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H1 2021 Product Sales year-on-year analysis (Details) - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended
Jun. 30, 2021
Mar. 31, 2021
Dec. 31, 2020
Sep. 30, 2020
Jun. 30, 2020
Mar. 31, 2020
Jun. 30, 2021
Product sales              
Product Sales $ 8,045 $ 7,257 $ 7,011 $ 6,520 $ 6,048 $ 6,311  
World              
Product sales              
Product Sales $ 8,045           $ 15,302
Actual %, year-on-year 33.00%           24.00%
CER %, year-on-year 27.00%           19.00%
Emerging Markets              
Product sales              
Product Sales $ 2,834           $ 5,423
Actual %, year-on-year 38.00%           26.00%
CER %, year-on-year 31.00%           20.00%
US              
Product sales              
Product Sales $ 2,470           $ 4,729
Actual %, year-on-year 23.00%           16.00%
Europe              
Product sales              
Product Sales $ 1,704           $ 3,243
Actual %, year-on-year 55.00%           41.00%
CER %, year-on-year 39.00%           28.00%
Established ROW              
Product sales              
Product Sales $ 1,037           $ 1,907
Actual %, year-on-year 17.00%           15.00%
CER %, year-on-year 12.00%           9.00%
Total Oncology              
Product sales              
Product Sales $ 3,286 2,981 2,908 2,831 2,609 2,502  
Total Oncology | World              
Product sales              
Product Sales $ 3,286           $ 6,267
Actual %, year-on-year 26.00%           23.00%
CER %, year-on-year 21.00%           18.00%
Total Oncology | Emerging Markets              
Product sales              
Product Sales $ 864           $ 1,626
Actual %, year-on-year 15.00%           11.00%
CER %, year-on-year 8.00%           6.00%
Total Oncology | US              
Product sales              
Product Sales $ 1,301           $ 2,494
Actual %, year-on-year 33.00%           28.00%
Total Oncology | Europe              
Product sales              
Product Sales $ 608           $ 1,183
Actual %, year-on-year 38.00%           33.00%
CER %, year-on-year 23.00%           20.00%
Total Oncology | Established ROW              
Product sales              
Product Sales $ 513           $ 964
Actual %, year-on-year 18.00%           19.00%
CER %, year-on-year 15.00%           14.00%
Tagrisso              
Product sales              
Product Sales $ 1,306 1,149 1,157 1,155 1,034 982  
Tagrisso | World              
Product sales              
Product Sales $ 1,306           $ 2,454
Actual %, year-on-year 26.00%           22.00%
CER %, year-on-year 21.00%           17.00%
Tagrisso | Emerging Markets              
Product sales              
Product Sales $ 390           $ 697
Actual %, year-on-year 24.00%           17.00%
CER %, year-on-year 15.00%           10.00%
Tagrisso | US              
Product sales              
Product Sales $ 438           $ 853
Actual %, year-on-year 24.00%           18.00%
Tagrisso | Europe              
Product sales              
Product Sales $ 244           $ 468
Actual %, year-on-year 49.00%           44.00%
CER %, year-on-year 34.00%           30.00%
Tagrisso | Established ROW              
Product sales              
Product Sales $ 234           $ 436
Actual %, year-on-year 16.00%           18.00%
CER %, year-on-year 13.00%           13.00%
Imfinzi              
Product sales              
Product Sales $ 604 556 555 533 492 462  
Imfinzi | World              
Product sales              
Product Sales $ 604           $ 1,160
Actual %, year-on-year 23.00%           22.00%
CER %, year-on-year 19.00%           18.00%
Imfinzi | Emerging Markets              
Product sales              
Product Sales $ 75           $ 133
CER %, year-on-year             99.00%
Imfinzi | US              
Product sales              
Product Sales $ 305           $ 597
Actual %, year-on-year 6.00%           4.00%
Imfinzi | Europe              
Product sales              
Product Sales $ 118           $ 227
Actual %, year-on-year 28.00%           36.00%
CER %, year-on-year 15.00%           23.00%
Imfinzi | Established ROW              
Product sales              
Product Sales $ 106           $ 203
Actual %, year-on-year 30.00%           35.00%
CER %, year-on-year 26.00%           30.00%
Lynparza              
Product sales              
Product Sales $ 588 543 496 464 419 397  
Lynparza | World              
Product sales              
Product Sales $ 588           $ 1,131
Actual %, year-on-year 40.00%           39.00%
CER %, year-on-year 35.00%           34.00%
Lynparza | Emerging Markets              
Product sales              
Product Sales $ 99           $ 186
Actual %, year-on-year 54.00%           54.00%
CER %, year-on-year 47.00%           50.00%
Lynparza | US              
Product sales              
