<SEC-DOCUMENT>0001654954-19-011226.txt : 20190930
<SEC-HEADER>0001654954-19-011226.hdr.sgml : 20190930
<ACCEPTANCE-DATETIME>20190930121324
ACCESSION NUMBER:		0001654954-19-011226
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20190930
FILED AS OF DATE:		20190930
DATE AS OF CHANGE:		20190930

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ASTRAZENECA PLC
		CENTRAL INDEX KEY:			0000901832
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-11960
		FILM NUMBER:		191125066

	BUSINESS ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA
		BUSINESS PHONE:		011 44 20 7304 5000

	MAIL ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ZENECA GROUP PLC
		DATE OF NAME CHANGE:	19930422
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>a1899o.htm
<DESCRIPTION>LYNPARZA MORE THAN DOUBLED THE TIME WITHOUT RADIOGRAPHIC DISEASE PROGRESSION IN PATIENTS WITH BRCA1/2- OR ATM-MUTATED METASTATIC CASTRATION-RESISTANT PROSTATE CANCER
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TO EXHIBITS</font></div>
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<font style="font-size: 13px; font-family: Times New Roman">1.</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-weight: bold; font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000">
Lynparza</font><font style="color: #000000">&#xA0;more than doubled
the time without radiographic disease progression in patients with
BRCA1/2- or ATM-mutated metastatic castration-resistant prostate
cancer</font></font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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&#xA0;</font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
30 September 2019 15:30 BST</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="font-style: italic; color: #000000">Lynparza</font><font style="color: #000000">&#xA0;more than doubled the time without
radiographic disease progression in patients with BRCA1/2- or
ATM-mutated metastatic castration-resistant prostate
cancer</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-weight: bold; font-style: italic; font-family: Times New Roman; font-size: 13px">
AstraZeneca and MSD's Lynparza reduced the risk of disease
progression or&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
death by 51% in men with homologous recombination repair (HRR) gene
mutations</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
First positive Phase III trial testing a targeted
treatment</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
in biomarker-selected prostate cancer patients</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
and MSD Inc., Kenilworth, N.J., US (MSD: known as Merck &amp; Co.,
Inc. inside the US and Canada) today presented detailed results
from the Phase III PROfound trial in 387 men with metastatic
castration-resistant prostate cancer (mCRPC) who have a mutation in
their homologous recombination repair (HRRm) genes and whose
disease had progressed on prior treatment with new hormonal agent
(NHA) treatments (e.g. abiraterone or enzalutamide).</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">The
trial was designed to analyse men with HRRm genes in two cohorts:
the primary endpoint was in those with mutations in BRCA1/2 or ATM
genes and then, if&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;(olaparib) showed
clinical benefit, a formal analysis was performed of the overall
trial population of men with HRRm genes (BRCA1/2, ATM, CDK12 and 11
other HRRm genes; key secondary endpoint).</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Results&#xA0;showed
a statistically significant and clinically meaningful improvement
with&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;in
the primary endpoint of radiographic progression-free survival
(rPFS), improving the time men with BRCA1/2- or ATM-mutated mCRPC
lived without disease progression or death to a median of 7.4
months vs. 3.6 months for those treated with abiraterone or
enzalutamide.&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;reduced the risk of
disease progression or death by 66% (equal to a hazard ratio of
0.34) for these men.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">The
trial also met the key secondary endpoint of rPFS in the overall
HRRm population, where&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;reduced the risk of
disease progression or death by 51% (equal to a hazard ratio of
0.49) and improved rPFS to a median of 5.8 months vs. 3.5 months
for abiraterone or enzalutamide.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">The
results were presented during the Presidential Symposium at the
2019 European Society of Medical Oncology (ESMO) congress in
Barcelona, Spain (Abstract #LBA12_PR).</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Results
also showed a trend at this interim analysis time point for
improvement in overall survival (OS), another key secondary
endpoint, in the two groups.&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;extended OS to 18.5
months vs.15.1 months for abiraterone or enzalutamide in men with
BRCA1/2- or ATM-mutated tumours, despite that at this interim
analysis 81% of patients on NHA crossed over to&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;at progression. A similar
trend in OS was observed at this interim analysis in the overall
HRRm population with a median of 17.5 months' OS for men treated
with&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;vs.
