: 2pt; padding-left: 2pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Notation
        Made by or on Behalf of Trustee</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 42 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Exhibit C</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>


<!-- Field: Page; Sequence: 43 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>THIS SECURITY IS A GLOBAL REGISTERED SECURITY WITHIN THE
MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY
MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE
REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED
IN THE INDENTURE.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ASTRAZENECA PLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">4.000% Notes due 2029</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 79%; font-size: 10pt; text-align: left">No. 001</TD>
    <TD STYLE="width: 21%; font-size: 10pt; text-align: right">$500,000,000</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">CUSIP No. 046353AT5</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">ISIN No. US046353AT52</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">ASTRAZENECA PLC, a public limited company
incorporated under the laws of England and Wales (herein called the &ldquo;Issuer&rdquo;, which term includes any successor Person
under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &amp; Co., or registered assigns,
the principal sum of Five Hundred Million Dollars on January 17, 2029 and to pay interest thereon from August 17, 2018 or from
the most recent Interest Payment Date (as defined below) to which interest has been paid or duly provided for, semiannually in
arrears on January 17 and July 17 in each year, commencing January 17, 2019 (each, an &ldquo;Interest Payment Date&rdquo;), at
the rate of 4.000% per annum, until the principal hereof is paid or made available for payment. The interest so payable, and punctually
paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name
this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date (as defined
below) for such interest which shall be the 15<SUP>th</SUP> calendar day preceding such Interest Payment Date (whether or not such
day is a Business Day (as defined below)), as the case may be. Any such interest not so punctually paid or duly provided for will
forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this
Security (or one or more Predecessor Securities) is registered at the close of business on a subsequent record date (the &ldquo;Special
Record Date&rdquo;) for the payment of such defaulted interest to be fixed by the Trustee (which shall not be less than five Business
Days prior to the date of payment of such defaulted interest), notice whereof shall be given to Holders of Securities of this series
not less than 15 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with
the requirements of any securities exchange on which the Securities of this series may be listed, and upon such</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 44 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">notice as may be required by such exchange,
all as more fully provided in said Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Issuer maintained for that purpose in
New York City, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts; <U>provided</U>, <U>however</U>, that at the option of the Issuer payment of interest may be made by
check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Unless the certificate of authentication
hereon has been executed by the Trustee by manual signature of an authorized signatory, this Security shall not be entitled to
any benefit under the Indenture or be valid or obligatory for any purpose.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 45 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">IN WITNESS WHEREOF, the Issuer has caused
this instrument to be duly executed manually or in facsimile.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated: August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">ASTRAZENECA PLC</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 16%; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">By:</TD>
    <TD STYLE="width: 84%; border-bottom: Black 1pt solid; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">/s/ Marc Dunoyer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">Name:&#9;Marc Dunoyer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">Title:&#9;Chief Financial Officer</TD></TR>
</TABLE>
<BR STYLE="clear: both">

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 16%; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">By:</TD>
    <TD STYLE="width: 84%; border-bottom: Black 1pt solid; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">/s/ Adrian Kemp</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">Name:&#9;Adrian Kemp</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">Title:&#9;Company Secretary</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center"><I>[Signature Page to Global Note]</I></P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<!-- Field: Page; Sequence: 46 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This is one of the Securities of the series
designated herein and referred to in the within-mentioned Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated:&#9;August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0.25in; text-indent: -0.25in"><FONT STYLE="font-size: 10pt; text-transform: uppercase">The Bank of New York</FONT> <FONT STYLE="font-size: 10pt">MELLON</FONT><BR>
<FONT STYLE="font-size: 10pt"><I>As Trustee</I></FONT></TD></TR>
</TABLE><BR STYLE="clear: both">


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt; width: 16%">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; padding-left: 0pt; text-indent: 0pt; width: 84%">L. O'Brien</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P><P STYLE="margin-top: 0; margin-bottom: 0; text-align: center"><I>[Signature Page to Global Note]</I></P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>



<!-- Field: Page; Sequence: 47 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">This Security is one of a duly authorized
issue of securities of the Issuer (herein called the &ldquo;Securities&rdquo;), issued and to be issued in one or more series under
an Indenture, dated as of April 1, 2004 (herein called the &ldquo;Indenture&rdquo; which term shall have the meaning assigned to
it in such instrument), among the Issuer and The Bank of New York Mellon (formerly known as The Bank of New York), as successor
Trustee (herein called the &ldquo;Trustee&rdquo;, which term includes any other successor trustee under the Indenture) to JPMorgan
Chase Bank, and reference is hereby made to the Indenture and to the Officers&rsquo; Certificate delivered pursuant to Section
2.08 of the Indenture with respect to this security for a statement of the respective rights, limitations of rights, duties and
immunities thereunder of the Issuer, the Trustee and the Holders of the Securities and of the terms upon which the Securities are,
and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited
in aggregate principal amount to U.S.$1,000,000,000.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Securities of this series are subject
to redemption, as a whole or in part, from time to time, at the election of the Issuer, upon not less than 15 nor more than 30
days&rsquo; notice, as follows: (i) prior to October 17, 2028 (the &ldquo;Par Call Date&rdquo;), at a Redemption Price equal to
the greater of (A) 100% of the principal amount of the Securities to be redeemed, and (B) as determined by the Quotation Agent
(as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (assuming
for this purpose that such series of Notes matured on the Par Call Date and not including any portion of such payments of interest
accrued as of the date of redemption) discounted to the date of redemption on a semiannual basis (assuming a 360-day year consisting
of twelve 30-day months) at the Treasury Rate plus 20 basis points, and (ii) on or after the Par Call Date, at a redemption price
equal to 100% of the principal amount of the Securities to be redeemed; plus, in each of cases (A) and (B) above, accrued interest
thereon to but excluding the date of redemption.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Business Day&rdquo; means any day which is not, in
London, England or New York, New York, or the place of payment of amounts payable in respect of the Securities, a Saturday, a Sunday,
a legal holiday or a day on which banking institutions are authorized or obligated by law, regulation or executive order to close.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Comparable Treasury Issue&rdquo; means the United
States Treasury security selected by the Quotation Agent as having a maturity comparable to the remaining term of the Securities
to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing
new issues of corporate debt securities of comparable maturity to the remaining term of such Securities (assuming for this purpose
that such Securities matured on the Par Call Date).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 48 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Comparable Treasury Price&rdquo; means, with respect
to any redemption date, (i) the average, as determined by the Quotation Agent, of the Reference Treasury Dealer Quotations for
such redemption date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, or (ii) if the Quotation
Agent obtains fewer than three such Reference Treasury Dealer Quotations, the average of all such Quotations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Quotation Agent&rdquo; means the Reference Treasury
Dealer appointed by the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Reference Treasury Dealer&rdquo; means (i) Citigroup
Global Markets Inc., Deutsche Bank Securities Inc., Goldman Sachs &amp; Co. LLC and J.P. Morgan Securities LLC, and their respective
successors; <I>provided, however</I>, that if the foregoing shall cease to be a primary U.S. Government securities dealer in New
York City (a &ldquo;Primary Treasury Dealer&rdquo;), the Issuer shall substitute therefor another Primary Treasury Dealer; and
(ii) any other Primary Treasury Dealer selected by the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Reference Treasury Dealer Quotations&rdquo; means,
with respect to each Reference Treasury Dealer and any redemption date, the average, as determined by the Quotation Agent, of the
bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted
in writing to the Trustee by such Reference Treasury Dealer at 5:00 p.m., New York City time, on the third Business Day preceding
such redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Treasury Rate&rdquo; means, with respect to any redemption
date, the rate per annum equal to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price
for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for
such redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture contains provisions to the
effect that, in the event of various tax law changes and other limited circumstances that require the Issuer to pay Additional
Amounts (as defined below), the Issuer may redeem the Securities of a series, in whole but not in part, at a price equal to 100%
of the principal amount of the Securities plus accrued interest thereon to but excluding the date of redemption, which provisions
apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">In the event of redemption of this Security
in part only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in
the name of the Holder hereof upon the cancellation hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 49 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture contains provisions for defeasance
at any time of the entire indebtedness on this Security upon compliance by the Issuer with certain conditions set forth thereon,
which provisions apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any amounts to be paid by the Issuer under
this Security of principal, premium and interest in respect of this Security will be paid without deduction or withholding for,
any and all present and future taxes, levies, duties, assessments, imposts or other governmental charges of whatever nature imposed,
assessed, levied or collected by or for the account of the government of any jurisdiction in which the Issuer is resident for tax
purposes or any political subdivision or taxing authority of such jurisdiction, unless such withholding or deduction is required
by law. If such deduction or withholding is at any time required, the Issuer will (subject to compliance by the Holder of this
Security with any relevant administrative requirements) pay such additional amounts (&ldquo;Additional Amounts&rdquo;) as will
result in the receipt of such amounts as would have been received by the Holder had no such withholding or deduction been required,
provided that the Issuer will not have to pay Additional Amounts if:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(i)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for the Holder&rsquo;s
(or certain related parties&rsquo;) connection to the jurisdiction in which the Issuer is resident for tax purposes, other than
by merely holding this Security or by receiving principal, premium, if any, or interest, if any, on this Security, or enforcing
this Security. These connections include where the Holder or related party:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been a domiciliary, national or resident of such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been engaged in a trade or business in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>has or had a permanent establishment in such jurisdiction; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been physically present in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(ii)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for presentation
of this Security for payment, if presentation is required, more than 30 days after this Security became due or payment was provided
for;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iii) &nbsp;the tax, levy, impost or other governmental
charge is an estate, inheritance, gift, sale, transfer, personal property or similar tax, levy, impost or other governmental charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 50 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iv)&nbsp;&nbsp;the tax, levy, impost or other governmental charge is payable in a manner that does not involve deduction or withholding from payments
on or in respect of this Security;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(v)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed or withheld but for the failure of the Holder or beneficial
owner, upon a reasonable request, addressed to the Holder, to comply with any certification, identification or other reporting
requirement concerning the Holder&rsquo;s or the beneficial owner&rsquo;s nationality, residence, identity or connection with any
jurisdiction in which the Issuer is resident for tax purposes, if compliance is required by any treaty, statute, regulation or
administrative practice of such jurisdiction as a condition to relief or exemption from such tax, levy, impost or other governmental
charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vi)&nbsp;
the tax, levy, impost or other governmental charge is required by Sections 1471 through 1474 of the Internal Revenue Code of 1986,
as amended (&ldquo;FATCA&rdquo;), any current or future U.S. Treasury Regulations or rulings promulgated thereunder, any intergovernmental
agreement between the United States and any other jurisdiction to implement FATCA (an &ldquo;IGA&rdquo;), any law, regulation or
other official guidance enacted in any jurisdiction implementing FATCA or an IGA, or any agreement with the U.S. Internal Revenue
Service under or with respect to FATCA; or</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vii) any combination of the taxes referred
to in (i) through (vi) above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, no payments of Additional
Amounts will be made with respect to any payment on this Security if the Holder of this Security is a fiduciary, partnership or
a person other than the sole beneficial owner of any payment, and, by the laws of the jurisdiction in which the Issuer is resident
for tax purposes, that payment would be required for tax purposes to be included in income of a beneficiary or settlor with respect
to the fiduciary, a member of that partnership or a beneficial owner who would not have been entitled to the Additional Amounts
had that beneficiary, settlor, partner or member owner been the Holder of this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Issuer will remit the full amount of
any taxes withheld to the applicable taxing authorities in accordance with the applicable law. The Issuer will also provide the
Trustee with documentation reasonably satisfactory to the Trustee evidencing the payment of any taxes in respect of which the Issuer
has paid Additional Amounts. The Issuer will provide copies of such documentation to the Holder of this Security upon request.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any reference in the Indenture or this
Security to principal, premium or interest in respect of this Security will be deemed also to refer to any Additional Amounts that
may be payable with respect to such principal, premium or interest under the obligations referred to herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 51 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Issuer and the rights of the
Holders of the Securities of each series to be affected under the Indenture at any time by the Issuer and the Trustee with the
consent of the Holders of a majority in principal amount of the Securities at the time Outstanding of each series to be affected.
The Indenture also contains provisions permitting the Holders of specified percentages in principle amount of the Securities of
each series at the time Outstanding, on behalf of the Holders of all Securities of such series to waive compliance by the Issuer
with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent
or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security
and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation
of such consent or waiver is made upon this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As set forth in, and subject to, the provisions
of the Indenture, no Holder of any Security of this series will have any right to institute any proceeding with respect to the
Indenture, this Security or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice
of a continuing Event of Default with respect to the Securities of this series, the Holders of not less than 25% in principal amount
of the Outstanding Securities of this series shall have made written request, and offered reasonable indemnity, to the Trustee
to institute such proceeding as trustee, and the Trustee shall not have received from the Holders of a majority in principal of
the Outstanding Securities of this series a direction inconsistent with such request and shall have failed to institute such proceeding
within 60 days; <U>provided</U>, <U>however</U>, that such limitations do not apply to a suit instituted by the Holder hereof for
the enforcement of payment of the principal (and premium, if any) or any interest on this Security on or after the respective due
dates expressed herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No reference herein to the Indenture and
no provision of this Security or of the Indenture shall alter or impair the obligation of the Issuer, which is absolute and unconditional,
to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency,
herein prescribed or to convert this Security as provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000 in excess thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No service charge shall be made for any
such registration of transfer or exchange, but the Issuer or the Trustee may require payment of a sum sufficient to cover any tax
or other governmental charge payable in connection therewith.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 52 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Prior to due presentation of this Security
for registration of transfer, the Issuer, the Trustee and any agent of the Issuer or the Trustee may treat the Person in whose
name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither of
the Issuer nor the Trustee nor any such agent shall be affected by notice to the contrary.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>This Security shall be governed by and
construed in accordance with the laws of the State of New York.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Unless otherwise defined herein, all terms
used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 53 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE OF PRINCIPAL AMOUNT</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The initial principal amount of this Security
shall be $500,000,000. The following decreases/increases in the principal amount of this Security have been made:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 26%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Date
        of Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Decrease
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Increase
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 22%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Total
        Principal Amount Following such Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 18%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Notation
        Made by or on Behalf of Trustee</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 54 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>THIS SECURITY IS A GLOBAL REGISTERED SECURITY WITHIN THE
MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY
MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE
REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED
IN THE INDENTURE.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ASTRAZENECA PLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">4.000% Notes due 2029</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 79%; font-size: 10pt; text-align: left">No. 002</TD>
    <TD STYLE="width: 21%; font-size: 10pt; text-align: right">$500,000,000</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">CUSIP No. 046353AT5</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">ISIN No. US046353AT52</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">ASTRAZENECA PLC, a public limited company
incorporated under the laws of England and Wales (herein called the &ldquo;Issuer&rdquo;, which term includes any successor Person
under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &amp; Co., or registered assigns,
the principal sum of Five Hundred Million Dollars on January 17, 2029 and to pay interest thereon from August 17, 2018 or from
the most recent Interest Payment Date (as defined below) to which interest has been paid or duly provided for, semiannually in
arrears on January 17 and July 17 in each year, commencing January 17, 2019 (each, an &ldquo;Interest Payment Date&rdquo;), at
the rate of 4.000% per annum, until the principal hereof is paid or made available for payment. The interest so payable, and punctually
paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name
this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date (as defined
below) for such interest which shall be the 15<SUP>th</SUP> calendar day preceding such Interest Payment Date (whether or not such
day is a Business Day (as defined below)), as the case may be. Any such interest not so punctually paid or duly provided for will
forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this
Security (or one or more Predecessor Securities) is registered at the close of business on a subsequent record date (the &ldquo;Special
Record Date&rdquo;) for the payment of such defaulted interest to be fixed by the Trustee (which shall not be less than five Business
Days prior to the date of payment of such defaulted interest), notice whereof shall be given to Holders of Securities of this series
not less than 15 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with
the requirements of any securities exchange on which the Securities of this series may be listed, and upon such</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 55 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">notice as may be required by such exchange,
all as more fully provided in said Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Issuer maintained for that purpose in
New York City, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts; <U>provided</U>, <U>however</U>, that at the option of the Issuer payment of interest may be made by
check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Unless the certificate of authentication
hereon has been executed by the Trustee by manual signature of an authorized signatory, this Security shall not be entitled to
any benefit under the Indenture or be valid or obligatory for any purpose.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 56 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">IN WITNESS WHEREOF, the Issuer has caused
this instrument to be duly executed manually or in facsimile.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated:&#9;August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding-left: 0pt; font-size: 10pt; text-indent: 0pt">ASTRAZENECA PLC</TD>
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding-left: 0pt; font-size: 10pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 11%; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">By:</TD>
    <TD STYLE="vertical-align: top; width: 85%; border-bottom: Black 1pt solid; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">/s/ Marc Dunoyer</TD>
    <TD STYLE="width: 4%; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">Name:&#9;Marc Dunoyer</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-left: 0pt; font-size: 10pt; text-indent: 0pt">Title:&#9;Chief Financial Officer</TD>
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD></TR>
</TABLE><BR STYLE="clear: both">

