<SEC-DOCUMENT>0001654954-22-005571.txt : 20220429
<SEC-HEADER>0001654954-22-005571.hdr.sgml : 20220429
<ACCEPTANCE-DATETIME>20220429063923
ACCESSION NUMBER:		0001654954-22-005571
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20220429
FILED AS OF DATE:		20220429
DATE AS OF CHANGE:		20220429

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ASTRAZENECA PLC
		CENTRAL INDEX KEY:			0000901832
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-11960
		FILM NUMBER:		22869958

	BUSINESS ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA
		BUSINESS PHONE:		011 44 20 7304 5000

	MAIL ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ZENECA GROUP PLC
		DATE OF NAME CHANGE:	19930422
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>a7847j.htm
<DESCRIPTION>FIRST QUARTER 2022 RESULTS
<TEXT>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
FORM 6-K</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">SECURITIES
AND EXCHANGE COMMISSION</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Washington,
D.C. 20549</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Report
of Foreign Issuer</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Pursuant
to Rule 13a-16 or 15d-16 of</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">the
Securities Exchange Act of 1934</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">For the
month of April 2022</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Commission
File Number: 001-11960</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">1
Francis Crick Avenue</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Cambridge
Biomedical Campus</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Cambridge
CB2 0AA</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">United
Kingdom</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Indicate
by check mark whether the registrant files or will file annual
reports under cover of Form 20-F or Form 40-F.</font></div>
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<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Form
20-F X Form 40-F __</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Indicate
by check mark if the registrant is submitting the Form 6-K in paper
as permitted by Regulation S-T Rule 101(b)(1):</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Indicate
by check mark if the registrant is submitting the Form 6-K in paper
as permitted by Regulation S-T Rule 101(b)(7): ______</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Indicate
by check mark whether the registrant by furnishing the information
contained in this Form is also thereby furnishing the information
to the Commission pursuant to Rule 12g3-2(b) under the Securities
Exchange Act of 1934.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Yes __
No X</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">If
&#x201C;Yes&#x201D; is marked, indicate below the file number
assigned to the Registrant in connection with Rule 12g3-2(b):
82-_____________</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">INDEX
TO EXHIBITS</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="margin-left: 0px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 36px">
<font style="font-family: Times New Roman; font-size: 13px;">1.</font></div>
<div style="text-align: justify; display: table-cell">First quarter 2022
results</div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
29 April 2022 07:00 GMT</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
First quarter 2022 results</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;Strong start to the year. Continued investment in the
pipeline to drive sustainable long-term growth.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Revenue and EPS summary</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 45%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 19%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 45%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="3" style="vertical-align: middle; width: 37%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;&#xA0;&#xA0; % Change</font></div>
</td>
</tr><tr>
<td style="vertical-align: bottom; width: 45%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 19%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222">CER</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">1</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
- Product Sales&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
10,980</font></div>
</td>
<td style="vertical-align: top; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
51&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 19%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
56&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 45%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
- Collaboration Revenue</font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
410</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 19%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
n/m&#xA0;</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">2</font></font></div>
</td>
<td style="vertical-align: top; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 45%; border-bottom: 2px solid #000000">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11,390</font></div>
</td>
<td style="vertical-align: top; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
56&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 19%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
60&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Reported</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">3</font><font style="color: #1F2222">&#xA0;EPS</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">4</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$0.25</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(79)</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 19%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(73)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 45%; border-bottom: 2px solid #000000">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Core</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">5</font><font style="color: #1F2222">&#xA0;EPS&#xA0;</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">6</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$1.89</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
16&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 19%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
20&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 45%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
Financial performance&#xA0;</font><font style="color: #1F2222">(growth numbers at CER)</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Total
Revenue increased 60% to $11,390m, reflecting growth across the
Company, the contribution of the Alexion medicines and
several&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font><font style="color: #1F2222">&#xA0;contracts that are expected to complete
delivery by half year 2022</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Total
Revenue from Oncology increased 25%</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">7</font><font style="color: #1F2222">,
including a milestone payment; Product Sales from Oncology
increased 18%. Total Revenue from CVRM</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">8</font><font style="color: #1F2222">&#xA0;increased
18%, R&amp;I</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">9</font><font style="color: #1F2222">&#xA0;increased
4% and Rare Disease increased 7%</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">10</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Operating
Margin in the quarter benefitted from phasing of
costs</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Core
EPS increased 20% to $1.89</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">FY
2022 guidance at CER reiterated</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Key milestones achieved since the prior results</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Key
data:&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">11</font><font style="color: #1F2222">&#xA0;in
HER2</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">12</font><font style="color: #1F2222">-low
breast cancer (DESTINY-Breast04), AZD8233 in hypercholesterolaemia
(ETESIAN, Phase IIb) and publication of data
for&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">&#xA0;in prostate cancer (PROpel) and nirsevimab
in RSV</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">13</font><font style="color: #1F2222">&#xA0;(MELODY/MEDLEY)</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Key
approvals:&#xA0;</font><font style="font-style: italic; color: #1F2222">Saphnelo</font><font style="color: #1F2222">&#xA0;and&#xA0;</font><font style="font-style: italic; color: #1F2222">Evusheld</font><font style="color: #1F2222">&#xA0;in the EU,&#xA0;</font><font style="font-style: italic; color: #1F2222">Ondexxya</font><font style="color: #1F2222">&#xA0;in Japan, and in the US, approvals
of&#xA0;</font><font style="font-style: italic; color: #1F2222">Ultomiris</font><font style="color: #1F2222">&#xA0;for gMG</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">14</font><font style="color: #1F2222">&#xA0;and&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">15</font><font style="color: #1F2222">&#xA0;for
early breast cancer (OlympiA)</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Other
key milestones: US FDA</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">16</font><font style="color: #1F2222">&#xA0;Breakthrough
Therapy Designation for&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">&#xA0;in HER2-low breast cancer
(DESTINY-Breast04), Priority Reviews for&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">&#xA0;in HER2-mutant metastatic non-small cell
lung cancer (DESTINY-Lung01), and&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font><font style="color: #1F2222">&#xA0;and tremelimumab in advanced liver cancer
(HIMALAYA), and EMA</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">17</font><font style="color: #1F2222">&#xA0;accelerated
assessment for nirsevimab in RSV
(MELODY/MEDLEY)</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Pascal Soriot, Chief Executive Officer, AstraZeneca,
said:</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
"2022 has started strongly for
AstraZeneca.&#xA0;</font><font style="font-style: italic; color: #1F2222">Farxiga</font><font style="color: #1F2222">&#xA0;achieved
$1bn revenue in the quarter and our Oncology medicines delivered
Product Sales growth of 18%, despite COVID-19 continuing to impact
cancer diagnosis and treatment. High-level results from the
DESTINY-Breast04 trial pointed to&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">'s potential to redefine treatment of HER2-low
metastatic breast cancer, and&#xA0;</font><font style="font-style: italic; color: #1F2222">Ultomiris</font><font style="color: #1F2222">&#xA0;became the first and only long-acting C5
inhibitor approved for generalised myasthenia gravis in the
US.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Today we have unveiled plans for a new strategic research and
development centre in the heart of Cambridge, Massachusetts'
scientific&#xA0;hub. In line with our sustainability commitments,
it will be designed to the highest environmental standards. Our
investments in pioneering science give us confidence of further
advances in the years to come." &#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Guidance</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; background-color: #FFFFFF; font-family: Times New Roman; font-size: 13px">
The Company reiterates FY 2022 guidance at CER.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: auto; margin-right: auto; margin-bottom: 6px; width: 100%; height: 1px; background-color: #000000">
<!--line--><br></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; background-color: #FFFFFF; font-family: Times New Roman; font-size: 13px">
Total Revenue is expected to increase by a high teens
percentage</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; background-color: #FFFFFF; font-family: Times New Roman; font-size: 13px">
Core EPS is expected to increase by a mid-to-high twenties
percentage</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; width: 100%; border-bottom: solid 1px #000000">
<!--Rule Below Paragraph--></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222; background-color: #FFFFFF">The
CER growth rates include the full-year contribution
of&#xA0;</font><font style="font-style: italic; color: #1F2222; background-color: #FFFFFF">Vaxzevria</font><font style="color: #1F2222; background-color: #FFFFFF">&#xA0;in
both FY 2021 and FY 2022</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Total
Revenue from COVID-19 medicines is anticipated to decline by a
low-to-mid twenties percentage, with an expected decline in sales
of&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font><font style="color: #1F2222">&#xA0;being partially offset by growth
in&#xA0;</font><font style="font-style: italic; color: #1F2222">Evusheld</font><font style="color: #1F2222">&#xA0;sales. The majority
of&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font><font style="color: #1F2222">&#xA0;revenue in 2022 is expected to come from
initial contracts. The Gross Margin from the COVID-19 medicines is
expected to be lower than the Company average</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Core
Operating Expenses are expected to increase by a low-to-mid teens
percentage, driven in substantial part by the full year integration
of Alexion expenses</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222; background-color: #FFFFFF">Emerging
Markets Total Revenue, including China, is expected to grow
mid-single-digits in FY 2022. China Total Revenue is expected to
decline by a mid-single-digit percentage in FY 2022, primarily due
to continued NRDL and VBP programme impacting various medicines.
The Company remains confident in the longer term outlook for
Emerging Markets, driven by a large market opportunity, broader
patient access and an increased mix of new
medicines</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; background-color: #FFFFFF; font-family: Arial; font-size: 5px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222; background-color: #FFFFFF">A
Core Tax Rate between 18-22%</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; background-color: #FFFFFF; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; background-color: #FFFFFF; font-family: Times New Roman; font-size: 13px">
AstraZeneca continues to recognise and actively manage the
heightened risks from COVID-19 and geopolitical and supply chain
uncertainties on overall business performance. Variations in
performance between quarters can be expected to
continue.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The Company is unable to provide guidance on a Reported basis
because AstraZeneca cannot reliably forecast material elements of
the Reported result, including any fair value adjustments arising
on acquisition-related liabilities, intangible asset impairment
charges and legal-settlement provisions. Please refer to the
cautionary statements section regarding forward-looking statements
at the end of this announcement.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Currency impact</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
If foreign-exchange rates for April to December 2022 were to remain
at the average of rates seen in Q1 2022, it is anticipated that
there would be a low single-digit adverse impact on Total Revenue
and a mid single-digit adverse impact on Core EPS versus the
financials at CER. The Company's foreign-exchange rate sensitivity
analysis is contained in Table 15.</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;1: Key elements of Total Revenue
performance</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 26%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 9%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 18%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Change</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 47%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: middle; width: 26%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Revenue type&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 47%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: middle; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Product Sales&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
10,980&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
51&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
56&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">$1,688m
from medicines acquired with Alexion&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Collaboration Revenue&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
410&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">$76m for&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">&#xA0;(Q1 2021: $39m), and milestone payments of
$175m for&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">&#xA0;and $70m for tralokinumab (Q1 2021:
$nil)</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11,390&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
56&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
60&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: bottom; width: 26%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Disease areas&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Oncology&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3,644&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
21&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
25&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Product
Sales up 14% (18% CER). Strong performance despite a continuing
COVID-19 impact on cancer diagnoses and
treatment&#xA0;rates</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CVRM</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,219&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
18&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">Farxiga</font><font style="color: #1F2222">&#xA0;grew 60% (67% at CER) to
$1,001m&#xA0;</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
R&amp;I</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,584&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">Pulmicort</font><font style="color: #1F2222">&#xA0;declined 34% primarily due to inclusion in
China's VBP</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">18</font><font style="color: #1F2222">&#xA0;programme,
implemented in October 2021&#xA0;</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
V&amp;I</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">19</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,814&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; color: #1F2222">
20</font><font style="color: #1F2222">&#xA0;&gt;6x&#xA0;</font></font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;6x&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">$1,145m from&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">21</font><font style="color: #1F2222">&#xA0;and
$469m from&#xA0;</font><font style="font-style: italic; color: #1F2222">Evusheld</font><font style="color: #1F2222">&#xA0;</font></font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">Majority of&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font><font style="color: #1F2222">&#xA0;revenue from initial contracts, several of
which completed during the quarter. In-line with
guidance,&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font><font style="color: #1F2222">&#xA0;revenue is expected to decline in later
quarters</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Rare Disease&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,694&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">Durable C5 franchise growth, including continued
conversion from&#xA0;</font><font style="font-style: italic; color: #1F2222">Soliris</font><font style="color: #1F2222">&#xA0;to&#xA0;</font><font style="font-style: italic; color: #1F2222">Ultomiris</font><font style="color: #1F2222">&#xA0;in PNH</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">22</font><font style="color: #1F2222">&#xA0;and
aHUS</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">23</font><font style="color: #1F2222">,
and&#xA0;</font><font style="font-style: italic; color: #1F2222">Soliris</font><font style="color: #1F2222">&#xA0;growth in gMG and NMOSD</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">24</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other Medicines</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
435&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(18)</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(15)</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11,390&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
56&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
60&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: bottom; width: 26%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222">Regions&#xA0;exc.&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria&#xA0;</font></font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,833&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
- China&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,575&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(6)</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(8)</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">Pricing pressure associated with the
NRDL</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">25</font><font style="color: #1F2222">&#xA0;and
VBP programmes</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
- Ex-China Emerging Markets&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,258&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
45&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
57&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">$110m
from medicines acquired with Alexion&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4,055&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
76&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
76&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">$1,014m
from medicines acquired with Alexion&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,150&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
63&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
73&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">$366m
from medicines acquired with Alexion&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,207&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
40&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
51&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">$208m
from medicines acquired with Alexion&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Total Revenue exc.&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font></font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
10,245&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
45&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
50&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">$1,698m
from medicines acquired with Alexion&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: bottom; width: 26%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222">Regions inc.&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font></font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 47%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3,364&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
30&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">Impacted by quarterly phasing
of&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
- China&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,622&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(3)</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(6)</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">In
line with FY 2022 guidance</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
- Ex-China Emerging Markets&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,742&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
91&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;2x&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4,134&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
79&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
79&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,284&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
48&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
57&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,608&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
85&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
98&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td colspan="2" style="vertical-align: top; width: 26%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11,390&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 8%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
56&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
60&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 47%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 26%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 8%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 8%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 47%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;2: Key elements of financial performance</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td colspan="5" style="vertical-align: top; width: 57%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
<td style="vertical-align: top; width: 1%;">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 42%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-weight: bold; font-family: Times New Roman; font-size: 13px">
Metric($m or %)</font></div>
</td>
<td style="vertical-align: top; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Reported</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Reported change</font></div>
</td>
<td style="vertical-align: top; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Core</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 7px; text-indent: 0px">
<font style="color: #1F2222; font-weight: bold; font-family: Times New Roman; font-size: 13px">
Corechange</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 42%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222">Comments</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">26</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11,390</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
56% Actual 60% CER</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11,390</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 7px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
56% Actual 60% CER</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 42%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">See
Table 1</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Gross Margin</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">27</font></font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
68%</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-6pp Actual-7pp CER</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
79%</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 7px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
+5pp Actual</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 7px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
+4pp CER</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 42%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">+
Contribution of Alexion</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">+
Increasing mix of Oncology sales</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;</font><font style="color: #1F2222">Increasing
mix of COVID-19 therapies</font></font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;</font><font style="color: #1F2222">China
impact of NRDL and VBP</font></font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;</font><font style="color: #1F2222">Increasing
impact from profit-sharing arrangements including
the&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">&#xA0;collaboration with MSD</font></font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;</font><font style="color: #1F2222">Reported
impacted by unwind of Alexion inventory fair value
adjustment</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
R&amp;D Expense</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,133</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
24% Actual 26% CER</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,186</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 7px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
33% Actual 36% CER</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 42%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">+
Increased investment in pipeline</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">+
Addition of Alexion R&amp;D&#xA0;</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;</font><font style="color: #1F2222">Beneficial
phasing of costs resulted in a Core R&amp;D-to-Total Revenue ratio
of 19% (FY 2021: 21%)</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
SG&amp;A Expense</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4,840</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
65% Actual 68% CER</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,946</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 7px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
23% Actual 25% CER</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 42%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">+
Addition of Alexion</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">+
Reported impacted by $775m legal settlement with Chugai
Pharmaceutical Co. Ltd and amortisation related to Alexion
acquisition</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;</font><font style="color: #1F2222">Beneficial
phasing of costs resulted in a Core SG&amp;A-to-Total Revenue ratio
of 26% (FY 2021: 30%)</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Other Operating Income</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">28</font></font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
97</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(92%) Actual</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(92%) CER</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
98</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 7px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(92%) Actual (92%) CER</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 42%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Limited
divestments in quarter, majority of income coming from royalties
and prior transactions</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Operating Margin</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8%</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-18pp Actual-18pp CER</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
35%</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Stable Actualand CER</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 42%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">See
Gross Margin and Expensescommentary above</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net Finance Expense</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
319</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13% Actual 7% CER</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
252</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 7px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
35% Actual 23% CER</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 42%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">+
Alexion debt financing costs</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;</font><font style="color: #1F2222">Reported
impacted by lower discount unwind on acquisition-related
liabilities</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tax Rate</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
30%</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
+27pp</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
21%</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
+13pp</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 42%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">In-line
with full year expectation of 18-22%</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -12px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">+
The Tax Rate in the comparable period of Q1 2021 was favourably
impacted by the disposal of Viela and settlements with tax
authorities</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
EPS</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$0.25</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(79%) Actual(73%) CER</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$1.89</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 7px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
16% Actual 20% CER</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 42%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Further
details of differences between Reported and Core are shown in Table
10</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Corporate and business development</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
In April 2022, AstraZeneca and Harbour BioMed (HBM) committed to a
global out-license agreement for HBM7022, a pre-clinical bispecific
antibody targeting Claudin18.2 and CD3. AstraZeneca will be granted
an exclusive global license for research, development,
registration, manufacturing, and commercialisation of
HBM7022.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HBM shall receive an upfront payment of $25m with the potential for
additional payments up to $325m pending achievement of certain
development, regulatory and commercial milestones. HBM is also
eligible to receive tiered royalties on net sales.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Sustainability summary</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
AstraZeneca published its eighth&#xA0;</font><font style="text-decoration: underline; color: #0000FF">annual Sustainability
Report</font><font style="color: #1F2222">&#xA0;and Sustainability
Data summary, released in conjunction with the 2021 Annual Report.
