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Collaboration Revenue (Details) - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Dec. 31, 2020
Dec. 31, 2019
Revenues            
Total collaboration revenue $ 175 $ 227 $ 238 $ 270 $ 727 $ 819
Nexium | Initial Collaboration Revenue | Japan            
Revenues            
Total collaboration revenue     75      
Crestor | Ongoing Collaboration Revenue | Spain            
Revenues            
Total collaboration revenue           39
Lynparza | Ongoing Collaboration Revenue | Regulatory milestones            
Revenues            
Total collaboration revenue       135 160 60
Lynparza | Ongoing Collaboration Revenue | Sales milestones            
Revenues            
Total collaboration revenue         300 450
Lynparza/Koselugo | Ongoing Collaboration Revenue | Option payments            
Revenues            
Total collaboration revenue           100
Enhertu | Ongoing Collaboration Revenue | Share of gross profits            
Revenues            
Total collaboration revenue     83 36 94  
Roxadustat | Ongoing Collaboration Revenue | Share of gross profits            
Revenues            
Total collaboration revenue     3 11 30  
Royal income | Ongoing Collaboration Revenue            
Revenues            
Total collaboration revenue     69 34 62 62
Other Ongoing Collaboration Revenue            
Revenues            
Total collaboration revenue     $ 8 $ 54 $ 81 $ 108