<SEC-DOCUMENT>0001654954-25-012262.txt : 20251028
<SEC-HEADER>0001654954-25-012262.hdr.sgml : 20251028
<ACCEPTANCE-DATETIME>20251028080256
ACCESSION NUMBER:		0001654954-25-012262
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20251028
FILED AS OF DATE:		20251028
DATE AS OF CHANGE:		20251028

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ASTRAZENECA PLC
		CENTRAL INDEX KEY:			0000901832
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-11960
		FILM NUMBER:		251421489

	BUSINESS ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		PROVINCE COUNTRY:   	X0
		ZIP:			CB2 0AA
		BUSINESS PHONE:		011 44 20 7304 5000

	MAIL ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		PROVINCE COUNTRY:   	X0
		ZIP:			CB2 0AA

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ZENECA GROUP PLC
		DATE OF NAME CHANGE:	19930422
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>a0174f.htm
<DESCRIPTION>KOSELUGO (SELUMETINIB) APPROVED IN THE EU
<TEXT>
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1.</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-weight: bold; font-style: italic; font-family: Times New Roman; font-size: 13px">
Koselugo (selumetinib) approved in the EU</font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
28 October 2025</font></div>
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&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; font-style: italic; color: #000000; font-size: 13px">
Koselugo</font><font style="color: #000000">&#xA0;</font><font style="font-weight: bold; color: #000000; font-size: 13px">approved in
the EU</font><font style="color: #000000">&#xA0;</font><font style="font-weight: bold; color: #000000; font-size: 13px">for plexiform
neurofibromas in adults with neurofibromatosis type
1</font></font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
Approval based on KOMET Phase III trial results which showed 20%
objective response rate in tumour size reduction</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
Alexion, AstraZeneca Rare Disease's&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;(selumetinib), an oral, selective MEK
inhibitor, has been approved in the European Union (EU) for the
treatment of symptomatic, inoperable plexiform neurofibromas (PN)
in adult patients with neurofibromatosis type 1
(NF1).</font><font style="font-size: 70%; vertical-align: top; color: #000000">1</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
The approval by&#xA0;the European Commission follows
the&#xA0;</font><font style="text-decoration: underline; color: #0000FF">positive
opinion</font><font style="color: #000000">&#xA0;of the Committee
for Medicinal Products for Human Use (CHMP) and&#xA0;is based on
results from KOMET, the largest and only placebo-controlled global
Phase III trial in this patient population, which were presented at
the 2025 American Society of Clinical Oncology (ASCO) Annual
Meeting and published in&#xA0;</font><font style="font-style: italic; text-decoration: underline; color: #0000FF">The
Lancet</font><font style="color: #000000">.</font><font style="font-size: 70%; vertical-align: top; color: #000000">2</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
NF1 is a rare, progressive, genetic condition usually diagnosed in
early childhood, but often progressing into adulthood, that can
impact every organ system.</font><font style="font-size: 70%; vertical-align: top; color: #000000">3,4</font><font style="color: #000000">&#xA0;Up
to 50% of people living with NF1 may develop a type of
non-malignant tumour called PN that may affect the brain, spinal
cord and nerves.</font><font style="font-size: 70%; vertical-align: top; color: #000000">4,5</font><font style="color: #000000">&#xA0;PN
may appear later in a person's life and can grow and become large,
leading to pain, disfigurement and muscle weakness, among other
debilitating symptoms.</font><font style="font-size: 70%; vertical-align: top; color: #000000">4,5</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
Prof. Pierre Wolkenstein, MD, PhD, Head of the Department of
Dermatology at Henri Mondor Hospital, APHP, Paris East University
(UPEC), and National Coordinating Investigator of the KOMET trial
in Europe, said: "The approval of&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;for adults with NF1 PN in Europe offers
patients and physicians a meaningful approach to close treatment
gaps beyond childhood. As demonstrated in the KOMET Phase III
trial, the most robust late-stage clinical trial conducted in this
patient group to-date, adults administered&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;saw significant tumour volume reduction with
a safety profile consistent with its established use in paediatric
patients, validating the clinical benefits
of&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;for newly diagnosed adults and those
transitioning to adult care."</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
Marc Dunoyer, Chief Executive Officer, Alexion, said: "The European
Commission approval extends the life-changing potential
of&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;to adults with NF1 PN in the region,
including continuity of care into adulthood. This milestone, along
with our pioneering leadership in NF1 PN treatment landscape,
embodies Alexion's unwavering commitment to addressing the unmet
needs in the rare disease community. We look forward to
bringing&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;to those adults in need across Europe as
soon as possible."</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
In the primary analysis of the trial,&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;showed a statistically significant objective
response rate (ORR) of 20% (n=14/71, 95% CI: 11.2, 30.9) compared
to 5% with placebo (n=4/74, 95% CI: 1.5, 13.3; p=0.01) by cycle 16.