The report outlines progress on strategic priorities, material
focus areas, challenges and aims for the
future.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; background-color: #FFFFFF; font-family: Times New Roman; font-size: 13px">
AstraZeneca continues to provide urgent humanitarian support in
Ukraine and neighbouring countries. To date, AstraZeneca has
committed over $7m to response efforts, including donations
of:</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222; background-color: #FFFFFF">Medicines&#xA0;</font><font style="color: #1F2222">to</font><font style="color: #1F2222; background-color: #FFFFFF">&#xA0;the
Company's humanitarian relief partner Direct Relief, which is
working directly with the Ukrainian Ministry of
Health</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222; background-color: #FFFFFF">Medicines
via The Red Cross affiliates in neighbouring
countries</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222; background-color: #FFFFFF">$2m
to support relief agencies working in Ukraine, Poland and
surrounding areas with a focus on providing healthcare and
humanitarian assistance. Funding is being provided to Project HOPE,
working with and through the World Health Organization, and
International Medical Corps</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; background-color: #FFFFFF; font-family: Arial; font-size: 5px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222; background-color: #FFFFFF">More
than $1m to UNICEF and The Red Cross</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Reporting changes for Q1 2022</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
AstraZeneca's Total Revenue and Product Sales tables in FY 2022
include a new disease area: BioPharmaceuticals: Vaccines &amp;
Immune Therapies (V&amp;I). This incorporates revenues
from&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font><font style="color: #1F2222">,&#xA0;</font><font style="font-style: italic; color: #1F2222">Evusheld</font><font style="color: #1F2222">,&#xA0;</font><font style="font-style: italic; color: #1F2222">FluMist</font><font style="color: #1F2222">,&#xA0;</font><font style="font-style: italic; color: #1F2222">Synagis</font><font style="color: #1F2222">&#xA0;and nirsevimab. In the FY 2021 quarterly and
annual reports,&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font><font style="color: #1F2222">&#xA0;and&#xA0;</font><font style="font-style: italic; color: #1F2222">Evusheld</font><font style="color: #1F2222">&#xA0;revenues were shown under COVID-19,
and&#xA0;</font><font style="font-style: italic; color: #1F2222">FluMist</font><font style="color: #1F2222">,&#xA0;</font><font style="font-style: italic; color: #1F2222">Synagis</font><font style="color: #1F2222">&#xA0;and nirsevimab revenues were shown under
Other Medicines. In addition, revenue from&#xA0;</font><font style="font-style: italic; color: #1F2222">Koselugo</font><font style="color: #1F2222">&#xA0;have moved from Oncology to Rare Disease,
and revenue from&#xA0;</font><font style="font-style: italic; color: #1F2222">Andexxa</font><font style="color: #1F2222">&#xA0;has moved from Rare Disease to
BioPharmaceuticals: CVRM.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The growth rate for each disease area has been calculated as though
these changes had been implemented in FY 2021.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Conference call</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
A conference call and webcast for investors and analysts will begin
today (29 April 2022) at 11:45 BST. Details can be accessed via
astrazeneca.com.</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Reporting calendar</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The Company intends to publish its half-year and second-quarter
results on Friday 29 July 2022.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Notes</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The following notes refer to pages one to five.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">1.&#xA0;&#xA0;&#xA0;
Constant exchange rates. The differences between Actual Change and
CER Change are due to foreign exchange movements between periods in
2022 vs 2021. CER financial measures are not accounted for
according to generally accepted accounting principles (GAAP)
because they remove the effects of currency movements from Reported
results.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">2.&#xA0;&#xA0;&#xA0;
Not meaningful</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">3.&#xA0;&#xA0;&#xA0;
Reported financial measures are the financial results presented in
accordance with UK-adopted International Accounting Standards and
International Financial Reporting Standards (IFRSs) as issued by
the International Accounting Standards Board (IASB) and
International Accounting Standards as adopted by the European
Union.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">4.&#xA0;&#xA0;&#xA0;
Earnings per share.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">5.&#xA0;&#xA0;&#xA0;
Core financial measures. These are non-GAAP financial measures
because, unlike Reported performance, they cannot be derived
directly from the information in the Group's Financial Statements.
See the Operating and financial review for a definition of Core
financial measures and a reconciliation of Core to Reported
financial measures.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">6.&#xA0;&#xA0;&#xA0;
The differences between Reported and Core measures are primarily
due to items related to the acquisition of Alexion, amortisation of
intangibles, impairments, restructuring charges, and, as previously
disclosed, a charge to provisions relating to a legal settlement
with Chugai Pharmaceutical Co. Ltd that will lead to a payment of
$775m in the Q2 2022. A full reconciliation between Reported EPS
and Core EPS is provided in Table 10 in the Financial performance
section of this document.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">7.&#xA0;&#xA0;&#xA0; In FY 2022, Total Revenue
from&#xA0;</font><font style="font-style: italic; color: #1F2222">Koselugo</font><font style="color: #1F2222">&#xA0;is included in Rare Disease (FY 2021:
Oncology), and Total Revenue from&#xA0;</font><font style="font-style: italic; color: #1F2222">Andexxa</font><font style="color: #1F2222">&#xA0;is included in BioPharmaceuticals: CVRM (FY
2021: Rare Disease). The growth rate for each disease area has been
calculated as though these changes had been implemented in FY
2021.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">8.&#xA0;&#xA0;&#xA0;
Cardiovascular, Renal &amp; Metabolism.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">9.&#xA0;&#xA0;&#xA0;
Respiratory &amp; Immunology.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">10.&#xA0;
FY 2022 Q1 growth rates on medicines acquired with Alexion have
been calculated on a pro forma basis comparing to the corresponding
period in the prior year, pre-acquisition as previously published
by Alexion. The growth rates shown for the Rare Disease and CVRM
disease areas include these pro forma adjustments.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">11.&#xA0; AstraZeneca is collaborating with
Daiichi Sankyo to develop and
commercialise&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">12.&#xA0;
Human epidermal growth factor receptor 2.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">13.&#xA0;
Respiratory syncytial virus.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">14.&#xA0;
Generalised myasthenia gravis.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">15.&#xA0; AstraZeneca is collaborating with MSD
(Merck &amp; Co., Inc. in the US and Canada) to develop and
commercialise&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">16.&#xA0;
US Food and Drug Administration.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">17.&#xA0;
European Medicines Agency.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">18.&#xA0;
Volume based procurement.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">19.&#xA0;
Vaccines &amp; Immune Therapies.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">20.&#xA0;
Growth rates greater than 100% are displayed as a multiple, for
example &#xD4;&gt;2x' signifies that the value is more than double
that of the comparable period</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">21.&#xA0;&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font><font style="color: #1F2222">&#xA0;is AstraZeneca's trademark for the Company's
supply of the AstraZeneca COVID-19 Vaccine. In the financial tables
in this report, '</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font><font style="color: #1F2222">&#xA0;Total Revenue' includes Collaboration
Revenue from sub-licensees that produce and supply the AstraZeneca
COVID-19 Vaccine under their own trademarks.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">22.&#xA0;
Paroxysmal nocturnal haemoglobinuria.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">23.&#xA0;
Atypical haemolytic uraemic syndrome.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">24.&#xA0;
Neuromyelitis optica spectrum disorder.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">25.&#xA0;
National Reimbursement Drug List.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">26.&#xA0;
The plus and minus signs in Table 2 indicate the directional impact
of the item being discussed, e.g. a plus sign in R&amp;D Expenses
signifies that the comment refers to an item that increased the
R&amp;D Expense relative to the prior year.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">27.&#xA0;
Gross Profit is defined as Total Revenue minus Cost of Sales. The
calculation of Reported and Core Gross Margin excludes the impact
of Collaboration Revenue and any associated costs, thereby
reflecting the underlying performance of Product
Sales.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">28.&#xA0;
Where AstraZeneca does not retain a significant ongoing interest in
medicines or potential new medicines, income from divestments is
reported within Reported and Core Other Operating Income and
Expense in the Company's financial statements.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Pipeline</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;3: Pipeline highlights since prior results
announcement</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Event</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Medicine</font></div>
</td>
<td style="vertical-align: middle; width: 36%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Indication / Trial</font></div>
</td>
<td style="vertical-align: middle; width: 36%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Event</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lynparza</font></div>
</td>
<td style="vertical-align: middle; width: 36%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
gBRCA</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[29]</font><font style="color: #1F2222; font-size: 13px">&#xA0;breast
cancer (adjuvant) (OlympiA)</font></font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory approval (US)</font></div>
</td>
</tr><tr>
<td rowspan="3" style="vertical-align: middle; width: 13%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
approvals and</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
other regulatory</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
actions</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Saphnelo</font></div>
</td>
<td style="vertical-align: middle; width: 36%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
SLE</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[30]</font></font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory approval (EU)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ondexxya</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Acute major bleed</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory approval (JP)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Evusheld</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
COVID-19 pre-exposure prophylaxis (PROVENT)</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory approval (EU)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ultomiris</font></div>
</td>
<td style="vertical-align: middle; width: 36%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
gMG (CHAMPION-MG)</font></div>
</td>
<td style="vertical-align: middle; width: 36%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory approval (US)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Biliary tract cancer (TOPAZ-1)</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (JP)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
Imfinzi</font><font style="color: #1F2222">&#xA0;+
tremelimumab</font></font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Advanced liver cancer (1st-line) (HIMALAYA)</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Priority review (US), regulatory submission (EU, JP)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lynparza</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Prostate cancer (1st-line) (PROpel)</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (JP)</font></div>
</td>
</tr><tr>
<td rowspan="2" style="vertical-align: middle; width: 13%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
submissions or</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
acceptances</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Enhertu</font></div>
</td>
<td style="vertical-align: middle; width: 36%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
HER2m NSCLC</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[31]</font><font style="color: #1F2222; font-size: 13px">&#xA0;(2nd-line+)
(DESTINY-Lung01)</font></font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Priority review (US)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Calquence</font></div>
</td>
<td style="vertical-align: middle; width: 36%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
CLL</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[32]</font><font style="color: #1F2222; font-size: 13px">&#xA0;(ELEVATE-TN)</font></font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (JP)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
nirsevimab</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
RSV (MELODY/MEDLEY)</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission and EMA accelerated assessment
(EU)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Evusheld</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
COVID-19 outpatient treatment (TACKLE)</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (US, EU)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ultomiris</font></div>
</td>
<td style="vertical-align: middle; width: 36%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Subcutaneous, PNH and aHUS</font></div>
</td>
<td style="vertical-align: middle; width: 36%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (EU)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cervical cancer (CALLA)</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Primary endpoint not met</font></div>
</td>
</tr><tr>
<td rowspan="3" style="vertical-align: middle; width: 13%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Major Phase III</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
data readouts</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
and other</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
developments</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Biliary tract cancer (TOPAZ-1)</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Orphan Drug Designation (JP)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Enhertu</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HER2+ breast cancer (2nd-line) (DESTINY-Breast03)</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Breakthrough Drug Designation (CN)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Enhertu</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HER2-low breast cancer(DESTINY-Breast04)</font></div>
</td>
<td style="vertical-align: middle; width: 36%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
Primary endpoint met, Breakthrough Drug Designation,
RTOR</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[33]</font><font style="color: #1F2222; font-size: 13px">&#xA0;(US)</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fasenra</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Nasal polyps (OSTRO)</font></div>
</td>
<td style="vertical-align: middle; width: 36%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Complete response letter (US)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Brilinta</font></div>
</td>
<td style="vertical-align: middle; width: 36%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 36%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Paediatric exclusivity (US)</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;4: Pipeline anticipated major news flow</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Timing</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Medicine</font></div>
</td>
<td style="vertical-align: middle; width: 35%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Indication / Trial</font></div>
</td>
<td style="vertical-align: middle; width: 35%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Event</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
H1 2022</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Biliary tract cancer (TOPAZ-1)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (US, EU)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lynparza</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Prostate cancer (1st-line) (PROpel)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (US)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Enhertu</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HER2+ breast cancer (2nd-line) (DESTINY-Breast03)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision (US), regulatory submission (CN)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Enhertu</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HER2-low breast cancer (3rd-line) (DESTINY-Breast04)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Forxiga</font></div>
</td>
<td style="vertical-align: middle; width: 35%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
CKD</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[34]</font><font style="color: #1F2222; font-size: 13px">&#xA0;(DAPA-CKD)</font></font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision (CN)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Farxiga</font></div>
</td>
<td style="vertical-align: middle; width: 35%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
HFpEF</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[35]</font><font style="color: #1F2222; font-size: 13px">&#xA0;(DELIVER)</font></font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
eplontersen</font></div>
</td>
<td style="vertical-align: middle; width: 35%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
hATTR-PN</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[36]</font><font style="color: #1F2222; font-size: 13px">&#xA0;(NEURO-TTRansform)</font></font></div>
</td>
<td style="vertical-align: middle; width: 35%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
Data readout</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[37]</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Brilinta</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Stroke (THALES)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision (CN)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tezspire</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Severe asthma (NAVIGATOR)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision (EU, JP)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
PT027</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Asthma</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (US)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Evusheld</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
COVID-19 outpatient treatment (EU)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision (EU)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Vaxzevria</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
COVID-19</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (US)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ultomiris</font></div>
</td>
<td style="vertical-align: middle; width: 35%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
NMOSD</font></div>
</td>
<td style="vertical-align: middle; width: 35%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
H2 2022</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tagrisso</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
EGFRm NSCLC (adjuvant) (ADAURA)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision (JP)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Biliary tract cancer (TOPAZ-1)</font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Liver cancer (locoregional)(EMERALD-1)</font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout, regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
NSCLC (1st-line) (PEARL)</font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
NSCLC (unresectable, Stg. III) (PACIFIC-2)</font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Limited-stage SCLC (ADRIATIC)</font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
Imfinzi</font><font style="color: #1F2222">&#xA0;+/-
tremelimumab</font></font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
NSCLC (1st-line) (POSEIDON)</font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
Imfinzi</font><font style="color: #1F2222">&#xA0;+/-
tremelimumab</font></font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Liver cancer (1L) (HIMALAYA)</font></div>
</td>
<td style="vertical-align: top; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lynparza</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
gBRCA breast cancer (adjuvant) (OlympiA)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision (EU, JP)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lynparza</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ovarian cancer (1st-line) (PAOLA-1)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision (CN)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lynparza</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Prostate cancer (1st-line) (PROpel)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Enhertu</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HER2+ breast cancer (3rd-line) (DESTINY-Breast02)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout, regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Enhertu</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HER2+ breast cancer (2nd-line) (DESTINY-Breast03)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision (EU, JP)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Enhertu</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HER2+ gastric cancer (2nd-line) (DESTINY-Gastric01)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision (EU)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Enhertu</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
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</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
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</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
capivasertib</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HR+/HER2-neg breast cancer (1st-line) (CAPItello-291)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Farxiga</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HFpEF (DELIVER)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
eplontersen</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
hATTR-PN</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (US)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fasenra</font></div>
</td>
<td style="vertical-align: middle; width: 35%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
EOE</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[38]</font><font style="color: #1F2222; font-size: 13px">&#xA0;(MESSINA)</font></font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
nirsevimab</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
RSV (MELODY/MEDLEY)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (US) and regulatory decision</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Evusheld</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
COVID-19 (TACKLE/PROVENT)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (JP, CN)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Evusheld</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
COVID-19 outpatient treatment (TACKLE)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Utomiris</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
gMG (CHAMPION-MG)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision (EU, JP)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ultomiris</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Subcutaneous, PNH and aHUS</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ultomiris</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
NMOSD</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Koselugo</font></div>
</td>
<td style="vertical-align: middle; width: 35%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
NF1-PN (SPRINT)</font></div>
</td>
<td style="vertical-align: middle; width: 35%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (CN), regulatory decision (JP)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2023</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tagrisso</font></div>
</td>
<td style="vertical-align: middle; width: 35%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
EGFRm</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[39]</font><font style="color: #1F2222; font-size: 13px">&#xA0;NSCLC
(1st-line) (FLAURA2)</font></font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout, regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tagrisso</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
EGFRm NSCLC (unresectable Stg. III) (LAURA)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout, regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Bladder cancer (muscle invasive) (NIAGARA)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout, regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Bladder cancer (1st-line) (NILE)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout, regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
NSCLC (neoadjuvant) (AEGEAN)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout, regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Liver cancer (adjuvant) (EMERALD-2)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout, regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
NSCLC (unresectable, Stg. III) (PACIFIC-2)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
NSCLC (1st-line) (PEARL)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Limited-stage SCLC (ADRIATIC)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lynparza</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
gBRCA breast cancer (adjuvant) (OlympiA)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (CN)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
Lynparza</font><font style="color: #1F2222">&#xA0;+&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font></font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Endometrial cancer (1st-line) (DUO-E)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
Lynparza</font><font style="color: #1F2222">&#xA0;+&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font></font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ovarian cancer (1st-line) (DUO-O)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Enhertu</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HER2-low breast cancer (2nd-line) (DESTINY-Breast06)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Calquence</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CLL (ELEVATE-TN)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory decision (JP)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Calquence</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CLL (ACE-CL-311)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Calquence</font></div>
</td>
<td style="vertical-align: middle; width: 35%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
MCL</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[40]</font><font style="color: #1F2222; font-size: 13px">&#xA0;(1st-line)
(ECHO)</font></font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
capivasertib</font></div>
</td>
<td style="vertical-align: middle; width: 35%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
TNBC</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[41]</font><font style="color: #1F2222; font-size: 13px">&#xA0;(locally
adv./met.)(CAPItello-290)&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout, regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
capivasertib</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HR+/HER2-neg breast cancer (1st-line) (CAPItello-291)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
camizestrant</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HR+/HER2-neg breast cancer (SERENA-6)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Dato-DXd</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
NSCLC (3rd-line) (TROPION-Lung01)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout, regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Farxiga</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Myocardial infarction (DAPA-MI)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
roxadustat</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Anaemia of myelodysplastic syndrome</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fasenra</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Bullous pemphigoid (FJORD)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fasenra</font></div>
</td>
<td style="vertical-align: middle; width: 35%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
CRwNP</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[42]</font><font style="color: #1F2222; font-size: 13px">&#xA0;(ORCHID)</font></font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fasenra</font></div>
</td>
<td style="vertical-align: middle; width: 35%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
EGPA</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[43]</font><font style="color: #1F2222; font-size: 13px">&#xA0;(MANDARA)</font></font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fasenra</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
EOE (MESSINA)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fasenra</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
HES (NATRON)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fasenra</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Severe asthma (MIRACLE)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
nirsevimab</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
RSV (MELODY/MEDLEY)</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission (JP, CN)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Soliris</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Guillain-Barre syndrome</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
ALXN1840</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Wilson disease</font></div>
</td>
<td style="vertical-align: middle; width: 35%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Regulatory submission</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
danicopan</font></div>
</td>
<td style="vertical-align: middle; width: 35%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
PNH with extravascular haemolysis</font></div>
</td>
<td style="vertical-align: middle; width: 35%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Data readout, regulatory submission</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Operating and financial review</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: auto; margin-right: auto; margin-bottom: 6px; width: 100%; height: 2px; background-color: #000000">
<!--line--><br></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
All narrative on growth and results in this section is based on
actual exchange rates, and financial figures are in US$ millions
($m), unless stated otherwise. The performance shown in this
announcement covers the three-month period to 31 March 2022
(&#xD4;the quarter' or &#xD4;Q1 2022') compared to the three-month
period to 31 March 2021 (Q1 2021), unless stated
otherwise.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Core financial measures, EBITDA, Net Debt, Initial Collaboration
Revenue and Ongoing Collaboration Revenue are non-GAAP financial
measures because they cannot be derived directly from the Group's
Interim Financial Statements. Management believes that these
non-GAAP financial measures, when provided in combination with
Reported results, provide investors and analysts with helpful
supplementary information to understand better the financial
performance and position of the Group on a comparable basis from
period to period. These non-GAAP financial measures are not a
substitute for, or superior to, financial measures prepared in
accordance with GAAP.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Core financial measures are adjusted to exclude certain significant
items, such as:</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Amortisation
and impairment of intangible assets, including impairment reversals
but excluding any charges relating to IT assets</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Charges
and provisions related to restructuring programmes, which includes
charges that relate to the impact of restructuring programmes on
capitalised IT assets as well as Post Alexion Acquisition Group
Review items</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Alexion
acquisition-related items, primarily fair-value adjustments on
acquired inventories and fair-value impact of replacement employee
share awards</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Other
specified items, principally the imputed finance charge relating to
contingent consideration on business combinations and legal
settlements</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Details on the nature of Core financial measures are provided on
page 54 of the&#xA0;</font><font style="text-decoration: underline; color: #0000FF">Annual Report and Form
20-F Information 2021</font><font style="color: #1F2222">.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Reference should be made to the Reconciliation of Reported to Core
financial measures table included in the financial performance
section in this announcement.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Gross Margin, previously termed Gross Profit Margin, is the
percentage by which Product Sales exceeds the Cost of sales,
calculated by dividing the difference between the two by the sales
figure. The calculation of Reported and Core Gross Margin excludes
the impact of Collaboration Revenue and any associated costs,
thereby reflecting the underlying performance of Product
Sales.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
EBITDA is defined as Reported Profit Before Tax after adding back
Net Finance Expense, results from Joint Ventures and Associates and
charges for Depreciation, Amortisation and Impairment. Reference
should be made to the Reconciliation of Reported Profit Before Tax
to EBITDA included in the financial performance section in this