Product Sales $ 269           $ 523
Actual %, year-on-year 29.00%           29.00%
Lynparza | Europe              
Product sales              
Product Sales $ 153           $ 301
Actual %, year-on-year 59.00%           52.00%
CER %, year-on-year 43.00%           38.00%
Lynparza | Established ROW              
Product sales              
Product Sales $ 67           $ 121
Actual %, year-on-year 35.00%           32.00%
CER %, year-on-year 30.00%           26.00%
Calquence              
Product sales              
Product Sales $ 280 209 182 145 107 88  
Calquence | World              
Product sales              
Product Sales 280           $ 490
Calquence | Emerging Markets              
Product sales              
Product Sales 5           7
Calquence | US              
Product sales              
Product Sales 250           445
Calquence | Europe              
Product sales              
Product Sales 22           32
Calquence | Established ROW              
Product sales              
Product Sales 3           6
Koselugo              
Product sales              
Product Sales 26 21 17 13 7    
Koselugo | World              
Product sales              
Product Sales 26           48
Koselugo | US              
Product sales              
Product Sales 26           47
Koselugo | Europe              
Product sales              
Product Sales             1
Enhertu              
Product sales              
Product Sales 3 1          
Enhertu | World              
Product sales              
Product Sales 3           4
Enhertu | Emerging Markets              
Product sales              
Product Sales 3           4
Zoladex              
Product sales              
Product Sales 244 221 216 230 217 225  
Zoladex | World              
Product sales              
Product Sales $ 244           $ 466
Actual %, year-on-year 12.00%           5.00%
CER %, year-on-year 5.00%           (1.00%)
Zoladex | Emerging Markets              
Product sales              
Product Sales $ 159           $ 296
Actual %, year-on-year 14.00%           3.00%
CER %, year-on-year 7.00%           (3.00%)
Zoladex | US              
Product sales              
Product Sales $ 3           $ 8
Actual %, year-on-year 2.00%           58.00%
Zoladex | Europe              
Product sales              
Product Sales $ 37           $ 74
Actual %, year-on-year 12.00%           9.00%
CER %, year-on-year (1.00%)           (1.00%)
Zoladex | Established ROW              
Product sales              
Product Sales $ 45           $ 88
Actual %, year-on-year 6.00%           9.00%
CER %, year-on-year 2.00%           3.00%
Faslodex              
Product sales              
Product Sales $ 105 122 130 138 146 166  
Faslodex | World              
Product sales              
Product Sales $ 105           $ 227
Actual %, year-on-year (28.00%)           (27.00%)
CER %, year-on-year (31.00%)           (31.00%)
Faslodex | Emerging Markets              
Product sales              
Product Sales $ 38           $ 80
Actual %, year-on-year (28.00%)           (20.00%)
CER %, year-on-year (30.00%)           (22.00%)
Faslodex | US              
Product sales              
Product Sales $ 7           $ 16
Actual %, year-on-year (35.00%)           (52.00%)
Faslodex | Europe              
Product sales              
Product Sales $ 30           $ 71
Actual %, year-on-year (43.00%)           (39.00%)
CER %, year-on-year (49.00%)           (45.00%)
Faslodex | Established ROW              
Product sales              
Product Sales $ 30           $ 60
Actual %, year-on-year (1.00%)           (3.00%)
CER %, year-on-year (2.00%)           (6.00%)
Iressa              
Product sales              
Product Sales $ 47 61 67 54 70 77  
Iressa | World              
Product sales              
Product Sales $ 47           $ 107
Actual %, year-on-year (34.00%)           (27.00%)
CER %, year-on-year (38.00%)           (31.00%)
Iressa | Emerging Markets              
Product sales              
Product Sales $ 36           $ 89
Actual %, year-on-year (38.00%)           (26.00%)
CER %, year-on-year (43.00%)           (31.00%)
Iressa | US              
Product sales              
Product Sales $ 3           $ 5
Actual %, year-on-year (30.00%)           (27.00%)
Iressa | Europe              
Product sales              
Product Sales $ 1           $ 3
Actual %, year-on-year (61.00%)           (66.00%)
CER %, year-on-year (68.00%)           (71.00%)
Iressa | Established ROW              
Product sales              
Product Sales $ 7           $ 10
Actual %, year-on-year 30.00%           (10.00%)
CER %, year-on-year 27.00%           (13.00%)
Arimidex              
Product sales              
Product Sales $ 29 44 36 42 58 50  
Arimidex | World              
Product sales              
