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Certain Transactions - Other Transactions - Additional Information (Detail) - USD ($) $ in Millions |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | ---
Jan. 08, 2018 | May 12, 2017 | Oct. 31, 2021 | Aug. 31, 2021 | Sep. 30, 2016 | Mar. 31, 2022 | Dec. 31, 2021 | Sep. 30, 2021 | Sep. 30, 2020 | Mar. 31, 2020 | Sep. 30, 2016 | Dec. 31, 2018 | Dec. 31, 2017
Alder [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Noncash or Part Noncash Acquisitions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment | $ 25 |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  |  |  |  |  |  | $ 25 |  |  |
Collaborative agreement milestone payments | $ 150 |  |  |  |  |  |  |  |  |  |  |  |
Otsuka [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Noncash or Part Noncash Acquisitions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment |  | $ 50 |  |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  |  |  |  | $ 35 | $ 15 |  |  |  |
Regeneron [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Noncash or Part Noncash Acquisitions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment |  |  |  |  |  |  |  |  |  |  | $ 250 |  |
Collaborative agreement milestone payments |  |  |  |  | $ 2,230 |  |  |  |  |  |  | $ 120 | $ 120
Research and development costs |  |  |  |  | $ 1,000 |  |  |  |  |  |  |  |
Alvotech [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Noncash or Part Noncash Acquisitions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative agreement milestone payments |  |  |  |  |  | $ 455 |  |  |  |  |  |  |
MedinCell [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Noncash or Part Noncash Acquisitions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative agreement milestone payments |  |  |  | $ 112 |  |  |  |  |  |  |  |  |
MODAG [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Noncash or Part Noncash Acquisitions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
License agreement potential aggregate milestone payments amount |  |  | $ 70 |  |  |  |  |  |  |  |  |  |
MODAG [Member] | Research and Development Expense [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Noncash or Part Noncash Acquisitions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  |  |  | $ 10 |  |  |  |  |  |

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