<SEC-DOCUMENT>0000950127-21-000066.txt : 20210719
<SEC-HEADER>0000950127-21-000066.hdr.sgml : 20210719
<ACCEPTANCE-DATETIME>20210719113450
ACCESSION NUMBER:		0000950127-21-000066
CONFORMED SUBMISSION TYPE:	F-6EF
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20210719
DATE AS OF CHANGE:		20210719
EFFECTIVENESS DATE:		20210719

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ASTRAZENECA PLC
		CENTRAL INDEX KEY:			0000901832
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		F-6EF
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-258002
		FILM NUMBER:		211097226

	BUSINESS ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA
		BUSINESS PHONE:		011 44 20 7304 5000

	MAIL ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ZENECA GROUP PLC
		DATE OF NAME CHANGE:	19930422

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Deutsche Bank Trust Co Americas/ ADR Group
		CENTRAL INDEX KEY:			0001471515
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			NY
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		F-6EF

	BUSINESS ADDRESS:	
		STREET 1:		60 WALL STREET
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10005
		BUSINESS PHONE:		212-319-7600

	MAIL ADDRESS:	
		STREET 1:		60 WALL STREET
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10005
</SEC-HEADER>
<DOCUMENT>
<TYPE>F-6EF
<SEQUENCE>1
<FILENAME>a21-30_f6ef.htm
<DESCRIPTION>REGISTRATION OF AMERICAN DEPOSITAR RECEIPT SHARES
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: White & Case
         Document created using EDGARfilings PROfile 7.5.0.0
         Copyright 1995 - 2021 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <table cellspacing="0" cellpadding="0" id="zc02d5b052bf941f0977e4ccbae8f0981" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 75.03%; vertical-align: top; border-bottom: 4px solid rgb(0, 0, 0);">
            <div style="font-weight: bold;">As filed with the Securities and Exchange Commission on July 19, 2021</div>
          </td>
          <td style="width: 24.97%; vertical-align: top; border-bottom: 4px solid rgb(0, 0, 0);">
            <div style="font-weight: bold;">Registration No. 333-</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 75.03%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td rowspan="1" style="width: 24.97%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>

    </table>
    <div>
      <div style="margin-bottom: 9pt;"><br>
      </div>
      <div><br>
      </div>
    </div>
    <div style="text-align: center; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-weight: bold;">Washington, D.C.&#160;&#160;20549</div>
    <div style="text-align: center;">______________________________</div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">FORM F-6</div>
    <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 FOR</div>
    <div style="text-align: center; font-weight: bold;">AMERICAN DEPOSITARY SHARES EVIDENCED BY AMERICAN DEPOSITARY RECEIPTS</div>
    <div style="text-align: center; margin-bottom: 6pt;">______________</div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">ASTRAZENECA PLC</div>
    <div style="text-align: center;">(Exact name of issuer of deposited securities as specified in its charter)</div>
    <div style="text-align: center; margin-bottom: 6pt;">____________</div>
    <div style="text-align: center; font-weight: bold;">Not Applicable</div>
    <div style="text-align: center;">(Translation of issuer&#8217;s name into English)</div>
    <div style="text-align: center; margin-bottom: 6pt; font-weight: bold;">____________</div>
    <div style="text-align: center; font-weight: bold;">England and Wales</div>
    <div style="text-align: center;">(Jurisdiction of incorporation or organization of issuer)</div>
    <div style="text-align: center; margin-bottom: 6pt;">______________________________</div>
    <div style="text-align: center; font-weight: bold;">Deutsche Bank Trust Company Americas</div>
    <div style="text-align: center; margin-bottom: 9pt;">(Exact name of depositary as specified in its charter)</div>
    <div style="text-align: center; font-weight: bold;">60 Wall Street</div>
    <div style="text-align: center; font-weight: bold;">New York, New York 10005</div>
    <div style="text-align: center; font-weight: bold;">(212) 250-9100</div>
    <div style="text-align: center;">(Address, including zip code, and telephone number, including area code, of depositary&#8217;s principal executive offices)</div>
    <div style="text-align: center; margin-bottom: 6pt;">____________</div>
    <div style="text-align: center; font-weight: bold;">CT Corporation System</div>
    <div style="text-align: center; font-weight: bold;">28 Liberty Street</div>
    <div style="text-align: center; font-weight: bold;">New York, NY 10005</div>
    <div style="text-align: center; font-weight: bold;">Tel: +1-212-894-8940</div>
    <div style="text-align: center;">(Address, including zip code, and telephone number, including area code, of agent for service)</div>
    <div style="text-align: center;">______________________________</div>
    <div style="text-align: center;">Copies to:</div>
    <table cellspacing="0" cellpadding="0" id="z9bf87f3d69d4487c801c08e18787478d" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Ethan A. Klinsgberg</div>
            <div style="text-align: center; font-weight: bold;">Sebastian L. Fain</div>
            <div style="text-align: center; font-weight: bold;">Freshfields Bruckhaus Deringer US LLP</div>
            <div style="text-align: center; font-weight: bold;">601 Lexington Avenue, 31<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">st</sup> Floor<br>
              New York, New York 10022<br>
              1-212-277-4001</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Francis Fitzherbert-Brockholes, Esq.</div>
            <div style="text-align: center; font-weight: bold;">White &amp; Case LLP</div>
            <div style="text-align: center; font-weight: bold;">5 Old Broad Street<br>
              London EC2N 1DW<br>
              United Kingdom</div>
            <div style="text-align: center; font-weight: bold;">+(44) 20 7532-1400</div>
          </td>
        </tr>

