<SEC-DOCUMENT>0001654954-19-000945.txt : 20190201
<SEC-HEADER>0001654954-19-000945.hdr.sgml : 20190201
<ACCEPTANCE-DATETIME>20190201090323
ACCESSION NUMBER:		0001654954-19-000945
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20190201
FILED AS OF DATE:		20190201
DATE AS OF CHANGE:		20190201

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ASTRAZENECA PLC
		CENTRAL INDEX KEY:			0000901832
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-11960
		FILM NUMBER:		19557892

	BUSINESS ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA
		BUSINESS PHONE:		011 44 20 7304 5000

	MAIL ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ZENECA GROUP PLC
		DATE OF NAME CHANGE:	19930422
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>a8718o.htm
<DESCRIPTION>FORXIGA RECEIVES POSITIVE EU CHMP OPINION
<TEXT>
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TO EXHIBITS</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">1.</font></div>
<div style="text-align: center; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold">Forxiga receives positive EU CHMP
opinion</font></font></div>
</div>
</div>
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&#xA0;</font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
1 February 2019 1:15pm&#xA0;GMT</font></div>
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&#xA0;</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="font-style: italic; color: #000000">Forxiga&#xA0;</font><font style="color: #000000">receives
positive EU CHMP opinion</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
for the treatment of adults with type-1 diabetes</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
Forxiga is the first oral medicine recommended for approval in
Europe</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
as an adjunct treatment to insulin for adults with type-1
diabetes</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: center"><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
The Committee for Medicinal Products for Human Use (CHMP) of the
European Medicines Agency (EMA) has recommended a new indication
for the marketing authorisation of&#xA0;</font><font style="font-style: italic; color: #000000">Forxiga</font><font style="color: #000000">&#xA0;(dapagliflozin), after adopting a positive
opinion for use as an oral adjunct treatment to insulin in adults
with type-1 diabetes (T1D)</font><font style="font-style: italic; color: #000000">.</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000">
Forxiga</font><font style="color: #000000">, a selective sodium
glucose cotransporter-2 (SGLT2) inhibitor, is the first oral
medicine to receive a positive recommendation from the EMA for use
in T1D as an adjunct to insulin in patients with BMI &#x2265; 27
kg/m2, when insulin alone does not provide adequate glycaemic
control despite optimal insulin therapy. The positive opinion is
based on Phase III data from the DEPICT
(Dapagliflozin&#xA0;Evaluation in&#xA0;Patients
With&#xA0;Inadequately Controlled Type&#xA0;1-Diabetes) clinical
programme.</font></font></div>
<div style="text-align: left"><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
Elisabeth Bj&#xF6;rk, Vice President, Head of Cardiovascular, Renal
and Metabolism, BioPharmaceuticals, said: "People with type-1
diabetes&#xA0;have not seen oral treatment innovation in decades
and we believe today's announcement signals an important
advancement for them, as well as a broader understanding of the
well-established clinical profile of&#xA0;</font><font style="font-style: italic; color: #000000">Forxiga</font><font style="color: #000000">&#xA0;for people living with metabolic
diseases."</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
The DEPICT clinical programme consists of two trials, DEPICT-1 and
-2, with the primary efficacy endpoint at 24 weeks and a long-term
extension up to 52 weeks. Both trials demonstrated
that&#xA0;</font><font style="font-style: italic; color: #000000">Forxiga</font><font style="color: #000000">, when given as an oral adjunct to adjustable
insulin in adults with inadequately-controlled T1D, showed
significant reductions from baseline in HbA1c (primary endpoint),
weight and total daily insulin dose (secondary endpoints) at 24 and
52 weeks, vs. placebo, at both 5mg and 10mg
doses.</font><font style="font-size: 70%; vertical-align: top; color: #000000">1,2,3</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000">
Forxiga</font><font style="color: #000000">&#xA0;is also under
regulatory review in the US and Japan for use as adjunct treatment
to insulin in adults with T1D.</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
About the DEPICT clinical programme</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
The DEPICT clinical trial programme consists of two clinical
trials: DEPICT-1 (NCT02268214) and DEPICT-2 (NCT02460978). DEPICT-1
and DEPICT-2 are 24-week, randomised, double-blinded,
parallel-controlled trials designed to assess the effects
of&#xA0;</font><font style="font-style: italic; color: #000000">Forxiga</font><font style="color: #000000">&#xA0;5mg or 10mg on glycaemic control in patients
with T1D inadequately controlled by insulin. All patients were
evaluated at week 24 and after a 28-week extension (52 weeks in
total).</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #000000">About&#xA0;</font><font style="font-style: italic; color: #000000">Forxiga</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000">