Product Sales $ 29           $ 73
Actual %, year-on-year (50.00%)           (32.00%)
CER %, year-on-year (53.00%)           (35.00%)
Arimidex | Emerging Markets              
Product sales              
Product Sales $ 20           $ 56
Actual %, year-on-year (58.00%)           (37.00%)
CER %, year-on-year (60.00%)           (40.00%)
Arimidex | Europe              
Product sales              
Product Sales $ 1           $ 2
Actual %, year-on-year 14.00%           26.00%
CER %, year-on-year (22.00%)           12.00%
Arimidex | Established ROW              
Product sales              
Product Sales $ 8           $ 15
Actual %, year-on-year (10.00%)           (10.00%)
CER %, year-on-year (11.00%)           (13.00%)
Casodex              
Product sales              
Product Sales $ 41 42 39 44 47 42  
Casodex | World              
Product sales              
Product Sales $ 41           $ 82
Actual %, year-on-year (14.00%)           (7.00%)
CER %, year-on-year (19.00%)           (13.00%)
Casodex | Emerging Markets              
Product sales              
Product Sales $ 32           $ 64
Actual %, year-on-year (14.00%)           (7.00%)
CER %, year-on-year (21.00%)           (14.00%)
Casodex | Europe              
Product sales              
Product Sales             $ 1
Actual %, year-on-year             (29.00%)
CER %, year-on-year             (10.00%)
Casodex | Established ROW              
Product sales              
Product Sales $ 9           $ 17
Actual %, year-on-year (12.00%)           (7.00%)
CER %, year-on-year (14.00%)           (10.00%)
Oncology, Others              
Product sales              
Product Sales $ 13 12 13 13 12 13  
Oncology, Others | World              
Product sales              
Product Sales $ 13           $ 25
Actual %, year-on-year 12.00%           (1.00%)
CER %, year-on-year 6.00%           (4.00%)
Oncology, Others | Emerging Markets              
Product sales              
Product Sales $ 7           $ 14
Actual %, year-on-year 24.00%           4.00%
CER %, year-on-year 18.00%           1.00%
Oncology, Others | Europe              
Product sales              
Product Sales $ 2           $ 3
Actual %, year-on-year 46.00%           19.00%
CER %, year-on-year (8.00%)           4.00%
Oncology, Others | Established ROW              
Product sales              
Product Sales $ 4           $ 8
Actual %, year-on-year (26.00%)           (13.00%)
CER %, year-on-year (20.00%)           (13.00%)
BioPharmaceuticals: total CVRM              
Product sales              
Product Sales $ 2,023 1,912 1,842 1,794 1,759 1,701  
BioPharmaceuticals: total CVRM | World              
Product sales              
Product Sales $ 2,023           $ 3,935
Actual %, year-on-year 15.00%           14.00%
CER %, year-on-year 9.00%           9.00%
BioPharmaceuticals: total CVRM | Emerging Markets              
Product sales              
Product Sales $ 975           $ 1,921
Actual %, year-on-year 16.00%           19.00%
CER %, year-on-year 9.00%           14.00%
BioPharmaceuticals: total CVRM | US              
Product sales              
Product Sales $ 525           $ 987
Actual %, year-on-year 6.00%            
BioPharmaceuticals: total CVRM | Europe              
Product sales              
Product Sales $ 363           $ 727
Actual %, year-on-year 31.00%           24.00%
CER %, year-on-year 18.00%           13.00%
BioPharmaceuticals: total CVRM | Established ROW              
Product sales              
Product Sales $ 160           $ 300
Actual %, year-on-year 9.00%           9.00%
CER %, year-on-year 3.00%           3.00%
Farxiga              
Product sales              
Product Sales $ 732 624 586 525 443 405  
Farxiga | World              
Product sales              
Product Sales $ 732           $ 1,356
Actual %, year-on-year 65.00%           60.00%
CER %, year-on-year 56.00%           53.00%
Farxiga | Emerging Markets              
Product sales              
Product Sales $ 297           $ 557
Actual %, year-on-year 80.00%           82.00%
CER %, year-on-year 70.00%           77.00%
Farxiga | US              
Product sales              
Product Sales $ 171           $ 302
Actual %, year-on-year 38.00%           27.00%
Farxiga | Europe              
Product sales              
Product Sales $ 198           $ 372
Actual %, year-on-year 86.00%           67.00%
CER %, year-on-year 67.00%           51.00%
Farxiga | Established ROW              
Product sales              
Product Sales $ 66           $ 125
Actual %, year-on-year 41.00%           53.00%
CER %, year-on-year 33.00%           44.00%
Brilinta              
Product sales              
Product Sales $ 375 374 363 385 437 408  
Brilinta | World              
Product sales              
Product Sales $ 375           $ 749
