_________ false

אופקו הלת', אינק	2 380
OPKO HEALTH, INC
Corporation no: 2279206	10018

	Israel Securities Authority			Tel Aviv Stock Exchange		C002 ( Public )		Reported via MAGNA:	23/06/2018
	www.isa.gov.il			www.tase.co.il				Reference:	2018-02-054849	Time of broadcast: 07:37 07:28:06

Immediate Report

Regulation 4 of the Securities Regulations, (Periodic and Immediate Reports of Foreign Corporation) 5761-2000

Delay the publication of a report _________ _________

1. The delay of the report can be done up to 72 hours maximum from the date of filling out the form.

2. Attention that in accordance with the provisions of the law, the reporting date must be simultaneous with the report in the foreign exchange.

The corporation is a foreign private issuer as defined by U.S. Securities Laws.

Attached hereto is a report on

interested party transaction

20180623Form4YUSigned.pdf

References of previous documents relating to this matter(the reference does not constitute incorporation by reference):
Stock Exchange/Market: NASDAQ GSM	Date of revision of form structure: 19/06/2018
Address: Ashlegan 16 , Kiryat Gat 8211804   Israel , Tel: 08-9300051 , Fax: 08-9300091
E-mail address: yphilip@opko.com   Company site: Www.Opko.Com
Previous names of reporting entity:
Name of the Signatory: Benor Sharon Position of Signatory in the reporting corporation: Chief Financial Officer Name of Employer Company:
Address: Golda Meir 7 , Nes-Ziona 7414002 Telephone: 08-9300051 Facsimile: 08-9300091 E-mail: sbenor@opko.com 1