Forxiga</font><font style="color: #000000">&#xA0;(dapagliflozin)</font><font style="font-weight: bold; color: #000000; font-family: Times New Roman">&#xA0;</font><font style="color: #000000">is
a first-in-class, oral once-daily selective inhibitor of human
sodium-glucose co-transporter 2 (SGLT2) indicated as both
monotherapy and as part of combination therapy to improve glycaemic
control, with the additional benefits of weight loss and blood
pressure reduction, as an adjunct to diet and exercise in adults
with T2D.&#xA0;</font><font style="font-style: italic; color: #000000">Forxiga</font><font style="color: #000000">&#xA0;has a robust clinical trial programme of
more than 35 completed and ongoing Phase IIb/III trials in over
35,000 patients, as well as more than 1.8 million patient-years'
experience.</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #000000">
About AstraZeneca in Cardiovascular, Renal &amp; Metabolism
(CVRM</font><font style="font-weight: bold; color: #3C4242">)</font> <font style="color: #000000"><br></font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
Cardiovascular, renal and metabolism together form one of
AstraZeneca's main therapy areas and a key growth driver for the
Company. By following the science to understand more clearly the
underlying links between the heart, kidneys and pancreas,
AstraZeneca is investing in a portfolio of medicines to protect
organs and improve outcomes by slowing disease progression,
reducing risks and tackling co-morbidities. Our ambition is to
modify or halt the natural course of CVRM diseases and potentially
regenerate organs and restore function, by continuing to deliver
transformative science that improves treatment practices and
cardiovascular health for millions of patients
worldwide.</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
About AstraZeneca</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
AstraZeneca is a global, science-led biopharmaceutical company that
focuses on the discovery, development and commercialisation of
prescription medicines, primarily for the treatment of diseases in
three therapy areas - Oncology, Cardiovascular, Renal &amp;
Metabolism and Respiratory. AstraZeneca operates in over 100
countries and its innovative medicines are used by millions of
patients worldwide. For more information, please
visit&#xA0;</font><font style="text-decoration: underline; color: #0000FF">astrazeneca.com/</font><font style="color: #000000">&#xA0;and
follow us on&#xA0;</font><font style="text-decoration: underline; color: #0000FF">Twitter</font><font style="color: #000000">@AstraZeneca.</font></font></div>
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</tr><tr>
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<font style="font-family: Times New Roman; font-size: 13px">+44 203
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<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
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Skelding</font></div>
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<td style="vertical-align: middle; width: 45%">
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<font style="font-family: Times New Roman; font-size: 13px">UK/Global</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">+44 203
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<font style="font-family: Times New Roman; font-size: 13px">+44 203
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<td style="vertical-align: middle; width: 45%">
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<font style="font-family: Times New Roman; font-size: 13px">UK/Global</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">+44
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
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<td style="vertical-align: middle; width: 45%">
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<font style="font-family: Times New Roman; font-size: 13px">US</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">+1 302
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">Investor
Relations</font></div>
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<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">Thomas
Kudsk Larsen</font></div>
</td>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: left"><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">+44 203
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</td>
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<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">Henry
Wheeler</font></div>
</td>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Oncology</font></div>
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<td style="vertical-align: middle; width: 21%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">+44 203
749 5797</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 34%">
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">Christer
Gruvris</font></div>
</td>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">BioPharma
- Cardiovascular; Metabolism</font></div>
</td>
<td style="vertical-align: middle; width: 21%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">+44 203
749 5711</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 34%">
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">Nick
Stone</font></div>
</td>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">BioPharma
- Respiratory; Renal</font></div>
</td>