Actual %, year-on-year (14.00%)           (11.00%)
CER %, year-on-year (18.00%)           (15.00%)
Brilinta | Emerging Markets              
Product sales              
Product Sales $ 74           $ 180
Actual %, year-on-year (52.00%)           (38.00%)
CER %, year-on-year (55.00%)           (40.00%)
Brilinta | US              
Product sales              
Product Sales $ 194           $ 360
Actual %, year-on-year 4.00%           2.00%
Brilinta | Europe              
Product sales              
Product Sales $ 90           $ 178
Actual %, year-on-year 13.00%           3.00%
CER %, year-on-year 1.00%           (7.00%)
Brilinta | Established ROW              
Product sales              
Product Sales $ 17           $ 31
Actual %, year-on-year 19.00%           6.00%
CER %, year-on-year             (7.00%)
Bydureon              
Product sales              
Product Sales $ 95 103 122 109 116 100  
Bydureon | World              
Product sales              
Product Sales $ 95           $ 198
Actual %, year-on-year (18.00%)           (9.00%)
CER %, year-on-year (20.00%)           (10.00%)
Bydureon | Emerging Markets              
Product sales              
Product Sales $ 1           $ 2
Actual %, year-on-year 97.00%           (6.00%)
CER %, year-on-year 77.00%           (7.00%)
Bydureon | US              
Product sales              
Product Sales $ 77           $ 162
Actual %, year-on-year (24.00%)           (12.00%)
Bydureon | Europe              
Product sales              
Product Sales $ 15           $ 29
Actual %, year-on-year 17.00%           20.00%
CER %, year-on-year 1.00%           7.00%
Bydureon | Established ROW              
Product sales              
Product Sales $ 2           $ 5
Actual %, year-on-year (19.00%)           (9.00%)
CER %, year-on-year (34.00%)           (22.00%)
Onglyza              
Product sales              
Product Sales $ 99 101 105 110 115 141  
Onglyza | World              
Product sales              
Product Sales $ 99           $ 200
Actual %, year-on-year (14.00%)           (22.00%)
CER %, year-on-year (18.00%)           (25.00%)
Onglyza | Emerging Markets              
Product sales              
Product Sales $ 51           $ 108
Actual %, year-on-year (3.00%)           9.00%
CER %, year-on-year (9.00%)           4.00%
Onglyza | US              
Product sales              
Product Sales $ 26           $ 44
Actual %, year-on-year (33.00%)           (58.00%)
Onglyza | Europe              
Product sales              
Product Sales $ 15           $ 31
Actual %, year-on-year 12.00%           6.00%
CER %, year-on-year             (4.00%)
Onglyza | Established ROW              
Product sales              
Product Sales $ 7           $ 17
Actual %, year-on-year (31.00%)           (25.00%)
CER %, year-on-year (39.00%)           (30.00%)
Byetta              
Product sales              
Product Sales $ 16 16 19 15 15 20  
Byetta | World              
Product sales              
Product Sales $ 16           $ 32
Actual %, year-on-year 6.00%           (9.00%)
CER %, year-on-year             (12.00%)
Byetta | Emerging Markets              
Product sales              
Product Sales $ 4           $ 8
Actual %, year-on-year             72.00%
CER %, year-on-year             79.00%
Byetta | US              
Product sales              
Product Sales $ 7           $ 15
Actual %, year-on-year (6.00%)           (20.00%)
Byetta | Europe              
Product sales              
Product Sales $ 3           $ 5
Actual %, year-on-year (19.00%)           (27.00%)
CER %, year-on-year (35.00%)           (38.00%)
Byetta | Established ROW              
Product sales              
Product Sales $ 2           $ 4
Actual %, year-on-year (16.00%)           (17.00%)
CER %, year-on-year (25.00%)           (26.00%)
Other diabetes              
Product sales              
Product Sales $ 15 13 12 11 10 13  
Other diabetes | World              
Product sales              
Product Sales $ 15           $ 29
Actual %, year-on-year 49.00%           23.00%
CER %, year-on-year 40.00%           17.00%
Other diabetes | Emerging Markets              
Product sales              
Product Sales $ 4           $ 8
Other diabetes | US              
Product sales              
Product Sales $ 6           $ 11
Actual %, year-on-year (4.00%)           (15.00%)
Other diabetes | Europe              
Product sales              
Product Sales $ 5           $ 9
Actual %, year-on-year 71.00%           53.00%
CER %, year-on-year 47.00%           35.00%
Other diabetes | Established ROW              
Product sales              
Product Sales             $ 1
Actual %, year-on-year             25.00%
CER %, year-on-year             18.00%
Lokelma              
Product sales              
Product Sales $ 39 33 28 21 17 11  
