<SEC-DOCUMENT>0001654954-24-014697.txt : 20241120
<SEC-HEADER>0001654954-24-014697.hdr.sgml : 20241120
<ACCEPTANCE-DATETIME>20241120111512
ACCESSION NUMBER:		0001654954-24-014697
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20241120
FILED AS OF DATE:		20241120
DATE AS OF CHANGE:		20241120

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ASTRAZENECA PLC
		CENTRAL INDEX KEY:			0000901832
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-11960
		FILM NUMBER:		241478827

	BUSINESS ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA
		BUSINESS PHONE:		011 44 20 7304 5000

	MAIL ADDRESS:	
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB2 0AA

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ZENECA GROUP PLC
		DATE OF NAME CHANGE:	19930422
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>a0144n.htm
<DESCRIPTION>DIRECTOR/PDMR SHAREHOLDING
<TEXT>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">FORM
6-K</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">SECURITIES
AND EXCHANGE COMMISSION</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Washington,
D.C. 20549</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Report
of Foreign Issuer</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Pursuant
to Rule 13a-16 or 15d-16 of</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">the
Securities Exchange Act of 1934</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">For the
month of November 2024</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Commission
File Number: 001-11960</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">1
Francis Crick Avenue</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Cambridge
Biomedical Campus</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Cambridge
CB2 0AA</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">United
Kingdom</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Indicate
by check mark whether the registrant files or will file annual
reports under cover of Form 20-F or Form 40-F.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Form
20-F X Form 40-F __</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Indicate
by check mark if the registrant is submitting the Form 6-K in paper
as permitted by Regulation S-T Rule 101(b)(1):</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Indicate
by check mark if the registrant is submitting the Form 6-K in paper
as permitted by Regulation S-T Rule 101(b)(7): ______</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Indicate
by check mark whether the registrant by furnishing the information
contained in this Form is also thereby furnishing the information
to the Commission pursuant to Rule 12g3-2(b) under the Securities
Exchange Act of 1934.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Yes __
No X</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">If
&#x201C;Yes&#x201D; is marked, indicate below the file number
assigned to the Registrant in connection with Rule 12g3-2(b):
82-_____________</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><br></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">INDEX
TO EXHIBITS</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<div style="display: table-row">
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<font style="font-weight: bold; font-style: italic; font-family: Times New Roman; font-size: 13px">
1.</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-weight: bold; font-style: italic; font-family: Times New Roman; font-size: 13px">
Director/PDMR Shareholding</font></div>
</div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
20 November 2024 16:00 GMT</font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
Transaction by Person Discharging Managerial
Responsibilities</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
PLC (the Company) announces that it was notified on 20 November
2024 that Tony Mok, Non-Executive Director, purchased 3,000 of the
Company's&#xA0;<font style="color: #000000">American Depositary
Shares (ADSs) on 19 November 2024</font>, as set out
below.&#xA0;<font style="color: #000000">Two ADSs are equivalent to
one of the</font>&#xA0;Company's ordinary shares of $0.25
each<font style="color: #000000">.</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 20%; border-left: 0.5pt solid #000000; border-top: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.35;">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #000000">PDMR</font><font style="color: #000000">&#xA0;</font></font></div>
</td>
<td style="vertical-align: top; width: 27%; border-left: 0.5pt solid #000000; border-top: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.35;">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #000000">Position</font><font style="color: #000000">&#xA0;</font></font></div>
</td>
<td style="vertical-align: top; width: 26%; border-left: 0.5pt solid #000000; border-top: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.35;">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #000000">Nature of the
transaction</font><font style="color: #000000">&#xA0;</font></font></div>
</td>
<td style="vertical-align: top; width: 12%; border-left: 0.5pt solid #000000; border-top: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.35;">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #000000">Quantity</font><font style="color: #000000">&#xA0;</font></font></div>
</td>
<td style="vertical-align: top; width: 16%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-top: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.35;">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #000000">Price</font><font style="color: #000000">&#xA0;</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 20%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.35;">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">T</font>ony Mok</font></div>
</td>
<td style="vertical-align: top; width: 27%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.35;">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">N</font>on-Executive Director</font></div>
</td>
<td style="vertical-align: top; width: 26%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.35;">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">Purchase of A</font>DSs<font style="color: #000000">&#xA0;</font></font></div>
</td>
<td style="vertical-align: top; width: 12%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.35;">
<font style="font-family: Times New Roman; font-size: 13px">3,000</font></div>
</td>
<td style="vertical-align: top; width: 16%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.35;">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">U</font>S$63.40</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Further
details are set out in the attached notification, made in
accordance with the requirements of the EU Market Abuse Regulation
(since it forms part of UK law pursuant to the European Union
(Withdrawal) Act 2018).</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="line-height: 1.15;">
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-top: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
1</font> <font style="font-family: Times New Roman; font-size: 13px"><br></font></div>
</td>
<td colspan="3" style="vertical-align: top; width: 97%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-top: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Details of the person discharging managerial responsibilities /
person closely associated</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">a)</font></div>
</td>
<td style="vertical-align: top; width: 34%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Name</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 63%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-family: Times New Roman; font-size: 13px">Tony
Mok</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
2</font> <font style="font-family: Times New Roman; font-size: 13px"><br></font></div>
</td>
<td colspan="3" style="vertical-align: top; width: 97%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Reason for the notification</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">a)</font>
<font style="font-family: Times New Roman; font-size: 13px"><br>
</font></div>
</td>
