<SEC-DOCUMENT>0001654954-26-003206.txt : 20260402
<SEC-HEADER>0001654954-26-003206.hdr.sgml : 20260402
<ACCEPTANCE-DATETIME>20260402092728
ACCESSION NUMBER:		0001654954-26-003206
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20260402
FILED AS OF DATE:		20260402
DATE AS OF CHANGE:		20260402

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ASTRAZENECA PLC
		CENTRAL INDEX KEY:			0000901832
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-11960
		FILM NUMBER:		26830964

	BUSINESS ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		PROVINCE COUNTRY:   	X0
		ZIP:			CB2 0AA
		BUSINESS PHONE:		011 44 20 7304 5000

	MAIL ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		1 FRANCIS CRICK AVENUE
		STREET 2:		CAMBRIDGE BIOMEDICAL CAMPUS
		CITY:			CAMBRIDGE
		PROVINCE COUNTRY:   	X0
		ZIP:			CB2 0AA

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ZENECA GROUP PLC
		DATE OF NAME CHANGE:	19930422
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>a2331z.htm
<DESCRIPTION>IMFINZI+IMJUDO IMPROVES PFS IN EARLY LIVER CANCER
<TEXT>
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TO EXHIBITS</font></div>
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<font style="font-weight: bold; font-style: italic; font-family: Times New Roman; font-size: 13px">
1.</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-weight: bold; font-style: italic; font-family: Times New Roman; font-size: 13px">
Imfinzi+Imjudo improves PFS in early liver cancer</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
2 April 2026</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; font-style: italic; color: #000000">
&#xA0;Imfinzi</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="font-weight: bold; color: #000000">plus&#xA0;</font><font style="font-weight: bold; font-style: italic; color: #000000">Imjudo</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="font-weight: bold; color: #000000">combined</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="font-weight: bold; color: #000000">with
lenvatinib and TACE</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="font-weight: bold; color: #000000">demonstrated
a statistically significant and clinically meaningful improvement
in progression-free survival in</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="font-weight: bold; color: #000000">embolisation-eligible&#xA0;unresectable
liver cancer in EMERALD-3 Phase III trial</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
Imfinzi plus Imjudo combined with lenvatinib and transarterial
chemoembolisation (TACE) showed trend toward improved overall
survival</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
Positive high-level results from the EMERALD-3 Phase III trial
showed AstraZeneca's&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;(durvalumab) in combination
with&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">&#xA0;(tremelimumab), lenvatinib and transarterial
chemoembolisation (TACE) demonstrated a statistically significant
and clinically meaningful improvement in the primary endpoint of
progression-free survival (PFS) versus TACE alone for patients with
unresectable hepatocellular carcinoma (HCC) eligible for
embolisation.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
At this interim analysis for overall survival (OS), a key secondary
endpoint, this combination also demonstrated a trend toward OS
improvement versus TACE alone.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
Patients in the investigational arms were treated with the STRIDE
regimen (Single Tremelimumab Regular Interval Durvalumab), with or
without lenvatinib, before TACE, and then alongside
TACE.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
Although not formally tested at this time, data for the treatment
arm evaluating the STRIDE regimen plus TACE versus TACE alone
showed strong trends toward improved PFS and OS.</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="color: #000000">The
trial will continue to follow OS and other key secondary endpoints
in both investigational arms.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
HCC is the most common type of liver cancer.</font><font style="font-size: 70%; vertical-align: top; color: #000000">1</font><font style="color: #000000">&#xA0;In
2026, more than 200,000 patients with HCC will be eligible for
embolisation, a standard-of-care procedure that blocks the blood
supply to the tumour and can also deliver chemotherapy directly to
the liver.</font><font style="font-size: 70%; vertical-align: top; color: #000000">2-4</font><font style="color: #000000">&#xA0;However,
most patients who receive embolisation experience disease
progression or recurrence within six to ten
months.</font><font style="font-size: 70%; vertical-align: top; color: #000000">5</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
Ghassan Abou-Alfa, MD, JD, MBA, PhD(hc), Attending Physician,
Professor of Medicine at Memorial Sloan Kettering Cancer Center,
and principal investigator in the trial said, "Dual immunotherapy
with durvalumab and tremelimumab in the STRIDE regimen represents a
meaningful advance for patients with embolisation-eligible liver
cancer, who currently lack systemic treatment options to keep their
cancer from progressing or recurring, with a trend of improving
survival. EMERALD</font><font style="color: #000000; font-family: Times New Roman">-</font><font style="color: #000000">3 shows we can now significantly reduce the risk
of disease progression with STRIDE as the immunotherapy backbone
alongside lenvatinib and TACE."</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
Susan Galbraith, Executive Vice President, Oncology Haematology
R&amp;D, AstraZeneca, said: "EMERALD</font><font style="color: #000000; font-family: Times New Roman">-</font><font style="color: #000000">3 now shows that bringing the dual immunotherapy
