<SEC-DOCUMENT>0001104659-20-012390.txt : 20200207
<SEC-HEADER>0001104659-20-012390.hdr.sgml : 20200207
<ACCEPTANCE-DATETIME>20200207125814
ACCESSION NUMBER:		0001104659-20-012390
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20191219
FILED AS OF DATE:		20200207
DATE AS OF CHANGE:		20200207

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ASTRAZENECA PLC
		CENTRAL INDEX KEY:			0000901832
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35112
		FILM NUMBER:		20586369

	BUSINESS ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA
		BUSINESS PHONE:		011 44 20 7304 5000

	MAIL ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA

	FORMER NAME:	
		FORMER CONFORMED NAME:	ZENECA GROUP PLC
		DATE OF NAME CHANGE:	19930422

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			MedImmune Ltd
		CENTRAL INDEX KEY:			0001790714
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35112
		FILM NUMBER:		20586370

	BUSINESS ADDRESS:	
		STREET 1:		MILSTEIN BUILDING, GRANTA PARK
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB21 6GH
		BUSINESS PHONE:		44 1223 471471

	MAIL ADDRESS:	
		STREET 1:		MILSTEIN BUILDING, GRANTA PARK
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB21 6GH

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Aevi Genomic Medicine, Inc.
		CENTRAL INDEX KEY:			0001138776
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				980217544
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		435 DEVON PARK DRIVE,
		STREET 2:		SUITE 715
		CITY:			WAYNE
		STATE:			PA
		ZIP:			19087
		BUSINESS PHONE:		610-254-4201

	MAIL ADDRESS:	
		STREET 1:		435 DEVON PARK DRIVE,
		STREET 2:		SUITE 715
		CITY:			WAYNE
		STATE:			PA
		ZIP:			19087

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MEDGENICS, INC.
		DATE OF NAME CHANGE:	20090623

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MEDGENICS INC
		DATE OF NAME CHANGE:	20010419
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>a4.xml
<DESCRIPTION>4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2019-12-19</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001138776</issuerCik>
        <issuerName>Aevi Genomic Medicine, Inc.</issuerName>
        <issuerTradingSymbol>GNMX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000901832</rptOwnerCik>
            <rptOwnerName>ASTRAZENECA PLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1 FRANCIS CRICK AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>CAMBRIDGE BIOMEDICAL CAMPUS</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>X0</rptOwnerState>
            <rptOwnerZipCode>CB2 0AA</rptOwnerZipCode>
            <rptOwnerStateDescription>UNITED KINGDOM</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001790714</rptOwnerCik>
            <rptOwnerName>MedImmune Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1 FRANCIS CRICK AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>CAMBRIDGE BIOMEDICAL CAMPUS</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>X0</rptOwnerState>
            <rptOwnerZipCode>CB2 0AA</rptOwnerZipCode>
            <rptOwnerStateDescription>UNITED KINGDOM</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2019-12-19</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>12946900</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>12946900</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">All of these securities were issued to MedImmune Limited in satisfaction of the Issuer's obligations to MedImmune Limited pursuant to the Option and License Agreement, dated August 6, 2019, between the Issuer and MedImmune Limited.</footnote>
        <footnote id="F2">All of these securities are owned by MedImmune Limited, which is a wholly-owned subsidiary of AstraZeneca PLC. AstraZeneca PLC may be deemed to beneficially own the shares held by MedImmune Limited, but disclaims beneficial ownership except to the extent of its pecuniary interest therein, if any.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>AstraZeneca PLC, By: /s/ Adrian Kemp</signatureName>
        <signatureDate>2020-02-07</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>MedImmune Limited, By: /s/ Adrian Kemp</signatureName>
        <signatureDate>2020-02-07</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