After 12 cycles, patients on placebo were switched
to&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;and patients on&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;remained on treatment for an additional 12
cycles.</font><font style="font-size: 70%; vertical-align: top; color: #000000">2</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
The safety profile of&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;in the KOMET Phase III trial was consistent
with its known profile and established use in paediatric
patients.</font><font style="font-size: 70%; vertical-align: top; color: #000000">2</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000">
Koselugo</font><font style="color: #000000">&#xA0;has been recently
approved in Japan and other countries for the treatment of adult
patients with NF1 who have symptomatic, inoperable PN based on data
from the KOMET Phase III trial, and additional regulatory reviews
are ongoing.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #000000; font-weight: bold; font-family: Times New Roman; font-size: 13px">
Notes</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #000000">
NF1</font><font style="color: #000000">&#xA0;</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
NF1 is a rare, progressive, genetic condition that is caused by a
spontaneous or inherited mutation in the NF1
gene.</font><font style="font-size: 70%; vertical-align: top; color: #000000">3,4</font><font style="color: #000000">&#xA0;NF1
is associated with a variety of symptoms, including soft lumps on
and under the skin (cutaneous neurofibromas) and, in up to 50% of
patients, tumours&#xA0;called plexiform neurofibromas (PN)&#xA0;may
develop on the nerve sheaths.</font><font style="font-size: 70%; vertical-align: top; color: #000000">4,5</font><font style="color: #000000">&#xA0;These
PN can cause clinical issues such as disfigurement, motor
dysfunction, pain, airway dysfunction, visual impairment and
bladder or bowel dysfunction.</font><font style="font-size: 70%; vertical-align: top; color: #000000">4,5</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
KOMET</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
KOMET is a global Phase III randomised, double-blind,
placebo-controlled, multicentre trial designed to evaluate the
efficacy and safety of&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;in adults with NF1 who have symptomatic,
inoperable PN. The trial enrolled 145 adults from 13 countries
across North America, South America, Europe, Asia and Australia,
with participants' baseline characteristics, including gender and
distribution of PN, reflective of the global adult NF1 patient
population. Patients were enrolled and randomised to
receive&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;or placebo (1:1) for 12 28-day cycles.
Participants were required to have diagnosis of NF1, at least one
symptomatic, inoperable PN measurable by volumetric MRI analysis,
chronic PN pain score documented during screening, adequate organ
and marrow function and stable chronic PN pain medication use at
enrolment.</font><font style="font-size: 70%; vertical-align: top; color: #000000">2,6</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
The primary endpoint is confirmed objective response rate (ORR) by
cycle 16 as assessed by ICR. ORR is defined as the percentage of
patients with confirmed complete response (disappearance of PNs) or
partial response (at least 20% reduction in tumour volume).
Secondary endpoints include improved PN-related pain and
health-related quality of life (HRQoL) at cycle
12.</font><font style="font-size: 70%; vertical-align: top; color: #000000">2,6</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
After 12 cycles, patients on placebo were switched
to&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;and patients on&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;remained on treatment for an additional 12
cycles. Patients who had the opportunity to complete 24 cycles of
treatment have the option to participate in a long-term extension
period and continue to receive&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">.</font><font style="font-size: 70%; vertical-align: top; color: #000000">2,6</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; font-style: italic; color: #000000">
Koselugo</font><font style="color: #000000">&#xA0;</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000">
Koselugo&#xA0;</font><font style="color: #000000">(selumetinib) is
a kinase inhibitor that blocks specific enzymes (MEK1 and MEK2),
which are involved in stimulating cells to grow. In NF1, these
enzymes are overactive, causing tumour cells to grow in an
unregulated way creating so-called plexiform neurofibromas (PN). By
blocking these enzymes,</font><font style="font-style: italic; color: #000000">&#xA0;Koselugo</font><font style="color: #000000">&#xA0;slows
down the growth of tumour cells and, therefore, the PN
growth.&#xA0;</font></font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
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<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000">
Koselugo</font><font style="color: #000000">&#xA0;is approved in
the US, EU, Japan, China and other countries for the treatment of
certain paediatric patients with NF1 who have symptomatic,
inoperable PN.</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000">
Koselugo</font><font style="color: #000000">&#xA0;is approved in
the EU, Japan and other countries for the treatment of adult
patients with NF1 who have symptomatic, inoperable PN, and
additional regulatory reviews are ongoing.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
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<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000">
Koselugo</font><font style="color: #000000">&#xA0;has been granted