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: top; width: 11%; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">By:</TD>
    <TD STYLE="vertical-align: top; width: 85%; border-bottom: Black 1pt solid; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">/s/ Adrian Kemp</TD>
    <TD STYLE="width: 4%; font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">Name:&#9;Adrian Kemp</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">Title:&#9;Company Secretary</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 0pt; font-size: 10pt; text-indent: 0pt">&nbsp;</TD></TR>
</TABLE>
<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center"><I>[Signature Page to Global Note]</I></P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<!-- Field: Page; Sequence: 57 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This is one of the Securities of the series
designated herein and referred to in the within-mentioned Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated: August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0.25in; text-indent: -0.25in"><FONT STYLE="font-size: 10pt; text-transform: uppercase">The Bank of New York</FONT> <FONT STYLE="font-size: 10pt">MELLON</FONT><BR>
<FONT STYLE="font-size: 10pt"><I>As Trustee</I></FONT></TD></TR>
</TABLE><BR STYLE="clear: both">
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: top; font-size: 10pt; width: 11%">By:</TD>
    <TD STYLE="vertical-align: top; border-bottom: Black 1pt solid; font-size: 10pt; width: 85%">L. O'Brien</TD>
    <TD STYLE="font-size: 10pt; width: 4%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>
<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center"><I>[Signature Page to Global Note]</I></P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


<!-- Field: Page; Sequence: 58 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">This Security is one of a duly authorized
issue of securities of the Issuer (herein called the &ldquo;Securities&rdquo;), issued and to be issued in one or more series under
an Indenture, dated as of April 1, 2004 (herein called the &ldquo;Indenture&rdquo; which term shall have the meaning assigned to
it in such instrument), among the Issuer and The Bank of New York Mellon (formerly known as The Bank of New York), as successor
Trustee (herein called the &ldquo;Trustee&rdquo;, which term includes any other successor trustee under the Indenture) to JPMorgan
Chase Bank, and reference is hereby made to the Indenture and to the Officers&rsquo; Certificate delivered pursuant to Section
2.08 of the Indenture with respect to this security for a statement of the respective rights, limitations of rights, duties and
immunities thereunder of the Issuer, the Trustee and the Holders of the Securities and of the terms upon which the Securities are,
and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited
in aggregate principal amount to U.S.$1,000,000,000.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Securities of this series are subject
to redemption, as a whole or in part, from time to time, at the election of the Issuer, upon not less than 15 nor more than 30
days&rsquo; notice, as follows: (i) prior to October 17, 2028 (the &ldquo;Par Call Date&rdquo;), at a Redemption Price equal to
the greater of (A) 100% of the principal amount of the Securities to be redeemed, and (B) as determined by the Quotation Agent
(as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (assuming
for this purpose that such series of Notes matured on the Par Call Date and not including any portion of such payments of interest
accrued as of the date of redemption) discounted to the date of redemption on a semiannual basis (assuming a 360-day year consisting
of twelve 30-day months) at the Treasury Rate plus 20 basis points, and (ii) on or after the Par Call Date, at a redemption price
equal to 100% of the principal amount of the Securities to be redeemed; plus, in each of cases (A) and (B) above, accrued interest
thereon to but excluding the date of redemption.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Business Day&rdquo; means any day which is not, in
London, England or New York, New York, or the place of payment of amounts payable in respect of the Securities, a Saturday, a Sunday,
a legal holiday or a day on which banking institutions are authorized or obligated by law, regulation or executive order to close.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Comparable Treasury Issue&rdquo; means the United
States Treasury security selected by the Quotation Agent as having a maturity comparable to the remaining term of the Securities
to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing
new issues of corporate debt securities of comparable maturity to the remaining term of such Securities (assuming for this purpose
that such Securities matured on the Par Call Date).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Comparable Treasury Price&rdquo; means, with respect
to any redemption date, (i) the average, as determined by the Quotation Agent, of the Reference Treasury Dealer Quotations for
such redemption date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, or (ii) if the Quotation
Agent obtains fewer than three such Reference Treasury Dealer Quotations, the average of all such Quotations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Quotation Agent&rdquo; means the Reference Treasury
Dealer appointed by the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 59 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Reference Treasury Dealer&rdquo; means (i) Citigroup
Global Markets Inc., Deutsche Bank Securities Inc., Goldman Sachs &amp; Co. LLC and J.P. Morgan Securities LLC, and their respective
successors; <I>provided, however</I>, that if the foregoing shall cease to be a primary U.S. Government securities dealer in New
York City (a &ldquo;Primary Treasury Dealer&rdquo;), the Issuer shall substitute therefor another Primary Treasury Dealer; and
(ii) any other Primary Treasury Dealer selected by the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Reference Treasury Dealer Quotations&rdquo; means,
with respect to each Reference Treasury Dealer and any redemption date, the average, as determined by the Quotation Agent, of the
bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted
in writing to the Trustee by such Reference Treasury Dealer at 5:00 p.m., New York City time, on the third Business Day preceding
such redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Treasury Rate&rdquo; means, with respect to any redemption
date, the rate per annum equal to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price
for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for
such redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture contains provisions to the
effect that, in the event of various tax law changes and other limited circumstances that require the Issuer to pay Additional
Amounts (as defined below), the Issuer may redeem the Securities of a series, in whole but not in part, at a price equal to 100%
of the principal amount of the Securities plus accrued interest thereon to but excluding the date of redemption, which provisions
apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">In the event of redemption of this Security
in part only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in
the name of the Holder hereof upon the cancellation hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture contains provisions for defeasance
at any time of the entire indebtedness on this Security upon compliance by the Issuer with certain conditions set forth thereon,
which provisions apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any amounts to be paid by the Issuer under
this Security of principal, premium and interest in respect of this Security will be paid without deduction or withholding for,
any and all present and future taxes, levies, duties, assessments, imposts or other governmental charges of whatever nature imposed,
assessed, levied or collected by or for the account of the government of any jurisdiction in which the Issuer is resident for tax
purposes or any political subdivision or taxing authority of such jurisdiction, unless such withholding or deduction is required
by law. If such deduction or withholding is at any time required, the Issuer will (subject to compliance by the Holder of this
Security with any relevant administrative requirements) pay such additional</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 60 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">amounts (&ldquo;Additional Amounts&rdquo;)
as will result in the receipt of such amounts as would have been received by the Holder had no such withholding or deduction been
required, provided that the Issuer will not have to pay Additional Amounts if:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(i)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for the Holder&rsquo;s
(or certain related parties&rsquo;) connection to the jurisdiction in which the Issuer is resident for tax purposes, other than
by merely holding this Security or by receiving principal, premium, if any, or interest, if any, on this Security, or enforcing
this Security. These connections include where the Holder or related party:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been a domiciliary, national or resident of such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been engaged in a trade or business in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>has or had a permanent establishment in such jurisdiction; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been physically present in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(ii)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for presentation
of this Security for payment, if presentation is required, more than 30 days after this Security became due or payment was provided
for;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iii) &nbsp;the tax, levy, impost or other governmental
charge is an estate, inheritance, gift, sale, transfer, personal property or similar tax, levy, impost or other governmental charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iv)&nbsp;&nbsp;the tax, levy, impost or other governmental charge is payable in a manner that does not involve deduction or withholding from payments
on or in respect of this Security;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(v)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed or withheld but for the failure of the Holder or beneficial
owner, upon a reasonable request, addressed to the Holder, to comply with any certification, identification or other reporting
requirement concerning the Holder&rsquo;s or the beneficial owner&rsquo;s nationality, residence, identity or connection with any
jurisdiction in which the Issuer is resident for tax purposes, if compliance is required by any treaty, statute, regulation or
administrative practice of such jurisdiction as a condition to relief or exemption from such tax, levy, impost or other governmental
charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vi)&nbsp;&nbsp;the tax, levy, impost or other governmental charge is required by Sections 1471 through 1474 of the Internal Revenue Code of 1986,
as amended (&ldquo;FATCA&rdquo;), any current or future U.S. Treasury Regulations or rulings promulgated thereunder, any intergovernmental
agreement between the United States and any other jurisdiction to implement FATCA (an &ldquo;IGA&rdquo;), any law, regulation or
other official guidance enacted in any jurisdiction implementing FATCA or an IGA, or any agreement with the U.S. Internal Revenue
Service under or with respect to FATCA; or</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vii) any combination of the taxes referred
to in (i) through (vi) above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, no payments of Additional
Amounts will be made with respect to any payment on this Security if the Holder of this Security is a fiduciary, partnership or
a person other than the sole beneficial owner of any payment, and, by the laws of the jurisdiction in which the Issuer is resident
for tax purposes, that payment would be required for tax purposes to be included in</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 61 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">income of a beneficiary or settlor with
respect to the fiduciary, a member of that partnership or a beneficial owner who would not have been entitled to the Additional
Amounts had that beneficiary, settlor, partner or member owner been the Holder of this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Issuer will remit the full amount of
any taxes withheld to the applicable taxing authorities in accordance with the applicable law. The Issuer will also provide the
Trustee with documentation reasonably satisfactory to the Trustee evidencing the payment of any taxes in respect of which the Issuer
has paid Additional Amounts. The Issuer will provide copies of such documentation to the Holder of this Security upon request.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any reference in the Indenture or this
Security to principal, premium or interest in respect of this Security will be deemed also to refer to any Additional Amounts that
may be payable with respect to such principal, premium or interest under the obligations referred to herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Issuer and the rights of the
Holders of the Securities of each series to be affected under the Indenture at any time by the Issuer and the Trustee with the
consent of the Holders of a majority in principal amount of the Securities at the time Outstanding of each series to be affected.
The Indenture also contains provisions permitting the Holders of specified percentages in principle amount of the Securities of
each series at the time Outstanding, on behalf of the Holders of all Securities of such series to waive compliance by the Issuer
with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent
or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security
and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation
of such consent or waiver is made upon this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As set forth in, and subject to, the provisions
of the Indenture, no Holder of any Security of this series will have any right to institute any proceeding with respect to the
Indenture, this Security or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice
of a continuing Event of Default with respect to the Securities of this series, the Holders of not less than 25% in principal amount
of the Outstanding Securities of this series shall have made written request, and offered reasonable indemnity, to the Trustee
to institute such proceeding as trustee, and the Trustee shall not have received from the Holders of a majority in principal of
the Outstanding Securities of this series a direction inconsistent with such request and shall have failed to institute such proceeding
within 60 days; <U>provided</U>, <U>however</U>, that such limitations do not apply to a suit instituted by the Holder hereof for
the enforcement of payment of the principal (and premium, if any) or any interest on this Security on or after the respective due
dates expressed herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No reference herein to the Indenture and
no provision of this Security or of the Indenture shall alter or impair the obligation of the Issuer, which is absolute and unconditional,
to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency,
herein prescribed or to convert this Security as provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000 in excess thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 62 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No service charge shall be made for any
such registration of transfer or exchange, but the Issuer or the Trustee may require payment of a sum sufficient to cover any tax
or other governmental charge payable in connection therewith.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Prior to due presentation of this Security
for registration of transfer, the Issuer, the Trustee and any agent of the Issuer or the Trustee may treat the Person in whose
name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither of
the Issuer nor the Trustee nor any such agent shall be affected by notice to the contrary.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>This Security shall be governed by and
construed in accordance with the laws of the State of New York.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Unless otherwise defined herein, all terms
used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 63 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE OF PRINCIPAL AMOUNT</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The initial principal amount of this Security
shall be $500,000,000. The following decreases/increases in the principal amount of this Security have been made:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 26%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Date
        of Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Decrease
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Increase
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 22%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Total
        Principal Amount Following such Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 18%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Notation
        Made by or on Behalf of Trustee</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 64 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Exhibit D</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>