announcement.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net Debt is defined as Interest-bearing loans and borrowings and
Lease liabilities, net of Cash and cash equivalents, Other
investments, and net derivative financial instruments. Reference
should be made to Note 3 &#xD4;Net Debt' included in the Notes to
the Interim Financial Statements in this announcement.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ongoing Collaboration Revenue is defined as Collaboration Revenue
excluding Initial Collaboration Revenue (which is defined as
Collaboration Revenue that is recognised at the date of completion
of an agreement or transaction, in respect of upfront
consideration). Ongoing Collaboration Revenue comprises, among
other items, royalties, milestone revenue and profit-sharing
income. Reference should be made to the Collaboration Revenue table
in this Operating and financial review.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The Company strongly encourages investors and analysts not to rely
on any single financial measure, but to review AstraZeneca's
financial statements, including the Notes thereto, and other
available Company reports, carefully and in their
entirety.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Due to rounding, the sum of a number of dollar values and
percentages may not agree to totals.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: auto; margin-right: auto; margin-bottom: 6px; width: 100%; height: 2px; background-color: #000000">
<!--line--><br></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;5: Disease area and medicine performance</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 44%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="4" style="vertical-align: bottom; width: 55%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 29%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Change</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Product Sales&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Total&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Oncology&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
3,388&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
30&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
14&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
18&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Tagrisso&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,304&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
599&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
617&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Calquence&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
414&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
98&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
100&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;9x&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;9x&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Orpathys&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Zoladex&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
240&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
12&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Faslodex&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
93&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(24)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(20)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Iressa&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(47)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(47)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Arimidex&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(27)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(25)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Casodex&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
21&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(48)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(47)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
- Others&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
12&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
BioPharmaceuticals: CVRM&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,207&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
19&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
14&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
17&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Farxiga&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,000&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
60&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
67&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Brilinta&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
325&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(13)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(10)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Lokelma</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
63&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
92&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
97&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
- Roxadustat</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
41&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Andexxa</font><font style="font-style: italic; font-size: 70%; vertical-align: top; color: #1F2222">10</font><font style="font-style: italic; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
33&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Crestor&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
267&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Seloken/Toprol-XL&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
244&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Bydureon</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
68&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(34)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(33)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Onglyza</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
68&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(33)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(31)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
- Others&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
98&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(15)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(13)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
BioPharmaceuticals: R&amp;I&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,509&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
13&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Symbicort&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
674&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Fasenra</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
308&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
18&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
22&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Breztri</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
87&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;3x&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;3x</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Saphnelo&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Pulmicort&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
217&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(34)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(34)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Daliresp&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
51&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(16)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(16)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Bevespi</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
-</font><font style="color: #1F2222">&#xA0;Others&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
146&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(9)</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(9)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 192px; margin-right: 0px; text-indent: -192px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
BioPharmaceuticals: V&amp;I&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,757&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
15&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;5x&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;6x&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,089&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
10&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;3x&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;4x&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Evusheld&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
469&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Synagis</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
200&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;8x&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;8x&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">FluMist</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222">Rare Disease</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">10&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,694&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
15&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
3&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
7&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222">- Soliris</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">10&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
990&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(5)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222">- Ultomiris</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">10&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
419&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
20&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
25&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222">- Strensiq</font><font style="font-size: 70%; vertical-align: top; color: #1F2222">10&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
208&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Koselugo&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
39&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
82&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
85&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Kanuma</font><font style="font-style: italic; font-size: 70%; vertical-align: top; color: #1F2222">10&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
38&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other Medicines&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
425&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
4&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(19)</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(15)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-&#xA0;</font><font style="font-style: italic; color: #1F2222">Nexium&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
332&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(18)</font></div>
</td>
<td style="vertical-align: top; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(13)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
- Others&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
93&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(22)</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(22)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Product Sales&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
10,980&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
96&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
51&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
56&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Collaboration Revenue&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
410&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
4&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
11,390&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
100&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
56&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
60&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;6: Collaboration Revenue</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 44%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="4" style="vertical-align: bottom; width: 55%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: bottom; width: 29%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;&#xA0;&#xA0; % Change</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: bottom; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Total</font></div>
</td>
<td style="vertical-align: bottom; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual</font></div>
</td>
<td style="vertical-align: bottom; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 1px">&#xA0;</font></div>
<div style="text-align: left">
<table cellpadding="0" cellspacing="0" style="text-align: left; width: 100%; font-family: Times New Roman; font-size: 13px; margin: 0px auto 0px 0px;">
<tr>
<td style="vertical-align: middle; width: 44%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
Lynparza</font><font style="color: #1F2222">: milestone
revenue</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
175</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
43</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 16%;">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
Enhertu</font><font style="color: #1F2222">: share of gross
profits</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
75</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
18</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
96</font></div>
</td>
<td style="vertical-align: middle; width: 16%;">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
96</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 44%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Royalty income</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
73</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
18</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 16%;">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 44%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tralokinumab: sales milestones</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
70</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 16%;">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid rgb(0, 0, 0);">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other Collaboration Revenue</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid rgb(0, 0, 0);">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
410</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
100</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;7: Total Revenue by region</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 44%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="4" style="vertical-align: middle; width: 55%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
% of&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 30%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Change&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;Actual&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3,364&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
30&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
30&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
- China&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,622&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
14&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(3)</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(6)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
- Ex-China&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,742&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
15&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
91&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;2x&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4,134&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
36&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
79&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
79&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,284&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
20&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
48&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
57&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,608&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
85&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
98&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 44%; border-bottom: 2px solid #000000">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
11,390&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
100&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
56&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
60&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Oncology</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Total Revenue increased by 21% (25% at CER) in Q1 2022 to $3,644m
and represented 32% of overall Total Revenue (Q1 2021: 41%). This
included&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">&#xA0;Collaboration Revenue of $175m
and&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">&#xA0;Collaboration Revenue of $76m. Product Sales
increased by 14% (18% at CER) in Q1 2022 to $3,388m, reflecting new
launches and increased patient access for&#xA0;</font><font style="font-style: italic; color: #1F2222">Tagrisso</font><font style="color: #1F2222">,&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font><font style="color: #1F2222">,&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">,&#xA0;</font><font style="font-style: italic; color: #1F2222">Calquence</font><font style="color: #1F2222">&#xA0;and&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">&#xA0;partially offset by declines in legacy
medicines and an adverse gross-to-net</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[44]</font><font style="color: #1F2222">&#xA0;movement
from the seasonal increase in Part-D related deductions typically
seen in the first quarter.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tagrisso</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,304</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
406</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
439</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
252</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
207</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
12%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2%</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
33%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
21%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11%</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Increased
adjuvant and 1st-line use offset by a continued adverse COVID-19
impact on diagnosis, testing and treatment</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Increased
1st-line use in China and continued growth in other Emerging
Markets</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">Tagrisso</font><font style="color: #1F2222">&#xA0;was admitted to the China NRDL in March 2021
for the 1st-line setting and renewed in the 2nd-line setting,
resulting in an adverse effect on the comparator period from lower
sales to distributors prior to the change and stock compensation
payments</font></font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Rising
demand from increased patient access in China has now offset the
impact of the March 2021 NRDL price reduction</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Greater
1st-line and adjuvant use, with longer duration of treatment,
partially offset by lower 2nd-line use and a continued adverse
COVID-19 impact</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">At
the end of Q1 rates of diagnosis, testing and treatment in lung
cancer are showing some signs of recovery, but remained around
5-15% below baseline</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Increased
use in 1st-line and adjuvant settings</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
599</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
58</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
315</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
125</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
101</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4%</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
23%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
12%</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">Increased use
of&#xA0;</font><font style="font-style: italic; color: #1F2222; font-size: 13px">Imfinzi</font><font style="color: #1F2222; font-size: 13px">&#xA0;to
treat patients with ES-SCLC</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[45]</font><font style="color: #1F2222; font-size: 13px">&#xA0;was
offset by impact from lower rates of diagnosis and treatment due to
the current COVID-19 wave</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Growth
in ex-China continued, offset in China by reduction in inventory
held by distributors and hospitals</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Growth
driven new patient starts across Stage III NSCLC and ES-SCLC,
despite the impact of COVID-19 on lung cancer diagnoses in recent
months, offset by unfavourable seasonal inventory and gross-to-net
movements</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">ES-SCLC
market penetration increased, as did the number of reimbursed
markets, offsetting the COVID-19 impact on rates of diagnosis and
treatment</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Growth
driven by new reimbursements</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lynparza</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
792</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
121</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
270</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
335</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
66</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
46%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
39%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;2x</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
22%</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
50%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
43%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;2x</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32%</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Product Sales</font></div>
</td>
<td style="vertical-align: top; width: 1%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
617</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
121</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
270</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
160</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
66</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
39%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
22%</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
43%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
16%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32%</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Total
Revenue includes a $175m regulatory milestone received from MSD and
recognised in the Europe geographic segment, in respect of the
approval in the US for the adjuvant treatment of patients with
breast cancer, based on the data from the OlympiA Phase III
trial</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">Product sales growth was driven
by further launches across multiple cancer types
globally.&#xA0;</font><font style="font-style: italic; color: #1F2222; font-size: 13px">Lynparza</font><font style="color: #1F2222; font-size: 13px">&#xA0;remains
the leading medicine in the PARP</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[46]</font><font style="color: #1F2222; font-size: 13px">-inhibitor
class globally across four tumour types, as measured by total
prescription volume</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">Patient access to&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">&#xA0;increased following admission to China's
NRDL as a 1st-line treatment for ovarian cancer patients with
effect from March 2021 and launches in other
markets</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Growth
in use in ovarian, breast and prostate cancers, offset by an
adverse gross-to-net movement related to seasonal increase in
Part-D related deductions typically seen in the first quarter, and
reductions in inventory held by distributors</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">Reimbursements introduced in
additional countries, increasing BRCAm-testing rates, and
successful 1st-line BRCAm ovarian, 2nd-line HRRm</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[47]</font><font style="color: #1F2222; font-size: 13px">&#xA0;prostate
and gBRCAm HER2-negative advanced breast cancer
launches</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Strong
year on year growth driven by new product launches and high levels
of HRD testing in Japan</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Enhertu</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
86</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
57</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
20</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;2x</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;7x</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
61%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;5x</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;2x</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;7x</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
61%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;5x</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Excluding
Japan, global in-market sales recorded by Daiichi Sankyo Company
Limited (Daiichi Sankyo) and AstraZeneca, amounted to $166m in the
quarter (Q1 2021: $81m)</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">US
in-market sales, recorded by Daiichi Sankyo, amounted to $119m in
the quarter (Q1 2021: $73m)</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">In
Japan, AstraZeneca receives a mid-single-digit percentage royalty
on sales made by Daiichi Sankyo</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Calquence</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
414</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
339</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
55</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
98%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;3x</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
74%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;5x</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;4x</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
100%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;3x</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
74%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;6x</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;4x</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Strong
performance despite COVID-19 impacts on CLL diagnosis rates,
benefitting from increased new patient market share</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Increased
market share in new patient starts after launches in the
region</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Orpathys</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
Total Revenue of $11m in the quarter (2021: $nil) was driven by the
2021 launch in China, where&#xA0;</font><font style="font-style: italic; color: #1F2222; font-size: 13px">Orpathys</font><font style="color: #1F2222; font-size: 13px">&#xA0;has
been approved for patients with lung cancer and
MET</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[48]</font><font style="color: #1F2222; font-size: 13px">&#xA0;gene
alterations.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other Oncology medicines</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 8%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 13%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Change</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER</font></div>
</td>
<td style="vertical-align: top; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Commentary</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Zoladex</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
247</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
10</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Increase
driven by usage in emerging markets</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Faslodex</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
93</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(24)</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(20)</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Iressa</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(47)</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(47)</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Arimidex</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(27)</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(25)</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Casodex</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
21</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(48)</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(47)</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Others</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
12</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: top; width: 62%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 16%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 1px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
BioPharmaceuticals</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Including Vaccines &amp; Immune Therapies medicines,
BioPharmaceuticals Total Revenue increased by 49% (53% at CER) in
Q1 2022 to $5,617m, representing 49% of overall Total Revenue (Q1
2021: 51%). Growth was driven by strong&#xA0;</font><font style="font-style: italic; color: #1F2222">Farxiga</font><font style="color: #1F2222">&#xA0;performance and growth in the COVID-19
medicines</font><font style="font-style: italic; color: #1F2222">.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cardiovascular, Renal &amp; Metabolism</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
CVRM Total Revenue increased by 14% (18% at CER) in Q1 2022, driven
by strong&#xA0;</font><font style="font-style: italic; color: #1F2222">Farxiga</font><font style="color: #1F2222">&#xA0;performance, to $2,219m and represented 19%
of overall Total Revenue (Q1 2021: 26%).</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Farxiga</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,001</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
391</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
193</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
318</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
99</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
60%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
50%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
48%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
83%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
64%</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
67%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
54%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
48%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
97%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
76%</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">The SGLT2</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[49]</font><font style="color: #1F2222; font-size: 13px">&#xA0;inhibitor
class saw growth in many regions, with&#xA0;</font><font style="font-style: italic; color: #1F2222; font-size: 13px">Farxiga</font><font style="color: #1F2222; font-size: 13px">&#xA0;volume
growing faster than the overall SGLT2 market in most major regions.
Performance also reflecting further HF and CKD launches and updated
treatment guidelines including from ESC</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[50]</font><font style="color: #1F2222; font-size: 13px">,
AHA</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[51]</font><font style="color: #1F2222; font-size: 13px">&#xA0;and
ACC</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[52]</font><font style="color: #1F2222; font-size: 13px">,
and beneficial impact from gross-to-net adjustments in the US
versus Q1 2021</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">China performance was enhanced by
uACR</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[53]</font><font style="color: #1F2222; font-size: 13px">&#xA0;and
MRF</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[54]</font><font style="color: #1F2222; font-size: 13px">&#xA0;testing
program, and solid growth in ex-China Emerging
Markets.&#xA0;</font><font style="font-style: italic; color: #1F2222; font-size: 13px">Forxiga's</font><font style="color: #1F2222; font-size: 13px">&#xA0;NRDL
status in China was renewed in the fourth quarter of
2021</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">Continued strong growth,
following the regulatory approval for HFrEF in May 2020, the
approval for the treatment of CKD in May 2021, and the
aforementioned gross-to-net adjustments. Both approvals included
patients with and without T2D</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[55]</font><font style="color: #1F2222; font-size: 13px">.&#xA0;</font><font style="font-style: italic; color: #1F2222; font-size: 13px">Farxiga</font><font style="color: #1F2222; font-size: 13px">&#xA0;continued
to gain in-class brand share driven by HF and CKD
launches.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">SGLT2
inhibitor class growth, the beneficial addition of cardiovascular
outcomes trial data to the label, the HFrEF regulatory approval in
November 2020, and CKD regulatory approval in August
2021</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">In
Japan, sales to collaborator Ono Pharmaceutical Co., Ltd, which
records in-market sales, more than doubled to $69m</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Brilinta</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
325</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
69</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
166</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
76</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(13%)</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(35%)</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(13%)</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(5%)</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(10%)</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(32%)</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(6%)</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1%)</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Continued
adverse China VBP impact and fewer elective procedures in the EU
and US due to the effects of the pandemic</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lokelma</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Total Revenue increased 92% (97% at CER) to $63m in the quarter,
driven by&#xA0;</font><font style="font-style: italic; color: #1F2222">Lokelma</font><font style="color: #1F2222">&#xA0;extending its branded market share lead in
the US and continued progress from recent launches across Europe.