STRIDE regimen earlier, alongside TACE and lenvatinib, can further
improve outcomes in earlier</font><font style="color: #000000; font-family: Times New Roman">-</font><font style="color: #000000">stage liver cancer. This builds on the HIMALAYA
Phase III trial data in patients with advanced, unresectable
disease, where the STRIDE regimen has already demonstrated durable
overall survival benefit. We are discussing these positive data
with global regulatory authorities while awaiting the final results
from the key secondary endpoints."</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
The safety profile for each combination was consistent with the
known profiles of each medicine, and there were no new safety
findings.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
These data will be presented at a forthcoming medical meeting and
shared with global regulatory authorities.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
+++</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #000000; font-weight: bold; font-family: Times New Roman; font-size: 13px">
Notes</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Liver cancer</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
Liver cancer, of which HCC is the most common type, is the
third-leading cause of cancer death.</font><font style="font-size: 70%; vertical-align: top; color: #000000">1,6</font><font style="color: #000000">&#xA0;In
2026, more than 200,000 patients will be diagnosed with
embolisation-eligible HCC.</font><font style="font-size: 70%; vertical-align: top; color: #000000">2</font><font style="color: #000000">&#xA0;Embolisation
is a standard-of-care procedure that blocks the blood supply to the
tumour and can also deliver chemotherapy directly to the
liver.</font><font style="font-size: 70%; vertical-align: top; color: #000000">3-4</font><font style="color: #000000">&#xA0;&#xA0;</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
Immunotherapy is a proven treatment modality in HCC with approved
options available for patients in later-line
settings.</font><font style="font-size: 70%; vertical-align: top; color: #000000">7</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
EMERALD-3</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
EMERALD-3 is a randomised, open-label, sponsor-blinded,
multicentre, global Phase III trial of a single priming dose
of&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">&#xA0;300mg added to&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;1500mg followed by&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;every four weeks (STRIDE regimen) plus TACE
with or without lenvatinib versus TACE alone in a total of 760
patients with unresectable HCC eligible for
embolisation.</font></font></div>
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Participants were randomised in a 1:1:1 ratio to Arm A
(TACE,&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">,&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">, lenvatinib), Arm B
(TACE,&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">,&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">) and Arm C (TACE) until each arm reached 175
participants. Randomisation was then continued in a 1:1 ratio to
treatment Arms A and C until each reached approximately 275
participants. Patients received&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;with&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo,</font><font style="color: #000000">&#xA0;plus TACE as needed, with or without
lenvatinib concurrently, followed by&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;with or without lenvatinib until
progression.</font></font></div>
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The trial was conducted in 171 centres across 22 countries,
including in North America, Europe, South America and Asia. The
primary endpoint is PFS for&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;plus&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">, lenvatinib and TACE versus TACE alone. Secondary
endpoints include OS for&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;plus&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">, lenvatinib and TACE, and PFS and OS
for&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;plus&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">&#xA0;and TACE versus TACE
alone.</font></font></div>
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<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
Imfinzi</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000; font-size: 13px">
Imfinzi</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="color: #000000; font-size: 13px">(durvalumab)
is a human monoclonal antibody that binds to the PD-L1 protein and
blocks the interaction of PD-L1 with the PD-1 and CD80 proteins,
countering the tumour's immune-evading tactics and releasing the
inhibition of immune responses.</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
In gastrointestinal (GI) cancer,&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;is approved in combination with chemotherapy
in locally advanced or metastatic biliary tract cancer (BTC) and in
combination with&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">&#xA0;in unresectable
HCC.&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;is
also approved as a monotherapy in unresectable HCC in Japan and the
EU.</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
In addition to its indications in GI
cancers,&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;is the global standard of care based on OS
in the curative-intent setting of unresectable, Stage III non-small
cell lung cancer (NSCLC) in patients whose disease has not
progressed after chemoradiotherapy (CRT).