<!-- Field: Page; Sequence: 65 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>THIS SECURITY IS A GLOBAL REGISTERED SECURITY WITHIN THE
MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY
MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE
REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED
IN THE INDENTURE.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ASTRAZENECA PLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">4.375% Notes due 2048</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 79%; font-size: 10pt; text-align: left">No. 001</TD>
    <TD STYLE="width: 21%; font-size: 10pt; text-align: right">$500,000,000</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">CUSIP No. 046353AU2</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">ISIN No. US046353AU26</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">ASTRAZENECA PLC, a public limited company
incorporated under the laws of England and Wales (herein called the &ldquo;Issuer&rdquo;, which term includes any successor Person
under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &amp; Co., or registered assigns,
the principal sum of Five Hundred Million Dollars on August 17, 2048 and to pay interest thereon from August 17, 2018 or from the
most recent Interest Payment Date (as defined below) to which interest has been paid or duly provided for, semiannually in arrears
on February 17 and August 17 in each year, commencing February 17, 2019 (each, an &ldquo;Interest Payment Date&rdquo;), at the
rate of 4.375% per annum, until the principal hereof is paid or made available for payment. The interest so payable, and punctually
paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name
this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date (as defined
below) for such interest which shall be the 15<SUP>th</SUP> calendar day preceding such Interest Payment Date (whether or not such
day is a Business Day (as defined below)), as the case may be. Any such interest not so punctually paid or duly provided for will
forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this
Security (or one or more Predecessor Securities) is registered at the close of business on a subsequent record date (the &ldquo;Special
Record Date&rdquo;) for the payment of such defaulted interest to be fixed by the Trustee (which shall not be less than five Business
Days prior to the date of payment of such defaulted interest), notice whereof shall be given to Holders of Securities of this series
not less than 15 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with
the requirements of any securities exchange on which the Securities of this series may</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 66 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">be listed, and upon such notice as may be
required by such exchange, all as more fully provided in said Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Issuer maintained for that purpose in
New York City, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts; <U>provided</U>, <U>however</U>, that at the option of the Issuer payment of interest may be made by
check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Unless the certificate of authentication
hereon has been executed by the Trustee by manual signature of an authorized signatory, this Security shall not be entitled to
any benefit under the Indenture or be valid or obligatory for any purpose.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 67 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">IN WITNESS WHEREOF, the Issuer has caused
this instrument to be duly executed manually or in facsimile.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated: August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-left: 0.25in; font-size: 10pt; text-indent: -0.25in">ASTRAZENECA PLC</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-left: 0.25in; font-size: 10pt; text-indent: -0.25in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 14%; font-size: 10pt">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; width: 86%; text-align: left">/s/ Marc Dunoyer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">Name:&#9; Marc Dunoyer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">Title:&#9;&nbsp;&nbsp;&nbsp;Chief Financial Officer</TD></TR>
</TABLE><BR STYLE="clear: both">
<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%; padding-right: 0pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; width: 14%; padding-right: 0pt; padding-left: 0pt; text-indent: 0pt">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; width: 86%; padding-right: 0pt; text-align: left">/s/ Adrian Kemp</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 0pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; font-size: 10pt; padding-right: 0pt; text-indent: 0pt">Name: Adrian Kemp</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-right: 0pt; padding-left: 0pt; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0pt; font-size: 10pt; padding-right: 0pt; text-indent: 0pt">Title:&#9;&nbsp;&nbsp;Company Secretary</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center"><I>[Signature Page to Global Note]</I></P>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P>

<!-- Field: Page; Sequence: 68 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This is one of the Securities of the series
designated herein and referred to in the within-mentioned Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated:&nbsp;August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0.25in; text-indent: -0.25in"><FONT STYLE="font-size: 10pt; text-transform: uppercase">The Bank of New York</FONT> <FONT STYLE="font-size: 10pt">MELLON</FONT><BR>
<FONT STYLE="font-size: 10pt"><I>As Trustee</I></FONT></TD></TR>
</TABLE><BR STYLE="clear: both">


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; width: 14%">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; width: 86%">L. O'Brien</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0"></P><P STYLE="margin-top: 0; margin-bottom: 0; text-align: center"><I>[Signature Page to Global Note]</I></P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