In China,&#xA0;</font><font style="font-style: italic; color: #1F2222">Lokelma</font><font style="color: #1F2222">&#xA0;was included on the NRDL from 1 January
2022.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Andexxa</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
On a pro forma basis, Total Revenue increased 48% (49% at CER) to
$43m.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Roxadustat</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue increased 1% (2% decrease at CER) to $41m. Total
Revenue also increased sequentially, benefitting from increased
volumes in China following NRDL price cuts.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other CVRM medicines</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 8%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 13%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Change</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER</font></div>
</td>
<td style="vertical-align: top; width: 62%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Crestor</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
268</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Sales
decline in the US and Europe offset by growth in Emerging
Markets</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Seloken/Toprol-XL</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
245</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
<td style="vertical-align: top; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">Emerging Markets sales impacted
by China VBP implementation of&#xA0;</font><font style="font-style: italic; color: #1F2222; font-size: 13px">Betaloc</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[56]</font><font style="color: #1F2222; font-size: 13px">&#xA0;oral
in H2 2021.&#xA0;</font><font style="font-style: italic; color: #1F2222; font-size: 13px">Betaloc</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font><font style="font-style: italic; color: #1F2222; font-size: 13px">ZOK</font><font style="color: #1F2222; font-size: 13px">&#xA0;VBP
to be implemented later in 2022</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Bydureon</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
68</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(34)</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(33)</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Continued
competitive pressures</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Onglyza</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
68</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(33)</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(31)</font></div>
</td>
<td style="vertical-align: top; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">Continued declines in
DPP-4</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[57]</font><font style="color: #1F2222; font-size: 13px">&#xA0;inhibitor
class</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Others</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
98</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(15)</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(13)</font></div>
</td>
<td style="vertical-align: top; width: 62%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 17%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Respiratory &amp; Immunology</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
R&amp;I Total Revenue, which included Collaboration Revenue of
$75m, increased by 2% in Q1 2022 (4% at CER) to $1,584m and
represented 14% of overall Total Revenue (Q1 2021: 21%). COVID-19
continued to have a material impact across markets and the
portfolio.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Symbicort</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
674</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
167</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
259</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
157</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
91</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2%)</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2%)</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(7%)</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1%)</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2%)</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3%</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">Symbicort</font><font style="color: #1F2222">&#xA0;remains the global market-volume and value
leader within the ICS/LABA class.</font></font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Market
share performance was driven by Established RoW and Emerging
Markets, and growth in anti-inflammatory reliever launch
markets</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">The
global ICS/LABA market continues to be eroded as fixed-dose triple
therapies (LAMA/LABA/ICS) continue to launch</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Driven
by growth outside China. China continues to be impacted by
fixed-dose triple therapy launches</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Maintained
total prescription market share in a declining ICS/LABA market as
fixed-dose triple therapy launches continue.&#xA0; Continued growth
in the authorised generic</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Sales
in Japan declined due to continued generic erosion</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fasenra</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
308</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
189</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
75</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
37</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
18%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;2x</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
22%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
20%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(5%)</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
22%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;2x</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
22%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
29%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2%</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">Expanded total market leadership in eosinophilic
asthma,&#xA0;</font><font style="font-style: italic; color: #1F2222">Fasenra</font><font style="color: #1F2222">&#xA0;is the leading IL-5 class biologic, in major
markets (US, Japan and some EU countries). COVID-19 continues to
impact total severe asthma market growth with most regions
experiencing a slower growth</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Sustained
growth driven by volume</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Increased
volume from sustained leadership in new to brand prescriptions, in
most EU markets</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
<td style="vertical-align: top; width: 0%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">In
Japan, revenues declined by 13% (5% at CER) to $23m, with rising
demand and sustained leadership in new to brand prescriptions,
offset by reduced demand from distributors ahead of expected
mandatory price reduction in April</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Breztri</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
87</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
22</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
53</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;3x</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;2x</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;4x</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;7x</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
46%</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;3x</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;2x</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;4x</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;8x</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
59%</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Continued
to gain market share within the fixed-dose triple markets; in US,
China and Japan.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Continued
its market share leadership within the fixed-dose triple market in
China, which continues to gain share from the ICS/LABA
class</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Progress
made in new to brand market share growth in the fixed-dose triple
market</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Launches
continued in Europe</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Sales
in Japan were impacted by COVID-19 restrictions</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Saphnelo</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Total Revenue of $11m in the quarter (Q1 2021: $nil) was driven by
the 2021 launch in the US, where&#xA0;</font><font style="font-style: italic; color: #1F2222">Saphnelo</font><font style="color: #1F2222">&#xA0;has been approved for
SLE.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tezspire</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
Tezspire</font><font style="color: #1F2222">&#xA0;is being
developed in collaboration with Amgen, and was approved in the US
for severe asthma in December 2021. Amgen will record sales in the
US and AstraZeneca's share of gross profits in the US will be
recognised as Collaboration Revenue. Outside of the US, AstraZeneca
will record Product Sales. In Q1 2022, AstraZeneca recognised $3m
of Collaboration Revenue from $7m of in-market sales recorded by
Amgen (Q1 2021: $nil).</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other R&amp;I Medicines</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 8%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 13%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Change</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER</font></div>
</td>
<td style="vertical-align: top; width: 62%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Pulmicort</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
217</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(34)</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(34)</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Revenue
from Emerging Markets decreased 43% to $164m</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">Pulmicort
Respules</font><font style="color: #1F2222">&#xA0;was included in
the latest round of VBP in China, implemented in October 2021,
resulted in significantly lower market access and a mandatory price
reduction.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Daliresp</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
51</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(16)</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(16)</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Bevespi</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Others</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
218</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32</font></div>
</td>
<td style="vertical-align: top; width: 62%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 17%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Vaccines &amp; Immune Therapies</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue from Vaccines and Immune Therapies medicines
increased from $301m in Q1 2021 to $1,814m in Q1 2022 and
represented 16% of overall Total Revenue (Q1 2021:
4%).</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Vaxzevria</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,145</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
530</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
79</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
135</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
400</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;4x</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;10x</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(40%)</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;10x</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;4x</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;10x</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(37%)</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;10x</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">The
majority of revenue in Q1 2022 came from initial, not-for-profit
contracts</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Growth
was driven by initial and commercial contracts in Latin America and
Asia</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">$46m
of Collaboration Revenue came from a Chinese
sub-licensee</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Purchases
by the US government for donation overseas</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">Sales were down versus Q1 2021, when Europe
accounted for 82% of&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font><font style="color: #1F2222">&#xA0;revenue as vaccination programmes were
rolled out in the UK and the EU</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Sales
in Japan, Canada and Australia</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Evusheld</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
469</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
89</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
307</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
66</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Emergency
Use Authorisation was granted in December 2021, and in Q1
2022</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">AstraZeneca fulfilled a proportion of the US
government order for 1.7m units of&#xA0;</font><font style="font-style: italic; color: #1F2222">Evusheld</font><font style="color: #1F2222">&#xA0;(a unit consists of one 150mg vial of
cilgavimab and one 150mg vial of tixagevimab). The remainder of
that order will be fulfilled before the end of
2022</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Multiple
government contracts</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">Evusheld</font><font style="color: #1F2222">&#xA0;was approved in the EU in the
quarter</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other V&amp;I Medicines</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 8%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 13%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Change</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER</font></div>
</td>
<td style="vertical-align: top; width: 62%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Synagis</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
200</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;8x</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&gt;8x</font></div>
</td>
<td style="vertical-align: top; width: 62%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">Q1 2022 captures all global revenues
from&#xA0;</font><font style="font-style: italic; color: #1F2222">Synagis</font><font style="color: #1F2222">&#xA0;by destination. In the comparable period,
revenues reflected AstraZeneca's ex-US collaboration agreement with
AbbVie, which expired on 30 June 2021 in which all ex-US revenue
was reported in Europe. The regional growth rates shown in Table 22
have also been impacted by the change</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
FluMist</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">Normal seasonality of&#xA0;</font><font style="font-style: italic; color: #1F2222">FluMist</font><font style="color: #1F2222">&#xA0;sales</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 17%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Rare Disease</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Rare Disease Total Revenue increased by 3% (7% at CER) pro forma in
Q1 2022 to $1,694m, representing 15% of overall Total Revenue (Q1
2021: 0%).&#xA0; Performance was driven by continued durability of
the C5 franchise, including continued conversion
from&#xA0;</font><font style="font-style: italic; color: #1F2222">Soliris</font><font style="color: #1F2222">&#xA0;to&#xA0;</font><font style="font-style: italic; color: #1F2222">Ultomiris</font><font style="color: #1F2222">&#xA0;in PNH and aHUS as well
as&#xA0;</font><font style="font-style: italic; color: #1F2222">Soliris</font><font style="color: #1F2222">&#xA0;growth in Neurology indications, gMG and
NMOSD.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The pro forma growth rates on medicines acquired with Alexion shown
in these tables have been calculated by comparing Q1 revenues with
the corresponding prior year pre-acquisition revenues previously
published by Alexion.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Soliris</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Arial; font-size: 5px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
990</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
71</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
591</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
221</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
107</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(5%)</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(41%)</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(15%)</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4%</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28%)</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(8%)</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11%</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">Performance driven by&#xA0;</font><font style="font-style: italic; color: #1F2222">Soliris</font><font style="color: #1F2222">&#xA0;growth in neurology indications, gMG and
NMOSD, offset by continued conversion to&#xA0;</font><font style="font-style: italic; color: #1F2222">Ultomiris</font><font style="color: #1F2222">&#xA0;in PNH and aHUS</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ex-US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Strong
underlying demand growth in EU and ERoW, EM growth impacted by
prior year tender market order timing</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ultomiris</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Arial; font-size: 5px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022 $m</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
419</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
24</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
220</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
105</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
70</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
20%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
54%</font></div>
</td>
<td style="vertical-align: top; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4%)</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER change</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
25%</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
65%</font></div>
</td>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7%</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Region</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Worldwide</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Continued
conversion and launches in new markets outside the US</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">Quarter-on-quarter revenue growth variability can
be expected due to&#xA0;</font><font style="font-style: italic; color: #1F2222">Ultomiris</font><font style="color: #1F2222">&#xA0;every eight-week dosing schedule and lower
average annual treatment cost per patient compared
to&#xA0;</font><font style="font-style: italic; color: #1F2222">Soliris</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Continued
COVID-19 impact on rate of aHUS diagnoses&#xA0;and treatment
coupled with hospital reimbursement dynamics favouring
Soliris</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ex-US</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 83%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Performance
driven by new market approvals for PNH</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other Rare Disease medicines</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 8%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 13%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Change</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 63%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER</font></div>
</td>
<td style="vertical-align: top; width: 61%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Commentary</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Strensiq</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
208</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: top; width: 61%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Performance
impacted by inventory and payer dynamics</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Koselugo</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
39</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
82</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
85</font></div>
</td>
<td style="vertical-align: top; width: 61%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Reimbursed
in 14 markets with ambition to continue expansion</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Kanuma</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
38</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15</font></div>
</td>
<td style="vertical-align: top; width: 61%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Performance
driven by markets outside the US</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 17%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 61%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other medicines (outside the main disease areas)</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 17%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 8%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 13%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Change</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 63%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER</font></div>
</td>
<td style="vertical-align: top; width: 61%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Commentary</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Nexium</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
338</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(17)</font></div>
</td>
<td style="vertical-align: top; width: 7%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(13)</font></div>
</td>
<td style="vertical-align: top; width: 61%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">Nexium
(oral) was included in China's VBP programme implemented in
February 2021 and Nexium (i.v.) was implemented in the fifth round
of VBP in October 2021.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Others</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
97</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(22)</font></div>
</td>
<td style="vertical-align: top; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(21)</font></div>
</td>
<td style="vertical-align: top; width: 61%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 17%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 61%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Financial performance</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: justify; margin-left: auto; margin-right: auto; margin-bottom: 6px; width: 100%; height: 2px; background-color: #000000">
<!--line--><br></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;8: Reported Profit and Loss</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 46%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2021</font></div>
</td>
<td colspan="3" style="vertical-align: middle; width: 27%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0; %
Change&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: -3px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: -2px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
11,390&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
7,320&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
56&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
60&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
- Product Sales</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
10,980</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
7,257</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
51</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
56</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
- Collaboration Revenue</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
410</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
63</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
n/m</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
n/m</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cost of Sales</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(3,511)</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,864)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
88</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
98</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Gross Profit</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
7,879&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
5,456&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
44&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
48&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Gross Margin</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
68.0%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
74.3%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
-6</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
-7</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Distribution Expense</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(125)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(99)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
26</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
32</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Total Revenue</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
1.1%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
1.4%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
R&amp;D Expense</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,133)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,713)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
24</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
26</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Total Revenue</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
18.7%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
23.4%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
+5</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
+5</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
SG&amp;A Expense</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4,840)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,929)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
65</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
68</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Total Revenue</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
42.5%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
40.0%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
-2</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
-2</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
OOI</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[58]</font><font style="color: #1F2222; font-size: 13px">&#xA0;&amp;
Expense</font></font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
97</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
1,180</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(92)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(92)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Total Revenue</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
0.9%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
16.1%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
-15</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
-15</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Operating Profit</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
878&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,895&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(54)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(46)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Operating Margin</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
7.7%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
25.9%</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
-18</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
-18</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net Finance Expense</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(319)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(283)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
13</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
7</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Joint Ventures and Associates</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(6)</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
38</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
53</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Profit before tax</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
553&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,608&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(66)</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(56)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Taxation</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(165)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(46)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
n/m</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
n/m</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tax rate</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
30%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
3%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Profit after tax</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
388&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,562&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(75)</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(68)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 46%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Earnings per share</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$0.25&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$1.19&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(79)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(73)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;9: Reconciliation of Reported Profit before tax to
EBITDA</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: bottom; width: 45%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: -1px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2021&#xA0;</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 27%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0; %
Change</font></div>
</td>
</tr><tr>
<td style="vertical-align: bottom; width: 45%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: -2px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Reported Profit before tax&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
553&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,608&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(66)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(56)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net Finance Expense&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
319</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
283</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
13</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
7</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Joint Venture and Associates&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
6</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
4</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
38</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
53</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 45%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Depreciation, Amortisation and Impairment&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
1,309</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
797</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
64</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
56</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 45%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
EBITDA&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,187</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,692</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(19)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(16)</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
EBITDA of $2,187m in the quarter (Q1 2021: $2,692m) has been
negatively impacted by the $1,180m (Q1 2021: $nil) unwind of
inventory fair value uplift recognised on the acquisition of
Alexion. The unwind of inventory fair value is expected to depress
EBITDA over the year in line with associated revenues.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;10: Reconciliation of Reported to Core financial
measures</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Reported</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Restructuring</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-weight: bold; font-family: Times New Roman; font-size: 13px">
Intangible Asset&#xA0;Amortisation &amp; Impairments</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Acquisition of Alexion</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222; font-size: 13px">
Core</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[59]</font></font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 20%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Core</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Change</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Actual&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Gross Profit</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">7,879</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">51</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">8</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">1,181</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">-</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">9,119</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">66</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">70</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Gross Margin</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222; font-size: 13px">
68.0%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222; font-size: 13px">
79.3%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222; font-size: 13px">
+5</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222; font-size: 13px">
+4</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Distribution Expense</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(125)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
1</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(124)</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
25</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
30</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
R&amp;D Expense</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,133)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
5</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(69)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
11</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,186)</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
33</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
36</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
SG&amp;A Expense</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4,840)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
17</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
1,098</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
17</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
762</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,946)</font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
23</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
25</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Operating Expense</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(7,098)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
23</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
1,029</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
28</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
762</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(5,256)</font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
27</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
29</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
OOI &amp; Expense</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
97</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
1</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
98</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(92)</font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(92)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Operating Profit</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">878</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">75</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">1,037</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">1,209</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">762</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">3,961</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">57</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">60</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Operating Margin</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222; font-size: 13px">
7.7%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222; font-size: 13px">
34.8%</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222; font-size: 13px">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222; font-size: 13px">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net Finance Expense</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(319)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
-</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
67</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(252)</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
35</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
23</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Taxation</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(165)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(15)</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(191)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(280)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(121)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(772)</font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
n/m</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
n/m</font><font style="font-weight: bold; color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
EPS</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">$0.25</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">$0.04</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">$0.55</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">$0.60</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">$0.45</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">$1.89</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">16</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">20</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Profit and Loss drivers</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Gross Profit</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">The
Gross Profit Margin (Reported and Core) in the quarter was impacted
by:</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 48px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Mix
effects. The increased sales of&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria,</font><font style="color: #1F2222">&#xA0;and medicines with profit-sharing
arrangements (primarily&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">) have a dilutive impact on the Gross Margin. The
increased contribution from Rare Disease and Oncology medicines
have a positive impact on the Gross Margin</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 48px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Pricing
pressure relating to the VBP and NRDL procurement programmes in
China</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Reported
Gross Profit was also impacted by the unwind of the fair value
adjustment to Alexion inventories at the date of acquisition. The
fair value uplift is expected to unwind through Reported Cost of
Sales over 2022 in line with associated revenues, and in Q1 2022,
the impact of the fair value uplift unwind on Cost of Sales was
$1,180m</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Variations
in Gross Margin performance between periods can be expected to
continue</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-family: Times New Roman; font-size: 13px">
R&amp;D Expense</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">The
increased Reported and Core R&amp;D Expense was driven
by:</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 48px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Increased
investment in several late-stage Oncology trials and the
advancement of a number of Phase&#xA0;II clinical development
programmes in BioPharmaceuticals</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 48px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">The
acquisition of Alexion in July 2021</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Reported
R&amp;D Expense in Q1 was also impacted by intangible asset
impairment reversals</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-family: Times New Roman; font-size: 13px">
SG&amp;A Expense</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">The
increased Reported and Core SG&amp;A Expense was driven primarily
by the acquisition of Alexion in July 2021</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Reported
SG&amp;A Expense was also impacted by amortisation of intangible
assets related to the Alexion acquisition and a $775m legal
settlement with Chugai Pharmaceutical Co. Ltd</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other Operating Income</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Other
Operating Income of $97m consisted primarily of royalties and
disposal proceeds on small divestments</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">In
Q1 2021, Other Operating Income of $1,180m included $776m of
divestment gains from AstraZeneca's share of Viela and $309m from
the commercial rights to Crestor in over 30 countries in Europe
(excluding UK and Spain)</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net Finance Expense</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">The
increase in Net Finance Expense in the quarter was driven by
financing costs on debt for the Alexion transaction, increased
interest on tax, and exchange movements</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Taxation</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Both
Reported and Core Tax rates are higher than the prior period due to
one-off items in 2021, including the non-taxable gain on the
divestment of Viela and updates to estimates of prior period tax
liabilities following settlements with tax
authorities</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">The
net cash paid for the quarter was $228m (Q1 2021: $332m)
representing 41% of Reported Profit Before Tax (Q1 2021:
21%)</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">The
Reported Tax rate of 30% was higher than Core Tax rate of 21% due
to the impact of Non-Core charges on the level of Reported Profit
Before Tax</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;11: Cash Flow summary</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 54%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2021&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Change&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 54%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 54%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Reported Operating Profit</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
878</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,895&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,017)</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 54%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Depreciation, Amortisation and Impairment</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
1,309</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
797&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
512</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 54%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Decrease in Working Capital and Short-term Provisions</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
1,804</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,210&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
594</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 54%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Gains on Disposal of Intangible Assets</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(10)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(310)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
300</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 54%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Gains on Disposal of Investments in Associates and Joint
Ventures</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
-</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(776)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
776</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 54%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Non-Cash and Other Movements</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(327)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(363)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
36</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 54%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Interest Paid</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(194)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(187)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(7)</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 54%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Taxation Paid</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(228)</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(332)</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
104</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 54%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net Cash Inflow from Operating Activities</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222">3,232</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,934&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222">1,298</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 54%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net Cash Inflow before Financing Activities</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222">3,064</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,489&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222">575</font><font style="color: #1F2222; font-size: 13px">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 54%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net Cash Outflow from Financing Activities</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(3,740)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,731)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,009)</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The increase in Net Cash Inflow from Operating Activities of
$1,298m primarily reflected an underlying improvement in business
performance, including the contribution from Alexion.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The Reported Operating Profit of $878m in the quarter includes a
negative impact of $1,180m relating to the unwind of the inventory
fair value uplift recognised on the acquisition of Alexion. This is
offset by a corresponding item (positive impact of $1,180m) in
Decrease in Working Capital and Short-term Provisions. Overall, the
unwind of the fair value uplift has no impact on Net Cash Inflow
from Operating Activities.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
The change in Working Capital and Short-term Provisions of $594m,
whilst being positively impacted by the aforementioned inventory
fair value uplift unwind, has been adversely impacted by the
reduction of&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font><font style="color: #1F2222">&#xA0;working capital balances predominantly
within Trade and other payables.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Capital Expenditure</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Capital Expenditure amounted to $219m in the quarter (Q1 2021:
$220m). The Company anticipates an increase in Capital Expenditure
relative to FY 2021, partly driven by an expansion in its capacity
for growth and the acquisition of Alexion.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;12: Net Debt summary</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 57%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At&#xA0;31 Mar&#xA0;2022&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At&#xA0;31 Dec&#xA0;2021&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At&#xA0;31 Mar&#xA0;2021&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 57%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 57%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash and cash equivalents</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5,762&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6,329&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7,636&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 57%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other investments</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
61&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
69&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
129&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 57%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash and investments</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
5,823</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
6,398</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
7,765</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 57%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Overdrafts and short-term borrowings</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(805)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(387)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(581)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 57%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lease liabilities</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(949)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(987)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(680)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 57%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Current instalments of loans</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,264)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,273)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,461)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 57%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Non-current instalments of loans</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28,081)</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28,134)</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(17,410)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 57%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Interest-bearing loans and borrowings</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(Gross Debt)</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(31,099)</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(30,781)</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(20,132)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 57%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net derivatives</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
59&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
61&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
162&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 57%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net Debt</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(25,217)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(24,322)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(12,205)</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net Debt increased by $895m in the year to date to $25,217m.
Details of the committed undrawn bank facilities are disclosed
within the going concern section of Note 1. Details of the
Company's solicited credit ratings are disclosed in Note
3.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Capital allocation</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The Board's aim is to continue to strike a balance between the
interests of the business, financial creditors and the Company's
shareholders. The Company's capital allocation priorities include
investing in the business and pipeline, maintaining a strong,
investment-grade credit rating, potential value-enhancing business
development opportunities, and supporting the progressive dividend
policy.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
In approving the declaration of dividends, the Board considers both
the liquidity of the company and the level of reserves legally
available for distribution. Dividends are paid to shareholders from
AstraZeneca PLC, a Group holding company with no direct operations.