    </table>
    <div style="text-align: center; margin-bottom: 9pt;">______________________________</div>
    <table cellspacing="0" cellpadding="0" id="z1c7763c59a4f4d39885edd7d6fab82d3" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 58%; vertical-align: top;">
            <div>It is proposed that this filing become effective under Rule 466:</div>
          </td>
          <td style="width: 42%; vertical-align: top;">
            <div>&#9746; &#160; immediately upon filing.</div>
            <div>&#9744;&#160; on (Date) at (Time).</div>
          </td>
        </tr>

    </table>
    <div style="text-align: justify;">If a separate registration statement has been filed to register the deposited shares, check the following box: &#9746;</div>
    <div style="text-align: center;">______________________________</div>
    <div style="text-align: center; font-weight: bold;">CALCULATION OF REGISTRATION FEE</div>
    <table cellspacing="0" cellpadding="0" border="0" id="zb8d1cd874f8741ee88de5bf5cd3b1db8" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 25.65%; vertical-align: bottom; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Title of each class<br>
              of Securities to be registered</div>
          </td>
          <td style="width: 17.7%; vertical-align: bottom; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Amount to be registered</div>
          </td>
          <td style="width: 22.13%; vertical-align: bottom; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Proposed<br>
              maximum aggregate price per unit <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
          </td>
          <td style="width: 21.24%; vertical-align: bottom; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Proposed<br>
              maximum aggregate offering price <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
          </td>
          <td style="width: 13.29%; vertical-align: bottom; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-right: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Amount of registration fee</div>
          </td>
        </tr>
        <tr>
          <td style="width: 25.65%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-bottom: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center;">American Depositary Shares,</div>
            <div style="text-align: center;">each representing 0.5 ordinary</div>
            <div style="text-align: center;">shares of AstraZeneca PLC</div>
          </td>
          <td style="width: 17.7%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-bottom: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center;">500,000,000 American Depositary Shares</div>
          </td>
          <td style="width: 22.13%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-bottom: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center;">$0.05</div>
          </td>
          <td style="width: 21.24%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-bottom: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center;">$25,000,000</div>
          </td>
          <td style="width: 13.29%; vertical-align: top; border-width: 1px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">$2,727.50</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="z6c1ad645de6d411ab8b3e16d74967124" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="vertical-align: top; width: 3.14%;">
              <div style="text-align: justify;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></div>
            </td>
            <td style="width: 92.86%; vertical-align: top;">
              <div style="text-align: justify;">For the purpose of this table only the term &#8220;unit&#8221; is defined as one American Depositary Share.</div>
            </td>
          </tr>
          <tr>
            <td style="vertical-align: top; width: 3.14%;">
              <div style="text-align: justify;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">2</sup></div>
            </td>
            <td style="width: 92.86%; vertical-align: top;">
              <div style="text-align: justify;">Estimated solely for the purpose of calculating the registration fee.&#160; Pursuant to Rule 457(k), such estimate is computed on the basis of the maximum aggregate fees or charges to be imposed in connection with
                the issuance of American Depositary Shares.</div>
            </td>
          </tr>