14.3 months for abiraterone or enzalutamide (analysis at 41% data
maturity).</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Jos&#xE9;
Baselga, Executive Vice President, Oncology R&amp;D, said: "Results
from PROfound demonstrate that, in addition to providing
substantial benefit as a precision medicine for men with metastatic
castration-resistant prostate cancer with BRCA-mutated
tumours,&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;is effective beyond just
BRCA in tumours with mutations in other genes associated with
homologous recombination repair. PROfound validates the concept of
PARP sensitivity across multiple genes associated with homologous
recombination repair in this disease and marks the first positive
Phase III trial using a molecular biomarker to identify men for
targeted treatment for metastatic castration-resistant prostate
cancer. We are working with global health authorities to
bring&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;to
these patients as quickly as possible."</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Roy
Baynes, Senior Vice President and Head of Global Clinical
Development, Chief Medical Officer, MSD Research Laboratories,
said: "The results from the Phase III PROfound trial are a
testament to MSD and AstraZeneca's lasting commitment to patients
with cancer. The trial met the primary endpoint in men with
metastatic castration-resistant prostate cancer that progressed on
prior hormonal therapy, a notoriously difficult-to-treat disease.
The benefit seen in patients beyond just those with BRCA mutations
underscores the potential value of genomic testing in prostate
cancer."</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Maha
Hussain, one of the principal investigators of the PROfound trial
and Deputy Director of the Robert H. Lurie Comprehensive Cancer
Center of Northwestern University, said: "We have seen advances in
the treatment over the last 15 years for men with metastatic
castration-resistant prostate cancer. However, to date treatments
for this state of disease continue to use 'one size fits all'
approaches overlooking the genomic make-up of the tumour and how it
could inform treatment decisions to better personalise care and
impact outcomes. I am thrilled by the PROfound results
and<font style="font-weight: bold">&#xA0;</font><font style="font-style: italic">Lynparza's</font><font style="font-weight: bold">&#xA0;</font>clinically meaningful benefit
which offers the potential of a molecularly targeted treatment for
this patient population with advanced disease. I am confident we
are now entering a new era of personalised care and precision
medicine for metastatic castration-resistant prostate
cancer."</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #000000">
Summary of results</font><font style="font-size: 70%; vertical-align: top; color: #000000">i</font></font></div>
<div>
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<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 28%; border-left: 0.5pt solid #000000; border-top: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
Cohort A</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
(BRCA1/2 or ATM)</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 30%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-top: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold">
Cohort A+B</font><font style="font-size: 70%; vertical-align: top">&#xA0;ii</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
(Overall HRRm)</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; font-family: Times New Roman; font-size: 13px">
Lynparza</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">n=162</font></div>
</td>
<td style="vertical-align: top; width: 15%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">pcNHA</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">n=83</font></div>
</td>
<td style="vertical-align: top; width: 9%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; font-family: Times New Roman; font-size: 13px">
Lynparza</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">n=256</font></div>
</td>
<td style="vertical-align: top; width: 22%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">pcNHA</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">n=131</font></div>
</td>
</tr><tr>
<td colspan="5" style="vertical-align: top; width: 100%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
rPFS</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Median,
months</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">7.4</font></div>
</td>
<td style="vertical-align: top; width: 15%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">3.6</font></div>
</td>
<td style="vertical-align: top; width: 9%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">5.8</font></div>
</td>
<td style="vertical-align: top; width: 22%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">3.5</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">%
progression-free at 6 months</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">59.8</font></div>
</td>
<td style="vertical-align: top; width: 15%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">22.6</font></div>
</td>
<td style="vertical-align: top; width: 9%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">49.7</font></div>
</td>
<td style="vertical-align: top; width: 22%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">23.7</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">%
progression-free at 12 months</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">28.1</font></div>
</td>
<td style="vertical-align: top; width: 15%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">9.4</font></div>
</td>