<!-- Field: Page; Sequence: 69 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">This Security is one of a duly authorized
issue of securities of the Issuer (herein called the &ldquo;Securities&rdquo;), issued and to be issued in one or more series under
an Indenture, dated as of April 1, 2004 (herein called the &ldquo;Indenture&rdquo; which term shall have the meaning assigned to
it in such instrument), among the Issuer and The Bank of New York Mellon (formerly known as The Bank of New York), as successor
Trustee (herein called the &ldquo;Trustee&rdquo;, which term includes any other successor trustee under the Indenture) to JPMorgan
Chase Bank, and reference is hereby made to the Indenture and to the Officers&rsquo; Certificate delivered pursuant to Section
2.08 of the Indenture with respect to this security for a statement of the respective rights, limitations of rights, duties and
immunities thereunder of the Issuer, the Trustee and the Holders of the Securities and of the terms upon which the Securities are,
and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited
in aggregate principal amount to U.S.$ 750,000,000.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Securities of this series are subject
to redemption, as a whole or in part, from time to time, at the election of the Issuer, upon not less than 15 nor more than 30
days&rsquo; notice, as follows: (i) prior to February 17, 2048 (the &ldquo;Par Call Date&rdquo;), at a Redemption Price equal to
the greater of (A) 100% of the principal amount of the Securities to be redeemed, and (B) as determined by the Quotation Agent
(as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (assuming
for this purpose that such series of Notes matured on the Par Call Date and not including any portion of such payments of interest
accrued as of the date of redemption) discounted to the date of redemption on a semiannual basis (assuming a 360-day year consisting
of twelve 30-day months) at the Treasury Rate plus 25 basis points, and (ii) on or after the Par Call Date, at a redemption price
equal to 100% of the principal amount of the Securities to be redeemed; plus, in each of cases (A) and (B) above, accrued interest
thereon to but excluding the date of redemption.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Business Day&rdquo; means any day which is not, in
London, England or New York, New York, or the place of payment of amounts payable in respect of the Securities, a Saturday, a Sunday,
a legal holiday or a day on which banking institutions are authorized or obligated by law, regulation or executive order to close.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Comparable Treasury Issue&rdquo; means the United
States Treasury security selected by the Quotation Agent as having a maturity comparable to the remaining term of the Securities
to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing
new issues of corporate debt securities of comparable maturity to the remaining term of such Securities (assuming for this purpose
that such Securities matured on the Par Call Date).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 70 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Comparable Treasury Price&rdquo; means, with respect
to any redemption date, (i) the average, as determined by the Quotation Agent, of the Reference Treasury Dealer Quotations for
such redemption date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, or (ii) if the Quotation
Agent obtains fewer than three such Reference Treasury Dealer Quotations, the average of all such Quotations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Quotation Agent&rdquo; means the Reference Treasury
Dealer appointed by the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Reference Treasury Dealer&rdquo; means (i) Citigroup
Global Markets Inc., Deutsche Bank Securities Inc., Goldman Sachs &amp; Co. LLC and J.P. Morgan Securities LLC, and their respective
successors; <I>provided, however</I>, that if the foregoing shall cease to be a primary U.S. Government securities dealer in New
York City (a &ldquo;Primary Treasury Dealer&rdquo;), the Issuer shall substitute therefor another Primary Treasury Dealer; and
(ii) any other Primary Treasury Dealer selected by the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Reference Treasury Dealer Quotations&rdquo; means,
with respect to each Reference Treasury Dealer and any redemption date, the average, as determined by the Quotation Agent, of the
bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted
in writing to the Trustee by such Reference Treasury Dealer at 5:00 p.m., New York City time, on the third Business Day preceding
such redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Treasury Rate&rdquo; means, with respect to any redemption
date, the rate per annum equal to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price
for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for
such redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture contains provisions to the
effect that, in the event of various tax law changes and other limited circumstances that require the Issuer to pay Additional
Amounts (as defined below), the Issuer may redeem the Securities of a series, in whole but not in part, at a price equal to 100%
of the principal amount of the Securities plus accrued interest thereon to but excluding the date of redemption, which provisions
apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">In the event of redemption of this Security
in part only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in
the name of the Holder hereof upon the cancellation hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 71 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture contains provisions for defeasance
at any time of the entire indebtedness on this Security upon compliance by the Issuer with certain conditions set forth thereon,
which provisions apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any amounts to be paid by the Issuer under
this Security of principal, premium and interest in respect of this Security will be paid without deduction or withholding for,
any and all present and future taxes, levies, duties, assessments, imposts or other governmental charges of whatever nature imposed,
assessed, levied or collected by or for the account of the government of any jurisdiction in which the Issuer is resident for tax
purposes or any political subdivision or taxing authority of such jurisdiction, unless such withholding or deduction is required
by law. If such deduction or withholding is at any time required, the Issuer will (subject to compliance by the Holder of this
Security with any relevant administrative requirements) pay such additional amounts (&ldquo;Additional Amounts&rdquo;) as will
result in the receipt of such amounts as would have been received by the Holder had no such withholding or deduction been required,
provided that the Issuer will not have to pay Additional Amounts if:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(i)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for the Holder&rsquo;s
(or certain related parties&rsquo;) connection to the jurisdiction in which the Issuer is resident for tax purposes, other than
by merely holding this Security or by receiving principal, premium, if any, or interest, if any, on this Security, or enforcing
this Security. These connections include where the Holder or related party:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been a domiciliary, national or resident of such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been engaged in a trade or business in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>has or had a permanent establishment in such jurisdiction; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been physically present in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(ii)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for presentation
of this Security for payment, if presentation is required, more than 30 days after this Security became due or payment was provided
for;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iii) &nbsp;the tax, levy, impost or other governmental
charge is an estate, inheritance, gift, sale, transfer, personal property or similar tax, levy, impost or other governmental charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 72 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iv) &nbsp;the tax, levy, impost or other governmental
charge is payable in a manner that does not involve deduction or withholding from payments on or in respect of this Security;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(v)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed or withheld but for the failure of the Holder or beneficial
owner, upon a reasonable request, addressed to the Holder, to comply with any certification, identification or other reporting
requirement concerning the Holder&rsquo;s or the beneficial owner&rsquo;s nationality, residence, identity or connection with any
jurisdiction in which the Issuer is resident for tax purposes, if compliance is required by any treaty, statute, regulation or
administrative practice of such jurisdiction as a condition to relief or exemption from such tax, levy, impost or other governmental
charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vi)&nbsp;
the tax, levy, impost or other governmental charge is required by Sections 1471 through 1474 of the Internal Revenue Code of 1986,
as amended (&ldquo;FATCA&rdquo;), any current or future U.S. Treasury Regulations or rulings promulgated thereunder, any intergovernmental
agreement between the United States and any other jurisdiction to implement FATCA (an &ldquo;IGA&rdquo;), any law, regulation or
other official guidance enacted in any jurisdiction implementing FATCA or an IGA, or any agreement with the U.S. Internal Revenue
Service under or with respect to FATCA; or</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vii) any combination of the taxes referred
to in (i) through (vi) above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, no payments of Additional
Amounts will be made with respect to any payment on this Security if the Holder of this Security is a fiduciary, partnership or
a person other than the sole beneficial owner of any payment, and, by the laws of the jurisdiction in which the Issuer is resident
for tax purposes, that payment would be required for tax purposes to be included in income of a beneficiary or settlor with respect
to the fiduciary, a member of that partnership or a beneficial owner who would not have been entitled to the Additional Amounts
had that beneficiary, settlor, partner or member owner been the Holder of this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Issuer will remit the full amount of
any taxes withheld to the applicable taxing authorities in accordance with the applicable law. The Issuer will also provide the
Trustee with documentation reasonably satisfactory to the Trustee evidencing the payment of any taxes in respect of which the Issuer
has paid Additional Amounts. The Issuer will provide copies of such documentation to the Holder of this Security upon request.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any reference in the Indenture or this
Security to principal, premium or interest in respect of this Security will be deemed also to refer to any Additional Amounts that
may be payable with respect to such principal, premium or interest under the obligations referred to herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 73 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Issuer and the rights of the
Holders of the Securities of each series to be affected under the Indenture at any time by the Issuer and the Trustee with the
consent of the Holders of a majority in principal amount of the Securities at the time Outstanding of each series to be affected.
The Indenture also contains provisions permitting the Holders of specified percentages in principle amount of the Securities of
each series at the time Outstanding, on behalf of the Holders of all Securities of such series to waive compliance by the Issuer
with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent
or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security
and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation
of such consent or waiver is made upon this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">As set forth in, and subject to, the provisions
of the Indenture, no Holder of any Security of this series will have any right to institute any proceeding with respect to the
Indenture, this Security or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice
of a continuing Event of Default with respect to the Securities of this series, the Holders of not less than 25% in principal amount
of the Outstanding Securities of this series shall have made written request, and offered reasonable indemnity, to the Trustee
to institute such proceeding as trustee, and the Trustee shall not have received from the Holders of a majority in principal of
the Outstanding Securities of this series a direction inconsistent with such request and shall have failed to institute such proceeding
within 60 days; <U>provided</U>, <U>however</U>, that such limitations do not apply to a suit instituted by the Holder hereof for
the enforcement of payment of the principal (and premium, if any) or any interest on this Security on or after the respective due
dates expressed herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No reference herein to the Indenture and
no provision of this Security or of the Indenture shall alter or impair the obligation of the Issuer, which is absolute and unconditional,
to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency,
herein prescribed or to convert this Security as provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000 in excess thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No service charge shall be made for any
such registration of transfer or exchange, but the Issuer or the Trustee may require payment of a sum sufficient to cover any tax
or other governmental charge payable in connection therewith.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 74 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Prior to due presentation of this Security
for registration of transfer, the Issuer, the Trustee and any agent of the Issuer or the Trustee may treat the Person in whose
name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither of
the Issuer nor the Trustee nor any such agent shall be affected by notice to the contrary.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>This Security shall be governed by and
construed in accordance with the laws of the State of New York.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Unless otherwise defined herein, all terms
used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 75 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE OF PRINCIPAL AMOUNT</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The initial principal amount of this Security
shall be $500,000,000. The following decreases/increases in the principal amount of this Security have been made:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 26%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Date
        of Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Decrease
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Increase
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 22%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Total
        Principal Amount Following such Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 18%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Notation
        Made by or on Behalf of Trustee</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 76 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>THIS SECURITY IS A GLOBAL REGISTERED SECURITY WITHIN THE
MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY
MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE
REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED
IN THE INDENTURE.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ASTRAZENECA PLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">4.375% Notes due 2048</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 79%; font-size: 10pt; text-align: left">No. 002</TD>
    <TD STYLE="width: 21%; font-size: 10pt; text-align: right">$250,000,000</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">CUSIP No. 046353AU2</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">ISIN No. US046353AU26</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">ASTRAZENECA PLC, a public limited company
incorporated under the laws of England and Wales (herein called the &ldquo;Issuer&rdquo;, which term includes any successor Person
under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &amp; Co., or registered assigns,
the principal sum of Two Hundred And Fifty Million Dollars on August 17, 2048 and to pay interest thereon from August 17, 2018
or from the most recent Interest Payment Date (as defined below) to which interest has been paid or duly provided for, semiannually
in arrears on February 17 and August 17 in each year, commencing February 17, 2019 (each, an &ldquo;Interest Payment Date&rdquo;),
at the rate of 4.375% per annum, until the principal hereof is paid or made available for payment. The interest so payable, and
punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in
whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date
(as defined below) for such interest which shall be the 15<SUP>th</SUP> calendar day preceding such Interest Payment Date (whether
or not such day is a Business Day (as defined below)), as the case may be. Any such interest not so punctually paid or duly provided
for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose
name this Security (or one or more Predecessor Securities) is registered at the close of business on a subsequent record date (the
&ldquo;Special Record Date&rdquo;) for the payment of such defaulted interest to be fixed by the Trustee (which shall not be less
than five Business Days prior to the date of payment of such defaulted interest), notice whereof shall be given to Holders of Securities
of this series not less than 15 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent
with the requirements of any securities exchange on which the Securities of this series may</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 77 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">be listed, and upon such notice as may be
required by such exchange, all as more fully provided in said Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Payment of the principal of (and premium,
if any) and any such interest on this Security will be made at the office or agency of the Issuer maintained for that purpose in
New York City, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts; <U>provided</U>, <U>however</U>, that at the option of the Issuer payment of interest may be made by
check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">Unless the certificate of authentication
hereon has been executed by the Trustee by manual signature of an authorized signatory, this Security shall not be entitled to
any benefit under the Indenture or be valid or obligatory for any purpose.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 78 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">IN WITNESS WHEREOF, the Issuer has caused
this instrument to be duly executed manually or in facsimile.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated: August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">ASTRAZENECA PLC</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 8%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; width: 92%">/s/ Marc Dunoyer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Name:&#9;Marc Dunoyer</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Title:&#9;Chief Financial Officer</FONT></TD></TR>
</TABLE><BR STYLE="clear: both">


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 8%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; width: 92%">/s/ Adrian Kemp</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Name:&#9;Adrian Kemp</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Title:&#9;Company Secretary</FONT></TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center"><I>[Signature Page to Global Note]</I></P>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P>


<!-- Field: Page; Sequence: 79 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This is one of the Securities of the series
designated herein and referred to in the within-mentioned Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Dated: August 17, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; padding-left: 0.25in; text-indent: -0.25in"><FONT STYLE="font-size: 10pt; text-transform: uppercase">The Bank of New York</FONT> <FONT STYLE="font-size: 10pt">MELLON</FONT><BR>
<FONT STYLE="font-size: 10pt"><I>As Trustee</I></FONT></TD></TR>
</TABLE><BR STYLE="clear: both">


<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 8%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; width: 92%">L. O'Brien</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 100%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0"></P><P STYLE="margin-top: 0; margin-bottom: 0; text-align: center"><I>[Signature Page to Global Note]</I></P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


<!-- Field: Page; Sequence: 80 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">This Security is one of a duly authorized
issue of securities of the Issuer (herein called the &ldquo;Securities&rdquo;), issued and to be issued in one or more series under
an Indenture, dated as of April 1, 2004 (herein called the &ldquo;Indenture&rdquo; which term shall have the meaning assigned to
it in such instrument), among the Issuer and The Bank of New York Mellon (formerly known as The Bank of New York), as successor
Trustee (herein called the &ldquo;Trustee&rdquo;, which term includes any other successor trustee under the Indenture) to JPMorgan
Chase Bank, and reference is hereby made to the Indenture and to the Officers&rsquo; Certificate delivered pursuant to Section
2.08 of the Indenture with respect to this security for a statement of the respective rights, limitations of rights, duties and
immunities thereunder of the Issuer, the Trustee and the Holders of the Securities and of the terms upon which the Securities are,
and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited
in aggregate principal amount to U.S.$ 750,000,000.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Securities of this series are subject
to redemption, as a whole or in part, from time to time, at the election of the Issuer, upon not less than 15 nor more than 30
days&rsquo; notice, as follows: (i) prior to February 17, 2048 (the &ldquo;Par Call Date&rdquo;), at a Redemption Price equal to
the greater of (A) 100% of the principal amount of the Securities to be redeemed, and (B) as determined by the Quotation Agent
(as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (assuming
for this purpose that such series of Notes matured on the Par Call Date and not including any portion of such payments of interest
accrued as of the date of redemption) discounted to the date of redemption on a semiannual basis (assuming a 360-day year consisting
of twelve 30-day months) at the Treasury Rate plus 25 basis points, and (ii) on or after the Par Call Date, at a redemption price
equal to 100% of the principal amount of the Securities to be redeemed; plus, in each of cases (A) and (B) above, accrued interest
thereon to but excluding the date of redemption.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Business Day&rdquo; means any day which is not, in
London, England or New York, New York, or the place of payment of amounts payable in respect of the Securities, a Saturday, a Sunday,
a legal holiday or a day on which banking institutions are authorized or obligated by law, regulation or executive order to close.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Comparable Treasury Issue&rdquo; means the United
States Treasury security selected by the Quotation Agent as having a maturity comparable to the remaining term of the Securities
to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing
new issues of corporate debt securities of comparable maturity to the remaining term of such Securities (assuming for this purpose
that such Securities matured on the Par Call Date).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Comparable Treasury Price&rdquo; means, with respect
to any redemption date, (i) the average, as determined by the Quotation Agent, of the Reference Treasury Dealer Quotations for
such redemption date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, or (ii) if the Quotation
Agent obtains fewer than three such Reference Treasury Dealer Quotations, the average of all such Quotations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Quotation Agent&rdquo; means the Reference Treasury
Dealer appointed by the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 81 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Reference Treasury Dealer&rdquo; means (i) Citigroup
Global Markets Inc., Deutsche Bank Securities Inc., Goldman Sachs &amp; Co. LLC and J.P. Morgan Securities LLC, and their respective
successors; <I>provided, however</I>, that if the foregoing shall cease to be a primary U.S. Government securities dealer in New
York City (a &ldquo;Primary Treasury Dealer&rdquo;), the Issuer shall substitute therefor another Primary Treasury Dealer; and
(ii) any other Primary Treasury Dealer selected by the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Reference Treasury Dealer Quotations&rdquo; means,
with respect to each Reference Treasury Dealer and any redemption date, the average, as determined by the Quotation Agent, of the
bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted
in writing to the Trustee by such Reference Treasury Dealer at 5:00 p.m., New York City time, on the third Business Day preceding
such redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&ldquo;Treasury Rate&rdquo; means, with respect to any redemption
date, the rate per annum equal to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price
for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for
such redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture contains provisions to the
effect that, in the event of various tax law changes and other limited circumstances that require the Issuer to pay Additional
Amounts (as defined below), the Issuer may redeem the Securities of a series, in whole but not in part, at a price equal to 100%
of the principal amount of the Securities plus accrued interest thereon to but excluding the date of redemption, which provisions
apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">In the event of redemption of this Security
in part only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in
the name of the Holder hereof upon the cancellation hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">The Indenture contains provisions for defeasance
at any time of the entire indebtedness on this Security upon compliance by the Issuer with certain conditions set forth thereon,
which provisions apply to this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0.25in">If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any amounts to be paid by the Issuer under
this Security of principal, premium and interest in respect of this Security will be paid without deduction or withholding for,
any and all present and future taxes, levies, duties, assessments, imposts or other governmental charges of whatever nature imposed,
assessed, levied or collected by or for the account of the government of any jurisdiction in which the Issuer is resident for tax
purposes or any political subdivision or taxing authority of such jurisdiction, unless such withholding or deduction is required
by law. If such deduction or withholding is at any time required, the Issuer will (subject to compliance by the Holder of this
Security with any relevant administrative requirements) pay such additional amounts (&ldquo;Additional Amounts&rdquo;) as will
result in the receipt of such amounts as would have</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 82 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">been received by the Holder had no such
withholding or deduction been required, provided that the Issuer will not have to pay Additional Amounts if:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(i)&nbsp;&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for the Holder&rsquo;s
(or certain related parties&rsquo;) connection to the jurisdiction in which the Issuer is resident for tax purposes, other than
by merely holding this Security or by receiving principal, premium, if any, or interest, if any, on this Security, or enforcing
this Security. These connections include where the Holder or related party:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been a domiciliary, national or resident of such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been engaged in a trade or business in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>has or had a permanent establishment in such jurisdiction; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>is or has been physically present in such jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(ii)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed, assessed, levied or collected but for presentation
of this Security for payment, if presentation is required, more than 30 days after this Security became due or payment was provided
for;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iii)&nbsp;&nbsp;the tax, levy, impost or other governmental charge is an estate, inheritance, gift, sale, transfer, personal property or similar
tax, levy, impost or other governmental charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iv)&nbsp;
the tax, levy, impost or other governmental charge is payable in a manner that does not involve deduction or withholding from payments
on or in respect of this Security;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(v)&nbsp;&nbsp;&nbsp;the
tax, levy, impost or other governmental charge would not have been imposed or withheld but for the failure of the Holder or beneficial
owner, upon a reasonable request, addressed to the Holder, to comply with any certification, identification or other reporting
requirement concerning the Holder&rsquo;s or the beneficial owner&rsquo;s nationality, residence, identity or connection with any
jurisdiction in which the Issuer is resident for tax purposes, if compliance is required by any treaty, statute, regulation or
administrative practice of such jurisdiction as a condition to relief or exemption from such tax, levy, impost or other governmental
charge;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vi)&nbsp;&nbsp;the tax, levy, impost or other governmental charge is required by Sections 1471 through 1474 of the Internal Revenue Code of 1986,
as amended (&ldquo;FATCA&rdquo;), any current or future U.S. Treasury Regulations or rulings promulgated thereunder, any intergovernmental
agreement between the United States and any other jurisdiction to implement FATCA (an &ldquo;IGA&rdquo;), any law, regulation or
other official guidance enacted in any jurisdiction implementing FATCA or an IGA, or any agreement with the U.S. Internal Revenue
Service under or with respect to FATCA; or</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(vii) any combination of the taxes referred
to in (i) through (vi) above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, no payments of Additional
Amounts will be made with respect to any payment on this Security if the Holder of this Security is a fiduciary, partnership or
a person other than the sole beneficial owner of any payment, and, by the laws of the jurisdiction in which the Issuer is resident
for tax purposes, that payment would be required for tax purposes to be included in income of a beneficiary or settlor with respect
to the fiduciary, a member of that partnership or a</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


