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Income Taxes - Effective Income Tax Rate Differs from Federal Statutory Rate (Detail)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Income Tax Disclosure [Abstract]      
Tax provision computed at the federal statutory rate 35.00% 35.00% 35.00%
State income tax provision, net of federal benefit 2.17% 3.93% 4.86%
Federal research credits (11.88%) (8.15%) (12.55%)
Foreign taxes (2.27%) (0.34%) 2.10%
Tax-exempt income (0.75%) (0.53%) (1.94%)
State tax incentives (2.71%) (2.77%) (5.04%)
Stock-based compensation 1.43% 2.53% 6.91%
Domestic production activity deduction (1.13%) (2.23%) (3.17%)
Bargain purchase   (2.64%)  
Impact of U.S. tax reform 26.70%    
Other, net 0.09% 0.08% 1.30%
Effective Tax Rate 46.65% 24.88% 27.47%