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Income Taxes - Effective Income Tax Rate Differs from Federal Statutory Rate (Detail)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Income Tax Disclosure [Abstract]      
Tax provision computed at the federal statutory rate 21.00% 35.00% 35.00%
State income tax provision, net of federal benefit 14.53% 2.17% 3.93%
Federal research credits 14.23% (11.88%) (8.15%)
Foreign taxes (11.45%) (2.27%) (0.34%)
Tax-exempt income 0.45% (0.75%) (0.53%)
State tax incentives 3.15% (2.71%) (2.77%)
Stock-based compensation (2.87%) 1.43% 2.53%
Domestic production activity deduction   (1.13%) (2.23%)
Bargain purchase 8.82%   (2.64%)
Impact of U.S. tax reform 12.00% 26.70%  
Global intangible low-taxed income (GILTI) (17.48%)    
Other, net (0.34%) 0.09% 0.08%
Effective Tax Rate 42.04% 46.65% 24.88%