Lokelma | World              
Product sales              
Product Sales 39           $ 72
Lokelma | Emerging Markets              
Product sales              
Product Sales $ 1           2
Actual %, year-on-year 79.00%            
CER %, year-on-year 78.00%            
Lokelma | US              
Product sales              
Product Sales $ 25           49
Lokelma | Europe              
Product sales              
Product Sales 3           5
Lokelma | Established ROW              
Product sales              
Product Sales 10           16
Roxadustat              
Product sales              
Product Sales 51 39          
Roxadustat | World              
Product sales              
Product Sales 51           90
Roxadustat | Emerging Markets              
Product sales              
Product Sales 51           90
Crestor              
Product sales              
Product Sales 265 274 298 300 281 301  
Crestor | World              
Product sales              
Product Sales $ 265           $ 539
Actual %, year-on-year (6.00%)           (7.00%)
CER %, year-on-year (11.00%)           (11.00%)
Crestor | Emerging Markets              
Product sales              
Product Sales $ 182           $ 372
Actual %, year-on-year 3.00%           1.00%
CER %, year-on-year (3.00%)           (4.00%)
Crestor | US              
Product sales              
Product Sales $ 19           $ 41
Actual %, year-on-year 10.00%           (10.00%)
Crestor | Europe              
Product sales              
Product Sales $ 12           $ 32
Actual %, year-on-year (61.00%)           (50.00%)
CER %, year-on-year (67.00%)           (54.00%)
Crestor | Established ROW              
Product sales              
Product Sales $ 52           $ 94
Actual %, year-on-year (8.00%)           (10.00%)
CER %, year-on-year (10.00%)           (12.00%)
Seloken/Toprol-XL              
Product sales              
Product Sales $ 266 250 200 225 218 177  
Seloken/Toprol-XL | World              
Product sales              
Product Sales $ 266           $ 515
Actual %, year-on-year 22.00%           30.00%
CER %, year-on-year 14.00%           24.00%
Seloken/Toprol-XL | Emerging Markets              
Product sales              
Product Sales $ 260           $ 503
Actual %, year-on-year 24.00%           34.00%
CER %, year-on-year 15.00%           27.00%
Seloken/Toprol-XL | US              
Product sales              
Product Sales             $ 1
Actual %, year-on-year (83.00%)           (88.00%)
Seloken/Toprol-XL | Europe              
Product sales              
Product Sales $ 3           $ 6
Actual %, year-on-year (20.00%)           (23.00%)
CER %, year-on-year (12.00%)           (20.00%)
Seloken/Toprol-XL | Established ROW              
Product sales              
Product Sales $ 3           $ 5
Actual %, year-on-year 25.00%           3.00%
CER %, year-on-year 14.00%           (8.00%)
Atacand              
Product sales              
Product Sales $ 23 34 63 54 59 66  
Atacand | World              
Product sales              
Product Sales $ 23           $ 57
Actual %, year-on-year (62.00%)           (55.00%)
CER %, year-on-year (61.00%)           (55.00%)
Atacand | Emerging Markets              
Product sales              
Product Sales $ 15           $ 20
Actual %, year-on-year (67.00%)           (79.00%)
CER %, year-on-year (68.00%)           (79.00%)
Atacand | US              
Product sales              
Product Sales             $ 2
Actual %, year-on-year             (56.00%)
Atacand | Europe              
Product sales              
Product Sales $ 8           $ 35
Actual %, year-on-year 31.00%            
CER %, year-on-year 32.00%            
CVRM, Others              
Product sales              
Product Sales $ 47 51 46 39 48 59  
CVRM, Others | World              
Product sales              
Product Sales $ 47           $ 98
Actual %, year-on-year (1.00%)           (7.00%)
CER %, year-on-year (9.00%)           (13.00%)
CVRM, Others | Emerging Markets              
Product sales              
Product Sales $ 35           $ 71
Actual %, year-on-year 20.00%           9.00%
CER %, year-on-year 10.00%           2.00%
CVRM, Others | Europe              
Product sales              
Product Sales $ 11           $ 25
Actual %, year-on-year (30.00%)           (19.00%)
CER %, year-on-year (33.00%)           (22.00%)
CVRM, Others | Established ROW              
Product sales              
Product Sales $ 1           $ 2
Actual %, year-on-year (57.00%)           (20.00%)
CER %, year-on-year (60.00%)           (23.00%)
BioPharmaceuticals: total Respiratory & Immunology              
Product sales              
Product Sales $ 1,420 1,541 1,528 1,161 1,117 1,551  
BioPharmaceuticals: total Respiratory & Immunology | World              
