Notifications from persons closely associated with a person dischargingmanagerial responsibilities in the Company

The Management Board of Ryvu Therapeutics S.A. with its registeredoffice in Krakow, Poland ("Company") hereby informs that on June 18,2025, the Company received two notifications prepared in accordance withArticle 19.1 of MAR from AUGEBIT Fundusz Inwestycyjny Zamknięty managedby FORUM TFI S.A. with its registered office in Kraków, and from theFundacja Rodziny Wesołowskich Fundacja Rodzinna w Krakowie, as personsclosely associated with Mr. Tadeusz Wesołowski - Vice Chairman of theSupervisory Board of the Company.

As a result of the event described in the submitted notifications, theshareholding of Mr. Tadeusz Wesołowski in the Company, through personsclosely associated with him, has not changed.

The content of the notifications is attached to this report.

Disclaimer: This English language translation has been prepared solelyfor the convenience of English-speaking readers. Despite all the effortsdevoted to this translation, certain discrepancies, omissions orapproximations may exist. In case of any differences between the Polishand the English versions, the Polish version shall prevail. RyvuTherapeutics S.A., its representatives and employees decline allresponsibility in this regard.