<td style="vertical-align: top; width: 9%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">22.1</font></div>
</td>
<td style="vertical-align: top; width: 22%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">13.5</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Hazard
ratio (95% CI)</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 28%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">0.34
(0.25-0.47)</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 30%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">0.49
(0.38-0.63)</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">p-value</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 28%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&lt;0.0001</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 30%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&lt;0.0001</font></div>
</td>
</tr><tr>
<td colspan="5" style="vertical-align: top; width: 100%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
Confirmed ORR</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Patients
with response (%)</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">33.3</font></div>
</td>
<td style="vertical-align: top; width: 15%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">2.3</font></div>
</td>
<td style="vertical-align: top; width: 9%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">21.7</font></div>
</td>
<td style="vertical-align: top; width: 22%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">4.5</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Odds
ratio (95% CI)</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 28%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">20.86
(4.18-379.18)</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 30%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">5.93
(2.01-25.40)</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">p-value</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 28%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&lt;0.0001</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 30%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">0.0006
(nominal)</font></div>
</td>
</tr><tr>
<td colspan="5" style="vertical-align: top; width: 100%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold">
Time to pain progression</font><font style="font-size: 70%; vertical-align: top">&#xA0;iii</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Median,
months</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">NR</font></div>
</td>
<td style="vertical-align: top; width: 15%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">9.92</font></div>
</td>
<td style="vertical-align: top; width: 9%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 22%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Hazard
ratio (95% CI)</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 28%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">0.44
(0.22-0.91)</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 30%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">p-value</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 28%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">0.0192</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 30%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="5" style="vertical-align: top; width: 100%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold">
OS (interim)</font><font style="font-size: 70%; vertical-align: top">&#xA0;iv</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Median,
months</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">18.5</font></div>
</td>
<td style="vertical-align: top; width: 15%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">15.1</font></div>
</td>
<td style="vertical-align: top; width: 9%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">17.5</font></div>
</td>
<td style="vertical-align: top; width: 22%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">14.3</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Hazard
ratio (95% CI)</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 28%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">0.64
(0.43-0.97)</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 30%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">0.67
(0.49-0.93)</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 42%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">p-value</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 28%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">0.0173</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 30%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">0.0063
(nominal)</font></div>
</td>
</tr></table>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
NR, not reached; ORR, objective response rate; pc, physician's
choice</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; color: #000000">
i&#xA0;</font><font style="color: #000000">Assessed by blinded
independent central review (BICR)</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; color: #000000">
ii&#xA0;</font><font style="color: #000000">Cohort B included
patients with any 1 of 12 other HRR mutations</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; color: #000000">
iii&#xA0;</font><font style="color: #000000">Time to pain
progression in Cohort A was a secondary endpoint included in the
formal testing hierarchy</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; color: #000000">
iv&#xA0;</font><font style="color: #000000">Interim analysis was
done at 38% (Cohort A) and 41% (Cohort A+B) data maturity; Alpha
spend at interim was 0.01; statistical significance not
