<SEC-DOCUMENT>0001654954-19-012884.txt : 20191114
<SEC-HEADER>0001654954-19-012884.hdr.sgml : 20191114
<ACCEPTANCE-DATETIME>20191114081504
ACCESSION NUMBER:		0001654954-19-012884
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20191114
FILED AS OF DATE:		20191114
DATE AS OF CHANGE:		20191114

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ASTRAZENECA PLC
		CENTRAL INDEX KEY:			0000901832
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-11960
		FILM NUMBER:		191216433

	BUSINESS ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA
		BUSINESS PHONE:		011 44 20 7304 5000

	MAIL ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ZENECA GROUP PLC
		DATE OF NAME CHANGE:	19930422
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>a3493t.htm
<DESCRIPTION>FDA ACCEPTS REGULATORY SUBMISSION FOR SELUMETINIB
<TEXT>
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AstraZeneca PLC</font></div>
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Francis Crick Avenue</font></div>
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TO EXHIBITS</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">1.</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">US
FDA accepts regulatory submission for selumetinib</font>
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">in
neurofibromatosis type 1 and grants Priority Review</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
14 November 2019 07:00 GMT</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-weight: bold; font-family: Times New Roman; font-size: 13px">
US FDA accepts regulatory submission for selumetinib</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
in neurofibromatosis type 1 and grants Priority Review</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-weight: bold; font-style: italic; font-family: Times New Roman; font-size: 13px">
AstraZeneca and MSD's selumetinib would become the first medicine
indicated for the treatment of paediatric patients with NF1
plexiform neurofibromas if approved</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca and MSD Inc., Kenilworth, N.J., US (MSD: known as Merck
&amp; Co., Inc. inside the US and Canada)&#xA0;today announced that
the US Food and Drug Administration (FDA) has accepted a New Drug
Application (NDA)&#xA0;and granted Priority Review
for&#xA0;selumetinib&#xA0;as a potential new medicine for
paediatric patients aged three years and older with
neurofibromatosis type 1 (NF1) and symptomatic, inoperable
plexiform neurofibromas (PNs).</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
This is the first acceptance of a regulatory submission for an oral
monotherapy for the treatment of NF1, a rare and incurable genetic
condition.&#xA0;A Prescription Drug User Fee Act (PDUFA) date is
set for the second quarter of 2020.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
The regulatory submission was based on positive results from the
National Cancer Institute (NCI) Cancer Therapy Evaluation Program
(CTEP)-sponsored SPRINT Phase II Stratum 1 trial. An Objective
Response Rate (ORR) was achieved in 66% of paediatric patients with
NF1 and symptomatic, inoperable PNs&#xA0;(n=33/50 patients) when
treated with selumetinib as a twice-daily oral monotherapy. ORR was
defined as the percentage of patients with a confirmed complete or
partial response of &#x2265; 20% tumour volume
reduction.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
Selumetinib, a MEK 1/2 inhibitor was granted&#xA0;US
FDA&#xA0;</font><font style="text-decoration: underline; color: #0000FF">Breakthrough Therapy
Designation</font><font style="color: #000000">&#xA0;in April
2019,&#xA0;Orphan Drug Designation&#xA0;in February
2018,&#xA0;</font><font style="text-decoration: underline; color: #0000FF">EU Orphan
Designation</font><font style="color: #000000">&#xA0;in August
2018&#xA0;and Swissmedic Orphan Drug Status in December
2018</font>.&#xA0;<font style="color: #000000">AstraZeneca and MSD
are jointly developing and commercialising selumetinib globally
under a license agreement.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
About SPRINT</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
SPRINT is a US NCI CTEP-sponsored Phase I/II trial. The Phase I
trial was designed to identify the optimal Phase II dosing regimen,
and the results were published in&#xA0;</font><font style="font-style: italic; text-decoration: underline; color: #0000FF">The&#xA0;New
England Journal of Medicine</font><font style="font-style: italic; text-decoration: underline; color: #0000FF">.</font><font style="font-size: 70%; vertical-align: top; color: #000000">1</font><font style="color: #000000">&#xA0;</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-weight: bold; font-family: Times New Roman; font-size: 13px">
About selumetinib&#xA0;&#xA0;&#xA0;&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
Selumetinib is a MEK 1/2 inhibitor. It is designed to inhibit the
MEK enzyme in the RAS/MAPK pathway, a cell-signalling pathway,
associated with cancer cell growth and proliferation in a number of
different tumour types.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
