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Income Taxes - Effective Income Tax Rate Differs from Federal Statutory Rate (Detail)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Income Tax Disclosure [Abstract]      
Tax provision computed at the federal statutory rate 21.00% 21.00% 21.00%
State income tax provision, net of federal benefit 11.10% 6.97% 14.53%
Federal research credits 57.63% 15.53% 14.23%
Foreign taxes (17.83%) 2.83% (11.45%)
Tax-exempt income 1.93% 0.49% 0.45%
State tax incentives   3.85% 3.15%
Change in valuation allowance 44.79% (172.82%)  
Foreign tax credits 17.90% 16.69%  
Stock-based compensation (23.36%) (6.01%) (2.87%)
Withholding taxes (20.83%)    
Bargain purchase     8.82%
Impact of CARES Act 45.65%    
Impact of U.S. tax reform     12.00%
Global intangible low-taxed income ("GILTI") (0.49%) (1.87%) (17.48%)
Other, net 0.56% (0.49%) (0.34%)
Effective Tax Rate 138.05% (113.83%) 42.04%