reached</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">The
safety and tolerability profile of&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;in the PROfound trial was
in line with that observed in prior clinical trials. The most
common adverse events (AEs) &#x2265;20% were anaemia (47%), nausea
(41%), fatigue/asthenia (41%), decreased appetite (30%) and
diarrhoea (21%). Grade 3 or above AEs were anaemia (22%), pulmonary
embolism (4%), fatigue/asthenia (3%), vomiting (2%), dyspnoea (2%),
urinary tract infection (2%), decreased appetite (1%), diarrhoea
(1%) and backpain (1%). 16% of patients on&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;discontinued treatment
due to AEs.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
and MSD are also exploring additional trials in prostate cancer,
including the ongoing Phase III PROpel trial,
testing&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;as a 1st-line therapy in
mCRPC, in combination with abiraterone.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-weight: bold; font-family: Times New Roman; font-size: 13px">
About PROfound</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">PROfound
is&#xA0;<font style="background-color: #FFFFFF">a prospective,
multicentre, randomised, open-label, Phase III trial testing the
efficacy and safety of&#xA0;</font><font style="font-style: italic; background-color: #FFFFFF">Lynparza</font><font style="background-color: #FFFFFF">&#xA0;versus
new hormonal agents (e.g. abiraterone or enzalutamide) in patients
with mCRPC who have progressed on prior treatment
with&#xA0;</font>new hormonal anticancer treatments&#xA0;and have a
qualifying tumour mutation in one of 15 genes involved in the HRR
pathway, including among them BRCA1/2, ATM and CDK12.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
About metastatic castration-resistant prostate cancer</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000; background-color: #FFFFFF">
Prostate&#xA0;</font><font style="color: #000000">cancer</font><font style="color: #000000; background-color: #FFFFFF">&#xA0;is the
second-most common cancer in men, with an estimated 1.3 million new
cases diagnosed worldwide in 2018 and is associated with a
significant mortality rate.</font><font style="font-size: 70%; vertical-align: top; color: #000000; background-color: #FFFFFF">1</font><font style="color: #000000; background-color: #FFFFFF">Development
of prostate cancer is often driven by male sex hormones called
androgens, including testosterone.</font><font style="font-size: 70%; vertical-align: top; color: #000000; background-color: #FFFFFF">2</font><font style="color: #000000; background-color: #FFFFFF">&#xA0;mCRPC
occurs when prostate cancer grows and spreads to other parts of the
body despite the use of androgen-deprivation therapy to block the
action of male sex hormones.</font><font style="font-size: 70%; vertical-align: top; color: #000000; background-color: #FFFFFF">2</font><font style="color: #000000; background-color: #FFFFFF">&#xA0;Approximately
10-20% of men with advanced prostate cancer will develop CRPC
within five years, and at least 84% of these will have metastases
at the time of CRPC diagnosis.</font><font style="font-size: 70%; vertical-align: top; color: #000000; background-color: #FFFFFF">3</font><font style="color: #000000; background-color: #FFFFFF">Of
men with no metastases at CRPC diagnosis, 33% are likely to develop
metastases within two years.</font><font style="font-size: 70%; vertical-align: top; color: #000000; background-color: #FFFFFF">3</font><font style="color: #000000; background-color: #FFFFFF">&#xA0;Despite
an increase in the number of available therapies for men with
mCRPC, five-year survival remains low.</font><font style="font-size: 70%; vertical-align: top; color: #000000; background-color: #FFFFFF">3</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 70%; vertical-align: top; color: #000000; background-color: #FFFFFF; font-family: Times New Roman">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; background-color: #FFFFFF">
About HRR gene mutations</font>&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">HRR is
a DNA repair process that allows for high-fidelity, error-free
repair of damaged DNA, in the form of double-strand breaks and
inter-strand crosslinks (amongst others).<font style="font-size: 70%; vertical-align: top">4</font><font style="font-size: 70%; vertical-align: top">,5</font>&#xA0;The inability
to properly repair DNA damage leads to genomic instability and
contributes to cancer aetiology.<font style="font-size: 70%; vertical-align: top">5&#xA0;</font>Deficiency in
HRR leads to a compromised ability to repair damaged DNA, and is a
feature of cancer cells that is a target for PARP inhibitors, such
as&#xA0;<font style="font-style: italic">Lynparza</font>.&#xA0;PARP
inhibitors block DNA damage repair by trapping of PARP bound to DNA
single-strand breaks which leads to replication fork stalling
causing their collapse and the generation of DNA double-strand
breaks which in turn lead to cancer cell death.<font style="font-size: 70%; vertical-align: top">4</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; background-color: #FFFFFF; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #000000">About&#xA0;</font><font style="font-style: italic; color: #000000">Lynparza</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000; background-color: #FFFFFF">
Lynparza</font><font style="color: #000000; background-color: #FFFFFF">&#xA0;(olaparib) is a
first-in-class PARP inhibitor and the first targeted treatment to
block DNA damage response (DDR) in cells/tumours harbouring a
deficiency in homologous recombination repair (HRR), such as