      </table>
      <div style="text-align: justify; margin-bottom: 9pt;">This registration statement may be executed in any number of counterparts, each of which shall be deemed an original, and all of such counterparts together shall constitute one and the same
        instrument.</div>
      <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <div style="text-align: center; margin-bottom: 12pt; font-weight: bold;">PART I<br>
      <br>
      <br>
      INFORMATION REQUIRED IN PROSPECTUS</div>
    <div style="text-align: justify; margin-bottom: 9pt;">The prospectus consists of the proposed form of American Depositary Receipt (&#8220;Receipt&#8221;) included as Exhibits A and B to the form of Deposit Agreement and filed as Exhibit (a) to the registration
      statement on Form F-6 (File No. 333-236014) previously filed by the registrant and is incorporated herein by reference.</div>
    <table cellspacing="0" cellpadding="0" id="z9cb9103effa14684b31573a01f43db9e" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 9.29%; vertical-align: top;">
            <div style="text-align: justify; font-weight: bold;">Item 1.</div>
          </td>
          <td style="width: 90.71%; vertical-align: top;">
            <div style="text-align: justify; font-weight: bold;">DESCRIPTION OF SECURITIES TO BE REGISTERED</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="zaad8093d9c87420bbfb89677fb780417" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="border-bottom: 1px solid #000000; vertical-align: bottom; width: 51.2%;" colspan="3">
            <div style="font-weight: bold;">Required Information</div>
          </td>
          <td style="width: 3.5%; vertical-align: bottom;">&#160;</td>
          <td style="border-bottom: 1px solid #000000; vertical-align: bottom; width: 45.3%;">
            <div style="font-weight: bold;">Location in Form of Receipt Filed Herewith as Prospectus</div>
          </td>
        </tr>
        <tr>
          <td style="vertical-align: top; width: 2.82%;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="vertical-align: top; width: 2.82%;">
            <div>1.</div>
          </td>
          <td style="width: 46.38%; vertical-align: top;" colspan="2">
            <div>Name of depositary and address of its principal executive office</div>
          </td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">
            <div>Face of Receipt &#8211; introductory paragraph</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="vertical-align: top; width: 2.82%;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="vertical-align: top; width: 2.82%;">
            <div>2.</div>
          </td>
          <td style="width: 46.38%; vertical-align: top;" colspan="2">
            <div>Title of Receipts and identity of deposited securities</div>
          </td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">
            <div>Face of Receipt &#8211; top center</div>
          </td>
        </tr>
        <tr>
          <td style="vertical-align: top; width: 2.82%;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 51.2%; vertical-align: top;" colspan="3">
            <div>Terms of Deposit:</div>
          </td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="height: auto; vertical-align: top; width: 4.82%;">&#160;</td>
          <td style="height: auto; vertical-align: top; width: 6.25%;">
            <div>(i)</div>
          </td>
          <td style="height: auto; vertical-align: top; width: 40.13%;">
            <div>The amount of deposited securities represented by one American Depositary Share (&#8220;ADS&#8221;)</div>
          </td>
          <td style="height: auto; vertical-align: top; width: 3.5%;">&#160;</td>
          <td style="height: auto; vertical-align: top; width: 45.3%;">
            <div>Face of Receipt &#8211; upper right corner</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">
            <div>(ii)</div>
          </td>
          <td style="width: 40.13%; vertical-align: top;">
            <div>The procedure for voting the deposited securities</div>
          </td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">
            <div>Reverse of Receipt &#8211; Articles 14 and 15</div>
          </td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">
            <div>(iii)</div>
          </td>
          <td style="width: 40.13%; vertical-align: top;">
            <div>The procedure for collecting and distributing dividends</div>
          </td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">
            <div>Reverse of Receipt &#8211; Articles 13 and 14</div>
          </td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">
            <div>(iv)</div>
          </td>
          <td style="width: 40.13%; vertical-align: top;">
            <div>The procedures for transmitting notices, reports and proxy soliciting material</div>
          </td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">
            <div>Face of Receipt &#8211; Article 12;</div>
            <div>Reverse of Receipt &#8211; Articles 14 and 15</div>
          </td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">
            <div>(v)</div>
          </td>
          <td style="width: 40.13%; vertical-align: top;">
            <div>The sale or exercise of rights</div>
          </td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">
            <div>Reverse of Receipt &#8211; Articles 13 and 14</div>
          </td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">
            <div>(vi)</div>
          </td>
          <td style="width: 40.13%; vertical-align: top;">
            <div>The deposit or sale of securities resulting from dividends, splits or plans of reorganization</div>
          </td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">
            <div>Face of Receipt &#8211; Articles 3, 6 and 9;</div>
            <div>Reverse of Receipt &#8211; Articles 13 and 16</div>
          </td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">
            <div>(vii)</div>
          </td>
          <td style="width: 40.13%; vertical-align: top;">
            <div>Amendment, extension or termination of the deposit arrangements</div>
          </td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">
            <div>Reverse of Receipt &#8211; Articles 20 and 21 (no provision for extension)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">
            <div>(viii)</div>
          </td>
          <td style="width: 40.13%; vertical-align: top;">
            <div>The rights of holders of Receipts to inspect the books of the depositary and the list of holders of Receipts</div>
          </td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">
            <div>Face of Receipt &#8211; Article 12</div>
          </td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">
            <div>(ix)</div>
          </td>
          <td style="width: 40.13%; vertical-align: top;">
            <div>Restrictions upon the right to transfer or withdraw the underlying securities</div>
          </td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">
            <div>Face of Receipt &#8211; Articles 2, 3, 4, 6, 8, 9 and 10;</div>
            <div>Reverse of Receipt &#8211; Article 22</div>
          </td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">
            <div>(x)</div>
          </td>
          <td style="width: 40.13%; vertical-align: top;">
            <div>Limitation on the depositary&#8217;s liability</div>
          </td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">
            <div>Face of Receipt &#8211; Articles 6 and 10;</div>
            <div>Reverse of Receipt &#8211; Articles 15, 16, 17 and 18</div>
          </td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 6.25%; vertical-align: top;">&#160;</td>
          <td style="width: 40.13%; vertical-align: top;">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">
            <div>3.</div>
          </td>
          <td style="width: 46.38%; vertical-align: top;" colspan="2">
            <div>Fees and charges that a holder of Receipts may have to pay, either directly or indirectly</div>
          </td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">
            <div>Face of Receipt &#8211; Article 9</div>
          </td>
        </tr>
        <tr>
          <td style="width: 4.82%; vertical-align: top;">&#160;</td>
          <td style="width: 46.38%; vertical-align: top;" colspan="2">&#160;</td>
          <td style="width: 3.5%; vertical-align: top;">&#160;</td>
          <td style="width: 45.3%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 9pt;"><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="zdb520e776c054cb6ab774ee9a86bbcb5" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 9.29%; vertical-align: top;">
            <div style="text-align: justify; font-weight: bold;">Item 2.</div>
          </td>
          <td style="width: 90.71%; vertical-align: top;">
            <div style="text-align: justify; font-weight: bold;">AVAILABLE INFORMATION</div>
          </td>
        </tr>