<td style="vertical-align: middle; width: 21%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">+44 203
749 5716</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 34%">
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">Josie
Afolabi</font></div>
</td>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Other</font></div>
</td>
<td style="vertical-align: middle; width: 21%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">+44 203
749 5631</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 34%">
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">Craig
Marks</font></div>
</td>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Finance;
Fixed Income</font></div>
</td>
<td style="vertical-align: middle; width: 21%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">+44
7881 615 764</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 34%">
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">Jennifer
Kretzmann</font></div>
</td>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Retail
Investors; Corporate Access</font></div>
</td>
<td style="vertical-align: middle; width: 21%">
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<font style="font-family: Times New Roman; font-size: 13px">+44 203
749 5824</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 34%">
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">US
toll-free</font></div>
</td>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: left"><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">+1 866
381 72 77</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 34%">
<div style="text-align: center"><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<div style="text-align: center"><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Adrian Kemp</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Company Secretary</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
References</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">&#xA0;
<font style="color: #244061; font-family: Times New Roman; font-size: 13px"><br>
</font></div>
<div style="text-align: left; margin-left: 48px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000; font-size: 13px">1.&#xA0;&#xA0;&#xA0;Dandona P,
Mathieu C, Phillip M, et al. Efficacy and safety of dapagliflozin
in patients with inadequately controlled type 1 diabetes
(DEPICT-1): 24-week results from a randomised controlled
trial.&#xA0;</font><font style="font-style: italic; color: #000000; font-size: 13px">Lancet</font><font style="color: #000000; font-size: 13px">&#xA0;</font><font style="font-style: italic; color: #000000; font-size: 13px">Diabetes
and Endocrinol.</font><font style="color: #000000; font-size: 13px">&#xA0;</font><font style="text-decoration: underline; color: #0000FF; font-size: 13px">http://dx.doi.org/10.1016/PII</font><font style="color: #000000; font-size: 13px">.
Published Online September 14, 2017</font><font style="font-style: italic; color: #000000; font-size: 13px">.</font></font></div>
<div style="text-align: left; margin-left: 48px; margin-right: 0px; text-indent: -24px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">2.&#xA0;&#xA0;&#xA0;Mathieu
C, Dandona, P, Gillard, P, et al. Ef&#xFB01;cacy and Safety of
Dapagli&#xFB02;ozin in Patients With Inadequately Controlled Type 1
Diabetes (the DEPICT-2 Study): 24-Week Results From a Randomized
Controlled Trial. Diabetes Care 2018;41:1938-1946.</font></div>
<div style="text-align: left; margin-left: 48px; margin-right: 0px; text-indent: -24px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">3.&#xA0;&#xA0;&#xA0;Dandona
P, Mathieu C, Phillip M, et al. Efficacy and safety of
dapagliflozin in patients with inadequately controlled type 1
diabetes: The Depict-1 52-week study. Diabetes Care 2018 Dec;
41(12): 2552-2559.</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: center"><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; font-family: Times New Roman; font-size: 13px">
SIGNATURES</font></div>
<div style="text-align: center"><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Pursuant
to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf
by the undersigned, thereunto duly authorized.</font></div>
<div style="text-align: center"><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center">
<table cellpadding="0" cellspacing="0" style="text-align: center; width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 71%">
<div style="text-align: center"><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
PLC</font></div>
</td>
</tr></table>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Date:
<font style="font-weight: bold; font-size: 13px">01 February
2019</font></font></div>
<div style="text-align: center"><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center">
<table cellpadding="0" cellspacing="0" style="text-align: center; width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 71%">
<div style="text-align: center"><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">By: /s/
Adrian Kemp</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 71%">
<div style="text-align: center"><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Name:
Adrian Kemp</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 71%">
<div style="text-align: center"><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Title:
Company Secretary</font></div>
</td>
</tr></table>
</div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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