XML 43 R35.htm IDEA: XBRL DOCUMENT v3.19.2
Sequential Quarterly Product Sales - 2018 (Details) - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Jun. 30, 2019
Product sales                      
Product Sales $ 5,718 $ 5,465 $ 5,768 $ 5,266 $ 5,030 $ 4,985 $ 5,487 $ 4,882 $ 4,940 $ 4,843 $ 1,540
Actual %, quarter-on-quarter 5.00% (5.00%) 10.00% 5.00% 1.00% (9.00%) 12.00% (1.00%) 2.00% (8.00%)  
CER %, quarter-on-quarter 5.00% (7.00%) 13.00% 8.00% 1.00% (11.00%) 12.00% (3.00%) 1.00% (6.00%)  
Oncology                      
Product sales                      
Product Sales $ 2,167 $ 1,892 $ 1,767 $ 1,597 $ 1,434 $ 1,230 $ 1,120 $ 1,026 $ 993 $ 885 740
Actual %, quarter-on-quarter 15.00% 7.00% 11.00% 11.00% 17.00% 10.00% 9.00% 3.00% 12.00% (5.00%)  
CER %, quarter-on-quarter 15.00% 6.00% 13.00% 14.00% 17.00% 8.00% 9.00% 1.00% 11.00%    
Tagrisso                      
Product sales                      
Product Sales $ 784 $ 630 $ 594 $ 506 $ 422 $ 338 $ 304 $ 248 $ 232 $ 171 314
Actual %, quarter-on-quarter 24.00% 6.00% 17.00% 20.00% 25.00% 11.00% 23.00% 7.00% 36.00% 16.00%  
CER %, quarter-on-quarter 25.00% 5.00% 19.00% 23.00% 25.00% 10.00% 22.00% 5.00% 34.00% 19.00%  
Iressa                      
Product sales                      
Product Sales $ 118 $ 134 $ 112 $ 131 $ 143 $ 132 $ 130 $ 137 $ 137 $ 124 34
Actual %, quarter-on-quarter (12.00%) 20.00% (15.00%) (8.00%) 8.00% 2.00% (5.00%)   10.00% 5.00%  
CER %, quarter-on-quarter (13.00%) 19.00% (13.00%) (5.00%) 8.00% (1.00%) (6.00%) (1.00%) 9.00% 8.00%  
Lynparza                      
Product sales                      
Product Sales $ 283 $ 237 $ 209 $ 169 $ 150 $ 119 $ 100 $ 81 $ 59 $ 57 68
Actual %, quarter-on-quarter 19.00% 13.00% 24.00% 13.00% 26.00% 19.00% 23.00% 37.00% 4.00% (8.00%)  
CER %, quarter-on-quarter 20.00% 13.00% 25.00% 15.00% 26.00% 18.00% 22.00% 33.00% 2.00% (6.00%)  
Imfinzi                      
Product sales                      
Product Sales $ 338 $ 295 $ 262 $ 187 $ 122 $ 62 $ 18   $ 1   88
Actual %, quarter-on-quarter 15.00% 13.00% 40.00% 53.00% 98.00%            
CER %, quarter-on-quarter 15.00% 13.00% 41.00% 52.00% 98.00%            
Calquence                      
Product sales                      
Product Sales $ 35 $ 29 $ 24 $ 18 $ 12 8 3        
Actual %, quarter-on-quarter 21.00% 21.00% 33.00% 50.00% 51.00%            
CER %, quarter-on-quarter 21.00% 21.00% 33.00% 50.00% 50.00%            
Faslodex                      
Product sales                      
Product Sales $ 267 $ 254 $ 269 $ 258 $ 247 $ 254 $ 238 $ 241 $ 248 $ 214 64
Actual %, quarter-on-quarter 5.00% (6.00%) 4.00% 4.00% (3.00%) 7.00% (1.00%) (3.00%) 16.00% (4.00%)  
