_________ false

C002	אופקו הלת', אינק		2
Public	OPKO HEALTH, INC
	10017	Corporation no: 2279206
	Stock Exchange/Market: NYSE
	2893
	380	Biscayne Boulevard 4400 , MIAMI, FLORIDA, U.S.A 19808 , ,
	Tel: 13055754100 , Fax: 13055754140
	E.mail address: Contact@Opko.Com	Reported via MAGNA: 10/11/2013
		Time of broadcast: 09:04 09:00:21
	Company site: Www.Opko.Com	Reference: 2013-02-186867

Israel Securities Authority		Tel Aviv Stock Exchange
www.isa.gov.il		www.tase.co.il

Immediate Report

Regulation 4 of the Securities Regulations, (Periodic and Immediate Reports of Foreign Corporation) 5761-2000

The corporation is a foreign private issuer as defined by U.S. Securities Laws.

Attached hereto is a report on Allotment of 25,000 options to Mr. Kolosov Dmitry a member of the board of directors of the Corporation. הקצאה של 25,000 אופציות הניתנות למימוש ל-25,000 מניות רגילות של החברה למר דימיטרי קולוסוב, דירקטור בחברה.

opko2_isa.pdf

References of previous documents relating to this matter(the reference does not constitute incorporation by reference):

Previous names of reporting entity:

Date of revision of form structure: 15/10/2013

Name of the Signatory: : Gerzi Ilan , Position of Signatory in the reporting corporation: Legal Adviser , Name of Employer Company: PEARL COHEN ZEDEK LATZER BARATZ .

Azrieli, Round Tower 18f Telephone: 03-6073777 , Facsimile: 03-6073778 , E-mail: IGERZI@PEARLCOHEN.COM 1