<!-- Field: Page; Sequence: 83 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">beneficial owner who would not have been
entitled to the Additional Amounts had that beneficiary, settlor, partner or member owner been the Holder of this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Issuer will remit the full amount of
any taxes withheld to the applicable taxing authorities in accordance with the applicable law. The Issuer will also provide the
Trustee with documentation reasonably satisfactory to the Trustee evidencing the payment of any taxes in respect of which the Issuer
has paid Additional Amounts. The Issuer will provide copies of such documentation to the Holder of this Security upon request.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any reference in the Indenture or this
Security to principal, premium or interest in respect of this Security will be deemed also to refer to any Additional Amounts that
may be payable with respect to such principal, premium or interest under the obligations referred to herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Issuer and the rights of the
Holders of the Securities of each series to be affected under the Indenture at any time by the Issuer and the Trustee with the
consent of the Holders of a majority in principal amount of the Securities at the time Outstanding of each series to be affected.
The Indenture also contains provisions permitting the Holders of specified percentages in principle amount of the Securities of
each series at the time Outstanding, on behalf of the Holders of all Securities of such series to waive compliance by the Issuer
with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent
or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security
and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation
of such consent or waiver is made upon this Security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As set forth in, and subject to, the provisions
of the Indenture, no Holder of any Security of this series will have any right to institute any proceeding with respect to the
Indenture, this Security or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice
of a continuing Event of Default with respect to the Securities of this series, the Holders of not less than 25% in principal amount
of the Outstanding Securities of this series shall have made written request, and offered reasonable indemnity, to the Trustee
to institute such proceeding as trustee, and the Trustee shall not have received from the Holders of a majority in principal of
the Outstanding Securities of this series a direction inconsistent with such request and shall have failed to institute such proceeding
within 60 days; <U>provided</U>, <U>however</U>, that such limitations do not apply to a suit instituted by the Holder hereof for
the enforcement of payment of the principal (and premium, if any) or any interest on this Security on or after the respective due
dates expressed herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No reference herein to the Indenture and
no provision of this Security or of the Indenture shall alter or impair the obligation of the Issuer, which is absolute and unconditional,
to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency,
herein prescribed or to convert this Security as provided in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Securities of this series are issuable
only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000 in excess thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 84 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">No service charge shall be made for any
such registration of transfer or exchange, but the Issuer or the Trustee may require payment of a sum sufficient to cover any tax
or other governmental charge payable in connection therewith.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Prior to due presentation of this Security
for registration of transfer, the Issuer, the Trustee and any agent of the Issuer or the Trustee may treat the Person in whose
name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither of
the Issuer nor the Trustee nor any such agent shall be affected by notice to the contrary.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>This Security shall be governed by and
construed in accordance with the laws of the State of New York.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Unless otherwise defined herein, all terms
used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


<!-- Field: Page; Sequence: 85 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SCHEDULE OF PRINCIPAL AMOUNT</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The initial principal amount of this Security
shall be $250,000,000. The following decreases/increases in the principal amount of this Security have been made:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 26%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Date
        of Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Decrease
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 17%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Increase
        in Principal Amount</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 22%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Total
        Principal Amount Following such Decrease/Increase</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="width: 18%; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Notation
        Made by or on Behalf of Trustee</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; padding-right: 2pt; padding-left: 2pt; text-indent: 0pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P>
</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P>
</TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P>
</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD>
    <TD STYLE="padding-right: 2pt; padding-left: 2pt; text-indent: 0pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 86; Options: Last -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>

</BODY>
</HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>5
<FILENAME>dp94630_0501.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 5.1&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR>
    <TD>
        <IMG SRC="image_001.jpg" ALT=""><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
</TABLE>


<P STYLE="margin: 0"></P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 74%">&nbsp;</TD>
    <TD STYLE="width: 26%"><P STYLE="margin: 0"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">London&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">Freshfields Bruckhaus Deringer
<FONT STYLE="font-variant: small-caps">llp&nbsp;</FONT></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">65 Fleet Street<BR>
London EC4Y 1HS&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">T&nbsp;&nbsp;+44
20 7936 4000 (Switchboard)&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 11.35pt"><FONT STYLE="font-size: 8pt">+44 20 7832
7022 (Direct)&nbsp;&nbsp;</FONT></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">F&nbsp;&nbsp;&nbsp;+44
        20 7108 7022&nbsp;</FONT></P>



</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>

<P STYLE="margin: 0">AstraZeneca PLC<BR>
1 Francis Crick Avenue <BR>
Cambridge Biomedical Campus<BR>
Cambridge<BR>
CB2 0AA<BR>
United Kingdom</P>&nbsp;</TD>
    <TD>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">LDE No 23&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt"><FONT STYLE="font-size: 8pt">E duncan.kellaway@&zwnj;freshfields.com&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">www.freshfields.com&nbsp;</FONT></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt"><B>Doc ID&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">LON49950030</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt"><B>Our Ref&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">DEGK/LC&nbsp;</FONT></P>


</TD></TR>
</TABLE>

<P STYLE="margin: 0"></P>

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">17 August 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Dear Sir/Madam</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">AstraZeneca PLC</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Prospectus Supplement to Registration
Statement on Form F-3</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Introduction</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In
connection with the automatic shelf registration statement on Form F-3 (the <B><I>Registration Statement</I></B>) filed with
the U.S. Securities and Exchange Commission (<B><I>SEC</I></B>) on 22 November 2016, as supplemented by a prospectus
supplement filed with the SEC on 14 August 2018 (the <B><I>Prospectus Supplement</I></B>) of AstraZeneca PLC, a public
limited company incorporated under the laws of England and Wales (the <B><I>Company</I></B>), under the United States
Securities Act of 1933, as amended (the <B><I>Securities Act</I></B>), we have been requested to render our opinion on
certain matters in connection with the Prospectus Supplement. The Registration Statement and Prospectus Supplement relate to
the registration under the Securities Act of the issuance and sale of US$850,000,000 aggregate principal amount of 3.500%
fixed rate notes due 2023, US$400,000,000 aggregate principal amount of floating rate notes due 2023, US$1,000,000,000
aggregate principal amount of 4.000% fixed rate notes due 2029 and US$750,000,000 aggregate principal amount of 4.375% fixed
rate notes due 2048 (collectively, the <B><I>Debt Securities</I></B>).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We
are acting as English legal advisers to you, the Company, for the purposes of giving this opinion. In so acting, we have examined
the following documents:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;&nbsp;</P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">Freshfields Bruckhaus Deringer
LLP is a limited liability partnership registered in England and Wales with registered number OC334789. It is authorised and regulated
by the Solicitors Regulation Authority. For regulatory information please refer to www.freshfields.com/support/legalnotice.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">A list of the members (and of
the non-members who are designated as partners) of Freshfields Bruckhaus Deringer LLP is available for inspection at its registered
office, 65 Fleet Street, London EC4Y 1HS. Any reference to a partner means a member, or a consultant or employee with equivalent
standing and qualifications, of Freshfields Bruckhaus Deringer LLP or any of its affiliated firms or entities.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<!-- Field: Page; Sequence: 1; Options: NewSection; Value: 2 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt"><IMG SRC="image_001.jpg" ALT=""></P><P STYLE="margin: 0pt"></P><P STYLE="margin: 0pt"></P><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->2<!-- Field: /Sequence --><FONT STYLE="font-family: Symbol">&iuml;</FONT>8</P><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(a)</TD><TD STYLE="text-align: justify">the Registration Statement;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(b)</TD><TD STYLE="text-align: justify">the Prospectus Supplement;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(c)</TD><TD STYLE="text-align: justify">a copy of the pricing agreement dated 14 August 2018 entered into between the Company, Citigroup
Global Markets Inc., Deutsche Bank Securities Inc., Goldman Sachs &amp; Co. LLC and J.P. Morgan Securities LLC (the <B><I>Pricing
Agreement</I></B>);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(d)</TD><TD STYLE="text-align: justify">a copy of the underwriting agreement of the Company dated 14 August 2018 (together with the Pricing
Agreement, the <B><I>Underwriting Agreement</I></B>);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(e)</TD><TD STYLE="text-align: justify">a copy of the current Articles of Association of the Company as at 17 August 2018 (the <B><I>Constitutional
Documents</I></B>);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(f)</TD><TD STYLE="text-align: justify">a copy of the Company&rsquo;s Certificate of Incorporation dated 17 June 1992, issued by the Registrar
of Companies of England and Wales, together with copies of the Company&rsquo;s Certificates of Incorporation on change of name
dated 13 July 1992, 25 September 1992, 16 February 1993 and 5 April 1999, respectively;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR>
    <TD></TD></TR>
</TABLE>
<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(g)</TD><TD STYLE="text-align: justify">a copy of the indenture dated 1 April 2004 entered into between the Company and the Bank of New
York Mellon, as successor Trustee to JPMorgan Chase Bank, under which the Debt Securities are to be issued (the <B><I>Indenture</I></B>);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(h)</TD><TD STYLE="text-align: justify">a company search carried out on 17 August 2018 with respect to the Company (carried out by us or
by LegalinX Limited trading as LegalinX-7Side on our behalf) of the public documents of the Company kept at Companies House in
Cardiff (the <B><I>Company Search</I></B>);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(i)</TD><TD STYLE="text-align: justify">a winding up enquiry of the Central Registry of Winding up Petitions (carried out by us or by LegalinX-7Side
on our behalf) on 17 August 2018 with respect to the Company (the <B><I>Winding-up Enquiry</I></B>);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(j)</TD><TD STYLE="text-align: justify">a certificate issued to us by the Company Secretary of the Company dated 17 August 2018 (the <B><I>Secretary&rsquo;s
Certificate</I></B>);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(k)</TD><TD STYLE="text-align: justify">an officer&rsquo;s certificate pursuant to Sections 2.01 and 2.08 of the Indenture (the <B><I>Officer&rsquo;s
Certificate</I></B>); and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(l)</TD><TD STYLE="text-align: justify">extracts from the minutes of meetings of the board of directors of the Company held on (i) 23 July
2003 authorising the execution and delivery of and performance of obligations under the Indenture, (ii) on 8-9 November 2016 authorising
the filing of the Registration Statement and (iii) 17 &ndash; 18 May 2018 and an extract of the written resolution dated 13 July
2018 of the Company&rsquo;s issuance committee established by the board of directors of the Company authorising the filing of the
Prospectus Supplement and the execution and delivery of and performance of obligations under, when issued, the Debt Securities,</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">and relied upon the statements as to factual
matters contained in or made pursuant to each of the above mentioned documents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>


