<SEC-DOCUMENT>0001654954-18-010661.txt : 20181001
<SEC-HEADER>0001654954-18-010661.hdr.sgml : 20181001
<ACCEPTANCE-DATETIME>20181001071116
ACCESSION NUMBER:		0001654954-18-010661
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20181001
FILED AS OF DATE:		20181001
DATE AS OF CHANGE:		20181001

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ASTRAZENECA PLC
		CENTRAL INDEX KEY:			0000901832
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-11960
		FILM NUMBER:		181095867

	BUSINESS ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA
		BUSINESS PHONE:		011 44 20 7304 5000

	MAIL ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ZENECA GROUP PLC
		DATE OF NAME CHANGE:	19930422
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>a4350c.htm
<DESCRIPTION>ATACAND AGREEMENT WITH CHEPLAPHARM COMPLETED
<TEXT>
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FORM 6-K</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">SECURITIES
AND EXCHANGE COMMISSION</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Washington,
D.C. 20549</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Pursuant
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<font style="font-family: Times New Roman; font-size: 13px">the
Securities Exchange Act of 1934</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">For the
month of <font style="font-weight: bold; font-size: 13px">Octobe</font><font style="font-weight: bold">r</font> <font style="font-weight: bold; font-size: 13px">2018</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Commission
File Number: 001-11960</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">1
Francis Crick Avenue</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Cambridge
Biomedical Campus</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Cambridge
CB2 0AA</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">United
Kingdom</font></div>
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by check mark whether the registrant files or will file annual
reports under cover of Form 20-F or Form 40-F.</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Form
20-F X Form 40-F __</font></div>
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by check mark if the registrant is submitting the Form 6-K in paper
as permitted by Regulation S-T Rule 101(b)(1):</font></div>
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as permitted by Regulation S-T Rule 101(b)(7): ______</font></div>
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by check mark whether the registrant by furnishing the information
contained in this Form is also thereby furnishing the information
to the Commission pursuant to Rule 12g3-2(b) under the Securities
Exchange Act of 1934.</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Yes __
No X</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">If
&#x201C;Yes&#x201D; is marked, indicate below the file number
assigned to the Registrant in connection with Rule 12g3-2(b):
82-_____________</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">INDEX
TO EXHIBITS</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">1.</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">Atacand
Agreement with Cheplapharm Completed</font></div>
</div>
</div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
1 October 2018 07:00 BST</font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="color: #000000; font-weight: bold; font-family: Times New Roman; font-size: 13px">
Agreement with Cheplapharm for rights to</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="font-style: italic; color: #000000">Atacand</font><font style="color: #000000">&#xA0;in 28 European countries
completed</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
AstraZeneca has completed an agreement with
Cheplapharm&#xA0;Arzneimittel GmbH&#xA0;(Cheplapharm) for the
commercial&#xA0;rights to&#xA0;</font><font style="font-style: italic; color: #000000">Atacand</font><font style="color: #000000">&#xA0;</font><font style="color: #000000; background-color: #FFFFFF">(candesartan
cilexetil)&#xA0;and&#xA0;</font><font style="font-style: italic; color: #000000; background-color: #FFFFFF">Atacand&#xA0;Plus</font><font style="color: #000000; background-color: #FFFFFF">&#xA0;(fixed-dose
combination of candesartan cilexetil and
hydrochlorothiazide)&#xA0;</font><font style="color: #000000">in
Europe.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000; background-color: #FFFFFF">
Under the terms of the agreement, AstraZeneca has received a
payment of&#xA0;</font><font style="color: #000000">$200 million
from Cheplapharm. A time-bound payment of $10 million as well as
sales-contingent milestones will also be payable.&#xA0;The present
value of the upfront and time-bound payments will be reported as
Other Operating Income in the company's financial statements in the
third quarter of 2018.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
AstraZeneca will continue to manufacture and
supply&#xA0;</font><font style="font-style: italic; color: #000000">Atacand</font><font style="color: #000000">&#xA0;and&#xA0;</font><font style="font-style: italic; color: #000000">Atacand</font><font style="color: #000000">&#xA0;</font><font style="font-style: italic; color: #000000">Plus</font><font style="color: #000000">&#xA0;under a supply agreement and will continue
to commercialise the medicines in all markets where it still holds
the rights</font><font style="color: #000000; background-color: #FFFFFF">.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-weight: bold; font-family: Times New Roman; font-size: 13px">
About Atacand</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000">
Atacand</font><font style="color: #000000">&#xA0;(candesartan
cilexetil) is a selective, AT1 subtype angiotensin II receptor
antagonist blocker (ARB) that is indicated for the treatment of
hypertension and heart failure.&#xA0;</font><font style="font-style: italic; color: #000000">Atacand</font><font style="color: #000000">&#xA0;</font><font style="color: #000000; font-family: Times New Roman">is also
available&#xA0;</font><font style="color: #000000">in Europe as a
fixed-dose combination of candesartan cilexetil and
hydrochlorothiazide (</font><font style="font-style: italic; color: #000000">Atacand</font><font style="color: #000000">&#xA0;</font><font style="font-style: italic; color: #000000">Plus</font><font style="color: #000000">).&#xA0;</font><font style="font-style: italic; color: #000000">Atacand</font><font style="color: #000000">&#xA0;is indicated for the management of
hypertension in adults and children/adolescents, as well as heart
failure in adults.&#xA0;</font><font style="font-style: italic; color: #000000">Atacand
Plus</font><font style="color: #000000">&#xA0;is indicated for the
management of hypertension when monotherapy is not sufficiently
effective.&#xA0;</font><font style="font-style: italic; color: #000000">Atacand</font><font style="color: #000000">&#xA0;was developed in collaboration with Takeda.
Each company holds the exclusive rights to the product in certain
markets. In other markets,&#xA0;</font><font style="font-style: italic; color: #000000">Atacand</font><font style="color: #000000">&#xA0;is co-marketed by both
parties.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
About AstraZeneca</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca is a global, science-led biopharmaceutical company that
focuses on the discovery, development and commercialisation of
prescription medicines, primarily for the treatment of diseases in
three therapy areas - Oncology, Cardiovascular, Renal &amp;
Metabolism and Respiratory. AstraZeneca operates in over 100
countries and its innovative medicines are used by millions of
patients worldwide.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
For more information, please visit&#xA0;</font><font style="text-decoration: underline; color: #0000FF">www.astrazeneca.com</font><font style="color: #000000">&#xA0;and
follow us on Twitter @AstraZeneca.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Karen
Birmingham</font></div>
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US</font></div>
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+1 302 885 2677</font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Thomas
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
Oncology</font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
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Cardiovascular; Metabolism</font></div>
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+44 7881 615 764</font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Jennifer
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
+1 866 381 7277</font></div>
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<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Adrian Kemp</font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Company Secretary</font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="text-decoration: underline; font-family: Times New Roman; font-size: 13px">
SIGNATURES</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Pursuant
to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf
by the undersigned, thereunto duly authorized.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
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<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
PLC</font></div>
</td>
</tr></table>
</div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Date:
<font style="font-weight: bold; font-size: 13px">01 October
2018</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">By: /s/
Adrian Kemp</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Name:
Adrian Kemp</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Title:
Company Secretary</font></div>
</td>
</tr></table>
</div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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