The ability of AstraZeneca PLC to make shareholder distributions is
dependent on the creation of profits for distribution and the
receipt of funds from subsidiary companies. The consolidated Group
reserves set out in the Condensed consolidated statement of
financial position do not reflect the profit available for
distribution to the shareholders of AstraZeneca PLC.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Summarised financial information for guarantee of securities of
subsidiaries</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
AstraZeneca Finance LLC ("AstraZeneca Finance") is the issuer of
0.700% Notes due 2024, 1.200% Notes due 2026, 1.750% Notes due 2028
and 2.250% Notes due 2031 (the "AstraZeneca Finance Notes"). Each
series of AstraZeneca Finance Notes has been fully and
unconditionally guaranteed by AstraZeneca PLC. AstraZeneca Finance
is 100% owned by AstraZeneca PLC and each of the guarantees by
AstraZeneca PLC is full and unconditional and joint and
several.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The AstraZeneca Finance Notes are senior unsecured obligations of
AstraZeneca Finance and rank equally with all of AstraZeneca
Finance's existing and future senior unsecured and unsubordinated
indebtedness. The guarantee by AstraZeneca PLC of the AstraZeneca
Finance Notes is the senior unsecured obligation of AstraZeneca PLC
and ranks equally with all of AstraZeneca PLC's existing and future
senior unsecured and unsubordinated indebtedness. Each guarantee by
AstraZeneca PLC is effectively subordinated to any secured
indebtedness of AstraZeneca PLC to the extent of the value of the
assets securing such indebtedness. The AstraZeneca Finance Notes
are structurally subordinated to indebtedness and other liabilities
of the subsidiaries of AstraZeneca PLC, none of which guarantee the
AstraZeneca Finance Notes.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC manages substantially all of its operations through
divisions, branches and/or investments in subsidiaries and
affiliates. Accordingly, the ability of AstraZeneca PLC to service
its debt and guarantee obligations is also dependent upon the
earnings of its subsidiaries, affiliates, branches and divisions,
whether by dividends, distributions, loans or
otherwise.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Please refer to the consolidated financial statements of
AstraZeneca PLC in our Annual Report on Form 20-F and reports on
Form 6-K with our quarterly financial results as filed or furnished
with the SEC for further financial information regarding
AstraZeneca PLC and its consolidated subsidiaries. For further
details, terms and conditions of the AstraZeneca Finance Notes
please refer to AstraZeneca PLC's Form 6-K furnished to the SEC on
28 May 2021.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Pursuant to Rule 13-01 and Rule 3-10 of Regulation S-X under the
Securities Act of 1933, as amended (the "Securities Act"), we
present below the summary financial information for AstraZeneca
PLC, as Guarantor, excluding its consolidated subsidiaries, and
AstraZeneca Finance, as the issuer, excluding its consolidated
subsidiaries. The following summary financial information of
AstraZeneca PLC and AstraZeneca Finance is presented on a combined
basis and transactions between the combining entities have been
eliminated. Financial information for non-guarantor entities has
been excluded. Intercompany balances and transactions between the
obligor group and the non-obligor subsidiaries are presented on
separate lines.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;13: Obligor group summarised Statement of comprehensive
income</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 64%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2021&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 64%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 64%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total revenue</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 64%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Gross profit</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 64%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Operating loss</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(20)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 64%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Loss for the period</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(155)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(166)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 64%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Transactions with subsidiaries that are not issuers or
guarantors</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
164&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,148&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;14: Obligor group summarised Statement of financial
position information</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 64%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At&#xA0;31 Mar&#xA0;2022&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At&#xA0;31 Mar 2021</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 64%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 64%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Current assets</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
19&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
28&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 64%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Non-current assets</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 64%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Current liabilities</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,682)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,656)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 64%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Non-current liabilities</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(25,605)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(17,072)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 64%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Amounts due from subsidiaries that are not issuers or
guarantors</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8,652&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6,243&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 64%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Amounts due to subsidiaries that are not issuers or
guarantors</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 17%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(297)</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(295)</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Foreign exchange</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The Company's transactional currency exposures on working-capital
balances, which typically extend for up to three months, are hedged
where practicable using forward foreign-exchange contracts against
the individual companies' reporting currency. Foreign-exchange
gains and losses on forward contracts for transactional hedging are
taken to profit or loss. In addition, the Company's external
dividend payments, paid principally in pounds sterling and Swedish
krona, are fully hedged from announcement to payment
date.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;15: Currency sensitivities</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The Company provides the following currency-sensitivity
information:</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 21%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 27%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Average exchange</font></div>
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
rates versus USD</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 28%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="color: #1F2222; font-size: 13px">Annual impact of 5%
strengthening in exchange rate versus USD ($m)</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[60]</font></font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Currency</font></div>
</td>
<td style="vertical-align: middle; width: 22%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Primary Relevance</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222; font-size: 13px">
FY 2021</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[61]</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222; font-size: 13px">
&#xA0;Q1 2022</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[62]</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Change</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Core Operating Profit</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CNY</font></div>
</td>
<td style="vertical-align: middle; width: 22%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6.43</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6.35</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;277</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;158&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
EUR</font></div>
</td>
<td style="vertical-align: top; width: 22%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
0.85</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
0.89</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(5)</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;317</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;160&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
JPY</font></div>
</td>
<td style="vertical-align: top; width: 22%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
109.83</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
116.32</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(6)</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;229</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;158&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-size: 13px">
Other</font><font style="font-size: 70%; vertical-align: top; color: #0000FF">[63]</font></font></div>
</td>
<td style="vertical-align: middle; width: 22%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;420</font></div>
</td>
<td style="vertical-align: top; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;196&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
GBP</font></div>
</td>
<td style="vertical-align: middle; width: 22%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Operating Expense</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
0.73</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
0.75</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;61</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;(93)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
SEK</font></div>
</td>
<td style="vertical-align: middle; width: 22%">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Operating Expense</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8.58</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9.33</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(8)</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;6</font></div>
</td>
<td style="vertical-align: top; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
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&#xA0;(82)</font></div>
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Sustainability</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">&#xA0;
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px"><br>
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Since the last quarterly report, AstraZeneca:</font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Published
its eighth&#xA0;</font><font style="text-decoration: underline; color: #0000FF">annual Sustainability
Report</font><font style="color: #1F2222">&#xA0;and&#xA0;</font><font style="text-decoration: underline; color: #0000FF">Sustainability Data
summary</font><font style="color: #1F2222">&#xA0;via its website
and social media, released in conjunction with the Annual Report.
Two fireside discussions from the accompanying investor roadshow
are available on the AstraZeneca IR website</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Facilitated
a Climate and Health Policy Roundtable at Expo 2020 Dubai with
global experts from the World Health Organisation, UNFCCC,
Sustainability Healthcare Coalition, and health and environmental
authorities from Sweden, Egypt, and the UAE to discuss the health
of people and the planet</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Convened
a hybrid summit on health system sustainability and resilience,
culminating in a global call to action to rebuild health system
integrity following the COVID-19 pandemic</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Access to healthcare</font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Released,
along with its sub-licensees, more than 2.8 billion vaccine doses,
for supply in over 180 countries. Approximately two-thirds of the
doses have gone to low and middle-income
countries</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">The
Company's Healthy Heart Africa (HHA) programme expanded into
Nigeria, its ninth country of operation, with the signing of a
Memorandum of Understanding with the Federal Government of Nigeria.
Launched the second phase in Tanzania with the Ministry of Health
and our local partner PATH. The two-year project aims to reach over
500,000 people, providing services and support at 35 primary health
care facilities. Since the programme launched in 2015, HHA has
conducted over 25 million blood pressure screenings, identified
over 4.8 million elevated readings, activated over 950 sites and
trained more than 9,000 healthcare workers and
volunteers</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Expanded
its Young Health Programme (YHP) into Italy and Israel, bringing
the number of countries to 34</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Awards
to two youth-led organisations tackling air pollution, through
the&#xA0;</font><font style="text-decoration: underline; color: #0000FF">Lead2030 Challenge in
partnership with One Young World (OYW)</font><font style="color: #1F2222">, in line with the Company's commitment to
SDG3.&#xA0;Winners receive mentorship from AstraZeneca, and a
Scholarship to attend the OYW Summit</font></font></div>
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<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Environmental protection</font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Announced
a&#xA0;</font><font style="text-decoration: underline; color: #0000FF">collaboration with
Honeywell</font><font style="color: #1F2222">&#xA0;to develop
next-generation respiratory inhalers (pMDI) with a near-zero Global
Warming Potential propellant. The innovation, using the propellant
HFO-1234ze, is a key element supporting the delivery of
AstraZeneca's Ambition Zero Carbon goals. AstraZeneca also
announced that by the end of 2025, 95% of its key suppliers will
have targets to limit global warming to
&lt;1.5C</font></font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Announced
two&#xA0;</font><font style="text-decoration: underline; color: #0000FF">new forestry
commitments in Ghana (three million trees) and the
US</font><font style="color: #1F2222">&#xA0;(one million trees) at
the Global Forest Summit, building on existing AZ Forest projects
in Australia, Indonesia, the UK</font></font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Marked
World Water Day with an updated&#xA0;</font><font style="text-decoration: underline; color: #1F2222">Position Paper
on&#xA0;</font><font style="text-decoration: underline; color: #0000FF">Water
Stewardship</font><font style="color: #1F2222">. The Company has
championed a water risk assessment of the global pharmaceutical
supply chain in collaboration with WWF Sweden. AstraZeneca also
joined the Alliance for Water Stewardship (</font><font style="text-decoration: underline; color: #0000FF">AWS</font><font style="color: #1F2222">)</font></font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Featured
in the Financial Times' list of&#xA0;</font><font style="text-decoration: underline; color: #0000FF">Europe's Climate
Leaders</font><font style="color: #1F2222">, for the second year
running. &#xA0;This recognises companies with the highest reduction
in Scope 1 and 2 emissions from 2015 to
2020&#xA0;</font></font></div>
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<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ethics and transparency</font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Revised
its&#xA0;</font><font style="text-decoration: underline; color: #0000FF">Global Standard for
Bioethics</font><font style="color: #1F2222">, which ensures its
ethical principles cover evolving R&amp;D
activities</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Marked
International Day of Women and Girls in Science and International
Women's Day with external and internal communications campaigns
featuring members of the Senior Executive team and other Company
scientists. AstraZeneca also signed the Wellbeing of
Women&#xA0;</font><font style="text-decoration: underline; color: #0000FF">Menopause Workplace
Pledge</font></font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Observed
Black History Month, with events hosted by the AstraZeneca African
Heritage Business Resource Group, Alexion Black Professionals
Network, AZ Inspire and the Inclusion and Diversity (I&amp;D)
team</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">Became
a founding member of Neurodiversity in Business and celebrated
Neurodiversity Week with the Company's TH!NK ERG programme of
events</font></font></div>
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<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Research and development</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">&#xA0;
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px"><br>
</font></div>
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<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
This section covers R&amp;D events and milestones in the period
since the prior results announcement.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
A comprehensive view of AstraZeneca's pipeline of medicines in
human trials can be found in the latest clinical trials appendix,
available on&#xA0;</font><font style="text-decoration: underline; color: #0000FF">www.astrazeneca.com/investor-relations</font><font style="color: #1F2222">.
The clinical trials appendix includes tables with details of the
ongoing clinical trials for AstraZeneca medicines and new molecular
entities in the pipeline.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Oncology</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Significant new trials in Oncology included, EMERALD-3, a Phase III
trial of&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font><font style="color: #1F2222">&#xA0;plus tremelimumab, with and without
lenvatinib, in combination with transarterial chemoembolisation in
patients with locoregional HCC, PACIFIC-9, a Phase III trial
of&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font><font style="color: #1F2222">&#xA0;plus oleclumab and&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font><font style="color: #1F2222">&#xA0;plus monalizumab in patients with locally
advanced, Stage III, unresectable non-small cell lung cancer who
have not progressed following platinum-based cCRT, and SAFFRON - a
Phase III trial of&#xA0;</font><font style="font-style: italic; color: #1F2222">Tagrisso</font><font style="color: #1F2222">&#xA0;in combination with AstraZeneca and
HUTCHMED's&#xA0;</font><font style="font-style: italic; color: #1F2222">Orpathys</font><font style="color: #1F2222">&#xA0;in patients EGFR-mutated NSCLC patients with
MET-driven tumours following progression after treatment
with&#xA0;</font><font style="font-style: italic; color: #1F2222">Tagrisso.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
AstraZeneca presented new data across its diverse portfolio of
cancer medicines at the American Society of Clinical Oncology
Genitourinary Cancers Symposium (ASCO GU) in February 2022.
Presentations included a late-breaking presentation by AstraZeneca
and MSD from the PROpel Phase III trial of&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">&#xA0;plus abiraterone, which showed the
combination significantly delayed disease progression in 1st-line
metastatic castration-resistant prostate cancer regardless of
biomarker status.&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">&#xA0;is the first PARP inhibitor to demonstrate
clinical benefit in combination with a new hormonal agent in this
setting.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
At the American Association for Cancer Research General Meeting
2022, new preclinical and early clinical data was presented across
its pipeline. Data from 60 presentations, including five oral and
three mini-oral presentations, featured the Company's next wave of
potential cancer medicines spanning its immuno-oncology, DNA Damage
Response and Antibody Drug Conjugate scientific platforms. This
includes key data shared from three potential new medicines that
illustrate the Company's innovative approach to designing molecules
that address key challenges in treating cancer, including the
ability to target different, complementary mechanisms.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-style: italic; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
During the period, the Company announced that the CALLA Phase III
trial for&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font><font style="color: #1F2222">&#xA0;given concurrently with CRT did not achieve
statistical significance for the primary endpoint of improving
progression-free survival versus CRT alone in the treatment of
patients with locally advanced cervical cancer.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
In April 2022 the Company announced the regulatory submission
acceptance for tremelimumab with Priority Review in the US, by the
US FDA. The submission is supported by data from the HIMALAYA
trial, in which a single priming dose of the
anti-CTLA4</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[64]</font><font style="color: #1F2222">&#xA0;antibody
added to&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font><font style="color: #1F2222">&#xA0;for the treatment of patients with
unresectable hepatocellular carcinoma significantly improved
overall survival. A supplemental Biologics Licence Application has
also been submitted for&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font><font style="color: #1F2222">&#xA0;in this indication. The Prescription Drug
User Fee Act date, the US FDA action date for their regulatory
decision, is during the fourth quarter of 2022, following the use
of a priority review voucher.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
During the period, AstraZeneca completed regulatory submissions for
tremelimumab and&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font><font style="color: #1F2222">&#xA0;in Japan. The submissions were based on data
from the aforementioned HIMALAYA trial, as well as the TOPAZ-1
trial in which&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font><font style="color: #1F2222">, in combination with standard-of-care
chemotherapy, demonstrated a statistically significant and
clinically meaningful overall survival benefit versus chemotherapy
alone as a 1st-line treatment for patients with advanced biliary
tract cancer.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-style: italic; font-family: Times New Roman; font-size: 13px">
Lynparza</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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In February 2022, AstraZeneca presented results from the PROpel
Phase III trial at the aforementioned 2022 ASCO GU meeting.
AstraZeneca and MSD's&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">&#xA0;in combination with abiraterone demonstrated
a statistically significant and clinically meaningful improvement
in rPFS</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[65]</font><font style="color: #1F2222">&#xA0;versus
abiraterone as a 1st-line treatment for patients with
mCRPC</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[66]</font><font style="color: #1F2222">&#xA0;with
or without HRR</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[67]</font><font style="color: #1F2222">&#xA0;gene
mutations.</font></font></div>
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Lynparza</font><font style="color: #1F2222">&#xA0;in combination
with abiraterone reduced the risk of disease progression or death
by 34% versus abiraterone alone (HR</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[68]</font><font style="color: #1F2222">&#xA0;0.66;
95% CI 0.54-0.81; p&lt;0.0001). Median rPFS was 24.8 months
for&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">&#xA0;plus abiraterone versus 16.6 for abiraterone
alone.</font></font></div>
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Results also showed a favourable trend towards improved
OS</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[69]</font><font style="color: #1F2222">&#xA0;with&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">&#xA0;plus
abiraterone versus abiraterone alone, however the difference did
not reach statistical significance at the time of this data cut-off
(analysis at 29% data maturity). The trial will continue to assess
OS as a key secondary endpoint.</font></font></div>
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During the period,&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">&#xA0;was also approved in the US for the adjuvant
treatment of patients with germline BRCA-mutated HER2-negative
high-risk early breast cancer who have already been treated with
chemotherapy either before or after surgery. The approval by the US
FDA was based on results from the OlympiA Phase III trial, in
which&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">&#xA0;demonstrated a statistically significant and
clinically meaningful improvement in invasive disease-free
survival, reducing the risk of invasive breast cancer recurrences,
second cancers or death, by 42% versus placebo (based on a HR of
0.58; 95% CI 0.46-0.74; p&lt;0.0001).</font></font></div>
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In March, new updated results from the OlympiA trial presented at
the European Society for Medical Oncology virtual plenary
showed&#xA0;</font><font style="font-style: italic; color: #1F2222">Lynparza</font><font style="color: #1F2222">&#xA0;demonstrated a statistically significant and
clinically meaningful improvement in the key secondary endpoint of
OS, reducing the risk of death by 32% versus placebo (based on a HR
of 0.68; 95% CI 0.50-0.91; p=0.0091).</font></font></div>
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Enhertu</font></div>
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In February 2022, AstraZeneca announced positive high-level results
from the DESTINY-Breast04 Phase III trial.&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">&#xA0;demonstrated a statistically significant and
clinically meaningful improvement in both PFS</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[70]</font><font style="color: #1F2222">&#xA0;and
OS in patients with HER2-low unresectable and/or metastatic breast
cancer previously treated with one or two prior lines of
chemotherapy, regardless of hormone receptor (HR) status, versus
physician's choice of chemotherapy.</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
The US FDA has subsequently notified AstraZeneca and Daiichi Sankyo
that the sBLA</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[71]</font><font style="color: #1F2222">&#xA0;for&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">&#xA0;has
been accepted and granted Breakthrough Therapy Designation for the
treatment of&#xA0;HER2-low unresectable and/or metastatic breast
cancer in patients previously treated with one or two prior lines
of chemotherapy.</font></font></div>
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The sBLA is being reviewed under the Real-Time Oncology Review
(RTOR) programme. RTOR allows the FDA to review components of an
application before submission of the complete
application.</font></div>
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In April 2022, AstraZeneca and Daiichi Sankyo were notified by the
US FDA that the sBLA for&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">&#xA0;has been accepted and granted Priority
Review for the treatment of adult patients with previously treated
HER2-mutant metastatic non-small cell lung cancer based on the
results of the DESTINY-Lung01 Phase II trial.</font></font></div>
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Primary results from previously-treated patients with
HER2-mutations (cohort 2) of DESTINY-Lung01 demonstrated a
confirmed objective response rate (ORR) of 54.9% (95% CI:
44.2-65.4) in patients treated with&#x202F;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">&#xA0;(6.4mg/kg).</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
During the period, the China Center for Drug Evaluation granted
Breakthrough Therapy Designation for&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">&#xA0;for the 2nd-line treatment of patients with
HER2+ metastatic breast cancer based on the results of the
DESTINY-Breast03 Phase III trial.</font></font></div>
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BioPharmaceuticals - CVRM</font></div>
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Brilinta</font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
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During the period, the US FDA granted AstraZeneca six months
paediatric exclusivity for&#xA0;</font><font style="font-style: italic; color: #1F2222">Brilinta</font><font style="color: #1F2222">.</font></font></div>
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Andexxa</font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
During the period,&#xA0;</font><font style="font-style: italic; color: #1F2222">Ondexxya</font><font style="color: #1F2222">&#xA0;was approved in Japan for patients treated
with Factor Xa inhibitors apixaban, rivaroxaban or edoxaban when
reversal of anticoagulation is needed due to life-threatening or
uncontrolled bleedings.&#xA0;</font><font style="font-style: italic; color: #1F2222">Ondexxya</font><font style="color: #1F2222">&#xA0;is approved in the EU, and in the US under
the trade name&#xA0;</font><font style="font-style: italic; color: #1F2222">Andexxa</font><font style="color: #1F2222">.</font></font></div>
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AZD8233</font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
At the American College of Cardiology's 71st Annual Scientific
Session, AstraZeneca and Ionis Pharmaceuticals, Inc. presented
Phase IIb data for AZD8233, an antisense oligonucleotide, in
development for the treatment of hypercholesterolemia. In the
ETESIAN Phase IIb trial, AZD8233 showed reduction in
LDL-C</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[72]</font><font style="color: #1F2222">&#xA0;&#xA0;levels
of 73% and PCSK9 reduction of 89%.</font></font></div>
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<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
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<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
BioPharmaceuticals &#xD0; R&amp;I</font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
As disclosed in the Sustainability section, AstraZeneca announced a
collaboration with Honeywell, to develop next-generation
respiratory inhalers (pMDI) using the propellant HFO-1234ze, which
has up to 99.9% less Global Warming Potential (GWP) than
propellants currently used in respiratory medicines. Recent results
from the first in-human Phase I trial of the near-zero GWP
propellant HFO-1234ze in a pMDI containing budesonide,
glycopyrronium, formoterol fumarate in healthy adults were
positive, demonstrating similar safety, tolerability and systemic
exposure of the active ingredients when compared
to&#xA0;</font><font style="font-style: italic; color: #1F2222">Breztri
Aerosphere</font><font style="color: #1F2222">&#xA0;(budesonide/glycopyrronium/formoterol
fumarate). AstraZeneca expects&#xA0;</font><font style="font-style: italic; color: #1F2222">Breztri</font><font style="color: #1F2222">&#xA0;to be the first medicine to transition to
this new pMDI platform, subject to regulatory
approval.</font></font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
As of 29 April 2022, significant new trials in Respiratory &amp;
Immunology in which the first patient was dosed included; HUDSON, a
Phase III trial of&#xA0;</font><font style="font-style: italic; color: #1F2222">Fasenra</font><font style="color: #1F2222">&#xA0;in eosinophilic gastritis and eosinophilic
gastroenteritis and,&#xA0; OBERON and TITANIA, Phase III trials of
tozorakimab in COPD.</font></font></div>
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<font style="text-decoration: underline; color: #1F2222; font-style: italic; font-family: Times New Roman; font-size: 13px">
Fasenra</font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
During the period, the US FDA issued a CRL</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[73]</font><font style="color: #1F2222">&#xA0;regarding
the sBLA for&#xA0;</font><font style="font-style: italic; color: #1F2222">Fasenra</font><font style="color: #1F2222">&#xA0;for patients with inadequately controlled
CRwNP</font></font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
The sBLA included data from the OSTRO Phase III trial, which met
both co-primary endpoints with a safety profile consistent with the
known profile of the medicine. The CRL requested additional
clinical data and AstraZeneca is working closely with the US FDA
regarding next steps. AstraZeneca remains committed to
bringing&#xA0;</font><font style="font-style: italic; color: #1F2222">Fasenra</font><font style="color: #1F2222">&#xA0;to patients with CRSwNP and a second Phase
III trial, ORCHID, in this indication is
ongoing.</font></font></div>
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<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="text-decoration: underline; color: #1F2222; font-style: italic; font-family: Times New Roman; font-size: 13px">
Saphnelo</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
During the period,&#xA0;</font><font style="font-style: italic; color: #1F2222">Saphnelo</font><font style="color: #1F2222">&#xA0;received approval in the EU as an add-on
therapy for the treatment of adult patients with moderate to
severe, active autoantibody-positive SLE, despite receiving
standard therapy, making it the first biologic for SLE approved in
Europe with an indication that is not restricted to patients with a
high degree of disease activity. The approval is based on results
from the&#xA0;</font><font style="font-style: italic; color: #1F2222">Saphnelo</font><font style="color: #1F2222">&#xA0;clinical development programme, which
included the TULIP 1 and TULIP 2 Phase III trials and the MUSE
Phase II trial. In these trials, more patients treated
with&#xA0;</font><font style="font-style: italic; color: #1F2222">Saphnelo</font><font style="color: #1F2222">&#xA0;experienced a reduction in overall disease
activity across all affected organ systems from baseline and
achieved sustained reduction in oral corticosteroid use compared to
placebo, with both groups receiving standard therapy.