<!-- Field: Page; Sequence: 2 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt"><IMG SRC="image_001.jpg" ALT=""></P><P STYLE="margin: 0pt"></P><P STYLE="margin: 0pt"></P><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->3<!-- Field: /Sequence --><FONT STYLE="font-family: Symbol">&iuml;</FONT>8</P><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This
opinion is confined to matters of English law (including case law) as at the date of this opinion and is governed by and should
be construed in accordance with English law. By giving this opinion, we do not assume any obligation to notify you of future changes
in law which may affect the opinions expressed in this opinion or otherwise to update this opinion in any respect. Accordingly,
we express no opinion herein with regard to any system of law other than the laws of England as currently applied by the English
courts. In particular, we express no opinion on European Union law as it affects any jurisdiction other than England. We also express
no opinion as to whether or not a foreign court (applying its own conflict of law rules) will act in accordance with the parties&rsquo;
agreement as to jurisdiction and/or choice of law or uphold the terms of the Indenture or the Debt Securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
the extent that the laws of the United States or, the laws of the State of New York may be relevant, we have made no independent
investigation of such laws and our opinion is subject to the effect of such laws, including the matters contained in the opinion
of Davis Polk &amp; Wardwell London LLP dated the date hereof to be filed on Form 6-K concurrently with this opinion. We express
no views in this opinion on the validity of the matters set out in such opinion.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Assumptions</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In
considering the above documents and in rendering this opinion we have with your consent and without any further enquiry assumed:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(a)</TD><TD STYLE="text-align: justify"><B><I>Authenticity</I></B>: the genuineness of all signatures, stamps and seals on, and the authenticity,
accuracy and completeness of, all documents submitted to us whether as originals or copies;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(b)</TD><TD STYLE="text-align: justify"><B><I>Copies</I></B>: the conformity to originals of all documents supplied to us as photocopies,
portable document format (PDF) copies, facsimile copies or e-mail conformed copies;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(c)</TD><TD STYLE="text-align: justify"><B><I>Drafts</I></B>: that, where a document has been examined by us in draft or specimen form,
it will be or has been executed in the form of that draft or specimen;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(d)</TD><TD STYLE="text-align: justify"><B><I>Secretary&rsquo;s Certificate and Officer&rsquo;s Certificate:</I></B> that each of the statements
contained in the Secretary&rsquo;s Certificate and Officer&rsquo;s Certificate is true and correct as at the date hereof;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(e)</TD><TD STYLE="text-align: justify"><B><I>Corporate Power: </I></B>that each of the parties to the Indenture (other than the Company)
has the necessary capacity and corporate power to execute, deliver and perform the Indenture, and that the Indenture has been duly
authorised and executed and delivered by each of the parties thereto in accordance with all applicable laws (other than in the
case of the Company, the laws of England) in the form filed as an exhibit to the Registration Statement;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(f)</TD><TD STYLE="text-align: justify"><B><I>Validity under all laws</I></B>: that the Indenture and, when issued, the Debt Securities
constitute legal, valid and binding obligations of each of the parties thereto enforceable under all applicable laws including
the laws of the United States and the laws of the State of New York by which they are expressed to be governed (other than in the
case of the Company, the laws of England); that satisfactory evidence of</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


<!-- Field: Page; Sequence: 3 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt"><IMG SRC="image_001.jpg" ALT=""></P><P STYLE="margin: 0pt"></P><P STYLE="margin: 0pt"></P><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->4<!-- Field: /Sequence --><FONT STYLE="font-family: Symbol">&iuml;</FONT>8</P><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: 0in">the laws of
the United States and the State of New York, which is required to be pleaded and proved as a fact in any proceedings before the
English Courts, could be so pleaded and proved; and that insofar as the laws and regulations of any other jurisdiction may be relevant
to (i) the obligations or rights of any of the parties under the Indenture, or (ii) any of the transactions contemplated by the
Indenture, such laws and regulations do not prohibit, and are not inconsistent with, the entering into and performance of any such
obligations, rights or transactions;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(g)</TD><TD STYLE="text-align: justify"><B><I>Filings under all laws</I></B>: that all consents, licences, approvals, notices, filings,
recordations, publications and registrations which are necessary under any applicable laws (other than, in the case of the Company,
the laws of England) in order to permit the execution, delivery or performance of the Indenture or to perfect, protect or preserve
any of the interests created by the Indenture, have been made or obtained, or will be made or obtained within the period permitted
or required by such laws or regulations;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(h)</TD><TD STYLE="text-align: justify"><B><I>No Amendments</I></B>: that the Indenture has not been amended, terminated, rescinded or
varied, that there has been no breach of any of its provisions by any of the parties thereto which would affect the opinions expressed
in this opinion, and that the Indenture is not affected in any way by any relevant provisions of any other document or agreement
or any course of dealings between the parties thereto;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(i)</TD><TD STYLE="text-align: justify"><B><I>Unknown Facts</I></B>: that there are no facts or circumstances (and no documents, agreements,
instruments or correspondence) which are not apparent from the face of the Indenture or which have not been disclosed to us that
may affect the validity or enforceability of the Indenture or any obligation therein or otherwise affect the opinions expressed
in this opinion;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(j)</TD><TD STYLE="text-align: justify"><B><I>Arm&rsquo;s Length Terms</I></B>: that the Indenture has been entered into for bona fide
commercial reasons and on arm&rsquo;s length terms by each of the parties thereto;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(k)</TD><TD STYLE="text-align: justify"><B><I>Company Search: </I></B>that the information revealed by the Company Search: (i) was accurate
in all respects and has not since the time of such search been altered; and (ii) was complete, and included all relevant information
which had been properly submitted to the Registrar of Companies;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(l)</TD><TD STYLE="text-align: justify"><B><I>Winding up Enquiry</I></B>: that the information revealed by our Winding-up Enquiry was accurate
in all respects and has not since the time of such enquiry been altered;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(m)</TD><TD STYLE="text-align: justify"><B><I>Representations</I></B>: that the terms of the Indenture and Underwriting Agreement, other
than, in the case of the Underwriting Agreement, as to matters of law on which we opine in this opinion, have been and will be
observed and performed by the parties thereto;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(n)</TD><TD STYLE="text-align: justify"><B><I>Financial crime, antitrust and criminal cartel, sanctions and human rights etc.</I></B>:
that the parties to the Indenture have complied (and will continue to comply) with all applicable anti-terrorism, anti-corruption,
anti-money laundering, anti-tax evasion, other financial crime, civil or criminal anti-trust, cartel, competition, public procurement,
state aid, sanctions and human rights laws and regulations which may</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


<!-- Field: Page; Sequence: 4 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt"><IMG SRC="image_001.jpg" ALT=""></P><P STYLE="margin: 0pt"></P><P STYLE="margin: 0pt"></P><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->5<!-- Field: /Sequence --><FONT STYLE="font-family: Symbol">&iuml;</FONT>8</P><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: 0in">affect the
Indenture, and that performance and enforcement of the Indenture is, and will continue to be, consistent with all such laws and
regulations; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(o)</TD><TD STYLE="text-align: justify"><B><I>Bad Faith, Fraud, Duress</I></B>: the absence of bad faith, breach of duty, breach of trust,
fraud, coercion, duress or undue influence on the part of any of the parties to the Indenture and their respective directors, employees,
agents or advisers (excepting ourselves).</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Opinion</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;On
the basis of and subject to the foregoing and the matters set out in paragraphs 7 and 8 below and any matters not disclosed to
us, and having regard to such considerations of English law in force, as at the date of this letter as we consider relevant, we
are of the opinion that:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(a)</TD><TD STYLE="text-align: justify"><B><I>Corporate Existence:</I></B> the Company has been duly incorporated in the United Kingdom
and registered in England and Wales as a public limited company;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(b)</TD><TD STYLE="text-align: justify"><B><I>Corporate Power:</I></B> the Company has the requisite corporate power and capacity to issue,
deliver and perform its obligations under, when issued, the Debt Securities in accordance with the terms of the Indenture;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(c)</TD><TD STYLE="text-align: justify"><B><I>Corporate Authority:</I></B> the Company has taken steps required under English law and its
Constitutional Documents to authorise the Company to enter into and perform its obligations under, when issued, the Debt Securities;
and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(d)</TD><TD STYLE="text-align: justify"><B><I>No Violation</I></B>: the execution and delivery of the Indenture and the performance of
the Company&rsquo;s obligations thereunder (in accordance with the terms of the Indenture) have been duly authorised by all necessary
corporate action on the part of the Company and do not and will not of themselves result in any violation by the Company of any
term of its Constitutional Documents or of any law or regulation having the force of law in England and applicable to the Company
as to performance.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Qualifications</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Our
opinion is subject to the following qualifications:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(a)</TD><TD STYLE="text-align: justify"><B><I>Company Search: </I></B>the Company Search is not capable of revealing conclusively whether
or not:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right; padding-right: 0pt; padding-left: 0pt; text-indent: 0pt">(i)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">a winding-up order has been made or a resolution passed for the winding-up of a company; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right; padding-right: 0pt; padding-left: 0pt; text-indent: 0pt">(ii)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">an administration order has been made; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right; padding-right: 0pt; padding-left: 0pt; text-indent: 0pt">(iii)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">a receiver, administrative receiver, administrator or liquidator has been appointed; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right; padding-right: 0pt; padding-left: 0pt; text-indent: 0pt">(iv)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">a court order has been made under the Cross-Border Insolvency Regulations 2006,</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


<!-- Field: Page; Sequence: 5 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt"><IMG SRC="image_001.jpg" ALT=""></P><P STYLE="margin: 0pt"></P><P STYLE="margin: 0pt"></P><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->6<!-- Field: /Sequence --><FONT STYLE="font-family: Symbol">&iuml;</FONT>8</P><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">since notice of these matters
may not be filed with the Registrar of Companies immediately and, when filed, may not be entered on the public microfiche of the
relevant company immediately.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: 0in">In addition,
the Company Search is not capable of revealing, prior to the making of the relevant order or the appointment of an administrator
otherwise taking effect, whether or not a winding-up petition or an application for an administration order has been presented
or notice of intention to appoint an administrator under paragraphs 14 or 22 of Schedule B1 to the Insolvency Act 1986 has been
filed with the court;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(b)</TD><TD STYLE="text-align: justify"><B><I>Winding up Enquiry</I></B>: the Winding-up Enquiry relates only to the presentation of: (i)
a petition for the making of a winding-up order or the making of a winding-up order by the court, (ii) an application to the High
Court of Justice in London for the making of an administration order and the making by such court of an administration order, and
(iii) a notice of intention to appoint an administrator or a notice of appointment of an administrator filed at the High Court
of Justice in London. It is not capable of revealing conclusively whether or not such a winding-up petition, application for an
administration order, notice of intention or notice of appointment has been presented or winding-up or administration order granted,
because;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right">(i)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">details of a winding-up petition or application for an administration order may not have been entered
on the records of the Central Registry of Winding-up Petitions immediately;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right">(ii)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">in the case of an application for the making of an administration order and such order and the
presentation of a notice of intention to appoint or notice of appointment, if such application is made to, order made by or notice
filed with, a court other than the High Court of Justice in London, no record of such application, order or notice will be kept
by the Central Registry of Winding-up Petitions;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right">(iii)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">a winding-up order or administration order may be made before the relevant petition or application
has been entered on the records of the Central Registry, and the making of such order may not have been entered on the records
immediately;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right">(iv)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">details of a notice of intention to appoint an administrator or a notice of appointment of an administrator
under paragraphs 14 and 22 of Schedule B1 of the Insolvency Act 1986 may not be entered on the records immediately (or, in the
case of a notice of intention to appoint, at all); and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right">(v)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">with regard to winding-up petitions, the Central Registry of Winding-up Petitions may not have
records of winding-up petitions issued prior to 1994;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(c)</TD><TD STYLE="text-align: justify"><B><I>Choice of Foreign Law: </I></B>the chosen laws are the laws of the United States and the
laws of the State of New York.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right">(i)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">the Documents could be modified by the English courts to the extent provided by and in the circumstances
set out in Regulation (EC) No</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


