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Operating profit - Other operating income and expense (Details) - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Dec. 31, 2020
Dec. 31, 2019
Operating profit, other operating income and expense            
Total other operating income and expense $ 128 $ 121 $ 1,308 $ 601 $ 1,528 $ 1,541
Brazikumab licence termination funding            
Operating profit, other operating income and expense            
Total other operating income and expense     51   107  
Monetisation of an asset previously licensed            
Operating profit, other operating income and expense            
Total other operating income and expense         120  
Atacand            
Operating profit, other operating income and expense            
Total other operating income and expense         400  
Other operating income and expense            
Operating profit, other operating income and expense            
Total other operating income and expense     132 200 446 389
Europe ex UK and Spain | Crestor            
Operating profit, other operating income and expense            
Total other operating income and expense     309      
Ex-US, India and Japan | Hypertension medicines            
Operating profit, other operating income and expense            
Total other operating income and expense       350 350  
India | Oxra and Oxramet            
Operating profit, other operating income and expense            
Total other operating income and expense     40      
Japan | Inderal, Tenormin, Seloken and Omepral            
Operating profit, other operating income and expense            
Total other operating income and expense       $ 51 51  
US | Synagis            
Operating profit, other operating income and expense            
Total other operating income and expense           515
Ex-China, Japan, US and Mexico | Losec            
Operating profit, other operating income and expense            
Total other operating income and expense           243
US, Canada, Europe and Russia | Seroquel and Seroquel XR            
Operating profit, other operating income and expense            
Total other operating income and expense           213
Various countries | Arimidex and Casodex            
Operating profit, other operating income and expense            
Total other operating income and expense           $ 181
Europe and ex-US | Nexium and Vimovo            
Operating profit, other operating income and expense            
Total other operating income and expense         $ 54  
Viela Bio            
Operating profit, other operating income and expense            
Total other operating income and expense     $ 776