&#xA0;</font></font></div>
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<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
BioPharmaceuticals &#xD0; Vaccines and Immune
Therapies</font></div>
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<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="text-decoration: underline; color: #1F2222; font-style: italic; font-family: Times New Roman; font-size: 13px">
Evusheld</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
During the period,&#xA0;</font><font style="font-style: italic; color: #1F2222">Evusheld</font><font style="color: #1F2222">&#xA0;was granted marketing authorisation in the
EU for the pre-exposure prophylaxis (prevention) of COVID-19 in a
broad population of adults and adolescents aged 12 years and older
weighing at least 40kg.</font></font></div>
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<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Preclinical authentic &#xD4;live' virus data from Washington
University School of Medicine demonstrated
that&#xA0;</font><font style="font-style: italic; color: #1F2222">Evusheld</font><font style="color: #1F2222">&#xA0;retains neutralising activity against the
highly transmissible Omicron BA.2 subvariant. This study also
showed that&#xA0;</font><font style="font-style: italic; color: #1F2222">Evusheld</font><font style="color: #1F2222">&#xA0;reduced viral burden and limited
inflammation in the lungs (in vivo) across all tested Omicron
variants.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Detailed results from the PROVENT Phase III pre-exposure
prophylaxis (prevention) trial, published
in&#xA0;</font><font style="font-style: italic; color: #1F2222">The</font><font style="color: #1F2222">&#xA0;</font><font style="font-style: italic; color: #1F2222">New England Journal of
Medicine</font><font style="color: #1F2222">, showed that
AstraZeneca's&#xA0;</font><font style="font-style: italic; color: #1F2222">Evusheld</font><font style="color: #1F2222">&#xA0;reduced the risk of developing symptomatic
COVID-19 by 77% in the primary analysis and by 83% in the six-month
follow-up analysis, compared to placebo. There were no cases of
severe disease or COVID-19 related deaths in
the&#xA0;</font><font style="font-style: italic; color: #1F2222">Evusheld</font><font style="color: #1F2222">&#xA0;group through the six-month follow
up.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Nirsevimab</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Nirsevimab was accepted under an accelerated assessment procedure
by the EMA, for the prevention of medically attended
LRTI</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[74]</font><font style="color: #1F2222">&#xA0;in
all infants from birth entering their first RSV
season.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Detailed results from the MELODY Phase III trial were published in
the New England Journal of Medicine and demonstrated that
nirsevimab showed 74.5% efficacy against medically attended LRTI
caused by RSV in healthy infants compared to placebo. Additionally,
results from the MEDLEY Phase II/III trial were also published in
the journal. The results demonstrated nirsevimab had a similar
safety and tolerability profile compared
to&#xA0;</font><font style="font-style: italic; color: #1F2222">Synagis</font><font style="color: #1F2222">,
and that serum levels of nirsevimab following dosing (on day 151)
in this trial were comparable with those observed in the MELODY
Phase III trial.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Rare Disease</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-style: italic; font-family: Times New Roman; font-size: 13px">
Ultomiris</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
Ultomiris</font><font style="color: #1F2222">&#xA0;was approved in
the US for the treatment of adult patients with gMG who are
anti-acetylcholine receptor antibody-positive, which represents 80%
of people living with the disease. The approval by the US FDA was
based on positive results from the CHAMPION-MG Phase III trial, in
which&#xA0;</font><font style="font-style: italic; color: #1F2222">Ultomiris</font><font style="color: #1F2222">&#xA0;was superior to placebo in the primary
endpoint of change from baseline in the Myasthenia
Gravis-Activities of Daily Living Profile (MG-ADL) total score at
Week 26, a patient-reported scale that assesses patients' abilities
to perform daily activities.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Interim Financial Statements</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: justify; margin-left: auto; margin-right: auto; margin-bottom: 6px; width: 100%; height: 2px; background-color: #000000">
<!--line--><br></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;16: Q1 2022 - Condensed consolidated statement of
comprehensive income</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td rowspan="2" style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
For the&#xA0;</font><font style="font-weight: bold; color: #1F2222">quarter</font><font style="color: #1F2222">&#xA0;ended 31 March</font></font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2022</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2021</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 1px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Revenue</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
11,390&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
7,320&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Product Sales</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
10,980</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
7,257</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Collaboration Revenue</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
410</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
63</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cost of Sales</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(3,511)</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,864)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Gross profit</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
7,879&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
5,456&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Distribution expense</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(125)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(99)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Research and development expense</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,133)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,713)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Selling, general and administrative expense</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4,840)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,929)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other operating income and expense</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
97&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,180&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Operating profit</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
878&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,895&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Finance income</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
20&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Finance expense</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(336)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(303)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Share of after tax losses in associates and joint
ventures</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(6)</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Profit before tax</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
553&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,608&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Taxation</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(165)</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(46)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Profit for the period</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
388&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,562&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other comprehensive income</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Items that will not be reclassified to profit or loss</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Remeasurement of the defined benefit pension liability</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
335&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
481&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net gains/(losses) on equity investments measured at fair value
through other comprehensive income</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
18&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(108)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fair value movements related to own credit risk on bonds designated
as fair value through profit or loss</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tax on items that will not be reclassified to profit or
loss</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(94)</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(94)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
259&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
280&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Items that may be reclassified subsequently to profit or
loss</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Foreign exchange arising on consolidation</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(219)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(107)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Foreign exchange arising on designated borrowings in net investment
hedges</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(32)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(302)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fair value movements on cash flow hedges</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(86)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fair value movements on cash flow hedges transferred to profit or
loss</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
121&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fair value movements on derivatives designated in net investment
hedges</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(8)</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Costs of hedging</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tax on items that may be reclassified subsequently to profit or
loss</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
26&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(242)</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(336)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other comprehensive income/(loss) for the period, net of
tax</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
17&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(56)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total comprehensive income for the period</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
405&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,506&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Profit attributable to:</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Owners of the Parent</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
386&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,561&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Non-controlling interests</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
388&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,562&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total comprehensive income attributable to:</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Owners of the Parent</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
405&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,506&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Non-controlling interests</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
405&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,506&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Basic earnings per $0.25 Ordinary Share</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$0.25&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$1.19&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Diluted earnings per $0.25 Ordinary Share</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$0.25&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
$1.18&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Weighted average number of Ordinary Shares in issue
(millions)</font></div>
</td>
<td style="vertical-align: middle; width: 23%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,548&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,312&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 62%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Diluted weighted average number of Ordinary Shares in issue
(millions)</font></div>
</td>
<td style="vertical-align: middle; width: 23%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,561&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 15%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,319&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 1px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;17: Condensed consolidated statement of financial
position</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 63%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At 31 Mar 2022</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At 31 Dec 2021</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At 31 Mar 2021</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Assets</font></div>
</td>
<td style="vertical-align: top; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Non-current assets</font></div>
</td>
<td style="vertical-align: top; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Property, plant and equipment</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9,061&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9,183&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8,189&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Right-of-use assets</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
954&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
988&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
660&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Goodwill</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
19,963&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
19,997&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11,765&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Intangible assets</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
41,265&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
42,387&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
20,347&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Investments in associates and joint ventures</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
63&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
69&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
88&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other investments</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,174&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,168&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
972&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Derivative financial instruments</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
87&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
102&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
115&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other receivables</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
864&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
895&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
549&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Deferred tax assets</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4,195&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4,330&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3,506&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
77,626&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
79,119&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
46,191&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Current assets</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Inventories</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7,624&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8,983&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4,278&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Trade and other receivables</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8,683&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9,644&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6,281&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other investments</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
61&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
69&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
129&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Derivative financial instruments</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
54&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
83&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
64&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Intangible assets</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
96&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
105&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Income tax receivable</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
367&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
663&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
347&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash and cash equivalents</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5,762&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6,329&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7,636&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Assets held for sale</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
368&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
22,647&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
26,244&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
18,735&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total assets</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
100,273&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
105,363&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
64,926&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Liabilities</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Current liabilities</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Interest-bearing loans and borrowings</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,069)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,660)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,042)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lease liabilities</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(225)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(233)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(216)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Trade and other payables</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(17,864)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(18,938)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(17,370)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Derivative financial instruments</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(35)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(79)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(16)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Provisions</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,423)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(768)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(875)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Income tax payable</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,124)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(916)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(994)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(22,740)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(22,594)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(21,513)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Non-current liabilities</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Interest-bearing loans and borrowings</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28,081)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28,134)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(17,410)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lease liabilities</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(724)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(754)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(464)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Derivative financial instruments</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(47)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(45)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Deferred tax liabilities</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(5,626)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(6,206)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,823)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Retirement benefit obligations</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,991)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,454)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,545)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Provisions</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(949)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(956)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(576)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other payables</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(3,756)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4,933)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(5,148)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(41,174)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(43,482)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28,967)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total liabilities</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(63,914)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(66,076)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(50,480)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net assets</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
36,359&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
39,287&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
14,446&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Equity</font></div>
</td>
<td style="vertical-align: top; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Capital and reserves attributable to equity holders of the
Parent</font></div>
</td>
<td style="vertical-align: top; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Share capital</font></div>
</td>
<td style="vertical-align: top; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
387&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
387&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
328&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Share premium account</font></div>
</td>
<td style="vertical-align: top; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
35,131&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
35,126&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7,976&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other reserves</font></div>
</td>
<td style="vertical-align: top; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,050&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,045&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,037&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Retained earnings</font></div>
</td>
<td style="vertical-align: top; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,228)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,710&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4,089&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
36,340&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
39,268&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
14,430&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Non-controlling interests</font></div>
</td>
<td style="vertical-align: top; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
19&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
19&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
16&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total equity</font></div>
</td>
<td style="vertical-align: top; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
36,359&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
39,287&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
14,446&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;18: Condensed consolidated statement of changes in
equity</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 25%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Share capital</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-weight: bold; font-family: Times New Roman; font-size: 13px">
Share premium account</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other reserves</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Retained earnings</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-weight: bold; font-family: Times New Roman; font-size: 13px">
Total attributable to owners of the parent</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-weight: bold; font-family: Times New Roman; font-size: 13px">
Non-controlling interests</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total equity</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At 1 Jan 2021</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
328&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7,971&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,024&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5,299&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15,622&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
16&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15,638&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Profit for the period</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,561&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,561&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,562&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other comprehensive loss</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(55)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(55)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(56)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Transfer to other reserves</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(13)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Transactions with owners:</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Dividends</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,490)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,490)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,490)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Issue of Ordinary Shares</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Share-based payments charge for the period</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
82&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
82&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
82&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Settlement of share plan awards</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(295)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(295)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(295)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net movement</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,210)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,192)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,192)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At 31 Mar 2021</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
328</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
7,976</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
2,037</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
4,089</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
14,430</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
16</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
14,446</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At 1 Jan 2022</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
387</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
35,126</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
2,045</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
1,710</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
39,268</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
19</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
39,287</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Profit for the period</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
386&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
386&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
388&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other comprehensive income</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
19&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
19&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Transfer to other reserves</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(5)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Transactions with owners:</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Dividends</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(3,046)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(3,046)</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(3,046)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Issue of Ordinary Shares</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Share-based payments charge for the period</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
182&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
182&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 13%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
182&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Settlement of share plan awards</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(474)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(474)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(474)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net movement</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,938)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,928)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,928)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 25%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At 31 Mar 2022</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
387</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
35,131</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
2,050</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,228)</font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
36,340</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 13%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
19</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
36,359</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;19: Condensed consolidated statement of cash
flows</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td rowspan="2" style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
For the&#xA0;</font><font style="font-weight: bold; color: #1F2222">quarter</font><font style="color: #1F2222">&#xA0;ended 31 March</font></font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2022&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2021&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 1px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash flows from operating activities</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Profit before tax</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
553&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,608&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Finance income and expense</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
319&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
283&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Share of after tax losses of associates and joint
ventures</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Depreciation, amortisation and impairment</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,309&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
797&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Decrease in working capital and short-term provisions</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,804&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,210&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Gains on disposal of intangible assets</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(10)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(310)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Gains on disposal of investments in associates and joint
ventures</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(776)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Non-cash and other movements</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(327)</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(363)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash generated from operations</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
3,654&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,453&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Interest paid</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(194)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(187)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tax paid</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(228)</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(332)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net cash inflow from operating activities</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
3,232&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,934&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash flows from investing activities</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Payments upon vesting of employee share awards attributable to
business combinations</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(55)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Payment of contingent consideration from business
combinations</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(182)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(171)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Purchase of property, plant and equipment</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(219)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(220)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Disposal of property, plant and equipment</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Purchase of intangible assets</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(144)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(249)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Disposal of intangible assets and assets held for sale</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
385&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
418&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Purchase of non-current asset investments</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Disposal of non-current asset investments</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Movement in short-term investments, fixed deposits and other
investing instruments</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
21&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
28&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Payments to associates and joint ventures</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(5)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(55)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Disposal of investments in associates and joint
ventures</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
776&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Interest received</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
24&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net cash (outflow)/inflow from investing activities</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(168)</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
555&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net cash inflow before financing activities</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
3,064&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,489&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash flows from financing activities</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Proceeds from issue of share capital</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Repayment of loans and borrowings</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Dividends paid</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,971)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,469)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Hedge contracts relating to dividend payments</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(77)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(23)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Repayment of obligations under leases</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(74)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(50)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Movement in short-term borrowings</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
301&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(190)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Payment of Acerta Pharma share purchase liability</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(920)</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net cash outflow from financing activities</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(3,740)</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,731)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net decrease in cash and cash equivalents in the
period</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(676)</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(242)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash and cash equivalents at the beginning of the
period</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6,038&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7,546&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Exchange rate effects</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(9)</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(67)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash and cash equivalents at the end of the period</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
5,353&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
7,237&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash and cash equivalents consist of:</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash and cash equivalents</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5,762&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7,636&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Overdrafts</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(409)</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(399)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 65%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
5,353&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
7,237&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Notes to the Interim Financial Statements</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Note 1: Basis of preparation and accounting policies</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
These unaudited Interim Financial Statements for the three months
ended 31 March 2022 have been prepared in accordance with
UK-adopted International Accounting Standards and with the
requirements of the Companies Act 2006 as applicable to companies
reporting under those standards. The Interim Financial Statements
also comply fully with International Financial Reporting Standards
(IFRSs) as issued by the International Accounting Standards Board
(IASB) and International Accounting Standards as adopted by the
European Union.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The unaudited Interim Financial Statements for the three months
ended 31 March 2022 include Alexion's results for the period.