Additionally,&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;is approved as a perioperative treatment in
combination with neoadjuvant chemotherapy in resectable NSCLC, and
in combination with a short course of&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">&#xA0;and chemotherapy for the treatment of
metastatic NSCLC.&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;is also approved for limited-stage small
cell lung cancer (SCLC) in patients whose disease has not
progressed following concurrent platinum-based CRT; and in
combination with chemotherapy for the treatment of extensive-stage
SCLC.</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
Perioperative&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;in combination with neoadjuvant chemotherapy
is approved in the US, EU, Japan and other countries for patients
with muscle-invasive bladder cancer based on results from the
NIAGARA Phase III trial. Additionally, in May
2025,&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;added to Bacillus Calmette-Gu&#xE9;rin
induction and maintenance therapy met the primary endpoint of
disease-free survival for patients with high-risk
non-muscle-invasive bladder cancer in the POTOMAC Phase III
trial.</font></font></div>
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<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000; font-size: 13px">
Imfinzi</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="color: #000000; font-size: 13px">in
combination with chemotherapy followed by&#xA0;</font><font style="font-style: italic; color: #000000; font-size: 13px">Imfinzi</font><font style="color: #000000; font-size: 13px">&#xA0;monotherapy
is approved as a 1st-line treatment for primary advanced or
recurrent endometrial cancer (mismatch repair deficient disease
only in the US and EU).&#xA0;</font><font style="font-style: italic; color: #000000; font-size: 13px">Imfinzi</font><font style="color: #000000; font-size: 13px">&#xA0;in
combination with chemotherapy followed by&#xA0;</font><font style="font-style: italic; color: #000000; font-size: 13px">Lynparza</font><font style="color: #000000; font-size: 13px">&#xA0;(olaparib)
and&#xA0;</font><font style="font-style: italic; color: #000000; font-size: 13px">Imfinzi</font><font style="color: #000000; font-size: 13px">&#xA0;is
approved for patients with mismatch repair proficient advanced or
recurrent endometrial cancer in the EU and
Japan.</font></font></div>
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Since the first approval in May 2017, more than 414,000 patients
have been treated with&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">. As part of a broad development
programme,&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;is being tested as a single treatment and in
combinations with other anti-cancer treatments for patients with
NSCLC, bladder cancer, breast cancer, ovarian cancer and several GI
cancers.</font></font></div>
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<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; color: #000000; font-family: Times New Roman; font-size: 13px">
Imjudo</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000">
Imjudo</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="color: #000000">(tremelimumab)
is a human monoclonal antibody that targets the activity of
cytotoxic T-lymphocyte-associated protein 4
(CTLA-4).&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">&#xA0;blocks the activity of CTLA-4, contributing
to T-cell activation, priming the immune response to cancer and
fostering cancer cell death. In addition to its approved
indications in liver and lung cancers,&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">&#xA0;is being tested in combination
with&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;across multiple tumour types including in
SCLC (ADRIATIC) and bladder cancer (VOLGA and
NILE).</font></font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca in GI cancers</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
AstraZeneca has a broad development programme for the treatment of
GI cancers across several medicines and a variety of tumour types
and stages of disease. In 2022, GI cancers collectively represented
approximately 5 million new cancer cases leading to approximately
3.3 million deaths.</font><font style="font-size: 70%; vertical-align: top; color: #000000">8</font></font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
Within this programme, the Company is committed to improving
outcomes in gastric, liver, biliary tract, oesophageal, pancreatic
and colorectal cancers.</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
In addition to its indications in BTC and
HCC,&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;is being assessed in combinations, including
with&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">, in oesophageal and gastric cancers in an
extensive development programme spanning early to late-stage
disease across settings.</font></font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000">
Enhertu</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="color: #000000">(trastuzumab
deruxtecan), a HER2-directed antibody drug conjugate (ADC), is
approved in the US and several other countries for HER2-positive
advanced gastric cancer.&#xA0;</font><font style="font-style: italic; color: #000000">Enhertu</font><font style="color: #000000">&#xA0;is jointly developed and commercialised by
AstraZeneca and Daiichi Sankyo.</font></font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
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<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-style: italic; color: #000000">
Lynparza</font><font style="color: #000000">, a first-in-class PARP
inhibitor, is approved in the US and several other countries for
the treatment of BRCA-mutated metastatic pancreatic
cancer.&#xA0;</font><font style="font-style: italic; color: #000000">Lynparza</font><font style="color: #000000">&#xA0;is developed and commercialised in
