Notification from person discharging managerial responsibilities in theCompany due to execution of the Stock Grant Program

The Management Board of Ryvu Therapeutics S.A. with its registeredoffice in Krakow, Poland (_quot;Company_quot;) hereby informs that the Companyreceived a notification prepared in accordance with Article 19.1 of MARfrom Mr. Hendrik Nogai - Member of the Management Board as from theperson discharging managerial responsibilities in the Company due to theimplementation of a non-diluting incentive program about which theCompany informed in the current reports No. 10/2021 of April 20th, 2021and No. 14/2021 of May 17th, 2021.The notification is attachedto this report.