Orphan Drug Designation in the US, EU, Japan and other countries
for the treatment of NF1.</font></font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
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<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; color: #000000">
AstraZeneca and MSD Strategic Collaboration</font><font style="color: #000000">&#xA0;</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
In July 2017, AstraZeneca and Merck &amp; Co., Inc., Rahway, NJ,
US, known as MSD outside the US and Canada, announced a global
strategic collaboration to co-develop and
co-commercialise&#xA0;</font><font style="font-style: italic; color: #000000">Lynparza</font><font style="color: #000000">&#xA0;(olaparib), a first-in-class PARP inhibitor,
and&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">. The companies may
develop&#xA0;</font><font style="font-style: italic; color: #000000">Lynparza&#xA0;</font><font style="color: #000000">and&#xA0;</font><font style="font-style: italic; color: #000000">Koselugo</font><font style="color: #000000">&#xA0;in
combination with other potential new medicines and as
monotherapies.&#xA0;</font></font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
Alexion, AstraZeneca Rare Disease, is focused on serving patients
and families affected by rare diseases and devastating conditions
through the discovery, development and delivery of life-changing
medicines. A pioneering leader in rare disease for more than three
decades, Alexion was the first to translate the complex biology of
the complement system into transformative medicines, and today it
continues to build a diversified pipeline across disease areas with
significant unmet need, using an array of innovative modalities. As
part of AstraZeneca, Alexion is continually expanding its global
geographic footprint to serve more rare disease patients around the
world. It is headquartered in Boston, US.&#xA0;</font></div>
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AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led
biopharmaceutical company that focuses on the discovery,
development, and commercialisation of prescription medicines in
Oncology, Rare Diseases, and BioPharmaceuticals, including
Cardiovascular, Renal &amp; Metabolism, and Respiratory &amp;
Immunology. Based in Cambridge, UK, AstraZeneca's innovative
medicines are sold in more than 125 countries and used by millions
of patients worldwide. Please visit&#xA0;</font><font style="text-decoration: underline; color: #0000FF">astrazeneca.com</font><font style="color: #000000">&#xA0;and
follow the Company on Social Media&#xA0;</font><font style="text-decoration: underline; color: #0000FF">@AstraZeneca</font><font style="color: #000000">.&#xA0;</font></font></div>
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References</font><font style="color: #000000">&#xA0;</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000; font-size: 13px">1.&#xA0;&#xA0;</font><font style="color: #000000">&#xA0;</font><font style="font-style: italic; color: #000000; font-size: 13px">Koselugo</font><font style="color: #000000">&#xA0;</font><font style="color: #000000; font-size: 13px; background-color: #FFFFFF">(selumetinib)
SmPC; October 2025.&#xA0;</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">2.&#xA0;&#xA0; Chen, AP, et al. KOMET: a phase 3,
multicentre, international, randomised, placebo-controlled study to
assess the efficacy and safety of selumetinib in adults with
neurofibromatosis type 1 and symptomatic, inoperable plexiform
neurofibromas.&#xA0;</font><font style="font-style: italic; color: #000000">The Lancet.</font><font style="color: #000000">&#xA0;2025;405(10496):2217-2230.</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">3.&#xA0;&#xA0; Tamura R. Current understanding of
neurofibromatosis type 1, 2, and schwannomatosis</font><font style="font-style: italic; color: #000000">. Int J Mol
Sci.</font><font style="color: #000000">&#xA0;2021;22(11):5850.</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">4.&#xA0;&#xA0; Hirbe AC, et al. Neurofibromatosis
type 1: a multidisciplinary approach to
care.&#xA0;</font><font style="font-style: italic; color: #000000">Lancet
Neurol.</font><font style="color: #000000">&#xA0;2014;13:834-843.</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">5.&#xA0;&#xA0; Bergqvist C, et al.
Neurofibromatosis 1 French national guidelines based on an
extensive literature review since 1966.&#xA0;</font><font style="font-style: italic; color: #000000">Orphanet J Rare
Dis</font><font style="color: #000000">.
2020;15(1):37.</font></font></div>
<div style="text-align: justify; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000; font-size: 13px">6.&#xA0;&#xA0;
ClinicalTrials.gov. Efficacy and safety of selumetinib in adults
with NF1 who have symptomatic, inoperable plexiform neurofibromas
(KOMET). NCT Identifier: NCT04924608. Available</font><font style="color: #000000">&#xA0;</font><font style="text-decoration: underline; color: #0000FF; font-size: 13px">here</font><font style="color: #000000; font-size: 13px">.
Accessed October 2025.</font></font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Matthew Bowden</font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Company Secretary</font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
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SIGNATURES</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Pursuant
to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf
by the undersigned, thereunto duly authorized.</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
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Date:</font> 28 October<font style="font-weight: bold">&#xA0;</font>2025</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">By: /s/
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