    </table>
    <div style="text-align: justify; text-indent: 36pt; margin-top: 9pt; margin-bottom: 9pt;">AstraZeneca PLC (the &#8220;Company&#8221;) is subject to the periodic reporting requirements of the United States Securities Exchange Act of 1934, as amended, and,
      accordingly, files certain reports with, and furnishes certain reports to, the United States Securities and Exchange Commission (the &#8220;Commission&#8221;).&#160; These reports can be retrieved from the Commission&#8217;s internet website (www.sec.gov) and can be
      inspected and copied at the public reference facilities maintained by the Commission at 100 F Street, N.E., Washington D.C. 20549.</div>
    <div style="text-align: center; margin-bottom: 12pt; font-weight: bold;">PART II<br>
      <br>
      <br>
      INFORMATION NOT REQUIRED IN PROSPECTUS</div>
    <table cellspacing="0" cellpadding="0" id="z3923a835dd76440e8fb8ac426278c9e1" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 9.29%; vertical-align: top;">
            <div style="text-align: justify; font-weight: bold;">Item 3.</div>
          </td>
          <td style="width: 90.71%; vertical-align: top;">
            <div style="text-align: justify; font-weight: bold;">EXHIBITS</div>
          </td>
        </tr>

    </table>
    <div style="margin-bottom: 9pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z524e30a6ad1f4092a0cd8f5a488c769a" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">
            <div style="text-align: justify;">(a)</div>
          </td>
          <td style="width: 82.14%; vertical-align: top;">
            <div style="text-align: justify;">Form of Deposit Agreement, by and among the Company, Deutsche Bank Trust Company Americas, as depositary (the &#8220;Depositary&#8221;), and all holders and beneficial owners from time to time of ADSs issued thereunder
              (&#8220;Deposit Agreement&#8221;).&#160; &#8212; Previously filed as Exhibit (a) to Form F-6 (File No. 333-236014) and incorporated herein by reference.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">&#160;</td>
          <td style="width: 82.14%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">
            <div style="text-align: justify;">(b)</div>
          </td>
          <td style="width: 82.14%; vertical-align: top;">
            <div style="text-align: justify;">Any other agreement to which the Depositary is a party relating to the issuance of the ADSs registered hereunder or the custody of the deposited securities represented thereby.&#160; &#8212; Not applicable.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">&#160;</td>
          <td style="width: 82.14%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">
            <div style="text-align: justify;">(c)</div>
          </td>
          <td style="width: 82.14%; vertical-align: top;">
            <div style="text-align: justify;">Every material contract relating to the deposited securities between the Depositary and the issuer of the deposited securities in effect at any time within the last three years.&#160; &#8212; Not applicable.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">&#160;</td>
          <td style="width: 82.14%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">
            <div style="text-align: justify;">(d)</div>
          </td>
          <td style="width: 82.14%; vertical-align: top;">
            <div style="text-align: justify;">Opinion of White &amp; Case LLP, counsel to the Depositary, as to the legality of the securities to be registered.&#160; &#8212; Filed herewith as Exhibit (d).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">&#160;</td>
          <td style="width: 82.14%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">
            <div style="text-align: justify;">(e)</div>
          </td>
          <td style="width: 82.14%; vertical-align: top;">
            <div style="text-align: justify;">Certification under Rule 466.&#160; &#8212; Filed herewith as Exhibit (e).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">&#160;</td>
          <td style="width: 82.14%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">
            <div style="text-align: justify;">(f)</div>
          </td>
          <td style="width: 82.14%; vertical-align: top;">
            <div style="text-align: justify;">Powers of attorney for certain officers and directors of the Company.&#160; &#8212; Set forth on the signature pages hereto.</div>
          </td>
        </tr>

    </table>
    <div style="margin-bottom: 9pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z86381844d5014db08e2f75deb3e5f34b" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 9.29%; vertical-align: top;">
            <div style="text-align: justify; font-weight: bold;">Item 4.</div>
          </td>
          <td style="width: 90.71%; vertical-align: top;">
            <div style="text-align: justify; font-weight: bold;">UNDERTAKINGS</div>
          </td>
        </tr>

    </table>
    <div style="margin-bottom: 9pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z288107976593491a9317968fbeea454c" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">
            <div style="text-align: justify;">(a)</div>
          </td>
          <td style="width: 82.14%; vertical-align: top;">
            <div style="text-align: justify;">The Depositary hereby undertakes to make available at the principal office of the Depositary in the United States, for inspection by holders of the ADR, any reports and communications received from the issuer
              of the deposited securities which are both (1) received by the Depositary as the holder of the deposited securities; and (2) made generally available to the holders of the underlying securities by the issuer.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">&#160;</td>
          <td style="width: 82.14%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.19%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 5.67%;">
            <div style="text-align: justify;">(b)</div>
          </td>
          <td style="width: 82.14%; vertical-align: top;">
            <div style="text-align: justify;">If the amount of fees charged is not disclosed in the prospectus, the Depositary undertakes to prepare a separate document stating the amount of any fee charged and describing the service for which it is
              charged and to deliver promptly a copy of such fee schedule without charge to anyone upon request.&#160; The Depositary undertakes to notify each registered holder of an ADR thirty (30) days before any change in the fee schedule.</div>
          </td>
        </tr>

