_________ false

C002	אופקו הלת', אינק		2
Public	OPKO HEALTH, INC
	10017	Corporation no: 2279206
	Stock Exchange/Market: NYSE
	2893
	380	Biscayne Boulevard 4400 , MIAMI, FLORIDA, U.S.A 19808 , ,
	Tel: 13055754100 , Fax: 13055754140
	E.mail address: Contact@Opko.Com	Reported via MAGNA: 23/03/2014
		Time of broadcast: 08:44 08:41:43
	Company site: Www.Opko.Com	Reference: 2014-02-020367

Israel Securities Authority		Tel Aviv Stock Exchange
www.isa.gov.il		www.tase.co.il

Immediate Report

Regulation 4 of the Securities Regulations, (Periodic and Immediate Reports of Foreign Corporation) 5761-2000

The corporation is a foreign private issuer as defined by U.S. Securities Laws.

Attached hereto is a report on Purchasing of Common Stock by Frost Gamma Investments Trust Frost Gamma Investments Trust- שינוי אחזקות בעלי עניין

form423414_isa.pdf

References of previous documents relating to this matter(the reference does not constitute incorporation by reference):

Previous names of reporting entity:

Date of revision of form structure: 02/03/2014

Name of the Signatory: : Gerzi Ilan , Position of Signatory in the reporting corporation: Legal Adviser , Name of Employer Company: PEARL COHEN ZEDEK LATZER BARATZ .

Azrieli, Round Tower 18f Telephone: 03-6073777 , Facsimile: 03-6073778 , E-mail: IGERZI@PEARLCOHEN.COM 1