collaboration with MSD (Merck &amp; Co., Inc. inside the US and
Canada).</font></font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
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<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
The Company is also assessing rilvegostomig, a PD-1/TIGIT
bispecific antibody, in combination with chemotherapy as an
adjuvant therapy in BTC, in combination with bevacizumab with or
without&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">&#xA0;as a 1st-line treatment in patients with
advanced HCC, and as a 1st-line treatment in patients with
HER2-negative, locally advanced unresectable or metastatic gastric
and gastroesophageal junction cancers.</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="color: #000000">Rilvegostomig
is also being evaluated in combination
with&#xA0;</font><font style="font-style: italic; color: #000000">Enhertu</font><font style="color: #000000">&#xA0;in
previously untreated, HER2-expressing, locally advanced or
metastatic BTC.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
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<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca is advancing multiple modalities that provide
complementary mechanisms for targeting Claudin 18.2, a promising
therapeutic target in gastric cancer. These include sonesitatug
vedotin, a potential first-in-class ADC licensed from KYM
Biosciences Inc., currently in Phase III development; AZD5863, a
novel Claudin 18.2/CD3 T-cell engager bispecific antibody licensed
from Harbour Biomed in Phase I development; and AZD4360, an ADC,
currently being evaluated in a Phase I/II trial in patients with
advanced solid tumours.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
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<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
In early development, AstraZeneca is developing AZD7003, a Glypican
3 (GPC3) armoured CAR T, in HCC.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca in immuno-oncology (IO)</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca is a pioneer in introducing the concept of
immunotherapy into dedicated clinical areas of high unmet medical
need. The Company has a comprehensive and diverse IO portfolio and
pipeline anchored in immunotherapies designed to overcome evasion
of the anti-tumour immune response and stimulate the body's immune
system to attack tumours.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
AstraZeneca strives to redefine cancer care and help transform
outcomes for patients with&#xA0;</font><font style="font-style: italic; color: #000000">Imfinzi</font><font style="color: #000000">&#xA0;as a monotherapy and in combination
with&#xA0;</font><font style="font-style: italic; color: #000000">Imjudo</font><font style="color: #000000">&#xA0;as well as other novel immunotherapies and
modalities. The Company is also investigating next-generation
immunotherapies like bispecific antibodies and therapeutics that
harness different aspects of immunity to target cancer, including
cell therapy and T-cell engagers.</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca is pursuing an innovative clinical strategy to bring
IO-based therapies that deliver long-term survival to new settings
across a wide range of cancer types. The Company is focused on
exploring novel combination approaches to help prevent treatment
resistance and drive longer immune responses. With an extensive
clinical programme, the Company also champions the use of IO
treatment in earlier disease stages, where there is the greatest
potential for cure.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca in oncology</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca is leading a revolution in oncology with the ambition
to provide cures for cancer in every form, following the science to
understand cancer and all its complexities to discover, develop and
deliver life-changing medicines to patients.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
The Company's focus is on some of the most challenging cancers. It
is through persistent innovation that AstraZeneca has built one of
the most diverse portfolios and pipelines in the industry, with the
potential to catalyse changes in the practice of medicine and
transform the patient experience.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca has the vision to redefine cancer care and, one day,
eliminate cancer as a cause of death.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
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<font style="text-decoration: underline; color: #0000FF; font-weight: bold; font-family: Times New Roman; font-size: 13px">
AstraZeneca</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">
AstraZeneca (LSE/STO/NYSE: AZN) is a global, science-led
biopharmaceutical company that focuses on the discovery,
development, and commercialisation of prescription medicines in
Oncology, Rare Diseases, and BioPharmaceuticals, including
Cardiovascular, Renal &amp; Metabolism, and Respiratory &amp;
Immunology. Based in Cambridge, UK, AstraZeneca's innovative
medicines are sold in more than 125 countries and used by millions
of patients worldwide. Please visit</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="text-decoration: underline; color: #0000FF">astrazeneca.com</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="color: #000000">and
follow the Company on Social Media</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="text-decoration: underline; color: #0000FF">@AstraZeneca</font><font style="color: #000000">.</font></font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Contacts</font></div>
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For details on how to contact the Investor Relations Team, please
click</font><font style="color: #000000; font-family: Times New Roman">&#xA0;</font><font style="text-decoration: underline; color: #0000FF">here</font><font style="color: #000000">.