    </table>
    <div style="margin-bottom: 9pt;"><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <div style="text-align: center; margin-bottom: 12pt; font-weight: bold;">SIGNATURES</div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 9pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that all the requirements for filing on
      Form F-6 are met and has duly caused this registration statement on Form F-6 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of New York, State of New York, on July 19, 2021.</div>
    <table cellspacing="0" cellpadding="0" id="z95ba27063cfd49a1b0eabdb513b13de4" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 47.9%; vertical-align: top;">&#160;</td>
          <td style="width: 52.1%; vertical-align: top;" colspan="4">
            <div>Legal entity created by the form of Deposit Agreement for the issuance of Receipts for ordinary shares, par value US$0.25 per share of AstraZeneca PLC.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 47.9%; vertical-align: top;">&#160;</td>
          <td style="width: 52.1%; vertical-align: top;" colspan="4">&#160;</td>
        </tr>
        <tr>
          <td style="width: 47.9%; vertical-align: top;">&#160;</td>
          <td style="width: 52.1%; vertical-align: top;" colspan="4">
            <div style="font-weight: bold;">Deutsche Bank Trust Company Americas, as Depositary</div>
          </td>
        </tr>
        <tr>
          <td style="width: 47.9%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.33%;">&#160;</td>
          <td style="width: 38.48%; vertical-align: top;" colspan="2">&#160;</td>
          <td style="width: 10.21%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 47.9%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.33%;">&#160;</td>
          <td style="width: 38.48%; vertical-align: top;" colspan="2">&#160;</td>
          <td style="width: 10.21%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 47.9%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.33%;">
            <div style="text-align: justify;">By:</div>
          </td>
          <td style="border-bottom: 1px solid #000000; vertical-align: top; white-space: nowrap; width: 38.48%;" colspan="2">/s/ Michael Fitzpatrick<br>
          </td>
          <td style="width: 10.21%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 47.9%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.33%;">&#160;</td>
          <td style="vertical-align: top; white-space: nowrap; width: 5.46%;">
            <div style="text-align: justify;">Name:</div>
          </td>
          <td nowrap="nowrap" style="width: 33.02%; vertical-align: top;">Michael Fitzpatrick</td>
          <td style="width: 10.21%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 47.9%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.33%;">&#160;</td>
          <td style="vertical-align: top; white-space: nowrap; width: 5.46%;">
            <div style="text-align: justify;">Title:</div>
          </td>
          <td nowrap="nowrap" style="width: 33.02%; vertical-align: top;">Vice President</td>
          <td style="width: 10.21%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 47.9%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.33%;">&#160;</td>
          <td style="width: 38.48%; vertical-align: top;" colspan="2">&#160;</td>
          <td style="width: 10.21%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 47.9%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.33%;">&#160;</td>
          <td style="width: 38.48%; vertical-align: top;" colspan="2">&#160;</td>
          <td style="width: 10.21%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 47.9%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.33%;">
            <div style="text-align: justify;">By:</div>
          </td>
          <td style="border-bottom: 1px solid #000000; vertical-align: top; width: 38.48%;" colspan="2">/s/ Jeff Margolick<br>
          </td>
          <td style="width: 10.21%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 9pt;">
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 45.5%; vertical-align: top;">&#160;</td>
            <td style="vertical-align: top; width: 3.18%;">&#160;</td>
            <td style="vertical-align: top; white-space: nowrap; width: 5.21%;">
              <div style="text-align: justify;">Name:</div>
            </td>
            <td nowrap="nowrap" style="width: 31.37%; vertical-align: top;">Jeff Margolick<br>
            </td>
            <td style="width: 9.74%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 45.5%; vertical-align: top;">&#160;</td>
            <td style="vertical-align: top; width: 3.18%;">&#160;</td>
            <td style="vertical-align: top; white-space: nowrap; width: 5.21%;">
              <div style="text-align: justify;">Title:</div>
            </td>
            <td nowrap="nowrap" style="width: 31.37%; vertical-align: top;">Director<br>
            </td>
            <td style="width: 9.74%; vertical-align: top;">&#160;</td>
          </tr>

