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Income Taxes - Effective Income Tax Rate Differs from Federal Statutory Rate (Detail)
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Income Tax Disclosure [Abstract]      
Tax provision computed at the federal statutory rate 21.00% 21.00% 35.00%
State income tax provision, net of federal benefit 6.97% 14.53% 2.17%
Federal research credits 15.53% 14.23% (11.88%)
Foreign taxes 2.83% (11.45%) (2.27%)
Tax-exempt income 0.49% 0.45% (0.75%)
State tax incentives 3.85% 3.15% (2.71%)
Change in valuation allowance (172.82%)    
Foreign tax credits 16.69%    
Stock-based compensation (6.01%) (2.87%) 1.43%
Domestic production activity deduction     (1.13%)
Bargain purchase   8.82%  
Impact of U.S. tax reform   12.00% 26.70%
Global intangible low-taxed income ("GILTI") (1.87%) (17.48%)  
Other, net (0.49%) (0.34%) 0.09%
Effective Tax Rate (113.83%) 42.04% 46.65%