Alexion was consolidated into the Group's results from 21 July
2021, hence Alexion's results are not included in the comparative
periods shown.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The unaudited Interim Financial Statements for the three months
ended 31 March 2022 were approved by the Board of Directors for
publication on 29 April 2022.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The annual financial statements of the Group for the year ended 31
December 2021 were prepared in accordance with UK-adopted
International Accounting Standards and with the requirements of the
Companies Act 2006. The annual financial statements also comply
fully with IFRSs as issued by the IASB and International Accounting
Standards as adopted by the European Union. Except for the
estimation of the interim income tax charge, the Interim Financial
Statements have been prepared applying the accounting policies that
were applied in the preparation of the Group's published
consolidated financial statements for the year ended 31 December
2021.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The comparative figures for the financial year ended 31 December
2021 are not the Group's statutory accounts for that financial
year. Those accounts have been reported on by the Group's auditors
and will be delivered to the registrar of companies; their report
was (i) unqualified, (ii) did not include a reference to any
matters to which the auditors drew attention by way of emphasis
without qualifying their report, and (iii) did not contain a
statement under section 498(2) or (3) of the Companies Act
2006.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Global and/or geopolitical events</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
There were no material accounting impacts identified relating to
COVID-19 during the three months ended 31 March 2022.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The Group's current focus is to continue compliant business
operations in Russia and Ukraine, focussing on safeguarding our
employees, ensuring continuity of supply of essential and
life-saving medicines and contributing to humanitarian relief
efforts. There are no material accounting impacts arising from the
conflict impacting our Q1 2022 reporting. The situation is dynamic
and any future impact on our business is uncertain. We continue to
closely monitor the situation.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The Group will continue to monitor these areas of increased
judgement, estimation and risk for material changes.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Going concern</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The Group has considerable financial resources available. As at 31
March 2022, the Group had $10.7bn in financial resources (cash and
cash-equivalent balances of $5.8bn and undrawn committed bank
facilities of $4.9bn available until April 2025, with only $2.3bn
of borrowings due within one year). All facilities contain no
financial covenants and were undrawn at 31 March 2022.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The Group's revenues are largely derived from sales of medicines
covered by patents which provide a relatively high level of
resilience and predictability to cash inflows, although government
price interventions in response to budgetary constraints are
expected to continue to affect adversely revenues in some of our
significant markets. The Group, however, anticipates new revenue
streams from both recently launched medicines and those in
development, and the Group has a wide diversity of customers and
suppliers across different geographic areas.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Consequently, the Directors believe that, overall, the Group is
well-placed to manage its business risks successfully.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Accordingly, the going concern basis has been adopted in these
Interim Financial Statements.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Legal proceedings</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
The information contained in Note 5 updates the disclosures
concerning legal proceedings and contingent liabilities in the
Group's&#xA0;</font><font style="text-decoration: underline; color: #0000FF">Annual Report and Form
20-F Information 2021</font><font style="color: #1F2222">.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Note 2: Intangible assets</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
In accordance with IAS 36 &#xD4;Impairment of Assets', reviews for
triggers at an individual asset or cash-generating-unit level were
conducted, and impairment tests carried out where triggers were
identified. As a result, total net impairment reversals of $94m
have been recorded against intangible assets during the three
months ended 31 March 2022 (Q1 2021: $55m charge). Net impairment
reversals in respect of medicines in development and launched
medicines were $77m (Q1 2021: $nil) and $nil (Q1 2021: $55m charge)
respectively.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Note 3: Net Debt</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
The table below provides an analysis of Net Debt and a
reconciliation of Net Cash Flow to the movement in Net Debt. The
Group monitors Net Debt as part of its capital-management policy as
described in Note 28 of the&#xA0;</font><font style="text-decoration: underline; color: #0000FF">Annual Report and Form
20-F Information 2021</font><font style="color: #1F2222">. Net Debt
is a non-GAAP financial measure.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;20: Net Debt</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 40%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At 1 Jan 2022</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash flow</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-weight: bold; font-family: Times New Roman; font-size: 13px">
Non-cash&amp; other</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Exchange movements</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At 31 Mar 2022</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Non-current instalments of loans</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28,134)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
47&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28,081)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Non-current instalments of leases</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(754)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
21&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(724)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total long-term debt</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28,888)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
-</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
27</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
56</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28,805)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Current instalments of loans</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,273)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,264)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Current instalments of leases</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(233)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
70&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(66)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(225)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Commercial paper</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(256)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(256)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Bank collateral</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(93)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
12&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(81)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other short-term borrowings excluding overdrafts</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(3)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(57)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(59)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Overdrafts</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(291)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(123)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(409)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total current debt</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1,893)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(350)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(61)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
10</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2,294)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Gross borrowings</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(30,781)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(350)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(34)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
66</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(31,099)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net derivative financial instruments</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
61&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
66&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(68)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
59&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net borrowings</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(30,720)</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(284)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(102)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
66</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(31,040)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash and cash equivalents</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6,329&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(553)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(14)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5,762&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other investments - current</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
69&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(10)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
61&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cash and investments</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
6,398</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(563)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
-</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(12)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
5,823</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 40%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net Debt</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(24,322)</font></div>
</td>
<td style="vertical-align: middle; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(847)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(102)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
54</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(25,217)</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Non-cash movements in the period include fair-value adjustments
under IFRS 9.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The Group has agreements with some bank counterparties whereby the
parties agree to post cash collateral on financial derivatives, for
the benefit of the other, equivalent to the market valuation of the
derivative positions above a predetermined threshold. The carrying
value of such cash collateral held by the Group was $81m (31
December 2021: $93m) and the carrying value of such cash collateral
posted by the Group was $64m (31 December 2021: $47m). Cash
collateral posted by the Group is presented within Cash and cash
equivalents.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The equivalent GAAP measure to Net Debt is &#xD4;liabilities
arising from financing activities', which excludes the amounts for
cash and overdrafts, other investments and non-financing
derivatives shown above and includes the Acerta Pharma share
purchase liability of $1,564m (31 December 2021: $2,458m), $824m of
which is shown in current other payables and $740m is shown in
non-current other payables.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Net Debt increased by $895m in the year to date to $25,217m.
Details of the committed undrawn bank facilities are disclosed
within the going concern section of Note 1.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 1px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
During the three months to 31 March 2022, there were no changes to
the Company's solicited credit ratings issued by Standard and
Poor's (long term: A-; short term: A-2) and from&#xA0;Moody's (long
term: A3; short term: P-2).</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Note 4: Financial Instruments</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
As detailed in the Group's most recent annual financial statements,
the principal financial instruments consist of derivative financial
instruments, other investments, trade and other receivables, cash
and cash equivalents, trade and other payables, lease liabilities
and interest-bearing loans and borrowings.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
All fair value gains and/or losses that are presented in Net
gains/(losses) on equity investments measured at fair value through
other comprehensive income in the Condensed consolidated statement
of comprehensive income for the three months ending 31 March 2022
are Level 1 fair value measurements.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Financial instruments measured at fair value include $1,235m of
other investments, $4,175m held in money-market funds, $308m of
loans designated at fair value through profit or loss and $59m of
derivatives as at 31 March 2022. The total fair value of
interest-bearing loans and borrowings at 31 March 2022, which have
a carrying value of $31,099m in the Condensed consolidated
statement of financial position, was $31,902m.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;21: Financial instruments - contingent
consideration</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 33%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 51%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2022</font></div>
</td>
<td style="vertical-align: middle; width: 15%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2021</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 1px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 34%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 21%; border-top: 1pt solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Diabetes alliance</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-top: 1pt solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-top: 1pt solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 34%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 21%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 34%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At 1 January</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 21%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,544&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
321&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,865&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3,323&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 34%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Settlements</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 21%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(173)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(9)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(182)</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(171)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 34%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Disposals</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 21%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(121)</font></div>
</td>
<td style="vertical-align: middle; width: 14%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(121)</font></div>
</td>
<td style="vertical-align: middle; width: 16%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 34%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Discount unwind</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 21%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
41&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
42&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
55&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 34%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
At 31 March</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 21%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
2,412</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
192</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 14%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
2,604</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
<td style="vertical-align: middle; width: 16%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
3,207</font><font style="color: #1F2222">&#xA0;</font></font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Contingent consideration arising from business combinations is
fair-valued using decision-tree analysis, with key inputs including
the probability of success, consideration of potential delays and
the expected levels of future revenues.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The contingent consideration balance relating to BMS's share of the
global diabetes alliance of $2,412m (31&#xA0;December 2021:
$2,544m) would increase/decrease by $241m with an increase/decline
in sales of 10%, as compared with the current
estimates.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Note 5: Legal proceedings and contingent liabilities</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
AstraZeneca is involved in various legal proceedings considered
typical to its business, including litigation and investigations
relating to product liability, commercial disputes, infringement of
intellectual property (IP) rights, the validity of certain patents,
anti-trust law and sales and marketing practices. The matters
discussed below constitute the more significant developments since
publication of the disclosures concerning legal proceedings in the
Company's Annual Report and Form 20-F Information 2021 (the
Disclosures). Unless noted otherwise below or in the Disclosures,
no provisions have been established in respect of the claims
discussed below.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
As discussed in the Disclosures, the majority of claims involve
highly complex issues. Often these issues are subject to
substantial uncertainties and, therefore, the probability of a
loss, if any, being sustained and/or an estimate of the amount of
any loss is difficult to ascertain.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Unless specifically identified below that a provision has been
taken, AstraZeneca considers each of the claims to represent a
contingent liability and discloses information with respect to the
nature and facts of the cases in accordance with IAS
37.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
There is one matter concerning legal proceedings in the
Disclosures, which is considered probable that an outflow will be
required, but for which we are unable to make an estimate of the
possible loss or range of possible losses at this
stage.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
In cases that have been settled or adjudicated, or where
quantifiable fines and penalties have been assessed and which are
not subject to appeal, or where a loss is probable and we are able
to make a reasonable estimate of the loss, AstraZeneca records the
loss absorbed or makes a provision for its best estimate of the
expected loss. The position could change over time and the
estimates that the Company made, and upon which the Company have
relied in calculating these provisions are inherently imprecise.
There can, therefore, be no assurance that any losses that result
from the outcome of any legal proceedings will not exceed the
amount of the provisions that have been booked in the accounts. The
major factors causing this uncertainty are described more fully in
the Disclosures and herein.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
AstraZeneca has full confidence in, and will vigorously defend and
enforce, its IP.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-weight: bold; font-family: Times New Roman; font-size: 13px">
Matters disclosed in respect of the fourth quarter of 2021 and to
29 April 2022</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Patent litigation</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-style: italic; font-family: Times New Roman; font-size: 13px">
Enhertu</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
US patent proceedings</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
As previously disclosed, in&#xA0;October 2020, Seagen Inc. (Seagen)
filed a complaint against Daiichi Sankyo Company, Limited (Daiichi
Sankyo) in the US District Court for the Eastern District of Texas
alleging that&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">&#xA0;infringes US Patent No. 10,808,039 (the
&#xD4;039 patent). AstraZeneca
co-commercialises&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu</font><font style="color: #1F2222">&#xA0;with Daiichi Sankyo, Inc. in the US. The
trial took place in April 2022. The jury found that the &#xD4;039
patent was infringed and awarded Seagen $41.82m in past damages.
The parties await the schedules for a bench trial on equitable
issues and for consideration of post-trial
motions.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
As previously disclosed, in December 2020 and January 2021,
AstraZeneca and Daiichi Sankyo filed post-grant review petitions
with the US Patent and Trademark Office (USPTO) alleging, inter
alia, that the &#xD4;039 patent is invalid for lack of written
description and enablement. The USPTO initially declined to
institute the post-grant reviews, but in April 2022, the USPTO
granted the rehearing requests, instituting both post-grant review
petitions. An oral hearing is scheduled for January 2023 and a
decision is expected by April 2023.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-style: italic; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
US patent proceedings</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
In March 2022, Bristol-Myers Squibb Co. and E.R. Squibb &amp; Sons,
LLC filed a lawsuit in US District Court for the District of
Delaware against AstraZeneca alleging that AstraZeneca's marketing
of&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font><font style="color: #1F2222">&#xA0;infringes several of their patents. No trial
date has been scheduled.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Patent proceedings outside the US</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
In February 2022, Ono Pharmaceuticals filed a lawsuit in Tokyo
District Court, Civil Division against AstraZeneca alleging that
AstraZeneca's marketing of&#xA0;</font><font style="font-style: italic; color: #1F2222">Imfinzi</font><font style="color: #1F2222">&#xA0;in Japan infringes several of their patents.
No trial date has been scheduled.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-style: italic; font-family: Times New Roman; font-size: 13px">
Symbicort</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
US patent proceedings</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
As previously disclosed, AstraZeneca is involved in ongoing ANDA
patent litigation with Mylan Pharmaceuticals Inc. (Mylan) and
Kindeva Drug Delivery L.P. (Kindeva) brought in the US District
Court for the Northern District of West Virginia (the District
Court). In March 2022, the US Court of Appeals for the Federal
Circuit (the Federal Circuit) denied AstraZeneca's Combined
Petition for Panel Rehearing and Rehearing En Banc of the Federal
Circuit's December 2021 decision and the case was remanded back to
the District Court for further proceedings. In April 2022, the
District Court entered a Stipulation and Order dismissing patent
infringement claims related to various asserted patents and
otherwise narrowing the issues for trial. A trial in the matter is
scheduled to commence in May 2022.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
In April 2022, AstraZeneca filed another ANDA action against Mylan
and Kindeva in the District Court asserting patent
infringement.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-style: italic; font-family: Times New Roman; font-size: 13px">
Tagrisso</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
US patent proceedings</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
In February 2020, in response to Paragraph IV notices from multiple
ANDA filers, AstraZeneca filed patent infringement lawsuits in the
US District Court for the District of Delaware. In its complaint,
AstraZeneca alleged that a generic version
of&#xA0;</font><font style="font-style: italic; color: #1F2222">Tagrisso</font><font style="color: #1F2222">, if approved and marketed, would infringe a US
Orange Book-listed&#xA0;</font><font style="font-style: italic; color: #1F2222">Tagrisso</font><font style="color: #1F2222">&#xA0;patent. In the fourth quarter of 2021,
AstraZeneca entered into settlement agreements with Zydus
Pharmaceuticals (USA) Inc., Cadila Healthcare Limited, MSN
Laboratories Pvt. Ltd., and MSN Pharmaceuticals Inc. In April 2022,
AstraZeneca entered into a settlement agreement with Alembic
Pharmaceuticals Limited. These settlements resolve all US patent
litigation between the parties relating to&#xA0;</font><font style="font-style: italic; color: #1F2222">Tagrisso</font><font style="color: #231F20">.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Patent proceedings outside the US</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
In Russia, in October 2021, AstraZeneca filed a lawsuit in the
Arbitration Court of the Moscow Region against Axelpharm, LLC to
prevent it from obtaining authorisation to market a generic version
of&#xA0;</font><font style="font-style: italic; color: #1F2222">Tagrisso</font><font style="color: #1F2222">&#xA0;prior to the expiration of AstraZeneca's
patents covering&#xA0;</font><font style="font-style: italic; color: #1F2222">Tagrisso</font><font style="color: #1F2222">. The lawsuit also names the Ministry of Health of
the Russian Federation as a third party. In March 2022, the court
dismissed the lawsuit, and AstraZeneca has filed an
appeal.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-style: italic; font-family: Times New Roman; font-size: 13px">
Ultomiris</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
As previously disclosed, Chugai Pharmaceutical Co., Ltd. (Chugai)
filed lawsuits against Alexion in the Delaware District Court as
well as in Tokyo District Court, alleging
that&#xA0;</font><font style="font-style: italic; color: #1F2222">Ultomiris</font><font style="color: #1F2222">&#xA0;infringed US and Japanese patents held by
Chugai.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
In March 2022, Alexion entered into a settlement agreement with
Chugai that resolves all patent disputes between the two companies
related to&#xA0;</font><font style="font-style: italic; color: #1F2222">Ultomiris</font><font style="color: #1F2222">.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
In accordance with the settlement agreement, Alexion and Chugai
have taken steps to withdraw patent infringement proceedings filed
with US District Court for the District of Delaware and Tokyo
District Court. Under the terms of the agreement, Alexion will make
a single payment of $775m in the second quarter of 2022, for which
a related charge was recognised through the non-core P&amp;L in the
first quarter of 2022. No further amounts are payable by either
party.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Product liability litigation</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; text-decoration: underline; color: #1F2222">
Onglyza</font><font style="text-decoration: underline; color: #1F2222">&#xA0;and&#xA0;</font><font style="font-style: italic; text-decoration: underline; color: #1F2222">Kombiglyze</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
In the US, AstraZeneca is defending various lawsuits alleging heart
failure, cardiac injuries, and/or death from treatment
with&#xA0;</font><font style="font-style: italic; color: #1F2222">Onglyza</font><font style="color: #1F2222">&#xA0;or&#xA0;</font><font style="font-style: italic; color: #1F2222">Kombiglyze</font><font style="color: #1F2222">. In February 2018, the Judicial Panel on
Multidistrict Litigation ordered the transfer of various pending
federal actions to the US District Court for the Eastern District
of Kentucky (the District Court) for consolidated pre-trial
proceedings with the federal actions pending in the District Court.
In the previously disclosed California State Court coordinated
proceeding, AstraZeneca's motion for summary judgment was granted
in March 2022. A motion for summary judgment is pending in the
District Court.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Commercial litigation</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Pay Equity Litigation (US)</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
AstraZeneca is defending a putative class and collective action
matter in the US District Court for the Northern District of
Illinois brought by three named plaintiffs, who are former
AstraZeneca pharmaceutical sales representatives. The case involves
claims under the federal and Illinois Equal Pay Acts, with the
plaintiffs alleging they were paid less than male employees who
performed substantially similar and/or equal work. The plaintiffs
seek various damages on behalf of themselves and the putative class
and/or collective, including without limitation backpay, liquidated
damages, compensatory and punitive damages, attorneys' fees, and
interest.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The Court has not set a trial date and no class or collective
certification has been sought or granted as of this
time.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Government investigations/proceedings</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-family: Times New Roman; font-size: 13px">
COVID-19 Vaccine Supply and Manufacturing Inquiries</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
As previously disclosed, in June 2021, Argentina's Federal Criminal
Prosecutor's Office (the Prosecutor) contacted AstraZeneca
Argentina seeking documents and electronic records in connection
with a local criminal investigation relating to the public
procurement and supply of&#xA0;</font><font style="font-style: italic; color: #1F2222">Vaxzevria</font><font style="color: #1F2222">&#xA0;in that country. In October 2021, the
Prosecutor filed a submission with the presiding court requesting
dismissal of the criminal investigation, and that request was
granted by the court in February 2022. This matter is now closed.
&#xA0;</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
In February 2022, a Brazilian Public Prosecutor filed a lawsuit
against several defendants including the Brazilian Federal
Government, AstraZeneca, and other COVID-19 vaccine manufacturers.
In April 2022, a Brazilian Court issued an order dismissing the
lawsuit.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #1F2222; font-family: Times New Roman; font-size: 13px">
US 340B Litigations and Proceedings</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
As previously disclosed, AstraZeneca is involved in several matters
relating to its contract pharmacy recognition policy under the 340B
Drug Pricing Program in the US. AstraZeneca has sought to intervene
in three lawsuits against several US government agencies and their
officials relating to the appropriate interpretation of the
governing statute for the 340B Drug Pricing Program. Two of the
three cases are currently stayed pending further proceedings and
the third case has been dismissed. Administrative Dispute
Resolution proceedings have also been initiated against AstraZeneca
before the US Health Resources and Services Administration.