Product sales              
Product Sales $ 1,420           $ 2,961
Actual %, year-on-year 27.00%           11.00%
CER %, year-on-year 21.00%           6.00%
BioPharmaceuticals: total Respiratory & Immunology | Emerging Markets              
Product sales              
Product Sales $ 343           $ 885
Actual %, year-on-year 56.00%           17.00%
CER %, year-on-year 45.00%           10.00%
BioPharmaceuticals: total Respiratory & Immunology | US              
Product sales              
Product Sales $ 597           $ 1,148
Actual %, year-on-year 27.00%           17.00%
BioPharmaceuticals: total Respiratory & Immunology | Europe              
Product sales              
Product Sales $ 318           $ 616
Actual %, year-on-year 19.00%           5.00%
CER %, year-on-year 7.00%           (5.00%)
BioPharmaceuticals: total Respiratory & Immunology | Established ROW              
Product sales              
Product Sales $ 162           $ 312
Actual %, year-on-year 3.00%           (8.00%)
CER %, year-on-year (5.00%)           (14.00%)
Symbicort              
Product sales              
Product Sales $ 680 691 680 599 653 790  
Symbicort | World              
Product sales              
Product Sales $ 680           $ 1,371
Actual %, year-on-year 4.00%           (5.00%)
CER %, year-on-year (1.00%)           (9.00%)
Symbicort | Emerging Markets              
Product sales              
Product Sales $ 141           $ 306
Actual %, year-on-year 5.00%           5.00%
CER %, year-on-year             2.00%
Symbicort | US              
Product sales              
Product Sales $ 264           $ 530
Actual %, year-on-year 6.00%           (5.00%)
Symbicort | Europe              
Product sales              
Product Sales $ 176           $ 344
Actual %, year-on-year 9.00%           (3.00%)
CER %, year-on-year (2.00%)           (12.00%)
Symbicort | Established ROW              
Product sales              
Product Sales $ 99           $ 191
Actual %, year-on-year (9.00%)           (20.00%)
CER %, year-on-year (17.00%)           (26.00%)
Pulmicort              
Product sales              
Product Sales $ 167 330 368 151 97 380  
Pulmicort | World              
Product sales              
Product Sales $ 167           $ 497
Actual %, year-on-year 72.00%           4.00%
CER %, year-on-year 59.00%           (2.00%)
Pulmicort | Emerging Markets              
Product sales              
Product Sales $ 119           $ 405
Actual %, year-on-year             9.00%
CER %, year-on-year 88.00%           2.00%
Pulmicort | US              
Product sales              
Product Sales $ 18           $ 35
Actual %, year-on-year 40.00%           (2.00%)
Pulmicort | Europe              
Product sales              
Product Sales $ 18           $ 34
Actual %, year-on-year 23.00%           (15.00%)
CER %, year-on-year 7.00%           (25.00%)
Pulmicort | Established ROW              
Product sales              
Product Sales $ 12           $ 23
Actual %, year-on-year 5.00%           (24.00%)
CER %, year-on-year (1.00%)           (30.00%)
Fasenra              
Product sales              
Product Sales $ 320 260 283 240 227 199  
Fasenra | World              
Product sales              
Product Sales $ 320           $ 580
Actual %, year-on-year 41.00%           36.00%
CER %, year-on-year 36.00%           32.00%
Fasenra | Emerging Markets              
Product sales              
Product Sales $ 5           $ 8
Actual %, year-on-year             25.00%
CER %, year-on-year             27.00%
Fasenra | US              
Product sales              
Product Sales $ 201           $ 357
Actual %, year-on-year 32.00%           31.00%
Fasenra | Europe              
Product sales              
Product Sales $ 73           $ 136
Actual %, year-on-year 72.00%           54.00%
CER %, year-on-year 55.00%           39.00%
Fasenra | Established ROW              
Product sales              
Product Sales $ 41           $ 79
Actual %, year-on-year 28.00%           34.00%
CER %, year-on-year 21.00%           27.00%
Daliresp/Daxas              
Product sales              
Product Sales $ 54 60 54 57 53 53  
Daliresp/Daxas | World              
Product sales              
Product Sales $ 54           $ 114
Actual %, year-on-year 3.00%           8.00%
CER %, year-on-year 3.00%           7.00%
Daliresp/Daxas | Emerging Markets              
Product sales              
Product Sales $ 1           $ 2
Actual %, year-on-year 29.00%           20.00%
CER %, year-on-year 23.00%           18.00%
Daliresp/Daxas | US              
Product sales              
Product Sales $ 49           $ 103
Actual %, year-on-year 10.00%           15.00%
Daliresp/Daxas | Europe              
Product sales              
Product Sales $ 4           $ 8