mutations in BRCA1 and/or BRCA2. Inhibition of PARP
with&#xA0;</font><font style="font-style: italic; color: #000000; background-color: #FFFFFF">Lynparza</font><font style="color: #000000; background-color: #FFFFFF">&#xA0;leads
to the trapping of PARP bound to DNA single-strand breaks, stalling
of replication forks, their collapse and the generation of DNA
double-strand breaks and cancer cell
death.&#xA0;</font><font style="font-style: italic; color: #000000; background-color: #FFFFFF">Lynparza</font><font style="color: #000000; background-color: #FFFFFF">&#xA0;is
being tested in a range of PARP-dependent tumour types with defects
and dependencies in the DDR pathway.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; background-color: #FFFFFF; font-weight: bold; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic">
Lynparza</font>&#xA0;is currently approved in 64 countries,
including those in the EU, for the maintenance treatment of
platinum-sensitive relapsed ovarian cancer, regardless of BRCA
status. It is approved in the US, the EU, Japan and several other
countries as 1st-line maintenance treatment of BRCA-mutated
advanced ovarian cancer following response to platinum-based
chemotherapy. It is also approved in 43 countries, including the US
and Japan, for germline BRCA-mutated, HER2-negative, metastatic
breast cancer, previously treated with chemotherapy; in the EU,
this includes locally-advanced breast cancer. Regulatory reviews
are underway in other jurisdictions for ovarian, breast and
pancreatic cancers.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000; background-color: #FFFFFF">
Lynparza</font><font style="color: #000000; background-color: #FFFFFF">, which is being
jointly developed and commercialised by AstraZeneca and MSD, is
approved for advanced ovarian cancer and metastatic breast cancer
and has been used in over 25,000 patients
worldwide.&#xA0;</font><font style="font-style: italic; color: #000000; background-color: #FFFFFF">Lynparza</font><font style="color: #000000; background-color: #FFFFFF">&#xA0;has
the broadest and most advanced clinical trial development programme
of any PARP inhibitor, and AstraZeneca and MSD are working together
to understand how it may affect multiple PARP-dependent tumours as
a monotherapy and in combination across multiple cancer
types.&#xA0;</font><font style="font-style: italic; color: #000000; background-color: #FFFFFF">Lynparza</font><font style="color: #000000; background-color: #FFFFFF">&#xA0;is
the foundation of AstraZeneca's industry-leading portfolio of
potential new medicines targeting DDR mechanisms in cancer
cells.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; background-color: #FFFFFF; font-weight: bold; font-family: Times New Roman; font-size: 13px">
About the AstraZeneca and MSD strategic oncology
collaboration</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000; background-color: #FFFFFF">
In July 2017, AstraZeneca and Merck &amp; Co., Inc., Kenilworth,
NJ, US, known as MSD outside the United States and Canada,
announced a global strategic oncology collaboration to co-develop
and co-commercialise&#xA0;</font><font style="font-style: italic; color: #000000; background-color: #FFFFFF">Lynparza</font><font style="color: #000000; background-color: #FFFFFF">,
the world's first PARP inhibitor, and potential new medicine
selumetinib, a MEK inhibitor, for multiple cancer types. Working
together, the companies will develop&#xA0;</font><font style="font-style: italic; color: #000000; background-color: #FFFFFF">Lynparza</font><font style="color: #000000; background-color: #FFFFFF">&#xA0;and
selumetinib in combination with other potential new medicines and
as monotherapies. Independently, the companies will
develop&#xA0;</font><font style="font-style: italic; color: #000000; background-color: #FFFFFF">Lynparza</font><font style="color: #000000; background-color: #FFFFFF">&#xA0;and
selumetinib in combination with their respective PD-L1 and PD-1
medicines.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; background-color: #FFFFFF; font-weight: bold; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; background-color: #FFFFFF; font-weight: bold; font-family: Times New Roman; font-size: 13px">
About AstraZeneca in Oncology</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; background-color: #FFFFFF; font-family: Times New Roman; font-size: 13px">
AstraZeneca has a deep-rooted heritage in Oncology and offers a
quickly-growing portfolio of new medicines that has the potential
to transform patients' lives and the Company's future. With at
least six new medicines to be launched between 2014 and 2020, and a
broad pipeline of small molecules and biologics in development, we
are committed to advance Oncology as one of AstraZeneca's four
Growth Platforms focused on lung, ovarian, breast and blood
cancers. In addition to our core capabilities, we actively pursue
innovative partnerships and investments that accelerate the
delivery of our strategy, as illustrated by our investment in
Acerta Pharma in haematology.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; background-color: #FFFFFF; font-family: Times New Roman; font-size: 13px">
By harnessing the power of four scientific platforms -
Immuno-Oncology, Tumour Drivers and Resistance, DNA Damage Response
and Antibody Drug Conjugates - and by championing the development
of personalised combinations, AstraZeneca has the vision to
redefine cancer treatment and one day eliminate cancer as a cause
of death.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
About AstraZeneca</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
AstraZeneca is a global, science-led biopharmaceutical company that