CER %, quarter-on-quarter 5.00% (6.00%) 5.00% 7.00% (2.00%) 5.00% (1.00%) (5.00%) 15.00% (3.00%)  
Zoladex                      
Product sales                      
Product Sales $ 197 $ 194 $ 182 $ 194 $ 192 $ 184 $ 187 $ 185 $ 178 $ 185 87
Actual %, quarter-on-quarter 2.00% 7.00% (6.00%) 1.00% 4.00% (2.00%) 1.00% 4.00% (4.00%) (21.00%)  
CER %, quarter-on-quarter 2.00% 5.00% (2.00%) 6.00% 5.00% (4.00%) 1.00% 2.00% (5.00%) (12.00%)  
Casodex                      
Product sales                      
Product Sales $ 57 $ 48 $ 46 $ 51 $ 52 $ 52 $ 54 $ 51 $ 54 $ 56 32
Actual %, quarter-on-quarter 19.00% 4.00% (10.00%) (2.00%)   (4.00%) 6.00% (6.00%) (4.00%) (7.00%)  
CER %, quarter-on-quarter 17.00% 4.00% (8.00%) 4.00% (2.00%) (6.00%) 6.00% (9.00%) (3.00%) (2.00%)  
Arimidex                      
Product sales                      
Product Sales $ 60 $ 51 $ 46 $ 55 $ 57 $ 54 $ 57 $ 54 $ 54 $ 52 24
Actual %, quarter-on-quarter 18.00% 11.00% (16.00%) (4.00%) 6.00% (5.00%) 6.00%   4.00% (9.00%)  
CER %, quarter-on-quarter 20.00% 9.00% (13.00%)   6.00% (7.00%) 6.00% (2.00%) 4.00% (7.00%)  
Oncology, Others                      
Product sales                      
Product Sales $ 28 $ 20 $ 23 $ 28 $ 37 $ 27 $ 29 $ 29 $ 30 $ 26 29
Actual %, quarter-on-quarter 40.00% (13.00%) (18.00%) (24.00%) 37.00% (7.00%)   (3.00%) 15.00% (10.00%)  
CER %, quarter-on-quarter 42.00% (17.00%) 13.00% (22.00%) 50.00% (20.00%) 3.00% (3.00%) 7.00% (3.00%)  
BioPharmaceuticals, CVRM                      
Product sales                      
Product Sales $ 1,658 $ 1,714 $ 1,747 $ 1,695 $ 1,623 $ 1,645 $ 1,939 $ 1,773 $ 1,775 $ 1,779 273
Actual %, quarter-on-quarter (3.00%) (2.00%) 3.00% 4.00% (1.00%) (15.00%) 9.00%     (2.00%)  
CER %, quarter-on-quarter (3.00%) (3.00%) 5.00% 8.00%   (17.00%) 9.00% (2.00%) (1.00%)    
Farxiga                      
Product sales                      
Product Sales $ 377 $ 349 $ 397 $ 355 $ 340 $ 299 $ 332 $ 285 $ 250 $ 207 72
Actual %, quarter-on-quarter 8.00% (12.00%) 12.00% 4.00% 14.00% (10.00%) 16.00% 14.00% 21.00% (13.00%)  
CER %, quarter-on-quarter 9.00% (12.00%) 13.00% 7.00% 15.00% (11.00%) 16.00% 11.00% 20.00% (13.00%)  
Brilinta                      
Product sales                      
Product Sales $ 389 $ 348 $ 376 $ 336 $ 316 $ 293 $ 299 $ 284 $ 272 $ 224 28
Actual %, quarter-on-quarter 12.00% (7.00%) 12.00% 6.00% 8.00% (2.00%) 5.00% 4.00% 21.00% (5.00%)  
CER %, quarter-on-quarter 12.00% (8.00%) 13.00% 9.00% 9.00% (4.00%) 5.00% 3.00% 20.00% (4.00%)  
Onglyza                      
Product sales                      
Product Sales $ 116 $ 153 $ 148 $ 140 $ 126 $ 129 $ 180 $ 127 $ 150 $ 154 26