Actual %, year-on-year (37.00%)           (36.00%)
CER %, year-on-year (36.00%)           (42.00%)
Daliresp/Daxas | Established ROW              
Product sales              
Product Sales             $ 1
Actual %, year-on-year (85.00%)           (56.00%)
CER %, year-on-year (80.00%)           (60.00%)
Bevespi              
Product sales              
Product Sales $ 13 13 12 14 10 12  
Bevespi | World              
Product sales              
Product Sales $ 13           $ 26
Actual %, year-on-year 34.00%           20.00%
CER %, year-on-year 33.00%           18.00%
Bevespi | Emerging Markets              
Product sales              
Product Sales $ 1           $ 2
Bevespi | US              
Product sales              
Product Sales $ 10           $ 20
Actual %, year-on-year 6.00%           (5.00%)
Bevespi | Europe              
Product sales              
Product Sales $ 2           $ 4
Breztri              
Product sales              
Product Sales 56 27 6 10 7 4  
Breztri | World              
Product sales              
Product Sales 56           82
Breztri | Emerging Markets              
Product sales              
Product Sales 17           27
Breztri | US              
Product sales              
Product Sales 31           43
Breztri | Europe              
Product sales              
Product Sales 1           1
Breztri | Established ROW              
Product sales              
Product Sales 7           11
Respiratory, Others              
Product sales              
Product Sales 130 160 125 90 70 113  
Respiratory, Others | World              
Product sales              
Product Sales $ 130           $ 291
Actual %, year-on-year 85.00%           58.00%
CER %, year-on-year 70.00%           47.00%
Respiratory, Others | Emerging Markets              
Product sales              
Product Sales $ 59           $ 135
Actual %, year-on-year             69.00%
CER %, year-on-year             55.00%
Respiratory, Others | US              
Product sales              
Product Sales 24           $ 60
Respiratory, Others | Europe              
Product sales              
Product Sales $ 44           $ 89
Actual %, year-on-year 5.00%            
CER %, year-on-year (6.00%)           (9.00%)
Respiratory, Others | Established ROW              
Product sales              
Product Sales $ 3           $ 7
Actual %, year-on-year 37.00%           (16.00%)
CER %, year-on-year 9.00%           (25.00%)
Total Other medicines              
Product sales              
Product Sales $ 454 548 733 734 563 557  
Total Other medicines | World              
Product sales              
Product Sales $ 454           $ 1,003
Actual %, year-on-year (19.00%)           (10.00%)
CER %, year-on-year (23.00%)           (14.00%)
Total Other medicines | Emerging Markets              
Product sales              
Product Sales $ 239           $ 536
Actual %, year-on-year 1.00%           10.00%
CER %, year-on-year (4.00%)           5.00%
Total Other medicines | US              
Product sales              
Product Sales $ 47           $ 100
Actual %, year-on-year (27.00%)           (34.00%)
Total Other medicines | Europe              
Product sales              
Product Sales $ 68           $ 145
Actual %, year-on-year (41.00%)           (40.00%)
CER %, year-on-year (45.00%)           (42.00%)
Total Other medicines | Established ROW              
Product sales              
Product Sales $ 100           $ 222
Actual %, year-on-year (31.00%)           (8.00%)
CER %, year-on-year (32.00%)           (12.00%)
Nexium              
Product sales              
Product Sales $ 336 403 377 401 377 338  
Nexium | World              
Product sales              
Product Sales $ 336           $ 739
Actual %, year-on-year (11.00%)           4.00%
CER %, year-on-year (14.00%)            
Nexium | Emerging Markets              
Product sales              
Product Sales $ 185           $ 419
Actual %, year-on-year 1.00%           13.00%
CER %, year-on-year (4.00%)           9.00%
Nexium | US              
Product sales              
Product Sales $ 35           $ 67
Actual %, year-on-year (14.00%)           (17.00%)
Nexium | Europe              
Product sales              
Product Sales $ 18           $ 36
Actual %, year-on-year 23.00%           (2.00%)
CER %, year-on-year 11.00%           (11.00%)
Nexium | Established ROW              
Product sales              
Product Sales $ 98           $ 217
Actual %, year-on-year (29.00%)           (4.00%)
CER %, year-on-year (31.00%)           (8.00%)
Synagis              
Product sales              
Product Sales $ 24 24 78 118 90 85  
Synagis | World              
Product sales              
Product Sales $ 24           $ 49
Actual %, year-on-year (73.00%)           (72.00%)
CER %, year-on-year (73.00%)           (72.00%)