<td style="vertical-align: top; width: 34%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Position/status</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 63%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-family: Times New Roman; font-size: 13px">Non-Executive
Director</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">b)</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
</div>
</td>
<td style="vertical-align: top; width: 34%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Initial
notification /Amendment</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 63%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-family: Times New Roman; font-size: 13px">Initial
notification</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
3</font> <font style="font-family: Times New Roman; font-size: 13px"><br></font></div>
</td>
<td colspan="3" style="vertical-align: top; width: 97%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Details of the issuer, emission allowance market participant,
auction platform, auctioneer or auction monitor</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">a)</font></div>
</td>
<td style="vertical-align: top; width: 34%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Name</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 63%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
PLC</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">b)</font></div>
</td>
<td style="vertical-align: top; width: 34%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">LEI</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 63%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-family: Times New Roman; font-size: 13px">PY6ZZQWO2IZFZC3IOL08</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
4</font></div>
</td>
<td colspan="3" style="vertical-align: top; width: 97%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-weight: bold; font-family: Times New Roman; font-size: 13px">
Details of the transaction(s): section to be repeated for (i) each
type of instrument; (ii) each type of transaction; (iii) each date;
and (iv) each place where transactions have been
conducted</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">a)</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 34%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Description
of the financial instrument, type of instrument</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-family: Times New Roman; font-size: 13px">Identification
code</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 63%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; background-color: #FFFFFF; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC American Depositary Shares</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; background-color: #FFFFFF; font-family: Times New Roman; font-size: 13px">
CUSIP: 046353108</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
</div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">b)</font></div>
</td>
<td style="vertical-align: top; width: 34%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Nature
of the transaction</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 63%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; background-color: #FFFFFF; font-family: Times New Roman; font-size: 13px">
Purchase of AstraZeneca PLC American Depositary Shares</font></div>
</td>
</tr><tr>
<td rowspan="2" style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">c)</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td rowspan="2" style="vertical-align: top; width: 34%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Price(s)
and volume(s)</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 31%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-family: Times New Roman; font-size: 13px">Price(s)</font></div>
</td>
<td style="vertical-align: top; width: 31%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Volume(s)</font></div>
</td>
</tr><tr>
<td style="vertical-align: bottom; width: 31%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">USD
63.398167</font></div>
</td>
<td style="vertical-align: top; width: 31%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
3,000</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">d)</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 34%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.15;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Aggregated
information</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.15;">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.15;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">-
Aggregated volume</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.15;">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.15;">
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; line-height: 1.15;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">-
Price</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 63%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Not
applicable - single transaction</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
</div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">e)</font></div>
</td>
<td style="vertical-align: top; width: 34%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Date
of the transaction</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 63%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-family: Times New Roman; font-size: 13px">19
November 2024</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 3%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">f)</font></div>
</td>
<td style="vertical-align: top; width: 34%; border-left: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">Place
of the transaction</font></div>
</td>
<td colspan="2" style="vertical-align: top; width: 63%; border-left: 0.5pt solid #000000; border-right: 0.5pt solid #000000; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; padding-bottom: 8px; line-height: 1.1;">
<font style="font-family: Times New Roman; font-size: 13px">XNAS</font></div>
</td>
</tr></table>
</div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="text-decoration: underline; color: #0000FF">AstraZeneca</font>&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
(LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical
company that focuses on the discovery, development, and
commercialisation of prescription medicines in Oncology, Rare
Diseases, and BioPharmaceuticals, including Cardiovascular, Renal
&amp; Metabolism, and Respiratory &amp; Immunology. Based in
Cambridge, UK, AstraZeneca's innovative medicines are sold in more
than 125 countries and used by millions of patients worldwide.
Please visit&#x202F;<font style="text-decoration: underline; color: #0000FF">astrazeneca.com</font>&#x202F;and
follow the Company on social media&#x202F;<font style="text-decoration: underline; color: #0000FF">@AstraZeneca</font><font style="color: #0000FF">&#xA0;</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
Contacts</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">For
details on how to contact the Investor Relations Team, please
click&#xA0;<font style="text-decoration: underline; color: #0000FF">here</font>. For Media
contacts, click&#xA0;<font style="text-decoration: underline; color: #0000FF">here</font>.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
Adrian Kemp</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
Company Secretary</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; font-family: Times New Roman; font-size: 13px">
SIGNATURES</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Pursuant
to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf
by the undersigned, thereunto duly authorized.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
PLC</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Date:
<font style="font-size: 13px">20 November 2024</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">By: /s/
Adrian Kemp</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Name:
Adrian Kemp</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 71%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Title:
Company Secretary</font></div>
</td>
</tr></table>
</div>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