Actual %, quarter-on-quarter (24.00%) 3.00% 6.00% 11.00% (2.00%) (28.00%) 42.00% (15.00%) (3.00%) 3.00%  
CER %, quarter-on-quarter (24.00%) 3.00% 8.00% 14.00% (2.00%) (29.00%) 42.00% (17.00%) (3.00%) 3.00%  
Bydureon                      
Product sales                      
Product Sales $ 141 $ 142 $ 138 $ 152 $ 155 $ 139 $ 147 $ 128 $ 146 $ 153 8
Actual %, quarter-on-quarter (1.00%) 3.00% (9.00%) (2.00%) 12.00% (5.00%) 15.00% (12.00%) (5.00%) 8.00%  
CER %, quarter-on-quarter (1.00%) 3.00% (9.00%) (1.00%) 11.00% (5.00%) 15.00% (14.00%) (5.00%) 8.00%  
Byetta                      
Product sales                      
Product Sales $ 25 $ 30 $ 32 $ 34 $ 29 $ 31 $ 48 $ 39 $ 43 $ 46 6
Actual %, quarter-on-quarter (17.00%) (6.00%) (6.00%) 17.00% (7.00%) (35.00%) 23.00% (9.00%) (7.00%) (16.00%)  
CER %, quarter-on-quarter (17.00%) (6.00%) (6.00%) 17.00% (3.00%) (38.00%) 23.00% (9.00%) (7.00%) (16.00%)  
Qtern                      
Product sales                      
Product Sales             $ 5        
Crestor                      
Product sales                      
Product Sales $ 310 $ 335 $ 353 $ 353 $ 338 $ 389 $ 594 $ 580 $ 560 $ 631 109
Actual %, quarter-on-quarter (7.00%) (5.00%)   4.00% (13.00%) (35.00%) 2.00% 4.00% (11.00%)    
CER %, quarter-on-quarter (7.00%) (6.00%) 2.00% 8.00% (12.00%) (36.00%) 2.00% 2.00% (12.00%) 3.00%  
Seloken/Toprol-XL                      
Product sales                      
Product Sales $ 168 $ 225 $ 160 $ 179 $ 173 $ 200 $ 168 $ 160 $ 181 $ 186 5
Actual %, quarter-on-quarter (25.00%) 41.00% (11.00%) 3.00% (14.00%) 19.00% 5.00% (12.00%) (3.00%) 4.00%  
CER %, quarter-on-quarter (25.00%) 39.00% (8.00%) 10.00% (13.00%) 18.00% 4.00% (14.00%) (4.00%) 6.00%  
Atacand                      
Product sales                      
Product Sales $ 56 $ 50 $ 58 $ 65 $ 66 $ 71 $ 73 $ 80 $ 72 $ 75 9
Actual %, quarter-on-quarter 12.00% (14.00%) (11.00%) (2.00%) (8.00%) (3.00%) (9.00%) 11.00% (4.00%) (7.00%)  
CER %, quarter-on-quarter 14.00% (15.00%) (9.00%) 5.00% (8.00%) (3.00%) (6.00%) 8.00% (5.00%) (6.00%)  
CVRM, Others                      
Product sales                      
Product Sales $ 68 $ 75 $ 75 $ 73 $ 73 $ 85 $ 80 $ 80 $ 90 $ 89 10
Actual %, quarter-on-quarter (9.00%)   3.00% (3.00%) (13.00%) 6.00%   (11.00%) 1.00% 3.00%  
CER %, quarter-on-quarter (8.00%)   3.00%   (11.00%) 4.00% (4.00%) (12.00%) (3.00%) 12.00%  
BioPharmaceuticals, Respiratory                      
Product sales                      
Product Sales $ 1,252 $ 1,283 $ 1,362 $ 1,142 $ 1,226 $ 1,181 $ 1,334 $ 1,092 $ 1,099 $ 1,181 262
Actual %, quarter-on-quarter (2.00%) (6.00%) 19.00% (7.00%) 4.00% (11.00%) 22.00% (1.00%) (7.00%) (2.00%)  