focuses on the discovery, development and commercialisation of
prescription medicines, primarily for the treatment of diseases in
three therapy areas - Oncology, Cardiovascular, Renal and
Metabolism (CVRM), and Respiratory. AstraZeneca operates in over
100 countries and its innovative medicines are used by millions of
patients worldwide.&#xA0;Please visit&#xA0;</font><font style="text-decoration: underline; color: #0000FF">astrazeneca.com</font><font style="color: #000000">&#xA0;and
follow us on Twitter&#xA0;</font><font style="text-decoration: underline; color: #0000FF">@</font><font style="text-decoration: underline; color: #0000FF">AstraZeneca</font><font style="text-decoration: underline; color: #0000FF">.</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px">BioPharmaceuticals
(CV, metabolism)</font></div>
</td>
<td style="vertical-align: middle; width: 7%;">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">+44 203
749 5711</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 7%;">
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">Nick
Stone</font></div>
</td>
<td style="vertical-align: middle; width: 10%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">BioPharmaceuticals
(respiratory, renal)</font></div>
</td>
<td style="vertical-align: middle; width: 7%;">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">+44 203
749 5716</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 7%;">
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">Josie
Afolabi</font></div>
</td>
<td style="vertical-align: middle; width: 10%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Other
medicines</font></div>
</td>
<td style="vertical-align: middle; width: 7%;">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">+44 203
749 5631</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 7%;">
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">Craig
Marks</font></div>
</td>
<td style="vertical-align: middle; width: 10%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Finance,
fixed income</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">+44
7881 615 764</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 7%;">
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">Jennifer
Kretzmann</font></div>
</td>
<td style="vertical-align: middle; width: 10%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Corporate
access, retail investors</font></div>
</td>
<td style="vertical-align: middle; width: 7%;">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">+44 203
749 5824</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 7%;">
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">US
toll-free</font></div>
</td>
<td style="vertical-align: middle; width: 10%;">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%;">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">+1 866
381 72 77</font></div>
</td>
</tr></table>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
References</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
1.&#xA0;Bray, F., Ferlay, et al. (2018). Global cancer statistics
2018: GLOBOCAN estimates of incidence and mortality worldwide for
36 cancers in 185 countries. CA:&#xA0;</font><font style="font-style: italic; color: #000000">A Cancer Journal for
Clinicians</font><font style="color: #000000">, 68(6),
pp.394-424.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
2. Cancer.Net. (2019). Treatment of metastatic castration-resistant
prostate cancer.&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="text-decoration: underline; color: #0000FF">
https://www.cancer.net/research-and-advocacy/asco-care-and-treatment-recommendations-patients/treatment-metastatic-castration-resistant-prostate-cancer&#xA0;</font><font style="color: #000000">[Accessed
September 2019].</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
3. Cancer.Net. (2019). Prostate Cancer - Statistics. Available
at:&#xA0;</font><font style="text-decoration: underline; color: #0000FF">www.cancer.net/cancer-types/prostate-cancer/statistics&#xA0;</font><font style="color: #000000">[Accessed
September 2019].</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
4. Li, X. and Heyer, W. (2008). Homologous recombination in DNA
repair and DNA damage tolerance.&#xA0;</font><font style="font-style: italic; color: #000000">Cell
Research</font><font style="color: #000000">, 18(1),
pp.99-113.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
5. Ledermann, J., Drew, Y. and Kristeleit, R. (2016). Homologous
recombination deficiency and ovarian
cancer.&#xA0;</font><font style="font-style: italic; color: #000000">European Journal of
Cancer</font><font style="color: #000000">, 60,
pp.49-58.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Adrian Kemp</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Company Secretary</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; font-family: Times New Roman; font-size: 13px">
SIGNATURES</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Pursuant
to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf
by the undersigned, thereunto duly authorized.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div>
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<tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
PLC</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Date:
<font style="font-weight: bold; font-size: 13px">30 September
2019</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">By: /s/
Adrian Kemp</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Name:
Adrian Kemp</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Title:
Company Secretary</font></div>
</td>
</tr></table>
</div>
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