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References</font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">1.&#xA0;&#xA0;
American Cancer Society. What is Liver Cancer? Available at:
https://www.cancer.org/cancer/types/liver-cancer/about/what-is-liver-cancer.html.
Accessed April 2026.&#xA0;</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">2.&#xA0;&#xA0;
AstraZeneca PLC. Investor Relations Epidemiology Spreadsheet. Top 8
Countries. Available at:</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">https://www.astrazeneca.com/investor-relations.html.
Accessed&#xA0;April&#xA0;2026.</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">3.&#xA0;&#xA0;
National Cancer Institute. Embolization. Available at:
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/embolization.
Accessed April 2026.&#xA0;&#xA0;&#xA0;</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">4.&#xA0;&#xA0; Kotsifa E,&#xA0;</font><font style="font-style: italic; color: #000000">et al.</font><font style="color: #000000">&#xA0;Transarterial Chemoembolization for
Hepatocellular Carcinoma: Why, When, How?&#xA0;</font><font style="font-style: italic; color: #000000">J Pers Med.</font><font style="color: #000000">2022;12(3):436.</font></font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">5.&#xA0;&#xA0; Meyer T,&#xA0;</font><font style="font-style: italic; color: #000000">et al.</font><font style="color: #000000">&#xA0;Sorafenib in combination with transarterial
chemoembolisation in patients with unresectable hepatocellular
carcinoma (TACE 2): a randomised placebo-controlled, double-blind,
phase 3 trial.&#xA0;</font><font style="font-style: italic; color: #000000">Lancet Gastroenterol
Hepatol.</font><font style="color: #000000">&#xA0;2017;2(8):565-575.</font></font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">6.&#xA0;&#xA0;
World Health Organization. Liver Cancer Fact Sheet. Available at:
https://gco.iarc.fr/today/data/factsheets/cancers/11-Liver-fact-sheet.pdf.
Accessed April 2026.&#xA0;</font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">7.&#xA0;&#xA0;
Colagrande&#xA0;S,&#xA0;</font><font style="font-style: italic; color: #000000">et al.</font><font style="color: #000000">&#xA0;Challenges of advanced hepatocellular
carcinoma.&#xA0;</font><font style="font-style: italic; color: #000000">World J
Gastroenterol.&#xA0;</font><font style="color: #000000">2016;22(34):7645-7659.&#xA0;</font></font></div>
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -24px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">8.&#xA0;&#xA0;
World Health Organization. World Fact Sheet. Available at:
https://gco.iarc.who.int/media/globocan/factsheets/populations/900-world-fact-sheet.pdf.
Accessed April 2026.</font></div>
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<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
Dr. Abou-Alfa provides consulting and advisory services to
AstraZeneca.</font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Matthew Bowden</font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
Company Secretary</font></div>
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<font style="font-weight: bold; color: #000000; font-family: Times New Roman; font-size: 13px">
AstraZeneca PLC</font></div>
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SIGNATURES</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Pursuant
to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf
by the undersigned, thereunto duly authorized.</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">AstraZeneca
PLC</font></div>
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<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 13px">
Date:</font> 02 April 2026</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">By: /s/
Matthew Bowden</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Name:
Matthew Bowden</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Title:
Company Secretary</font></div>
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