CER %, quarter-on-quarter (2.00%) (6.00%) 21.00% (4.00%) 4.00% (13.00%) 21.00% (3.00%) (8.00%) (1.00%)  
Symbicort                      
Product sales                      
Product Sales $ 585 $ 585 $ 636 $ 619 $ 672 $ 634 $ 752 $ 668 $ 706 $ 677 171
Actual %, quarter-on-quarter   (8.00%) 3.00% (8.00%) 6.00% (16.00%) 13.00% (5.00%) 4.00% (9.00%)  
CER %, quarter-on-quarter 1.00% (8.00%) 4.00% (5.00%) 6.00% (17.00%) 12.00% (7.00%) 3.00% (7.00%)  
Pulmicort                      
Product sales                      
Product Sales $ 333 $ 383 $ 389 $ 264 $ 287 $ 346 $ 371 $ 242 $ 226 $ 337 40
Actual %, quarter-on-quarter (13.00%) (2.00%) 47.00% (8.00%) (17.00%) (7.00%) 53.00% 7.00% (33.00%) 17.00%  
CER %, quarter-on-quarter (13.00%) (2.00%) 51.00% (4.00%) (17.00%) (8.00%) 51.00% 5.00% (33.00%) 19.00%  
Daliresp/Daxas                      
Product sales                      
Product Sales $ 56 $ 48 $ 54 $ 52 $ 45 $ 38 $ 53 $ 53 $ 48 $ 44 1
Actual %, quarter-on-quarter 17.00% (11.00%) 4.00% 16.00% 19.00% (28.00%)   10.00% 9.00% 7.00%  
CER %, quarter-on-quarter 19.00% (13.00%) 4.00% 18.00% 22.00% (30.00%) (2.00%) 8.00% 9.00% 10.00%  
Tudorza/Eklira                      
Product sales                      
Product Sales $ 13 $ 20 $ 19 $ 18 $ 39 $ 34 $ 42 $ 37 $ 34 $ 37 3
Actual %, quarter-on-quarter (35.00%) 5.00% 6.00% (54.00%) 15.00% (19.00%) 14.00% 9.00% (8.00%) 3.00%  
CER %, quarter-on-quarter (30.00%)   11.00% (59.00%) 15.00% (21.00%) 14.00% 6.00% (8.00%) 6.00%  
Duaklir                      
Product sales                      
Product Sales $ 17 $ 20 $ 22 $ 23 $ 22 $ 28 $ 23 $ 21 $ 16 $ 19 1
Actual %, quarter-on-quarter (15.00%) (9.00%) (4.00%) 5.00% (22.00%) 22.00% 10.00% 31.00% (16.00%)    
CER %, quarter-on-quarter (14.00%) (9.00%)   5.00% (19.00%) 17.00% 10.00% 18.00% (15.00%)    
Fasenra                      
Product sales                      
Product Sales $ 167 $ 129 $ 125 $ 86 $ 65 $ 21         42
Actual %, quarter-on-quarter 29.00% 3.00% 45.00% 32.00%              
CER %, quarter-on-quarter 30.00% 2.00% 46.00% 34.00%              
Bevespi                      
Product sales                      
Product Sales $ 10 $ 10 $ 10 $ 10 $ 8 $ 5 $ 8 $ 4 $ 3 $ 1  
Actual %, quarter-on-quarter       25.00% 61.00% (38.00%)   33.00%   (67.00%)  
CER %, quarter-on-quarter       25.00% 60.00% (38.00%)   33.00%   (50.00%)  
Respiratory, Others                      
Product sales                      
Product Sales $ 71 $ 88 $ 107 $ 70 $ 88 $ 75 $ 85 $ 67 $ 66 $ 66 4
Actual %, quarter-on-quarter (19.00%) (20.00%) 53.00% (20.00%) 17.00% (12.00%) 27.00% 2.00%   (20.00%)  
