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Basis of preparation and accounting policies (Details) - USD ($) $ in Millions | 3 Months Ended | 6 Months Ended |
--- | --- | --- | ---
Jun. 30, 2025 | Jun. 30, 2024 | Jun. 30, 2025 | Jun. 30, 2024 | Dec. 31, 2024
Disclosure of detailed information about borrowings [line items] |  |  |  |  |
Product revenue | $ 14,449 | $ 12,934 | $ 27,963 | $ 25,568 |
Alliance revenue | 654 | 482 | 1,293 | 939 |
Borrowings | 32,839 |  | 32,839 |  | $ 30,295
Going concern |  |  |  |  |
Financial resources | 11,900 |  | 11,900 |  |
Cash and cash equivalents | 7,058 | $ 6,916 | 7,058 | $ 6,916 | $ 5,488
Undrawn committed bank facilities | 4,900 |  | 4,900 |  |
Due within one year |  |  |  |  |
Disclosure of detailed information about borrowings [line items] |  |  |  |  |
Borrowings | $ 6,900 |  | $ 6,900 |  |

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