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
As previously disclosed, in January 2021, AstraZeneca filed a
separate lawsuit in federal court in Delaware alleging that an
Advisory Opinion issued by the Department of Health and Human
Services violates the Administrative Procedure Act. In June 2021,
the Court found in favour of AstraZeneca, invalidating the Advisory
Opinion.&#xA0;Prior to the Court's ruling, however, in May 2021,
the US government issued new and separate letters to AstraZeneca
(and other companies) asserting that our contract pharmacy policy
violates the 340B statute. AstraZeneca amended the complaint to
include allegations challenging the letter sent in May, and in
February 2022, the Court ruled in favour of AstraZeneca
invalidating those letters sent by the US Government. The US
government has appealed the decision.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #1F2222">
&#xA0;Table 22: Q1 2022 - Product Sales year-on-year
analysis</font><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">[75]</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 20%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td colspan="3" style="vertical-align: middle; width: 20%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 36px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
World</font></div>
</td>
<td colspan="3" style="vertical-align: middle; width: 18%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Emerging Markets</font></div>
</td>
<td colspan="2" style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
US</font></div>
</td>
<td colspan="3" style="vertical-align: middle; width: 16%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Europe</font></div>
</td>
<td colspan="3" style="vertical-align: middle; width: 17%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Established RoW</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Act % chg</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER % chg</font></div>
</td>
<td style="vertical-align: middle; width: 4%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Act % chg</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER % chg</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
% Change</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Act % chg</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER % chg</font></div>
</td>
<td style="vertical-align: middle; width: 1%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Act % chg</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
CER % chg</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Oncology</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
3,388</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
14</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
18</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
895</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
17</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
19</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,374</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
17</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
650</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
13</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
21</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
469</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
4</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
12</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tagrisso</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,304</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
406</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
33</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
439</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
252</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
12</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
21</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
207</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
599</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
58</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
315</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
125</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
23</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
101</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
12</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lynparza</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
617</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
121</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
39</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
43</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
270</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
160</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
16</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
66</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
22</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Calquence</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
414</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
98</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
339</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
74</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
55</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Enhertu</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Orpathys</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Zoladex</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
240</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
12</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
167</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
22</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
23</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(19)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
34</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(9)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(3)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
35</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(18)</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(9)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Faslodex</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
93</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(24)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(20)</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
44</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(41)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(59)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(56)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
27</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(8)</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Iressa</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(47)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(47)</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
27</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(50)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(50)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(16)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(48)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(44)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(35)</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(30)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Arimidex</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
32</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(27)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(25)</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
25</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(30)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(29)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
51</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(56)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(56)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(7)</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Casodex</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
21</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(48)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(47)</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(59)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(59)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(24)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(24)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(10)</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Others</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
12</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 4%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
49</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
61</font></div>
</td>
<td style="vertical-align: middle; width: 1%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(29)</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(24)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
BioPharmaceuticals: CVRM*</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,207</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
14</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
17</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,025</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
8</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
11</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
522</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
482</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
31</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
40</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
178</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
28</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
37</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Farxiga</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,000</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
60</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
67</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
391</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
50</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
54</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
193</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
48</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
318</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
83</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
97</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
98</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
66</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
78</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Brilinta</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
325</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(13)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(10)</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
69</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(35)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(32)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
166</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
76</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(13)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(6)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(5)</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Lokelma</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
63</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
92</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
97</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
39</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
62</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Roxadustat</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
41</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
41</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Andexxa*</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
33</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
24</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(7)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Crestor</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
267</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
197</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
18</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(16)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(48)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(44)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
41</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Seloken/Toprol-XL</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
244</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
238</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(7)</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Bydureon</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
68</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(34)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(33)</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
60</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
63</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
57</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(34)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
10</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(23)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(92)</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(91)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Onglyza</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
68</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(33)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(31)</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
34</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(42)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(40)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
18</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(31)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(26)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(45)</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(44)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Others</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
98</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(15)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(13)</font></div>
</td>
<td style="vertical-align: middle; width: 4%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
51</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(58)</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
37</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(20)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(19)</font></div>
</td>
<td style="vertical-align: middle; width: 1%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(27)</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(20)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
BioPharmaceuticals: R&amp;I</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,509</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
437</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(19)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(19)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
645</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
17</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
277</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(7)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
150</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
5</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Symbicort</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
674</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
167</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
259</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
157</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(7)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
91</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Fasenra</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
308</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
18</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
22</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
189</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
22</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
75</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
20</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
29</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
37</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(5)</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Pulmicort</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
217</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(34)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(34)</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
164</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(43)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(43)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
22</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
26</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
18</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
20</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
13</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
24</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
28</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Breztri</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
87</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
22</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
53</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
46</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
59</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Saphnelo</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Daliresp</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
51</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(16)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(16)</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(25)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
47</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(13)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(45)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(41)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Bevespi</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
14</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
51</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
30</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
10</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
16</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
24</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
24</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
35</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Others</font></div>
</td>
<td style="vertical-align: bottom; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
146</font></div>
</td>
<td style="vertical-align: bottom; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(9)</font></div>
</td>
<td style="vertical-align: bottom; width: 7%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(9)</font></div>
</td>
<td style="vertical-align: bottom; width: 4%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
74</font></div>
</td>
<td style="vertical-align: bottom; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(3)</font></div>
</td>
<td style="vertical-align: bottom; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4)</font></div>
</td>
<td style="vertical-align: bottom; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
53</font></div>
</td>
<td style="vertical-align: bottom; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
47</font></div>
</td>
<td style="vertical-align: bottom; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17</font></div>
</td>
<td style="vertical-align: bottom; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(62)</font></div>
</td>
<td style="vertical-align: bottom; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(60)</font></div>
</td>
<td style="vertical-align: bottom; width: 1%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2</font></div>
</td>
<td style="vertical-align: bottom; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(53)</font></div>
</td>
<td style="vertical-align: bottom; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(51)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
BioPharmaceuticals: V&amp;I</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,757</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
630</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
386</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
286</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
15</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
22</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
455</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Vaxzevria</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,089</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
475</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
79</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
135</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(40)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(37)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
400</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Evusheld</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
469</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
89</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
307</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
65</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Synagis</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
200</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
66</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(97)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
87</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
47</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
FluMist</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 4%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(98)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(98)</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 1%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4)</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(2)</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Rare Disease*</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,694</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
3</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
115</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(12)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
3</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,020</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
361</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
8</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
198</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
10</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Soliris*</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
990</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(5)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
71</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(41)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
591</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
221</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(15)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(8)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
107</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
11</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Ultomiris*</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
419</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
20</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
25</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
24</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
220</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
105</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
54</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
65</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
70</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4)</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Strensiq*</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
208</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
65</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
68</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
161</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
3</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
19</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
19</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
19</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Koselugo</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
39</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
82</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
85</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
5</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
30</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
43</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Kanuma*</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
38</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
9</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15</font></div>
</td>
<td style="vertical-align: middle; width: 4%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
42</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
59</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
18</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
8</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
12</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(1)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
<td style="vertical-align: middle; width: 1%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
2</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
10</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other medicines</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
425</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(19)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(15)</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
204</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(31)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(29)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
39</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(24)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
36</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(31)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
(28)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
146</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
19</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
30</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Nexium</font></div>
</td>
<td style="vertical-align: middle; width: 7%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
332</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(18)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(13)</font></div>
</td>
<td style="vertical-align: middle; width: 4%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
144</font></div>
</td>
<td style="vertical-align: middle; width: 6%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(38)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(36)</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
33</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
4</font></div>
</td>
<td style="vertical-align: middle; width: 2%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
15</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(17)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(11)</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
140</font></div>
</td>
<td style="vertical-align: middle; width: 5%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17</font></div>
</td>
<td style="vertical-align: middle; width: 11%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
28</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Others</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
93</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(22)</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(22)</font></div>
</td>
<td style="vertical-align: middle; width: 4%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
60</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4)</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(4)</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(71)</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
21</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(39)</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
(37)</font></div>
</td>
<td style="vertical-align: middle; width: 1%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
6</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
n/m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 20%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total Product Sales</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
10,980</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
51</font></div>
</td>
<td style="vertical-align: middle; width: 7%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
56</font></div>
</td>
<td style="vertical-align: middle; width: 4%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
3,306</font></div>
</td>
<td style="vertical-align: middle; width: 6%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
28</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
30</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
3,986</font></div>
</td>
<td style="vertical-align: middle; width: 8%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
76</font></div>
</td>
<td style="vertical-align: middle; width: 2%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
2,092</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
36</font></div>
</td>
<td style="vertical-align: middle; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
46</font></div>
</td>
<td style="vertical-align: middle; width: 1%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,596</font></div>
</td>
<td style="vertical-align: middle; width: 5%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
83</font></div>
</td>
<td style="vertical-align: middle; width: 11%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
97</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 1px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;23: Collaboration Revenue</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 63%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2021</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
Lynparza</font><font style="color: #1F2222">: regulatory
milestones</font></font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
175</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
Enhertu</font><font style="color: #1F2222">: share of gross
profits</font></font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
75</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
38</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Royalty income</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
73</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
18</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Tralokinumab: sales milestones</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
70</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other Ongoing Collaboration Revenue</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
17</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
7</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
410</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
63</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Table&#xA0;24: Other Operating Income and Expense</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 63%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2022</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Q1 2021</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
$m</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Brazikumab licence termination funding</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
35</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
26</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Divestment of Viela Bio, Inc. shareholding</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
776</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #1F2222">
Crestor</font><font style="color: #1F2222">&#xA0;(Europe ex-UK and
Spain)</font></font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
-</font></div>
</td>
<td style="vertical-align: middle; width: 18%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
309</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
62</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
69</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 63%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Total</font></div>
</td>
<td style="vertical-align: middle; width: 0%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
97</font></div>
</td>
<td style="vertical-align: middle; width: 18%; border-bottom: 2px solid #000000">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1,180</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Other shareholder information</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Financial calendar</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Announcement of half year and second quarter results
&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0; 29
July 2022</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Announcement of year to date and third quarter results
&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0; 10 November
2022</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Announcement of full year and fourth quarter
results&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;
&#xA0; 9 February 2023 (tentative)</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Dividends are normally be paid as follows:</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
First interim:&#xA0; &#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;
Announced with the half-year and second-quarter results and paid in
September</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Second interim:&#xA0; &#xA0;&#xA0; Announced with full-year and
fourth-quarter results and paid in March</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
The record date for the first interim dividend for 2022, payable on
12 September 2022, will be 12 August 2022. The ex-dividend date
will be 11 August 2022.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Contacts</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
For details on how to contact the Investor Relations Team,
please&#xA0;</font><font style="text-decoration: underline; color: #0000FF">click
here</font><font style="color: #1F2222">. For Media
contacts,&#xA0;</font><font style="text-decoration: underline; color: #0000FF">click
here</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 16px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Addresses for correspondence</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: middle; width: 27%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 20%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 26%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 26%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 27%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Registered office</font></div>
</td>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Registrar and transfer office</font></div>
</td>
<td style="vertical-align: middle; width: 26%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Swedish Central Securities Depository</font></div>
</td>
<td style="vertical-align: middle; width: 26%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
US depositary</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Deutsche Bank Trust Company Americas</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 27%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
1 Francis Crick Avenue</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cambridge Biomedical Campus</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cambridge</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
CB2 0AA</font></div>
</td>
<td style="vertical-align: middle; width: 20%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Equiniti Limited</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Aspect House</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
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db@astfinancial.com</font></div>
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</div>
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<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Trademarks</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Trademarks of the AstraZeneca group of companies appear throughout
this document in italics. Medical publications also appear
throughout the document in italics. AstraZeneca, the AstraZeneca
logotype and the AstraZeneca symbol are all trademarks of the
AstraZeneca group of companies. Trademarks of companies other than
AstraZeneca that appear in this document
include&#xA0;</font><font style="font-style: italic; color: #1F2222">Arimidex&#xA0;</font><font style="color: #1F2222">and&#xA0;</font><font style="font-style: italic; color: #1F2222">Casodex</font><font style="color: #1F2222">,
owned by AstraZeneca or Juvis&#x17D; (depending on
geography);&#xA0;</font><font style="font-style: italic; color: #1F2222">Duaklir</font><font style="color: #1F2222">&#xA0;and&#xA0;</font><font style="font-style: italic; color: #1F2222">Eklira</font><font style="color: #1F2222">, trademarks of Almirall,
S.A.;&#xA0;</font><font style="font-style: italic; color: #1F2222">Enhertu,</font><font style="color: #1F2222">&#xA0;a trademark of Daiichi
Sankyo;&#xA0;</font><font style="font-style: italic; color: #1F2222">Seloken</font><font style="color: #1F2222">, owned by AstraZeneca or Taiyo Pharma Co., Ltd
(depending on geography);&#xA0;</font><font style="font-style: italic; color: #1F2222">Synagis</font><font style="color: #1F2222">, owned by AstraZeneca or AbbVie Inc. (depending
on geography);&#xA0;and&#xA0;</font><font style="font-style: italic; color: #1F2222">Tezspire</font><font style="color: #1F2222">, a trademark of Amgen, Inc.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
Information on or accessible through AstraZeneca's websites,
including www.astrazeneca.com&#xA0;</font><font style="text-decoration: underline; color: #0000FF">astrazeneca.com</font><font style="color: #1F2222">,
does not form part of and is not incorporated into this
announcement.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
AstraZeneca</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222">
AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led
biopharmaceutical company that focuses on the discovery,
development, and commercialisation of prescription medicines in
Oncology, Rare Disease, and BioPharmaceuticals, including
Cardiovascular, Renal &amp; Metabolism, and Respiratory &amp;
Immunology. Based in Cambridge, UK, AstraZeneca operates in over
100 countries and its innovative medicines are used by millions of
patients worldwide. Please visit&#xA0;</font><font style="text-decoration: underline; color: #0000FF">astrazeneca.com</font><font style="color: #1F2222">&#xA0;and
follow the Company on Twitter&#xA0;</font><font style="text-decoration: underline; color: #0000FF">@AstraZeneca</font><font style="color: #1F2222">.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #1F2222; font-family: Times New Roman; font-size: 13px">
Cautionary statements regarding forward-looking
statements</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
In order, among other things, to utilise the 'safe harbour'
provisions of the US Private Securities Litigation Reform Act of
1995, AstraZeneca (hereafter &#xD4;the Group') provides the
following cautionary statement:</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
This document contains certain forward-looking statements with
respect to the operations, performance and financial condition of
the Group, including, among other things, statements about expected
revenues, margins, earnings per share or other financial or other
measures. Although the Group believes its expectations are based on
reasonable assumptions, any forward-looking statements, by their
very nature, involve risks and uncertainties and may be influenced
by factors that could cause actual outcomes and results to be
materially different from those predicted. The forward-looking
statements reflect knowledge and information available at the date
of preparation of this document and the Group undertakes no
obligation to update these forward-looking statements. The Group
identifies the forward-looking statements by using the words
'anticipates', 'believes', 'expects', 'intends' and similar
expressions in such statements. Important factors that could cause
actual results to differ materially from those contained in
forward-looking statements, certain of which are beyond the Group's
control, include, among other things:</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Arial; font-size: 5px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of failure or delay in delivery of pipeline or launch of new
medicines</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of failure to meet regulatory or ethical requirements for
medicine development or approval</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of failures or delays in the quality or execution of the
Group's commercial strategies</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of pricing, affordability, access and competitive
pressures</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of failure to maintain supply of compliant, quality
medicines</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of illegal trade in the Group's medicines</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
impact of reliance on third-party goods and
services</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of failure in information technology or
cybersecurity</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of failure of critical processes</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of failure to collect and manage data in line with legal and
regulatory requirements and strategic
objectives</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of failure to attract, develop, engage and retain a diverse,
talented and capable workforce</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of failure to meet regulatory or ethical expectations on
environmental impact, including climate change</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of the safety and efficacy of marketed medicines being
questioned</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of adverse outcome of litigation and/or governmental
investigations</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">intellectual
property-related risks to our products</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of failure to achieve strategic plans or meet targets or
expectations</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of failure in financial control or the occurrence of
fraud</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
risk of unexpected deterioration in the Group's financial
position</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #1F2222; font-family: Times New Roman">&#x2012;&#xA0;&#xA0;&#xA0;&#xA0;</font><font style="color: #1F2222">the
impact that global and/or geopolitical events such as the COVID-19
pandemic and the Russia-Ukraine war, may have or continue to have
on these risks, on the Group's ability to continue to mitigate
these risks, and on the Group's operations, financial results or
financial condition</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
Nothing in this document, or any related presentation/webcast,
should be construed as a profit forecast.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #1F2222; font-family: Times New Roman; font-size: 13px">
- End of document -</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[29]</font><font style="color: #1F2222">&#xA0;A breast cancer gene
mutation.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[30]</font><font style="color: #1F2222">&#xA0;Systemic lupus
erythematosus.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[31]</font><font style="color: #1F2222">&#xA0;Non-small cell lung
cancer.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[32]</font><font style="color: #1F2222">&#xA0;Chronic lymphocytic
leukaemia.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[33]</font><font style="color: #1F2222">&#xA0;Real-Time Oncology
Review.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[34]</font><font style="color: #1F2222">&#xA0;Chronic kidney
disease.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[35]</font><font style="color: #1F2222">&#xA0;Heart failure with
preserved ejection fraction.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[36]</font><font style="color: #1F2222">&#xA0;Hereditary amyloid
transthyretin polyneuropathy.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[37]</font><font style="color: #1F2222">&#xA0;Interim analysis, as
disclosed by Ionis Pharmaceuticals, Inc.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[38]</font><font style="color: #1F2222">&#xA0;Eosinophilic
oesophagitis.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[39]</font><font style="color: #1F2222">&#xA0;Epidermal growth
factor receptor mutation.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[40]</font><font style="color: #1F2222">&#xA0;Mantle cell
lymphoma.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[41]</font><font style="color: #1F2222">&#xA0;Triple negative
breast cancer.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[42]</font><font style="color: #1F2222">&#xA0;Chronic
rhinosinusitis with nasal polyps.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[43]</font><font style="color: #1F2222">&#xA0;</font><font style="color: #3F4444">Eosinophilic granulomatosis with
polyangiitis.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[44]</font><font style="color: #1F2222">&#xA0;Sales of medicines
through managed care and other channels are subject to rebates,
discounts, return fees, etc.&#xA0; An estimate of the likely levels
of these items is subtracted from the gross (or total) sales of a
medicine in order to establish the net product sales.
A&#xA0;</font><font style="font-style: italic; color: #1F2222">gross-to-net
adjustment</font><font style="color: #1F2222">&#xA0;corrects any
divergence between the actual and prior estimated level of rebate,
discount or fee, once those items are known.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[45]</font><font style="color: #1F2222">&#xA0;Extensive stage
non-small cell lung cancer.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[46]</font><font style="color: #1F2222">&#xA0;Poly ADP ribose
polymerase.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[47]</font><font style="color: #1F2222">&#xA0;Homologous
recombination repair gene mutation.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[48]</font><font style="color: #1F2222">&#xA0;Mesenchymal&#xD0;epithelial
transition.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[49]</font><font style="color: #1F2222">&#xA0;Sodium-glucose
co-transporter-2.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[50]</font><font style="color: #1F2222">&#xA0;European Society of
Cardiology.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[51]</font><font style="color: #1F2222">&#xA0;American Heart
Association.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[52]</font><font style="color: #1F2222">&#xA0;American College of
Cardiology.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[53]</font><font style="color: #1F2222">&#xA0;Urine albumin
creatine ratio.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[54]</font><font style="color: #1F2222">&#xA0;Meaured renal
function.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[55]</font><font style="color: #1F2222">&#xA0;Type-2
diabetes.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[56]</font><font style="color: #1F2222">&#xA0;</font><font style="font-style: italic; color: #1F2222">Betaloc</font><font style="color: #1F2222">&#xA0;is the brand name
for&#xA0;</font><font style="font-style: italic; color: #1F2222">Seloken</font><font style="color: #1F2222">&#xA0;in China.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[57]</font><font style="color: #1F2222">&#xA0;Dipeptidyl peptidase
IV.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[58]</font><font style="color: #1F2222">&#xA0;Other Operating
Income.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[59]</font><font style="color: #1F2222">&#xA0;Core financial
measures are adjusted to exclude certain items. For more
information on the Reported to Core financial adjustments, please
refer to the Operating and financial review.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[60]</font><font style="color: #1F2222">&#xA0;Based on best
prevailing assumptions around currency
profiles.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[61]</font><font style="color: #1F2222">&#xA0;Based on average
daily spot rates in FY 2021.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[62]</font><font style="color: #1F2222">&#xA0;Based on average
daily spot rates from 1 January 2022 to 31 March
&#xA0;2022.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[63]</font><font style="color: #1F2222">&#xA0;Other currencies
include AUD, BRL, CAD, KRW and RUB.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[64]</font><font style="color: #1F2222">&#xA0;An immune checkpoint
receptor.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[65]</font><font style="color: #1F2222">&#xA0;</font><font style="color: #3F4444">Radiographic progression-free
survival.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[66]</font><font style="color: #1F2222">&#xA0;Metastatic
castration-resistant prostate cancer.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[67]</font><font style="color: #1F2222">&#xA0;Homologous
recombination repair.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[68]</font><font style="color: #1F2222">&#xA0;Hazard
ratio.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[69]</font><font style="color: #1F2222">&#xA0;Overall
survival.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[70]</font><font style="color: #1F2222">&#xA0;</font><font style="color: #3F4444">Progression-free survival.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[71]</font><font style="color: #1F2222">&#xA0;Supplemental
Biologics License Application.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[72]</font><font style="color: #1F2222">&#xA0;Low-density
lipoprotein cholesterol.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[73]</font><font style="color: #1F2222">&#xA0;Complete response
letter.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[74]</font><font style="color: #1F2222">&#xA0;Lower respiratory
tract infections.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: -12px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 70%; vertical-align: top; text-decoration: underline; color: #0000FF">
[75]</font><font style="color: #1F2222">&#xA0;The table provides an
analysis of year-on-year Product Sales, with Actual and CER growth
rates reflecting year-on-year growth. Due to rounding, the sum of a
number of dollar values and percentages may not agree to totals. *
FY 2022 Q1 growth rates on medicines acquired with Alexion have
been calculated on a pro forma basis comparing to the corresponding
period in the prior year, pre-acquisition as previously published
by Alexion. The growth rates shown for Rare Disease and CVRM
disease area totals include these pro forma
adjustments.</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; font-family: Times New Roman; font-size: 13px">
SIGNATURES</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Pursuant
to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf
by the undersigned, thereunto duly authorized.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
PLC</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Date:
<font style="font-size: 13px">29 April 2022</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">By: /s/
Adrian Kemp</font></div>
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<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Name:
Adrian Kemp</font></div>
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</tr><tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Title:
Company Secretary</font></div>
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