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<xs:schema xmlns:marksandspencer="http://marksandspencer.com/xbrl/2024" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2020-01-21" targetNamespace="http://marksandspencer.com/xbrl/2024" xmlns:xs="http://www.w3.org/2001/XMLSchema">
  <xs:import schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/instance" />
  <xs:import schemaLocation="https://www.esma.europa.eu/taxonomy/2022-03-24/esef_cor.xsd" namespace="https://www.esma.europa.eu/taxonomy/2022-03-24/esef_cor" />
  <xs:import schemaLocation="http://www.xbrl.org/lrr/arcrole/esma-arcrole-2018-11-21.xsd" namespace="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" />
  <xs:import schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" namespace="http://xbrl.org/2005/xbrldt" />
  <xs:import schemaLocation="https://www.xbrl.org/dtr/type/2020-01-21/types.xsd" namespace="http://www.xbrl.org/dtr/type/2020-01-21" />
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="213800EJP14A79ZG1X44-2025-03-29_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="213800EJP14A79ZG1X44-2025-03-29_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="213800EJP14A79ZG1X44-2025-03-29_lab-en.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="213800EJP14A79ZG1X44-2025-03-29_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="https://www.esma.europa.eu/taxonomy/2022-03-24/esef_cor-lab-en.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="https://www.esma.europa.eu/taxonomy/2022-03-24/esef_cor-gen-en.xml" xlink:type="simple" />
      <link:roleType id="ProfitOrLoss" roleURI="http://marksandspencer.com/xbrl/2024/roles/ProfitOrLoss">
        <link:definition>01 - Profit or loss</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfComprehensiveIncome" roleURI="http://marksandspencer.com/xbrl/2024/roles/StatementOfComprehensiveIncome">
        <link:definition>02 - Statement of comprehensive income</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfFinancialPosition" roleURI="http://marksandspencer.com/xbrl/2024/roles/StatementOfFinancialPosition">
        <link:definition>03 - Statement of financial position</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NotesAndMandatoryItems" roleURI="http://marksandspencer.com/xbrl/2024/roles/NotesAndMandatoryItems">
        <link:definition>04 - Notes and Mandatory Items</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfChangesInEquity" roleURI="http://marksandspencer.com/xbrl/2024/roles/StatementOfChangesInEquity">
        <link:definition>05 - Statement of changes in equity</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfCashFlows" roleURI="http://marksandspencer.com/xbrl/2024/roles/StatementOfCashFlows">
        <link:definition>06 - Statement of cash flows</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfCashFlowsParenthetical" roleURI="http://marksandspencer.com/xbrl/2024/roles/StatementOfCashFlowsParenthetical">
        <link:definition>07 - Statement of cash flows (Parenthetical)</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Anchoring" roleURI="http://marksandspencer.com/xbrl/2024/roles/Anchoring">
        <link:definition>99 - Groups all anchored elements</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
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  <xs:element id="marksandspencer_AdjustingItems" xbrli:balance="credit" xbrli:periodType="duration" name="AdjustingItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_ProfitBeforeTaxAndAdjustingItemsNonGAAPMeasure" xbrli:balance="credit" xbrli:periodType="duration" name="ProfitBeforeTaxAndAdjustingItemsNonGAAPMeasure" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_AdjustedBasicEarningsPerShare" xbrli:balance="credit" xbrli:periodType="duration" name="AdjustedBasicEarningsPerShare" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_AdjustedDilutedEarningsPerShare" xbrli:balance="credit" xbrli:periodType="duration" name="AdjustedDilutedEarningsPerShare" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_CurrentPartnershipLiabilityToTheMarksSpencerUKPensionScheme" xbrli:balance="credit" xbrli:periodType="instant" name="CurrentPartnershipLiabilityToTheMarksSpencerUKPensionScheme" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_CurrentBorrowingsAndOtherFinancialLiabilities" xbrli:balance="credit" xbrli:periodType="instant" name="CurrentBorrowingsAndOtherFinancialLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_NonCurrentBorrowingsAndOtherFinancialLiabilities" xbrli:balance="credit" xbrli:periodType="instant" name="NonCurrentBorrowingsAndOtherFinancialLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_CashFlowHedgesRecognisedInInventories" xbrli:balance="credit" xbrli:periodType="duration" name="CashFlowHedgesRecognisedInInventories" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_TaxOnCashFlowHedgesRecognisedInInventories" xbrli:balance="debit" xbrli:periodType="duration" name="TaxOnCashFlowHedgesRecognisedInInventories" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_PurchaseSaleOfCurrentFinancialAssetsClassifiedAsInvestingActivites" xbrli:balance="debit" xbrli:periodType="duration" name="PurchaseSaleOfCurrentFinancialAssetsClassifiedAsInvestingActivites" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_PaymentOfPartnershipLiabilityToTheMarksSpencerUKPensionSchemeClassifiedAsFinancingActivities" xbrli:balance="credit" xbrli:periodType="duration" name="PaymentOfPartnershipLiabilityToTheMarksSpencerUKPensionSchemeClassifiedAsFinancingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_TransactionsWithNonControllingInterest" xbrli:balance="credit" xbrli:periodType="duration" name="TransactionsWithNonControllingInterest" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_InterestPaidOnLeaseLiabilities" xbrli:balance="debit" xbrli:periodType="duration" name="InterestPaidOnLeaseLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_OutstandingNotesRepurchased" xbrli:balance="credit" xbrli:periodType="duration" name="OutstandingNotesRepurchased" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_InterestPayableOnMediumTermNotes" xbrli:balance="credit" xbrli:periodType="duration" name="InterestPayableOnMediumTermNotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="marksandspencer_DescriptionOfAccountingPolicyForAlternativePerformanceMeasures" xbrli:periodType="duration" name="DescriptionOfAccountingPolicyForAlternativePerformanceMeasures" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xs:element id="marksandspencer_DescriptionOfAccountingPolicyForMSBank" xbrli:periodType="duration" name="DescriptionOfAccountingPolicyForMSBank" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xs:element id="marksandspencer_DescriptionOfAccountingPolicyForReserves" xbrli:periodType="duration" name="DescriptionOfAccountingPolicyForReserves" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xs:element id="marksandspencer_DisclosureOfAdjustingItems" xbrli:periodType="duration" name="DisclosureOfAdjustingItems" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xs:element id="marksandspencer_DisclosureOfMarksAndSpencerScottishLimitedPartnership" xbrli:periodType="duration" name="DisclosureOfMarksAndSpencerScottishLimitedPartnership" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
</xs:schema>