About NF1</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
NF1 is an incurable genetic condition that affects one in every
3,000 to 4,000 individuals.</font><font style="font-size: 70%; vertical-align: top; color: #000000">2,3</font><font style="color: #000000">&#xA0;It
is caused by a spontaneous or inherited mutation in
the&#xA0;NF1&#xA0;gene and is associated with many symptoms,
including soft lumps on and under the skin (cutaneous
neurofibromas), skin pigmentation (so-called 'cafe au
lait'&#xA0;spots) and, in 30-50% of patients, tumours develop on
the nerve sheaths (plexiform neurofibromas).</font><font style="font-size: 70%; vertical-align: top; color: #000000">1</font><font style="color: #000000">&#xA0;These
plexiform neurofibromas can cause clinical issues such as pain,
motor dysfunction, airway dysfunction, bowel/bladder dysfunction
and disfigurement as well as having the potential to transform into
malignant peripheral nerve sheath tumours
(MPNST).</font><font style="font-size: 70%; vertical-align: top; color: #000000">1</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
People with NF1 may experience a number of complications such as
learning difficulties, visual impairment, twisting and curvature of
the spine, high blood pressure, and epilepsy. NF1 also increases a
person's risk of developing other cancers, including malignant
brain tumours, MPNST and leukaemia. Symptoms begin during early
childhood, with varying degrees of severity, and can reduce life
expectancy by up to 15 years.</font><font style="font-size: 70%; vertical-align: top; color: #000000">4</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
About the AstraZeneca and MSD strategic oncology
collaboration</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">In July
2017, AstraZeneca and Merck &amp; Co., Inc., Kenilworth, NJ, US,
known as MSD outside the United States and Canada, announced a
global strategic oncology collaboration to co-develop and
co-commercialise&#xA0;<font style="font-style: italic">Lynparza</font>, the world's first PARP
inhibitor, and potential new medicine selumetinib, a MEK inhibitor,
for multiple cancer types. Working together, the companies will
develop&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;and selumetinib in
combination with other potential new medicines and as
monotherapies. Independently, the companies will
develop&#xA0;<font style="font-style: italic">Lynparza</font>&#xA0;and selumetinib in
combination with their respective PD-L1 and PD-1
medicines.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
About AstraZeneca in Oncology</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
has a deep-rooted heritage in Oncology and offers a quickly-growing
portfolio of new medicines that has the potential to transform
patients' lives and the Company's future. With at least six new
medicines to be launched between 2014 and 2020, and a broad
pipeline of small molecules and biologics in development, we are
committed to advance Oncology as one of AstraZeneca's four Growth
Platforms focused on lung, ovarian, breast and blood cancers. In
addition to our core capabilities, we actively pursue innovative
partnerships and investments that accelerate the delivery of our
strategy, as illustrated by our investment in Acerta Pharma in
haematology.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">By
harnessing the power of four scientific platforms -
Immuno-Oncology, Tumour Drivers and Resistance, DNA Damage Response
and Antibody Drug Conjugates - and by championing the development
of personalised combinations, AstraZeneca has the vision to
redefine cancer treatment and one day eliminate cancer as a cause
of death.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
About AstraZeneca</font></div>
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AstraZeneca is a global, science-led biopharmaceutical company that
focuses on the discovery, development and commercialisation of
prescription medicines, primarily for the treatment of diseases in
three therapy areas - Oncology, Cardiovascular, Renal and
Metabolism, and Respiratory. AstraZeneca operates in over 100
countries and its innovative medicines are used by millions of
patients worldwide. Please visit&#xA0;</font><font style="text-decoration: underline; color: #0000FF">astrazeneca.com</font><font style="color: #000000">&#xA0;and
follow the Company on Twitter&#xA0;</font><font style="text-decoration: underline; color: #0000FF">@</font><font style="text-decoration: underline; color: #0000FF">AstraZeneca</font><font style="text-decoration: underline; color: #0000FF">.</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Rob
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<font style="font-family: Times New Roman; font-size: 13px">Oncology</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">+44 203
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<font style="font-family: Times New Roman; font-size: 13px">Rebecca