      </table>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 9pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, AstraZeneca PLC certifies that it has reasonable grounds to believe that all the requirements for filing on
      Form F-6 are met and has duly caused this registration statement on Form F-6 to be signed on its behalf by the undersigned, thereunto duly authorized, in London, England, on July 19, 2021.</div>
    <table cellspacing="0" cellpadding="0" id="zf22802deb39a46dda288ec5f66644773" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45.5%; vertical-align: top;">&#160;</td>
          <td style="width: 54.5%; vertical-align: top;" colspan="4">
            <div style="text-align: justify; font-weight: bold;">AstraZeneca PLC</div>
          </td>
        </tr>
        <tr>
          <td style="width: 45.5%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.18%;">&#160;</td>
          <td style="width: 39.58%; vertical-align: top;" colspan="2">&#160;</td>
          <td style="width: 9.74%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.5%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.18%;">&#160;</td>
          <td style="width: 39.58%; vertical-align: top;" colspan="2">&#160;</td>
          <td style="width: 9.74%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.5%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.18%;">
            <div style="text-align: justify;">By:</div>
          </td>
          <td style="border-bottom: 1px solid #000000; vertical-align: top; white-space: nowrap; width: 39.58%;" colspan="2">
            <div>
              <div style="text-align: justify;">/s/ Adrian Kemp</div>
            </div>
          </td>
          <td style="width: 9.74%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.5%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.18%;">&#160;</td>
          <td style="vertical-align: top; white-space: nowrap; width: 5.21%;">
            <div style="text-align: justify;">Name:</div>
          </td>
          <td nowrap="nowrap" style="width: 31.37%; vertical-align: top;">
            <div style="text-align: justify;">Adrian Kemp</div>
          </td>
          <td style="width: 9.74%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.5%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.18%;">&#160;</td>
          <td style="vertical-align: top; white-space: nowrap; width: 5.21%;">
            <div style="text-align: justify;">Title:</div>
          </td>
          <td nowrap="nowrap" style="width: 31.37%; vertical-align: top;">
            <div style="text-align: justify;">Company Secretary</div>
          </td>
          <td style="width: 9.74%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 9pt;"><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <div style="text-align: center; margin-bottom: 12pt; font-weight: bold;">POWER OF ATTORNEY</div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 9pt;"><font style="font-weight: bold;">KNOW ALL PERSONS BY THESE PRESENTS,&#160;</font>that each person whose signature appears below constitutes and appoints each of Adrian Kemp, Matthew
      Bowden, Alistair Collins and Jonathan Slade, his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any or
      all amendments (including post-effective amendments) to this registration statement and any and all related registration statements pursuant to Rule 462(b) of the Securities Act of 1933, as amended, and to file the same, with all exhibits thereto,
      and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their substitute or substitutes, may lawfully do or cause to be
      done by virtue hereof.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 9pt;">Under the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons on July 19, 2021, in the capacities
      indicated.</div>
    <table cellspacing="0" cellpadding="0" id="z918169167a684d85b4360a557adc7bfb" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: bottom; width: 43.15%;">
            <div style="text-align: center; font-weight: bold;">Signature</div>
          </td>
          <td style="border-bottom: 1px solid; vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">
            <div style="font-weight: bold;">Title</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.15%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: bottom; width: 43.15%;">
            <div>
              <div>/s/ Pascal Soriot</div>
            </div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">
            <div>Executive Director and Chief Executive Officer<br>
              (Principal Executive Officer)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.15%; vertical-align: bottom;">
            <div>Pascal Soriot</div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: bottom; width: 43.15%;">
            <div>
              <div>/s/ Marc Dunoyer</div>
            </div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">
            <div>Executive Director and Chief Financial Officer<br>
              (Principal Financial Officer)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.15%; vertical-align: bottom;">
            <div>Marc Dunoyer</div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 43.15%; vertical-align: bottom;">&#160;&#160; <br>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;"><br>
          </td>
        </tr>
        <tr>
          <td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: bottom; width: 43.15%;">
            <div>
              <div>/s/ Mani Sharma</div>
            </div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">
            <div>SVP, Group Financial Controller<br>
              (Principal Accounting Officer)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.15%; vertical-align: bottom;">
            <div>Mani Sharma</div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 43.15%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: bottom; width: 43.15%;">
            <div>
              <div>/s/ Leif Johansson</div>
            </div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">
            <div>Non-Executive Chairman of the Board</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.15%; vertical-align: bottom;">
            <div>Leif Johansson</div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 43.15%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: bottom; width: 43.15%;">
            <div>
              <div>/s/ Philip Broadley</div>
            </div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">
            <div>Senior Independent Non-Executive Director</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.15%; vertical-align: bottom;">
            <div>Philip Broadley</div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 43.15%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: bottom; width: 43.15%;">
            <div>
              <div>/s/ Euan Ashley</div>
            </div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">
            <div>Non-Executive Director</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.15%; vertical-align: bottom;">
            <div>Euan Ashley</div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 43.15%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: bottom; width: 43.15%;">
            <div>
              <div>/s/ Michel Demar&#233;</div>
            </div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">
            <div>Non-Executive Director</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.15%; vertical-align: bottom;">
            <div>Michel Demar&#233;</div>
          </td>
          <td style="vertical-align: bottom; width: 56.85%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 9pt;"><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z1050443788fe491e84e84dff79ce911a" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="border-bottom: 1px solid #000000; vertical-align: bottom; width: 43.19%;">
            <div style="text-align: center; font-weight: bold;">Signature</div>
          </td>
          <td style="border-bottom: 1px solid; vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">
            <div style="font-weight: bold;">Title</div>
          </td>
        </tr>
        <tr>
          <td style="border-bottom: 1px solid #000000; vertical-align: bottom; width: 43.19%;">
            <div>
              <div>/s/ Deborah DiSanzo</div>
            </div>
          </td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">
            <div>Non-Executive Director</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.19%; vertical-align: bottom;">
            <div>Deborah DiSanzo</div>
          </td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 43.19%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="border-bottom: 1px solid #000000; vertical-align: bottom; width: 43.19%;">
            <div>
              <div>/s/ Diana Layfield</div>
            </div>
          </td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">
            <div>Non-Executive Director</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.19%; vertical-align: bottom;">
            <div>Diana Layfield</div>
          </td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 43.19%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="border-bottom: 1px solid #000000; vertical-align: bottom; width: 43.19%;">
            <div>
              <div>/s/ Sheri McCoy</div>
            </div>
          </td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">
            <div>Non-Executive Director</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.19%; vertical-align: bottom;">
            <div>Sheri McCoy</div>
          </td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 43.19%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="border-bottom: 1px solid #000000; vertical-align: bottom; width: 43.19%;">
            <div>
              <div>/s/ Tony Mok</div>
            </div>
          </td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">
            <div>Non-Executive Director</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.19%; vertical-align: bottom;">
            <div>Tony Mok</div>
          </td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 43.19%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="border-bottom: 1px solid #000000; vertical-align: bottom; width: 43.19%;">
            <div>
              <div>/s/ Nazneen Rahman</div>
            </div>
          </td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">
            <div>Non-Executive Director</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.19%; vertical-align: bottom;">
            <div>Nazneen Rahman</div>
          </td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 43.19%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>
        <tr>
          <td style="border-bottom: 1px solid #000000; vertical-align: bottom; width: 43.19%;">
            <div>
              <div>/s/ Marcus Wallenberg</div>
            </div>
          </td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">
            <div>Non-Executive Director</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.19%; vertical-align: bottom;">
            <div>Marcus Wallenberg</div>
          </td>
          <td style="vertical-align: bottom; width: 56.81%; padding: 0px 0px 0px 20px;">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 9pt;"><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <div style="text-align: justify; margin-bottom: 9pt; font-weight: bold;">SIGNATURE OF AUTHORIZED REPRESENTATIVE IN THE UNITED STATES</div>
    <div style="text-align: justify; text-indent: 72pt; margin-bottom: 9pt;">Pursuant to the Securities Act of 1933, as amended, the undersigned, the duly authorized representative in the United States of AstraZeneca PLC, has signed this registration
      statement in Wilmington, Delaware, United States of America on July 19, 2021.</div>
    <table cellspacing="0" cellpadding="0" id="z1d9d9447c2bd4c66ad1b1312e28e0eb6" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45.5%; vertical-align: top;">&#160;</td>
          <td style="width: 54.5%; vertical-align: top;" colspan="4">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.5%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.18%;">&#160;</td>
          <td style="width: 41.23%; vertical-align: top;" colspan="2">&#160;</td>
          <td style="width: 8.1%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.5%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.18%;">&#160;</td>
          <td style="width: 41.23%; vertical-align: top;" colspan="2">&#160;</td>
          <td style="width: 8.1%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.5%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="vertical-align: top; width: 3.18%; padding-bottom: 2px;">
            <div style="text-align: justify;">By:</div>
          </td>
          <td style="border-bottom: 1px solid #000000; vertical-align: top; white-space: nowrap; width: 41.23%;" colspan="2">
            <div>
              <div style="text-align: justify;">/s/ Mariam Koohdary</div>
            </div>
          </td>
          <td style="width: 8.1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.5%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.18%;">&#160;</td>
          <td style="vertical-align: top; white-space: nowrap; width: 5.21%;">
            <div style="text-align: justify;">Name:</div>
          </td>
          <td nowrap="nowrap" style="width: 33.02%; vertical-align: top;">
            <div style="text-align: justify;">Mariam Koohdary</div>
          </td>
          <td style="width: 8.1%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.5%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.18%;">&#160;</td>
          <td style="vertical-align: top; white-space: nowrap; width: 5.21%;">
            <div style="text-align: justify;">Title:</div>
          </td>
          <td nowrap="nowrap" style="width: 33.02%; vertical-align: top;">
            <div>Duly authorized Representative of AstraZeneca PLC in the United States</div>
          </td>
          <td style="width: 8.1%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 9pt;"><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <div style="text-align: center; margin-bottom: 12pt; font-weight: bold;">Index to Exhibits</div>
    <table cellspacing="0" cellpadding="0" id="z3d19741cbffb4d9baf44487b2fe5f4d9" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: justify; font-weight: bold;"><u>Exhibit</u></div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: justify; font-weight: bold;"><u>Document</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: justify;">(d)</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: justify;">Opinion of White &amp; Case LLP, counsel to the Depositary</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: justify;">(e)</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: justify;">Certification under Rule 466</div>
          </td>
        </tr>