<!-- Field: Page; Sequence: 6 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt"><IMG SRC="image_001.jpg" ALT=""></P><P STYLE="margin: 0pt"></P><P STYLE="margin: 0pt"></P><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->7<!-- Field: /Sequence --><FONT STYLE="font-family: Symbol">&iuml;</FONT>8</P><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 0pt 1.1in; text-align: justify; text-indent: 0in">593/2008 on
the law applicable to contractual obligations (the <B><I>Rome I Regulation</I></B>). In addition, we express no opinion as to the
choice of law to govern contractual obligations falling outside the scope of the Rome I Regulation; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 87.3pt; text-align: justify; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right">(ii)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">certain trusts could be modified by the English courts to the extent provided by and in the circumstances
set out in the Hague Convention on the Law Applicable to Trusts and their Recognition, as enacted by the Recognition of Trusts
Act 1987;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(d)</TD><TD STYLE="text-align: justify"><B><I>Foreign Courts: </I></B>no opinion is given as to whether or not the chosen court will take
jurisdiction, or whether the English courts would grant a stay of any proceedings commenced in England, or whether the English
courts would grant any ancillary relief in relation to proceedings commenced in a foreign court;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(e)</TD><TD STYLE="text-align: justify"><B><I>Choice of Foreign Jurisdiction</I></B>: this opinion, and the term &ldquo;enforceable&rdquo;
as used above, is not to be taken to imply that any obligation would necessarily be capable of enforcement in all circumstances
in accordance with its terms. In particular:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right">(i)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">an English court will not necessarily grant any remedy the availability of which is subject to
equitable considerations or which is otherwise in the discretion of the court. In particular, orders for specific performance and
injunctions are, in general, discretionary remedies under English law and specific performance is not available where damages are
considered by the court to be an adequate alternative remedy;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right">(ii)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">claims may become barred under the Limitation Act 1980 or the Foreign Limitation Periods Act 1984
or may be or become subject to the defence of set off or to counterclaim;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right">(iii)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">where obligations are to be performed in a jurisdiction outside England, they may not be enforceable
in England to the extent that performance would be illegal under the laws, or contrary to the exchange control regulations, of
the other jurisdiction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in; text-align: right">(iv)</TD><TD STYLE="text-align: justify; padding-left: 0.1in">the enforcement of obligations may be limited by the provisions of English law applicable to agreements
held to have been frustrated by events happening after their execution; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(f)</TD><TD STYLE="text-align: justify"><B><I>Insolvency</I></B>: this opinion is subject to all applicable laws relating to insolvency,
bankruptcy, administration, reorganisation, liquidation or analogous circumstances and other similar laws of general application
relating to or affecting generally the enforcement of creditor&rsquo;s rights and remedies from time to time.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Observations</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B><I>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Factual
Statements:</I></B> It should be understood that we have not been responsible for investigating or verifying the accuracy of the
facts, including the statements of foreign law, or the reasonableness of any statement or opinion or intention contained in or
relevant to any document referred to herein, or that no material facts have been omitted therefrom.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;&nbsp;</P>


<!-- Field: Page; Sequence: 7 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt"><IMG SRC="image_001.jpg" ALT=""></P><P STYLE="margin: 0pt"></P><P STYLE="margin: 0pt"></P><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->8<!-- Field: /Sequence --><FONT STYLE="font-family: Symbol">&iuml;</FONT>8</P><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We
consent to the filing of this opinion as an Exhibit to the report on Form 6-K to be filed by the Company on the date hereof
and to the reference to our firm under the heading &ldquo;Validity of the Notes&rdquo; in the Prospectus Supplement. In
giving such consent, we do not thereby admit that we are within the category of persons whose consent is required by the
Securities Act or by the rules and regulations promulgated thereunder.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">Yours faithfully</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in"><BR>
/s/ Freshfields Bruckhaus Deringer LLP</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>


<!-- Field: Page; Sequence: 8; Options: Last -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

</BODY>
</HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.2
<SEQUENCE>6
<FILENAME>dp94630_0502.htm
<DESCRIPTION>EXHIBIT 5.2
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">



<P STYLE="margin: 0"></P>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: left"><B></B></P>

<P STYLE="margin-top: 0; margin-bottom: 0; text-align: right"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 10pt"><B>Exhibit
5.2</B></FONT></P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 73%; font-size: 7.5pt">&nbsp;</TD>
    <TD STYLE="width: 17%; font-size: 8pt; padding-right: 2pt; padding-left: 2pt"><B>New York</B><BR>
<B>Menlo Park</B><BR>
<B>Washington DC</B><BR>
<B>S&atilde;o Paulo</B><BR>
<B>London</B></TD>
    <TD STYLE="width: 10%; font-size: 8pt; padding-right: 2pt; padding-left: 2pt"><B>Paris</B><BR>
<B>Madrid</B><BR>
<B>Tokyo</B><BR>
<B>Beijing</B><BR>
<B>Hong Kong</B></TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"><IMG SRC="dpwlogo.jpg" ALT=""></P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 26%; white-space: nowrap"><P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">Davis
                           Polk &amp; Wardwell London LLP&nbsp;</FONT></P>
        <P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">5 Aldermanbury Square<BR>
        London EC2V 7HR&nbsp;</FONT></P></TD>
    <TD STYLE="width: 46%; padding-right: 2pt; padding-left: 2pt"><P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">020
7418 1300 tel&nbsp;</FONT></P>
        <P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">020 7418 1400 fax</FONT></P>
        <P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></P></TD>
    <TD STYLE="width: 28%; font-size: 10pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
</TABLE>


<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>



<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Arial, Helvetica, Sans-Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 100%; font-size: 10pt"><FONT STYLE="font-size: 10pt">August 17, 2018</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">AstraZeneca PLC<BR>
1 Francis Crick Avenue<BR>
Cambridge Biomedical Campus<BR>
Cambridge CB2 0AA<BR>
England</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">Ladies and Gentlemen:</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">AstraZeneca PLC, a corporation organized under the laws of England
and Wales (the &ldquo;<B>Company</B>&rdquo;), has filed with the Securities and Exchange Commission a Registration Statement on
Form F-3ASR (File No. 333-214756) (the &ldquo;<B>Registration Statement</B>&rdquo;) and the related Prospectus (the &ldquo;<B>Prospectus</B>&rdquo;)
for the purpose of registering under the Securities Act of 1933, as amended (the &ldquo;<B>Securities Act</B>&rdquo;), certain
securities, including $850,000,000 aggregate principal amount of the Company&rsquo;s 3.500% Notes due 2023, $400,000,000 aggregate
principal amount of the Company&rsquo;s Floating Rate Notes due 2023, $1,000,000,000 aggregate principal amount of the Company&rsquo;s
4.000% Notes due 2029 and $750,000,000 aggregate principal amount of the Company&rsquo;s 4.375% Notes due 2048 (collectively, the
&ldquo;<B>Securities</B>&rdquo;). The Securities are to be issued pursuant to the provisions of the Indenture dated as of April
1, 2004 (the &ldquo;<B>Indenture</B>&rdquo;) between the Company and The Bank of New York Mellon, as successor trustee (the &ldquo;<B>Trustee</B>&rdquo;)
to JPMorgan Chase Bank. The Securities are to be sold pursuant to the Underwriting Agreement dated August 14, 2018 (the &ldquo;<B>Shelf
Underwriting Agreement</B>&rdquo;) and the Pricing Agreement dated August 14, 2018 among the Company and the several underwriters
(collectively, the &ldquo;<B>Underwriters</B>&rdquo;) named in Schedule I thereto (the &quot;<B>Pricing Agreement</B>&rdquo; and,
together with the Shelf Underwriting Agreement, the &quot;<B>Underwriting Agreement</B>&rdquo;).</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">We, as your counsel, have examined originals or copies of such
documents, corporate records, certificates of public officials and other instruments as we have deemed necessary or advisable for
the purpose of rendering this opinion.</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>


<!-- Field: Page; Sequence: 1; Options: NewSection; Value: 2 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt"></P><TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"><TR><TD STYLE="vertical-align: top; width: 46%; font-size: 10pt">AstraZeneca PLC</TD><TD STYLE="vertical-align: bottom; width: 15%; font-size: 10pt; text-align: center"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->2<!-- Field: /Sequence --></TD><TD STYLE="vertical-align: bottom; width: 39%; font-size: 10pt; text-align: right">August 17, 2018</TD></TR></TABLE><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">In rendering the opinions expressed herein, we have, without
independent inquiry or investigation, assumed that (i) all documents submitted to us as originals are authentic and complete, (ii)
all documents submitted to us as copies conform to authentic, complete originals, (iii) all signatures on all documents that we
reviewed are genuine, (iv) all natural persons executing documents had and have the legal capacity to do so, (v) all statements
in certificates of public officials and officers of the Company that we reviewed were and are accurate and (vi) all representations
made by the Company as to matters of fact in the documents that we reviewed were and are accurate.</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">Based upon the foregoing, and subject to the additional assumptions
and qualifications set forth below, we advise you that, in our opinion, assuming the Securities have been duly executed and authenticated
in accordance with the provisions of the Indenture and delivered to and paid for by the Underwriters pursuant to the Underwriting
Agreement, the Securities will constitute valid and binding obligations of the Company, enforceable in accordance with their terms,
subject to applicable bankruptcy, insolvency and similar laws affecting creditors&rsquo; rights generally, concepts of reasonableness
and equitable principles of general applicability, provided that we express no opinion as to (x) the enforceability of any waiver
of rights under any usury or stay law or (y) the validity, legally binding effect or enforceability of any provision that permits
holders to collect any portion of stated principal amount upon acceleration of the Securities to the extent determined to constitute
unearned interest.</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">In connection with the opinion expressed above, we have assumed
that the Company is validly existing as a corporation under the laws of England and Wales. In addition, we have assumed that the
Indenture and the Securities (collectively, the &ldquo;<B>Documents</B>&rdquo;) are valid, binding and enforceable agreements of
each party thereto. We have also assumed that the execution, delivery and performance by each party to each Document to which it
is a party (a) are within its corporate powers, (b) do not contravene, or constitute a default under, the certificate of incorporation
or bylaws or other constitutive documents of such party, (c) require no action by or in respect of, or filing with, any governmental
body, agency or official and (d) do not contravene, or constitute a default under, any provision of applicable law or regulation
or any judgment, injunction, order or decree or any agreement or other instrument binding upon such party.</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">We are members of the Bar of the State of New York and the foregoing
opinion is limited to the laws of the State of New York and the federal laws of the United States, except that we express no opinion
as to any law, rule or regulation that is applicable to the Company, the Documents or such transactions solely because such law,
rule or regulation is part of a regulatory regime applicable to any party to any of the Documents or any of its affiliates due
to the specific assets or business of such party or such affiliate. Insofar as the foregoing opinion involves matters governed
by the laws of England and Wales, we have relied, without independent inquiry or investigation, on the opinion of Freshfields Bruckhaus
Deringer LLP to be filed as an exhibit to a report on Form 6-K to be filed by the Company on the date hereof and our opinion is
subject to the qualifications, assumptions and limitations set forth therein.</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">We hereby consent to the filing of this opinion as an exhibit
to a report on Form 6-K to be filed by the Company on the date hereof and its incorporation by reference into the Registration
Statement and further consent to the reference to our name under the caption &ldquo;Validity of the Notes&rdquo; in the prospectus
supplement which is a part of the Registration Statement. In giving this consent, we do not admit that we are in the category of
persons whose consent is required under Section 7 of the Securities Act.</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">Very truly yours,</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">/s/ Davis Polk &amp; Wardwell London LLP</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>


<!-- Field: Page; Sequence: 3; Options: Last -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->



