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Income Taxes - Effective Income Tax Rate Differs from Federal Statutory Rate (Detail)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
Tax provision computed at the federal statutory rate 21.00% 21.00% 21.00%
State income tax provision, net of federal benefit 13.33% 11.10% 6.97%
Federal research credits 53.77% 57.63% 15.53%
Foreign taxes (4.69%) (17.83%) 2.83%
Tax-exempt income 3.75% 1.93% 0.49%
State tax incentives     3.85%
Change in valuation allowance (75.26%) (44.79%) (172.82%)
Non-deductible transaction costs (39.48%)    
Foreign tax credits 0.14% 17.90% 16.69%
Stock-based compensation 10.74% (23.36%) (6.01%)
Withholding taxes 0.14% (20.83%)  
Alabama law change (25.39%)    
Impact of CARES Act   45.65%  
Return to accrual 9.48%    
Global intangible low-taxed income ("GILTI") (4.29%) (0.49%) (1.87%)
Other, net (0.19%) 0.56% (0.49%)
Effective Tax Rate (36.95%) 138.05% (113.83%)