    </table>
    <div style="margin-bottom: 9pt;"><br>
    </div>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.D CONTRACTS
<SEQUENCE>2
<FILENAME>a21-30_ex99d.htm
<DESCRIPTION>OPINION TO THE DEPOSITARY
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: White & Case
         Document created using EDGARfilings PROfile 7.5.0.0
         Copyright 1995 - 2021 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <div style="text-align: right;"><br>
    </div>
    <div style="margin-bottom: 12pt;">July 19, 2021</div>
    <div>Deutsche Bank Trust Company Americas,</div>
    <div style="text-indent: 0pt; margin-left: 18pt;">as Depositary under the Deposit Agreement</div>
    <div style="text-indent: 0pt; margin-left: 18pt;">referred to below</div>
    <div style="margin-bottom: 12pt;">60 Wall Street<br>
      New York, NY 10005<br>
      United States</div>
    <div style="margin-top: 18pt; margin-bottom: 9pt;">Ladies and Gentlemen,</div>
    <div style="text-indent: 28.35pt; margin-bottom: 9pt;">We refer to the Registration Statement on Form F-6 (the &#8220;Registration Statement&#8221;) relating to American Depositary Shares (&#8220;ADSs&#8221;) evidenced by American Depositary Receipts (&#8220;Receipts&#8221;), each ADS
      representing 0.5 ordinary shares of AstraZeneca PLC (the &#8220;Company&#8221;).</div>
    <div style="text-indent: 28.35pt; margin-bottom: 9pt;">In rendering the opinions set forth herein, we have assumed that (i) the Deposit Agreement previously filed as Exhibit (a) to Form F-6 (File No. 333-236014) and incorporated herein by reference in
      the Registration Statement (the &#8220;Deposit Agreement&#8221;) has been duly authorized, executed and delivered by the Company and will constitute a valid and legally binding obligation of the Company enforceable against it in accordance with its terms, (ii)
      the relevant Deposited Securities (as defined in the Deposit Agreement) will have been duly deposited with a custodian under and in accordance with the Deposit Agreement and all applicable laws and regulations, (iii) the choice of New York law
      contained in the Deposit Agreement is legal and valid under the laws of England and Wales and (iv) insofar as any obligation under the Deposit Agreement is to be performed in, or by a party organized under the laws of, any jurisdiction outside of the
      United States of America, its performance will not be illegal or ineffective in any jurisdiction by virtue of the law of that jurisdiction.</div>
    <div style="text-indent: 28.35pt; margin-bottom: 9pt;">Based upon and subject to the foregoing, we are of the opinion that the ADSs covered by the Registration Statement, when evidenced by Receipts that are duly executed and delivered by the Depositary
      (as defined in the Deposit Agreement) and issued in accordance with the terms of the Deposit Agreement, will be validly issued and will entitle the registered holders thereof to the rights specified in the Deposit Agreement and those Receipts.</div>
    <div style="text-indent: 28.35pt; margin-bottom: 9pt;">The foregoing opinion is limited to the laws of the State of New York and we express no opinion as to the laws of any other jurisdiction.</div>
    <div style="text-indent: 28.35pt; margin-bottom: 9pt;">We hereby consent to the use of this opinion as Exhibit (d) to the Registration Statement.&#160; In giving such consent, we do not admit hereby that we are within the category of persons whose consent
      is required under Section&#160;7 of the Securities Act of 1933.</div>
    <div style="margin-bottom: 9pt;"><br>
    </div>
    <div style="margin: 0px 0px 24pt;">Very truly yours,</div>
    <div style="margin: 0px 0px 24pt;">/s/ White &amp; Case LLP<br>
    </div>
    <div style="text-align: justify;">FF-B:AD-S</div>
    <div><br>
    </div>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.E UNDR CONTR
<SEQUENCE>3
<FILENAME>a21-30_ex99e.htm
<DESCRIPTION>RULE 466 CERTIFICATE
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: White & Case
         Document created using EDGARfilings PROfile 7.5.0.0
         Copyright 1995 - 2021 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <div style="text-align: right;">Exhibit (e)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Certification under Rule 466</div>
    <div>&#160;</div>
    <div>The depositary, Deutsche Bank Trust Company Americas, represents and certifies the following:</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">(1)&#160;&#160;That it previously had filed a registration statement on Form F-6 (File No. 333-236014) which the U.S. Securities and Exchange Commission declared effective, with terms of deposit identical to the terms of deposit
      of this Form F-6 registration statement; and</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">(2)&#160;&#160;That its ability to designate the date and time of effectiveness under Rule 466 has not been suspended.</div>
    <div style="text-indent: 36pt;"> <br>
    </div>
    <br>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="zb08862f3495541d7a5027a0f845a1782">