<P STYLE="margin: 0"></P>



</BODY>
</HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>image_001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
begin 644 image_001.jpg
M_]C_X  02D9)1@ ! 0$ > !X  #_VP!#  ," @," @,# P,$ P,$!0@%!00$
M!0H'!P8(# H,# L*"PL-#A(0#0X1#@L+$!80$1,4%145# \7&!84&!(4%13_
MVP!# 0,$! 4$!0D%!0D4#0L-%!04%!04%!04%!04%!04%!04%!04%!04%!04
M%!04%!04%!04%!04%!04%!04%!04%!3_P  1"  Q =H# 2(  A$! Q$!_\0
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M&ZMO#VHR12*>C*RVY!'N*[CP3XVT3XC^%K#Q)X;OTU31+]6>VNXT95D 8J2
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M #O?\#*IK2G/O;\/^"?6U?(O_!4K_DT^_P#^PM9?^A-7UU7R+_P5*_Y-/O\
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M?,SC) ->%?\ !1#4H=8_:0_9\O[?=]GNA;3Q[UVMM:\C89'8X-=S_P %??\
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M<$'D$$'D5[U\,_B=X;^#O['/PX\5^*]173-%L?".D&24J79F:TA"HBCEF8D
M ?R!-?,W_!0+X2:3\"_V&_!_@?0[S4+[2=*\31"";5)$DG(D2]E(9D1%.&D(
M&%' %<1^V+J4EG^RY^R3%?;F\+-I^GS:DN"5)2RM=F1W/EM<?K5PHQK4J=-/
M1RE]Q$JDJ52<VM>5'=_MN?&;QK\5/V3]8O\ _A5=]X8\$WTUE/#K&MZK#'>,
MGVA#&PLD5F 8X^\ZD YP1U]&_9Y^-WA[]GO_ ()\^!O&7B7[1)8V]O)#%;6B
M!IKB9[N8)&@) R<$Y)  4FM3_@I)=VVH?L9>(+JSECGLYI].DAEA(*.C7,15
ME(X(((Q7-?!+X2^$?CE_P3W^'7@KQ=J*:5%JBR)IMUYR)*MZMQ<-'Y08X=]H
MD^0<E=_3J,TZ<L+'FC://K;T+M..(ERN[Y?U/6=+_:&\;7&B^!-?OOA3+!X>
M\5WEA;+<V6M+=3V$=VRB*:>(0KA!O4MACMSS7O=?FQX0U;XP_P#!/WXO^"?!
M/B?73XW^$_B2\33;&4[C]FW.B9C5LO"Z;U;R@61E)QSROZ3UQ8JE&FTX6Y7L
MU?7[^QUX>HYIJ5[K=/\ X!\&_P#!7W_DB7@S_L81_P"DTU;'[;WQ/\"?&#]F
M^;P/X+UK2OB#XWU2XLAI6D^&[B/4KJ.2.6-Y)"L)8H!$)5+''WL>M8__  5]
M_P"2)>#/^QA'_I--79_MT?!'P#+^R_K_ (H30=+T3Q#H=M;WFGZQ8VT=M<)*
M)(P$WJ 2&W;=I[D$<@&N^BXJ&'YM[NWWHXZJDYUK=E^3-C5?BYKW[&/[*_@6
M7Q/X.U7Q5/I.D6MGJ5U9W=NL%E+A42*1F?><%E0,J,O'7D9S?"_[<WB;Q1X#
M\&>+X?@SJJ>'==U&#3[K5WU:%;6S::]-LA3Y3),!QEC&@W';GD&O%O&7Q \1
M_$O_ ()+7.M>*;B:^U/S[>U%_<-NDNHXM4CC21CU+87:2>24)/)KZ6_X)X_\
MF<_#K_KC>?\ I;<5G4IPITI5*D4Y<[3U?J73G.=10A*RY4^A!X5_;'D\3_M1
MR?!B;P'J&@7MO%--/?:G>PEPJP^:FV*+>I#J5(/F< ],]*_B;]LZY\-?M*>&
M?A!=_#O4M-N]:G01ZGJ5] JM;L759XTB,F]6,; !G4C'(!XKQ6Q86G_!7[4?
M.(C^TZ2!#NXW_P#$KCZ?]\-^1H_::_Y2A? [_L$V?_I5?U2P])S2Y=X7Z[V%
M[:IRMWVE;Y'T]\:/VH_#OPB\7:#X+M]/OO%GC[764:?X<TD+YI5B0))9'(6-
M/E;DG/RDXP"1=\-_&3Q++\5M+\#^*O P\.W&J:3<:K:7]KJRWL#"%XTEB;]T
MA#CSD/&1AAS7QCX;UU/#G_!7'7&\4NL,M\'M--FF!507L8Q %)[L@*>[,1U-
M?I17)7IPH*"M>\;W]>WH=%&<JSD[VL[6]#\^?V+'6/\ ;Q_:1=V"JMU?$LQP
M /[0/->^_!G]HSXB?&36+AK'X6Z3!X3M-1-A-XFB\6&:WG"L!+):+]C4W"KR
M,C:K," W!(^ K[X;^/?BA\>/VJ-*\ :Q+8Z@EU?S7>FP+B35;<7S;[97!RI(
MYP/OX"G )K[V_82_:%TCXY?!?3[.&UMM(\1>&8HM-U/2;:-8DBVKMCECC'"Q
MN%/  VLKKV!/=C*:475MS:17733]3DPM1W5.]M_GK^A\T_L@>+M;\'?M$?M.
MWF@^#-3\;7IUV4?8M-N;6 IB]NSEFGE3CM\@8^U?2G[/7[:FG?&SXE:[\/-8
M\(:IX#\::4CRMINHR+*'5"H<;@JD,-P.,8*\@FO%O^"?7_)TG[3G_8<D_P#2
MZ[JKHZA?^"OVN;0!NTE2<=_^)7#3K0A5J5%):J*=_1+Y!1E.G"#3T<FK?-GU
M#=?&SQ9JGQ(\:^%/"?P]&N)X5:VBNM2O=:2RCGEFMDN%CB'E.20LB@YP 2.>
M:Y_X,_MA6'QJ\-^,9-(\&ZU_PF/A.86^I>$TEMS<ERS*#%+(\<;@&-P<E6&P
M_*<KNX?P3^UOXP_:"^/WBKX>?#BUT'P[HWAM9OMFO>(+>6]GG\N40DPV\<L0
M&7/&YR-HR>2%KR[_ ()VQ7,'[4W[1<=[<)=WB:C*LUQ'%Y2R.+ZXW,$R=H)R
M<9.,XR:YOJ\8TYN<;.*3W?X^OX&WMG*I%1E=-M?\-Z'MO[,_[;+?M*:IXZM]
M.\!7VG_\(S;PRQVJW\4MU>N[2+Y8#B..,CR_XI,<]13_ ( ?MJGX[?'CQ+\-
MCX&O/"LV@V%S<W4VHWJ23B:&XAA:$Q(NU<&5LD.WW:^<_P#@E#_HOQ4^,]K+
M^[N!]GS&W7Y9[@-^1(_.K/[&O_*2OX\_]<=:_P#3K;5O5PU*,ZT5'X4FM_(R
MIUZDHTFWNVF?4/AO]J2]^*'CKQ?X?^&O@IO%-IX5N/L6HZO?ZJFGP-<Y<>7"
M/+D9QE&&XA1QZ$$^E_"/Q]?_ !(\'C5]4\.77A348[RYLKC2KN02/$\,S1$A
MP &4E,A@,$$$5\2?&[]E;Q9\*_$?B7X]?L^>.DBM&,^L:EHL,X>*;8[O<+&5
MS'-&#O/E./E(8*2< ?4O[(/Q^N?VDO@GIOB_4-/ATS5?M$ME>P6V[R3+&1\T
M>XD[65E."3@DC)QFN2O1IJE[2EJM%UNGYG31J3<^2IO^#7D>G>.O^1(\0_\
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MW.D(375/#T>:I!1M:/,M7V1S1K5>6$G*]Y6Z'T)I_P"V!K7Q.^+7BGP/\)?
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MZE:I%5$]'>^WRM_P3G_AW^WUXG^+/P]USQ3X1^!^LZ[%I=W/#(D&KVZ0I''
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M[&[TG0K>2YNKG3KJ%DFVH%^9D81LJY[MBME3J<_*XO:VW6W^9DZD.7F4EO\
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MW=FD8Q@N6*L@HHHJ"CY\_:M_Y!:_]<8__1IJ+]DW_D'W/^Y)_P"AK117I?\
M,,<7_+\^B****\T[0HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "
MBBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **
A** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@#__9

end
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>8
<FILENAME>dpwlogo.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
begin 644 dpwlogo.jpg
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M 0$! 0$! 0        $" P0%!@<("0H+$  " 0,# @0#!04$!    7T! @,
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M%:6WW/"G_P""I'[1VG!;O5_A#X MM/C8&9IM!^(&E*4/51?W>ORQ6['LS12
M?W376N&\L:<88V?/T7/3M\_W9P?ZU9O"SE@:48+=JG4O\OWQ^@7[*7[</@O]
MI.XF\*W>COX&^(UG:27Y\.7-\NH:?KFGVX3[7?>'-2\F![@P;PTUI-!'-&A\
MQ?,C5W3P<UR7$96U*ZJ47]I=+][:?,^CRC/L/F3="WLL335W':+[\MVW\F^_
MH?<A('&<$=NG6O%V\K'O^B$W 8P0/3@C_/6A-='MY6#;I8-PZ9'L*8>@9P<
MCZ?Y^M*S6VP6?2Q^?WC[]I']HCPY^U'I'PC\._""VU;X4WGB/P5IEYX[/A+Q
MI=S6VF:]%I[Z[?#7++4TTF(V3W-R!(]N4C\G]Z&VMGW*.!RZ66RQ%3%RAC(\
MW+33BHZ7LK<KEK_B/GL1F.9TLTAA*.$@\(W%2FXS<K-J[4E-176WN,_0+.#C
M]!_A7B.R7:Q]#Z:>6P@/.!^72DFMD_D%K=.4^0/VU?VAO%W[-?PPT'QMX,T?
MPYK6IZKXWT[PS-:^)H=3FL8[*\T77M2DGB72M3L95NA-I4"J6E9-LC@H205]
M?)L!1S#%O#UI3IP4)23@XIW5OYHR5M>QXN>YE6RK!K$4(PE/G4;34FM?*,H/
M\3\[=/\ ^"DO[6>J:4NNZ5\"O".I:&?-VZQIO@GXF7VEL(':.XVZA:>(Y(#Y
M<B.CD.=K*0V""*]YY!E,9^R>+JTZO\LJE):/;3V29\S#B;.Y052.7TIT]?>C
M3JVT\_;-)]SZS_9-_P""@.F?'WQ0GPW\:>%;7P/X\N;:[NM#ETZ^GO?#WB+[
M#&9[VPMEO$2ZTS5HK9)IUMYFG61()=LH=-C>3FF1U,!3=>A+VF'75V;7SC96
M\[(]K)^(J>/JO"UJ?U?$IV45=+TLVW?YGZ/$[?\ 9KP+VZ/Y'TWW+RV$#=N/
MH./ZT]HMV:MT>@/2RY6O/H?F:O[:WQ*_X;1_X9N_X1GP./!O_":OX;_MH6NO
M?\),+)?#[:MY_G_V]]A^U?:!LS]BV;/X,\U]'_8^&_L=YASU?;*'-R\T%"_,
MEMR<UO\ MX^4_MW%K/5E?LZ*H>TY;\L_:6LW\7M.6_\ VX'[//[:WQ)^+G[3
M?B?X)Z_X9\#Z;X:T2?Q_%;:GH]KKT6NR+X4U1K&P,\M[KUQ:DRQKNFV6J9;[
M@0<4\PR?#8++J6+I3JNI-4VU*4.7WXJ3LE"+W>GO/3<,LSS%XS-*^!J4Z,:5
M)U$G",U/W9-*[=22UMK:*/TSR,XR,CMZ9_E7S?R9]59K:R'4#/YI?^"B_'[8
M7C7M_P 2?X>GT_YEC2C7Z)D?_(EA'9>SKOMM5J_Y'Y?Q%IGL_P"[4HI?.C2Z
M'](<NF:;JVD+IVJ:?9:EI]W91PW5A?VL%W9W,,D*J\4]M<1O'+&RD@JRD$'D
M5^?<TH3<HRE%IZ--JVOD?I4:-)THPE3BX\JT<5V/YQ_B3X=L_P!FC]O33[3P
M(O\ 9.C:/\1?!FMZ/8P.XBL-%\8#3IM3T5,MG[ MMJFHVBQL<>250Y R?O\
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M V8E .":\S+L=4RVO[>E",YI-6E=+7T/5S3+*>9X=8:I4E2C%W3BK_A='2_
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%_P S_]D!

end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
