TheManagement Board of Medinice S.A. with its registered office in Warsaw(the "Issuer"), with reference to current report No. 4/2026 dated 23January 2026 concerning the execution of a letter of intent (the "LoI")with an international entity operating in the cardiac surgery market,hereby informs that on 28 April 2026 the Parties agreed to extend thevalidity of the LoI until 30 June 2026.

Theextension of the LoI confirms the Parties' intention to continuediscussions regarding the potential sale of the CoolCryo project. Inline with the arrangements agreed to date, the contemplated transactionwould include the transfer of rights to the CoolCryo project, togetherwith its global patent protection, with particular focus on Europe andthe United States.

TheIssuer emphasizes that the extension of the LoI does not constitute theexecution of a definitive agreement and does not guarantee that thetransaction will be completed. The detailed terms of the potentialtransaction, including the final purchase price and payment structure,remain subject to further negotiations and will be set out in adefinitive agreement.

Thisinformation is publicly disclosed given that the continuation ofdiscussions may lead to significant changes in the structure of theIssuer's assets and could have a material impact on its financialposition and asset valuation.

TheIssuer will provide further updates on any material developmentsrelating to this matter through separate current reports, as appropriate.