Synagis | US              
Product sales              
Product Sales $ 3           $ 5
Actual %, year-on-year (78.00%)           (77.00%)
Synagis | Europe              
Product sales              
Product Sales $ 21           $ 44
Actual %, year-on-year (72.00%)           (71.00%)
CER %, year-on-year (72.00%)           (71.00%)
Seroquel XR/IR              
Product sales              
Product Sales $ 21 29 19 35 27 36  
Seroquel XR/IR | World              
Product sales              
Product Sales $ 21           $ 50
Actual %, year-on-year (23.00%)           (21.00%)
CER %, year-on-year (19.00%)           (21.00%)
Seroquel XR/IR | Emerging Markets              
Product sales              
Product Sales $ 11           $ 25
Actual %, year-on-year (26.00%)           (9.00%)
CER %, year-on-year (27.00%)           (8.00%)
Seroquel XR/IR | US              
Product sales              
Product Sales $ 3           $ 10
Actual %, year-on-year             (29.00%)
Seroquel XR/IR | Europe              
Product sales              
Product Sales $ 7           $ 14
Actual %, year-on-year (5.00%)           (4.00%)
CER %, year-on-year 2.00%           (3.00%)
Seroquel XR/IR | Established ROW              
Product sales              
Product Sales             $ 1
Actual %, year-on-year             (88.00%)
CER %, year-on-year (87.00%)           (88.00%)
Losec/Prilosec              
Product sales              
Product Sales $ 46 54 39 45 45 54  
Losec/Prilosec | World              
Product sales              
Product Sales $ 46           $ 100
Actual %, year-on-year 2.00%           1.00%
CER %, year-on-year (6.00%)           (5.00%)
Losec/Prilosec | Emerging Markets              
Product sales              
Product Sales $ 38           $ 84
Actual %, year-on-year 2.00%           4.00%
CER %, year-on-year (7.00%)           (4.00%)
Losec/Prilosec | US              
Product sales              
Actual %, year-on-year (68.00%)           (90.00%)
Losec/Prilosec | Europe              
Product sales              
Product Sales $ 8           $ 15
Actual %, year-on-year 49.00%           56.00%
CER %, year-on-year 42.00%           55.00%
Losec/Prilosec | Established ROW              
Product sales              
Product Sales             $ 1
Actual %, year-on-year (82.00%)           (90.00%)
CER %, year-on-year (87.00%)           (92.00%)
FluMist              
Product sales              
Product Sales $ 1 2 179 116      
FluMist | World              
Product sales              
Product Sales 1           $ 3
FluMist | Emerging Markets              
Product sales              
Product Sales             1
FluMist | Europe              
Product sales              
Product Sales             2
FluMist | Established ROW              
Product sales              
Product Sales 1            
Other, Others              
Product sales              
Product Sales 26 36 $ 41 $ 19 $ 24 $ 44  
Other, Others | World              
Product sales              
Product Sales $ 26           $ 62
Actual %, year-on-year 10.00%           (9.00%)
CER %, year-on-year 1.00%           (13.00%)
Other, Others | Emerging Markets              
Product sales              
Product Sales $ 5           $ 7
Other, Others | US              
Product sales              
Product Sales $ 6           $ 18
Actual %, year-on-year (30.00%)           (46.00%)
Other, Others | Europe              
Product sales              
Product Sales $ 14           $ 34
Actual %, year-on-year 14.00%           20.00%
CER %, year-on-year (3.00%)           11.00%
Other, Others | Established ROW              
Product sales              
Product Sales $ 1           $ 3
Actual %, year-on-year 39.00%           (16.00%)
CER %, year-on-year 55.00%           (14.00%)
COVID 19              
Product sales              
Product Sales $ 862 275          
COVID 19 | World              
Product sales              
Product Sales 862           $ 1,136
COVID 19 | Emerging Markets              
Product sales              
Product Sales 413           455
COVID 19 | Europe              
Product sales              
Product Sales 347           572
COVID 19 | Established ROW              
Product sales              
Product Sales 102           109
Pandemic COVID-19 Vaccine              
Product sales              
Product Sales 862 $ 275          
Pandemic COVID-19 Vaccine | World              
Product sales              
Product Sales 862           1,136
Pandemic COVID-19 Vaccine | Emerging Markets              
Product sales              
Product Sales 413           455
Pandemic COVID-19 Vaccine | Europe              
Product sales              
Product Sales 347           572
Pandemic COVID-19 Vaccine | Established ROW              
Product sales              
Product Sales $ 102           $ 109