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<font style="font-family: Times New Roman; font-size: 13px">Oncology</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">+1 301
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<font style="font-family: Times New Roman; font-size: 13px">Matt
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<font style="font-family: Times New Roman; font-size: 13px">BioPharmaceuticals</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Jennifer
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<font style="font-family: Times New Roman; font-size: 13px">+44
203&#xA0;749 5762</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Christina Malmberg
H&#xE4;gerstrand</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Michele
Meixell</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">+1 302
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Relations</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Thomas
Kudsk Larsen</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Henry
Wheeler</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Oncology</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">+44 203
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<font style="font-family: Times New Roman; font-size: 13px">Christer
Gruvris</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">BioPharmaceuticals
(CV, Metabolism)</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">+44 203
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<font style="font-family: Times New Roman; font-size: 13px">Nick
Stone</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">BioPharmaceuticals
(Renal), ESG</font></div>
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<td style="vertical-align: middle; width: 21%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">+44 203
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<font style="font-family: Times New Roman; font-size: 13px">Josie
Afolabi</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">BioPharmaceuticals
(Respiratory),</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">other
medicines</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Craig
Marks</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Finance,
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<font style="font-family: Times New Roman; font-size: 13px">+44
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<font style="font-family: Times New Roman; font-size: 13px">Corporate
access, retail investors</font></div>
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<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px">US
toll-free</font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
References</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
1. Dombi E, et al. Activity of Selumetinib in Neurofibromatosis
Type 1-Related Plexiform Neurofibromas.&#xA0;</font><font style="font-style: italic; color: #000000">N Engl J
Med</font><font style="color: #000000">.
2016;375:2550-2560.</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000; font-size: 13px">
2. National Institute of Neurological Disorders and Stroke.
Neurofibromatosis Fact Sheet. "What is NF1?" Available
at:&#xA0;</font><font style="text-decoration: underline; color: #0000FF; font-size: 13px">https://www.ninds.nih.gov/disorders/patient-caregiver-education/fact-sheets/neurofibromatosis-fact-sheet
#3162_2</font><font style="color: #000000; font-size: 13px">&#xA0;Accessed October
2019.</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000; font-size: 13px">
3. ASCO Cancer.Net. Neurofibromatosis Type 1. Available
at&#xA0;</font><font style="text-decoration: underline; color: #0000FF; font-size: 13px">https://www.cancer.net/cancer-types/neurofibromatosis-type-1</font><font style="color: #000000; font-size: 13px">&#xA0;Accessed
June 2019.</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
4. Evans DGR,&#xA0;</font><font style="font-style: italic; color: #000000">et al</font><font style="color: #000000">. Reduced Life Expectancy Seen in Hereditary
Diseases Which Predispose to Early-Onset
Tumors.&#xA0;</font><font style="font-style: italic; color: #000000">Appl Clin
Genet</font><font style="color: #000000">.
2013;6:53-61.</font></font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Adrian Kemp</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Company Secretary</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="text-decoration: underline; font-family: Times New Roman; font-size: 13px">
SIGNATURES</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Pursuant
to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf
by the undersigned, thereunto duly authorized.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
PLC</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Date:
<font style="font-weight: bold; font-size: 13px">14 November
2019</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">By: /s/
Adrian Kemp</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Name:
Adrian Kemp</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Title:
Company Secretary</font></div>
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