CER %, quarter-on-quarter (23.00%) (19.00%) 57.00% (13.00%) 16.00% (20.00%) 30.00% 4.00% (4.00%) (19.00%)  
Other medicines                      
Product sales                      
Product Sales $ 641 $ 576 $ 892 $ 832 $ 747 $ 929 $ 1,094 $ 991 $ 1,073 $ 998 265
Actual %, quarter-on-quarter 11.00% (35.00%) 7.00% 12.00% (20.00%) (15.00%) 10.00% (8.00%) 8.00% (24.00%)  
CER %, quarter-on-quarter 13.00% (41.00%) 22.00% 15.00% (20.00%) (16.00%) 10.00% (9.00%) 7.00% (22.00%)  
Nexium                      
Product sales                      
Product Sales $ 393 $ 363 $ 390 $ 422 $ 442 $ 448 $ 427 $ 469 $ 595 $ 461 236
Actual %, quarter-on-quarter 8.00% (7.00%) (8.00%) (5.00%) (1.00%) 5.00% (9.00%) (21.00%) 29.00% (6.00%)  
CER %, quarter-on-quarter 9.00% 3.00% (7.00%) 97.00% (1.00%) 3.00% (9.00%) (22.00%) 28.00% (4.00%)  
Synagis                      
Product sales                      
Product Sales $ 96 $ 53 $ 251 $ 164 $ 26 $ 224 $ 234 $ 153 $ 70 $ 230  
Actual %, quarter-on-quarter 81.00% (79.00%) 53.00%   (89.00%) (4.00%) 53.00%   (70.00%) (24.00%)  
CER %, quarter-on-quarter 81.00% (90.00%)     (88.00%) (4.00%) 53.00%   (70.00%) (24.00%)  
Seroquel XR/IR                      
Product sales                      
Product Sales $ 32 $ 37 $ 56 $ 77 $ 131 $ 97 $ 156 $ 113 $ 135 $ 104 11
Actual %, quarter-on-quarter (14.00%) (34.00%) (27.00%) (41.00%) 35.00%   38.00% (16.00%) 30.00% (36.00%)  
CER %, quarter-on-quarter (13.00%) (32.00%) (31.00%) 6.00% 37.00% 40.00% 36.00% (16.00%) 30.00% (35.00%)  
Losec/Prilosec                      
Product sales                      
Product Sales $ 68 $ 76 $ 60 $ 67 $ 76 $ 69 $ 69 $ 66 $ 68 $ 68 13
Actual %, quarter-on-quarter (11.00%) 27.00% (10.00%) (12.00%) 10.00%   5.00% (3.00%)   15.00%  
CER %, quarter-on-quarter (11.00%) 27.00% (8.00%) 85.00% 11.00% (4.00%) 5.00% (6.00%) (3.00%) 18.00%  
Movantik/Moventig                      
Product sales                      
Product Sales $ 22 $ 25 $ 25 $ 32 $ 24 $ 28 $ 30 $ 30 $ 32 $ 30  
Actual %, quarter-on-quarter (12.00%)   (22.00%) 33.00% (14.00%) (7.00%)   (6.00%) 7.00% 15.00%  
CER %, quarter-on-quarter (12.00%)   (22.00%) 167.00% (14.00%) (7.00%)   (6.00%) 7.00% 15.00%  
FluMist/Fluenz                      
Product sales                      
Product Sales     $ 75 $ 35     58 $ 20      
Other, Others                      
Product sales                      
Product Sales $ 30 $ 22 $ 35 $ 35 $ 48 $ 63 $ 120 $ 140 $ 173 $ 105 $ 5
Actual %, quarter-on-quarter 36.00% (29.00%)   (27.00%) (25.00%) (62.00%) (14.00%) (19.00%) 65.00% (48.00%)  
CER %, quarter-on-quarter 50.00% (54.00%) 31.00%   (26.00%) (45.00%) (15.00%) (21.00%)   44.00%