        <tr>
          <td style="width: 45.47%; vertical-align: top;">&#160;</td>
          <td colspan="4" style="width: 54.53%; vertical-align: top;">
            <div style="font-weight: bold;">Deutsche Bank Trust Company Americas, solely in its capacity as Depositary</div>
          </td>
        </tr>
        <tr>
          <td style="width: 45.47%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.16%;">&#160;</td>
          <td colspan="2" style="width: 39.61%; vertical-align: top;">&#160;</td>
          <td style="width: 9.77%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.47%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.16%;">&#160;</td>
          <td colspan="2" style="width: 39.61%; vertical-align: top;">&#160;</td>
          <td style="width: 9.77%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.47%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.16%;">
            <div style="text-align: justify;">By:</div>
          </td>
          <td colspan="2" style="border-bottom: 1px solid #000000; vertical-align: top; white-space: nowrap; width: 39.61%;">/s/ Michael Fitzpatrick<br>
          </td>
          <td style="width: 9.77%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.47%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.16%;">&#160;</td>
          <td style="vertical-align: top; white-space: nowrap; width: 5.2%;">
            <div style="text-align: justify;">Name:</div>
          </td>
          <td nowrap="nowrap" style="width: 31.41%; vertical-align: top;">Michael Fitzpatrick<br>
          </td>
          <td style="width: 9.77%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.47%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.16%;">&#160;</td>
          <td style="vertical-align: top; white-space: nowrap; width: 5.2%;">
            <div style="text-align: justify;">Title:</div>
          </td>
          <td nowrap="nowrap" style="width: 31.41%; vertical-align: top;">Vice President<br>
          </td>
          <td style="width: 9.77%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.47%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.16%;">&#160;</td>
          <td colspan="2" style="width: 39.61%; vertical-align: top;">&#160;</td>
          <td style="width: 9.77%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.47%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.16%;">&#160;</td>
          <td colspan="2" style="width: 39.61%; vertical-align: top;">&#160;</td>
          <td style="width: 9.77%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45.47%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top; width: 3.16%;">
            <div style="text-align: justify;">By:</div>
          </td>
          <td colspan="2" style="border-bottom: 1px solid #000000; vertical-align: top; width: 39.61%;">/s/ Jeff Margolick<br>
          </td>
          <td style="width: 9.77%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 9pt;">
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 45.5%; vertical-align: top;">&#160;</td>
            <td style="vertical-align: top; width: 3.18%;">&#160;</td>
            <td style="vertical-align: top; white-space: nowrap; width: 5.21%;">
              <div style="text-align: justify;">Name:</div>
            </td>
            <td nowrap="nowrap" style="width: 31.37%; vertical-align: top;">Jeff Margolick<br>
            </td>
            <td style="width: 9.74%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 45.5%; vertical-align: top;">&#160;</td>
            <td style="vertical-align: top; width: 3.18%;">&#160;</td>
            <td style="vertical-align: top; white-space: nowrap; width: 5.21%;">
              <div style="text-align: justify;">Title:</div>
            </td>
            <td nowrap="nowrap" style="width: 31.37%; vertical-align: top;">Director<br>
            </td>
            <td style="width: 9.74%; vertical-align: top;">&#160;</td>
          </tr>

      </table>
    </div>
    <br>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
