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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001178913-10-001243.txt : 20100511
<SEC-HEADER>0001178913-10-001243.hdr.sgml : 20100511
<ACCEPTANCE-DATETIME>20100511120727
ACCESSION NUMBER:		0001178913-10-001243
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100511
DATE AS OF CHANGE:		20100511
EFFECTIVENESS DATE:		20100511

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PLURISTEM THERAPEUTICS INC
		CENTRAL INDEX KEY:			0001158780
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				980351734
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			0630

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-141827
		FILM NUMBER:		10819780

	BUSINESS ADDRESS:	
		STREET 1:		MATAM ADVANCED TECHNOLOGY PARK
		STREET 2:		BUILDING NO. 20
		CITY:			HAIFA
		STATE:			L3
		ZIP:			31905
		BUSINESS PHONE:		972-4-850-1080

	MAIL ADDRESS:	
		STREET 1:		MATAM ADVANCED TECHNOLOGY PARK
		STREET 2:		BUILDING NO. 20
		CITY:			HAIFA
		STATE:			L3
		ZIP:			31905

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PLURISTEM LIFE SYSTEMS INC
		DATE OF NAME CHANGE:	20030701

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AI SOFTWARE INC
		DATE OF NAME CHANGE:	20010906
</SEC-HEADER>
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<TYPE>D
<SEQUENCE>1
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<TEXT>
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    <submissionType>D</submissionType>

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        <cik>0001158780</cik>
        <entityName>PLURISTEM THERAPEUTICS INC</entityName>
        <issuerAddress>
            <street1>MATAM ADVANCED TECHNOLOGY PARK</street1>
            <street2>BUILDING NO. 20</street2>
            <city>HAIFA</city>
            <stateOrCountry>L3</stateOrCountry>
            <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
            <zipCode>31905</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>011-972-74-7107171</issuerPhoneNumber>
        <jurisdictionOfInc>NEVADA</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>A.I. Software, Inc.</previousName>
            <previousName>Pluristem Life Systems, Inc.</previousName>
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            <previousName>PLURISTEM LIFE SYSTEMS INC</previousName>
            <previousName>AI SOFTWARE INC</previousName>
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            <overFiveYears>true</overFiveYears>
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    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Zami</firstName>
                <lastName>Aberman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Pluristem Therapeutics Inc.</street1>
                <street2>MATAM Advanced Technology Park</street2>
                <city>Haifa</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>31905</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Israel</firstName>
                <lastName>Ben-Yoram</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Pluristem Therapeutics Inc.</street1>
                <street2>MATAM Advanced Technology Park</street2>
                <city>Haifa</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>31905</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Isaac</firstName>
                <lastName>Braun</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Pluristem Therapeutics Inc.</street1>
                <street2>MATAM Advanced Technology Park</street2>
                <city>Haifa</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>31905</zipCode>
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            <relatedPersonRelationshipList>
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        <relatedPersonInfo>
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                <firstName>Nachum</firstName>
                <lastName>Rosman</lastName>
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            <relatedPersonAddress>
                <street1>Pluristem Therapeutics Inc.</street1>
                <street2>MATAM Advanced Technology Park</street2>
                <city>Haifa</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>31905</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mark</firstName>
                <lastName>Germain</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Pluristem Therapeutics Inc.</street1>
                <street2>MATAM Advanced Technology Park</street2>
                <city>Haifa</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>31905</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Yaky</firstName>
                <lastName>Yanay</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Pluristem Therapeutics Inc.</street1>
                <street2>MATAM Advanced Technology Park</street2>
                <city>Haifa</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>31905</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Shai</firstName>
                <lastName>Pines</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Pluristem Therapeutics Inc.</street1>
                <street2>MATAM Advanced Technology Park</street2>
                <city>Haifa</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>31905</zipCode>
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            <relatedPersonRelationshipList>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Hava</firstName>
                <lastName>Meretzki</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Pluristem Therapeutics Inc.</street1>
                <street2>MATAM Advanced Technology Park</street2>
                <city>Haifa</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>31905</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Doron</firstName>
                <lastName>Shorrer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Pluristem Therapeutics Inc.</street1>
                <street2>MATAM Advanced Technology Park</street2>
                <city>Haifa</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>31905</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-04-26</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse>Item 11 Note: No minimum investment.</clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>250000</totalOfferingAmount>
            <totalAmountSold>250000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>PLURISTEM THERAPEUTICS INC</issuerName>
                <signatureName>/s/ Yaky Yanay</signatureName>
                <nameOfSigner>Yaky Yanay</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2010-05-11</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
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