Notice regarding the availability of proxy materials for Annual Meeting of Stockholders to be held on June 24, 2021הודעה בדבר זמינות פרוקסי לאסיפה ש false

אופקו הלת', אינק	2 380
OPKO HEALTH, INC
Corporation no: 2279206	13156

	Israel Securities Authority			Tel Aviv Stock Exchange		C002 ( Public )		Reported via MAGNA:	01/05/2021
	www.isa.gov.il			www.tase.co.il				Reference:	2021-02-074934	Time of broadcast: 17:21 17:21

Immediate Report

Regulation 4 of the Securities Regulations, (Periodic and Immediate Reports of Foreign Corporation) 5761-2000

The corporation is a foreign private issuer as defined by U.S. Securities Laws.

Attached hereto is a report on

Notice regarding the availability of proxy materials for Annual Meeting of Stockholders to be held on June 24, 2021 הודעה בדבר זמינות פרוקסי לאסיפה שנתית אשר תתקיים ביום 24 ביוני, 2021

20210501Proxy_isa.pdf

References of previous documents relating to this matter(the reference does not constitute incorporation by reference):
Stock Exchange/Market: NASDAQ GSM	Date of revision of form structure: 20/04/2021
Address: Ashlegan 16 , Kiryat Gat 8211804   Israel , Tel: 08-9300051 , Fax: 08-9543101
E-mail address: gfaibish@opko.com   Company site: Www.Opko.Com
Previous names of reporting entity:
Name of the Signatory: Faibish Gabriel Position of Signatory in the reporting corporation: General Counsel Name of Employer Company:
Address: Ashlegan 16 , Kiryat Gat 8211804 Telephone: 08-9300051 Facsimile: 08-9300091 E-mail: gfaibish@opko.com 1